Journal
PUBLIC HEALTH NUTRITION
Volume 23, Issue 17, Pages 3148-3159Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1368980019003835
Keywords
Mediterranean dietary pattern; Western dietary pattern; Breast cancer; SUN Project; Cohort study
Funding
- Spanish Government-Instituto de Salud Carlos III
- European Regional Development Fund (FEDER) [RD 06/0045]
- CIBER-OBN [PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, G03/140]
- Navarra Regional Government [45/2011, 122/2014, 41/2016]
- University of Navarra
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Objective: Due to the growing interest in the role of dietary patterns (DPs) on chronic diseases, we assessed the association between a posteriori identified DPs in the Seguimiento Universidad de Navarra (SUN) Project - a prospective cohort study in a Mediterranean country - and breast cancer (BC) risk. Design: DPs were ascertained through a principal component analysis based on 31 predefined food groups. BC cases were initially identified through self-report or, if deceased, from death certificates or by notification by the next kin. Women reporting BC were asked to provide a copy of their medical report and diagnoses for confirmation purposes. We fitted Cox regression models to assess the association between adherence to the identified DPs and BC risk. Setting: Spanish university graduates. Participants: We included 10 713 young and middle-aged - mainly premenopausal - women. Results: After a median follow-up of 10 center dot 3 years, we identified 100 confirmed and 168 probable incident BC cases. We described two major DPs: 'Western dietary pattern' (WDP) and 'Mediterranean dietary pattern' (MDP). A higher adherence to a WDP was associated with an increased risk of overall BC (multivariable-adjusted HR for confirmed BC Q4 v. Q1 1 center dot 70; 95 % CI 0 center dot 93, 3 center dot 12; P for trend = 0 center dot 045). Contrarily, adherence to a MDP was inversely associated with premenopausal BC (multivariable-adjusted HR Q4 v. Q1 0 center dot 33; 95 % CI 0 center dot 12, 0 center dot 91). No significant associations were observed for postmenopausal BC. Conclusions: Whereas a higher adherence to the WDP may increase the risk of BC, a higher adherence to the MDP may decrease the risk of premenopausal BC.
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