Review
Oncology
Rebecca Karkia, Sarah Wali, Annette Payne, Emmanouil Karteris, Jayanta Chatterjee
Summary: Endometrial cancer is a common and increasing disease in women. Currently, there is no widely available, accurate, non-invasive test for the diagnosis of endometrial cancer. This review summarizes the current research on blood and urine tests for the diagnosis of this cancer, and identifies potential candidates that need further exploration. The study evaluates the diagnostic accuracy of different biomarkers and provides a reference guide for future research on candidate biomarkers.
Review
Biochemistry & Molecular Biology
Alexander G. Raufi, Michael S. May, Matthew J. Hadfield, Attila A. Seyhan, Wafik S. El-Deiry
Summary: Pancreatic cancer is a highly aggressive malignancy with late detection and high recurrence rate. Liquid biopsies represent an emerging group of technologies that can help with diagnosis, prognosis, treatment response prediction, and recurrence detection. Although not yet approved for routine use, the increasing sensitivity and specificity of contemporary liquid biopsy platforms will likely change clinical practice in the near future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Yanbing Lu, Xin Li, Yun Liu, Jiabin Li, Zhezhou Chen, Xianmeng Meng, Wanming Li, Jin Fang
Summary: Liquid biopsy, using a W3-based molecular beacon (MAB-W3-3G), can detect CTCs and exosomes in the blood of tumor patients. This method has high specificity, plasma stability, and can be completed without sample pretreatment or routine washing procedures. The enumeration of W3-positive CTCs and quantitation of positive exosomes showed potential for more precise clinical diagnosis of colorectal cancer (CRC).
ANALYTICAL CHEMISTRY
(2023)
Review
Oncology
Stephanie Jordaens, Karen Zwaenepoel, Wiebren Tjalma, Christophe Deben, Koen Beyers, Vanessa Vankerckhoven, Patrick Pauwels, Alex Vorsters
Summary: This review aimed to explore the use of urine sampling as a liquid biopsy for noninvasive cancer research. The analysis found that many publications did not report the preanalytical parameters of urine samples, despite the importance of standardization. Urine is being used for various cancer types and contains different analytes. Standard practice protocols and further research are needed to enhance the clinical utility of urine in cancer research and detection.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Sae Seul Choi, Sae Eun Kim, Seon Young Oh, Young-Ho Ahn
Summary: Circular RNAs (circRNAs) with closed-loop structures have been identified as potential liquid biopsy markers for lung cancer diagnosis, prognosis, and treatment monitoring due to their stability and functional versatility.
Review
Oncology
Fumie Igari, Hisashi Tanaka, Armando E. Giuliano
Summary: Liquid biopsy is a rapidly developing field in oncology that detects cancer through DNA, RNA, and protein analysis in body fluids. It provides real-time reporting of tumor burden and is applicable for screening tumor types without standard screening approaches. Genetic mutation and DNA methylation profiling are the main methods for liquid biopsy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Genetics & Heredity
Fei Qi, Fan Gao, Ye Cai, Xueer Han, Yao Qi, Jiawen Ni, Jianfeng Sun, Shengquan Huang, Shaohua Chen, Chunlin Wu, Philipp Kapranov
Summary: Early cancer detection is crucial for positive clinical outcomes. Current methods are often invasive and limited in scope, highlighting the need for non-invasive diagnostics like liquid biopsy. Whole-blood transcriptome analysis shows promise as a reliable biomarker for pan-cancer detection, with long non-coding RNAs demonstrating superior performance.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Shiyu Li, Ming Yi, Bing Dong, Ximin Tan, Suxia Luo, Kongming Wu
Summary: Exosomes, as a new type of liquid biopsy, have the potential to be diagnostic or prognostic biomarkers by delivering cargos including nucleic acids and protein, involving in tumorigenesis, tumor growth, metastasis, and drug resistance.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Gastroenterology & Hepatology
Takumi Onoyama, Shumpei Ishikawa, Hajime Isomoto
Summary: Gastric cancer is a major health concern, and genomics has become an indispensable tool for its treatment. Genomics can help identify new therapeutic targets and provide personalized treatment for patients. Additionally, genomics can predict the anti-tumor effects of immune checkpoint inhibitors and select suitable patients for treatment. Liquid biopsy analysis is also helpful in predicting the genomic status of gastric cancer.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Materials Science, Multidisciplinary
David Caballero, Rui L. Reis, Subhas C. Kundu
Summary: Cancer is a global health issue causing millions of deaths annually. Highly metastatic cancers and late tumor detection present challenges in treatment. Complementary tissue-engineered approaches, such as bioengineered cancer traps, offer potential solutions for early diagnosis and treatment. These traps selectively capture and limit the spread of cancer cells, allowing for liquid biopsy and precision medicine treatments.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Biochemistry & Molecular Biology
Sylvan C. Baca, Ji-Heui Seo, Matthew P. Davidsohn, Brad Fortunato, Karl Semaan, Shahabbedin Sotudian, Gitanjali Lakshminarayanan, Miklos Diossy, Xintao Qiu, Talal El Zarif, Hunter Savignano, John Canniff, Ikenna Madueke, Renee Maria Saliby, Ziwei Zhang, Rong Li, Yijia Jiang, Len Taing, Mark Awad, Cindy H. Chau, James A. Decaprio, William D. Figg, Tim F. Greten, Aaron N. Hata, F. Stephen Hodi, Melissa E. Hughes, Keith L. Ligon, Nancy Lin, Kimmie Ng, Matthew G. Oser, Catherine Meador, Heather A. Parsons, Mark M. Pomerantz, Arun Rajan, Jerome Ritz, Manisha Thakuria, Sara M. Tolaney, Patrick Y. Wen, Henry Long, Jacob E. Berchuck, Zoltan Szallasi, Toni K. Choueiri, Matthew L. Freedman
Summary: Researchers have developed a comprehensive method for analyzing the epigenome of cancer in patient plasma, which can infer the expression levels of diagnostic markers and drug targets and detect epigenetic mechanisms of resistance.
