Article
Oncology
Ines Leao, Catarina Garcia, Pedro Antunes, Ana Campolargo, Isabel Dias, Edite Coimbra, Pedro Oliveira, Horacio Zenha, Horacio Costa, Andreia Capela, Sofia Viamonte, Alberto J. Alves, Ana Joaquim
Summary: Head and neck cancer treatment can have negative impact on health-related quality of life and treatment efficacy. Exercise training may bring benefits to these patients. This study aimed to analyze the acute effects of treatment on patients and their preferences for exercise training. The findings suggest that an exercise training program can improve the physical fitness of patients and reduce toxicities.
Review
Cell Biology
Kaveri T. S. Aiyer, Lisa J. Kroon, Geert J. L. H. van Leenders
Summary: This study conducted a systematic review of the literature to investigate the prognostic value of comedonecrosis in prostate cancer. It found weak evidence suggesting an association between comedonecrosis and adverse outcomes such as biochemical recurrence and metastasis, but the results were heterogeneous and lacked correction for confounding factors.
Review
Biochemistry & Molecular Biology
Maria Jose Rodrigo-Gonzalo, Susana Gonzalez-Manzano, Roberto Mendez-Sanchez, Celestino Santos-Buelga, Jose Ignacio Recio-Rodriguez
Summary: Polyphenols have been shown to have positive effects on chronic diseases and cognitive function, possibly through their ability to counteract neuroinflammation. A review of 14 studies found that nutritional interventions with flavanols, flavonols, or stilbenes improved cognitive deterioration in individuals over 50 years old. The greatest benefits were observed with high doses and longer treatment duration. Cognitive tests and fMRI were used to assess the improvements, and improvements in analytical parameters and blood pressure were also reported.
Review
Oncology
Orellana-Jaen Jesus, Carrasco-Paez Luis, Mora-Fernandez Matilde
Summary: This scoping review explores the effect of physical activity levels and exercise programs on cancer-related cognitive impairment in breast cancer survivors. The findings suggest that increasing physical activity and using exercise programs may have the potential to improve brain health in these survivors. However, methodological heterogeneity needs to be addressed, and further research is needed to apply these findings in a clinical setting.
Review
Oncology
Laura Burgess, Soumyajit Roy, Scott Morgan, Shawn Malone
Summary: Traditionally, high-risk prostate cancer is treated with a combination of radiotherapy and androgen deprivation therapy. Recent advancements in systemic treatment and radiotherapy have expanded the treatment spectrum for this patient population. Emerging evidence has redefined the role of surgery and identified new systemic therapy options, as well as ushered in a new era in patient selection, risk stratification, and treatment tailoring with the use of advanced imaging modalities and genomic classifiers.
Article
Oncology
Natalia Araujo, Adriana Costa, Catarina Lopes, Luisa Lopes-Conceicao, Augusto Ferreira, Filipa Carneiro, Jorge Oliveira, Samantha Morais, Luis Pacheco-Figueiredo, Luis Ruano, Vitor Tedim Cruz, Susana Pereira, Nuno Lunet
Summary: The impact of prostate cancer on cognitive performance may be negligible in the short term, unlike other types of cancer.
Review
Psychiatry
Yazen Alnefeesi, Ashley Siegel, Leanna M. W. Lui, Kayla M. Teopiz, Roger C. M. Ho, Yena Lee, Flora Nasri, Hartej Gill, Kangguang Lin, Bing Cao, Joshua D. Rosenblat, Roger S. McIntyre
Summary: The prevalence and etiology of cognitive impairment in COVID-19 patients, especially in relation to inflammation and cytokine storms, indicate a significant impact on brain health. High rates of cognitive deficits, primarily delirium, are reported, with inflammatory markers potentially playing a crucial role in mediating these impairments.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Oncology
Silvia Soares, Susana G. Guerreiro, Natalia Cruz-Martins, Isabel Faria, Pilar Baylina, Maria Goreti Sales, Miguel A. Correa-Duarte, Ruben Fernandes
Summary: Research on miRNomics has shown great potential in cancer personalized medicine, especially in understanding the mechanisms of radioresistance in prostate cancer patients undergoing radiation therapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Yi Yang, Kun Wang, Hengxu Liu, Jiawei Qu, Yan Wang, Peijie Chen, TingRan Zhang, Jiong Luo
Summary: This paper comprehensively summarizes the origin, development, participation forms, and fitness effects of the Otago exercise program (OEP). The study found that OEP is beneficial for improving the cognitive function, lower limb muscle strength, and balance ability of older adults, and preventing falls. It also helps improve the falling efficiency and subjective wellbeing of older adults. However, the neural mechanism for preventing falls is not clear, and further research is needed on how to combine OEP with emerging technologies.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Francesco Esperto, Loris Cacciatore, Francesco Tedesco, Antonio Testa, Pasquale Calle, Alberto Ragusa, Noemi Deanesi, Antonio Minore, Francesco Prata, Aldo Brassetti, Rocco Papalia, Roberto Mario Scarpa
Summary: This study retrospectively selected 577 patients who underwent prostate biopsy between 2020 and 2021 to assess the rate of lost patients due to the lack of a robotic platform. The results showed that 68.3% of patients were not treated in our hospital due to the lack of a robotic platform.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cell Biology
Sana Belkahla, Insha Nahvi, Supratim Biswas, Irum Nahvi, Nidhal Ben Amor
Summary: Prostate cancer is the most common type of cancer affecting modern men after lung cancer, especially in regions with a high human development index. Despite some success in treatment and management, controlling the rapid advancement of prostate cancer remains a challenge for scientists and clinicians. There has been a consistent increase in prostate cancer incidence in the gulf countries in recent years.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Alicja Popiolek, Bartosz Brzoszczyk, Piotr Jarzemski, Aleksandra Chyrek-Tomaszewska, Radoslaw Wieczor, Alina Borkowska, Maciej Bielinski
Summary: PSA levels at a distant postoperative time and free T level after hormonal treatment may be biomarkers of cognitive function. There was a strong correlation between PSA levels and verbal memory and executive function tests, with a trend observed for visuospatial memory. Free T levels after hormonal treatment were significantly correlated with executive functions, with the impact of comorbid diabetes on these correlations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Farnaz Aghazadeh Shabestari, Saba Vaezi, Atefe Abak, Hamed Shoorei, Arash Karimi, Mohammad Taheri, Abbas Basiri
Summary: Quercetin is a flavonoid agent found in fruits and vegetables, known for its anti-inflammatory, antioxidant, and anticancer effects, specifically targeting prostate cancer. It can inhibit cell cycle transition and induce apoptosis in neoplastic cells, showing differential cytotoxic effects on cancerous cells compared to normal prostate cells. Moreover, quercetin may enhance the effects of other therapeutic options against prostate cancer, such as in combination with TRAIL as a novel modality for treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Behavioral Sciences
Janine S. Spitzhuettl, Martin Kronbichler, Lisa Kronbichler, Valentin Benzing, Valerie Siegwart, Manuela Pastore-Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Claudia M. Roebers, Maja Steinlin, Kurt Leibundgut, Regula Everts
Summary: This study found that even without brain tumors, non-central nervous system cancer and its treatment can lead to persistent cerebral alterations in resting-state network connectivity. Patients showed lower executive functions compared to controls, and functional hyperconnectivity was related to weaker memory performance in the patients' group.
BRAIN AND BEHAVIOR
(2021)
Review
Oncology
Oscar Y. Y. Franco-Rocha, Kimberly A. A. Lewis, Kayla D. D. Longoria, Alexa De La Torre Schutz, Michelle L. L. Wright, Shelli R. R. Kesler
Summary: This scoping review synthesized the available literature on cancer-related cognitive impairment (CRCI) in racial and ethnic minority populations. The findings suggest that there are disparities in CRCI among racial and ethnic minoritized individuals, with Black and non-white patients being more likely to experience CRCI compared to their white counterparts. The study suggests the need for standardized guidelines in measuring and reporting the racial and ethnic composition of research samples, differentiation of CRCI findings by racial and ethnic subgroups, consideration of the influence of structural racism on health outcomes, and development of strategies to promote the participation of racial and ethnic minority groups.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)