Review
Oncology
Masanori Oshi, Vijayashree Murthy, Hideo Takahashi, Michelle Huyser, Maiko Okano, Yoshihisa Tokumaru, Omar M. Rashid, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Summary: Liquid biopsy, including urine analysis, has become a popular and less invasive method for detecting circulating tumor cells and nucleic acids in cancer patients. It allows for longitudinal repeat sampling and can provide real-time information on tumor evolution, making it a powerful tool for diagnosis and treatment monitoring in both urological and non-urological cancers. Advances in extraction methods of urinary substances have shown close relationships with carcinogenesis, metastasis, and therapeutic response in various types of cancers.
Article
Oncology
Nuria Carmona-Ule, Miriam Gonzalez-Conde, Carmen Abuin, Juan F. Cueva, Patricia Palacios, Rafael Lopez-Lopez, Clotilde Costa, Ana Belen Davila-Ibanez
Summary: In this study, circulating tumor cells (CTCs) were cultured in vitro using growth factors and Nanoemulsions. The cultured CTCs showed mesenchymal and stem cell characteristics, and their culture duration was predictive of progression-free survival in breast cancer patients. The subset of CTCs capable of ex vivo growth may represent the population with metastatic potential in vivo.
Review
Oncology
Edoardo Garbo, Benedetta Del Rio, Giorgia Ferrari, Massimiliano Cani, Valerio Maria Napoli, Valentina Bertaglia, Enrica Capelletto, Christian Rolfo, Silvia Novello, Francesco Passiglia
Summary: To address the issue of high overdiagnosis and false positive rates associated with LDCT-based screening, there is a need for new diagnostic biomarkers, with liquid biopsy ncRNAs detection emerging as a promising approach.
Review
Biochemistry & Molecular Biology
Ana Julia Aguiar de Freitas, Rhafaela Lima Causin, Muriele Bertagna Varuzza, Stephanie Calfa, Cassio Murilo Trovo Hidalgo Filho, Tatiana Takahasi Komoto, Cristiano de Padua Souza, Marcia Maria Chiquitelli Marques
Summary: Liquid biopsy is a new technique that can assess the molecular heterogeneity of breast cancer, aiding in personalized treatment, early screening, and accurate diagnosis. By sampling tumor components from biological samples such as blood, this method can detect circulating tumor cells, circulating tumor DNA, and other markers, providing guidance for breast cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Mark Reddick, Anil K. Pillai, Srinivas Bollineni, Sanjeeva Kalva
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2015)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Alison Palumbo, Seth Toomay, Kanwar Singh, Sanjeeva Kalva
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2017)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Eddie Hyatt, Harold Park, Rajiv Srinivasa, Sanjeeva Kalva
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2017)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Anil Kumar Pillai, Allen M. Joseph, Mark Reddick, Seth Toomay, Sanjeeva Kalva
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2014)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Resmi A. Charalel, Paul B. Lewis, Aliaksei Salei, Andrew Cantos, Gregory Dubel, Kevin M. Baskin, Michael T. Kassin, Olga R. Brook, Ragheed Al-Dulaimi, Sanjeeva P. Kalva, Thomas J. Ward, Jeremy C. Durack, Rajesh P. Shah
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shoban Haridass, Sanjeeva Kalva, Bijesh Yadav, Shyamkumar Nidugala Keshava
Summary: This study surveyed the factors affecting the work-life balance of interventional radiologists and found that having a tough time with administration and not having time to do things one enjoys are the major risk factors for burnout.
INDIAN JOURNAL OF RADIOLOGY AND IMAGING
(2023)
Article
Gastroenterology & Hepatology
Edward Wolfgang Lee, Bijan Eghtesad, Guadalupe Garcia-Tsao, Ziv J. Haskal, Virginia Hernandez-Gea, Hamed Jalaeian, Sanjeeva P. Kalva, Arpan Mohanty, Dominique Thabut, Juan G. Abraldes
Article
Radiology, Nuclear Medicine & Medical Imaging
Patrick D. Sutphin, Sanjeeva P. Kalva
RADIOLOGY-CARDIOTHORACIC IMAGING
(2021)