Article
Neurosciences
Stephanie Raymann, Sina M. Schalbetter, Ron Schaer, Alexandra C. Bernhardt, Flavia S. Mueller, Urs Meyer, Ulrike Weber-Stadlbauer
Summary: Prenatal immune activation can have transgenerational effects on brain and behavior, affecting cognitive functions and gene expression patterns across multiple generations. These effects are found to be transmitted through both maternal and paternal lineages and are accompanied by changes in maternal care behavior.
Article
Biochemistry & Molecular Biology
Tertia D. Purves-Tyson, Ulrike Weber-Stadlbauer, Juliet Richetto, Debora A. Rothmond, Marie A. Labouesse, Marcello Polesel, Kate Robinson, Cynthia Shannon Weickert, Urs Meyer
Summary: The research indicates that immune-related changes in the dopaminergic areas of the midbrain of schizophrenia patients are associated with a subgroup showing high immune status. The study also suggests that maternal immune activation (MIA) may be one of the contributing factors underlying persistent neuroimmune changes in the midbrain of people with schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
Article
Immunology
J. P. Nakamura, A. Schroeder, A. Gibbons, S. Sundram, R. A. Hill
Summary: The study shows that maternal immune activation during pregnancy impacts schizophrenia-related cognitive constructs, but this is highly dependent on the timing of infection and the offspring's sex. Early MIA exposure causes female-specific cognitive disruptions, while late exposure affects male cognition, influencing neurodevelopmental processes.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Neurosciences
Giuseppe Talani, Francesca Biggio, Ashish Avinash Gorule, Valentina Licheri, Eleonora Saolini, Daniele Colombo, Gabriele Sarigu, Michele Petrella, Francescangelo Vedele, Giovanni Biggio, Enrico Sanna
Summary: The repeated maternal separation (RMS) model was used to study the long-term effects of early-life stress on brain neurophysiology in mice. The study found significant changes in synaptic transmission and cognitive performance in male mice exposed to RMS. Female mice also showed some changes, but to a lesser extent. Furthermore, the study found that early injection of estrogen prevented the effects of RMS.
Article
Biochemistry & Molecular Biology
Rebecca M. Woods, Jarred M. Lorusso, Isabella Harris, Hager M. Kowash, Christopher Murgatroyd, Joanna C. Neill, Jocelyn D. Glazier, Michael Harte, Reinmar Hager
Summary: Exposure to maternal immune activation (MIA) in utero increases the risk of neurodevelopmental disorders. The study investigates the relationship between MIA and cognitive deficits by focusing on Reelin signalling in the brain. The findings suggest that dysregulation of Reelin signalling due to MIA contributes to cognitive deficits through altered NMDA receptor function.
Article
Pharmacology & Pharmacy
Wen-Qiang Ge, Ou-Yang Zhan-Mu, Chao Chen, Hong Zhang, Xiao-Yu Wang, Xin Liu, Li Li, Yu-Ye Lan, Chen-Nan Li, Jia-Can Sun, Run-Lin Shi, Zi-Yue Dou, Hui-Lin Pan, Hong-Ping Li, Xiang-Hong Jing, Man Li
Summary: Electroacupuncture (EA) reduces chronic itch by activating CB1 receptors on glutamatergic neurons and inhibiting CB1 receptors on GABAergic neurons in the vlPAG, thereby reducing the release of 5-HT in the medulla oblongata and GRPR signaling in the spinal cord. This study advances our understanding of the therapeutic mechanisms of EA on chronic itch and guides the selection of optimal parameters and acupoints for treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Aodan Laighneach, Lieve Desbonnet, John P. Kelly, Gary Donohoe, Derek W. Morris
Summary: The study combined multiple gene expression studies to investigate genes, pathways, and cell types dysregulated in MIA mouse models, finding consistent dysregulation of genes linked to SCZ and ASD. The cellular location of molecular mechanisms between the MIA model and neurodevelopmental disease was identified, improving understanding of prenatal infection as an environmental stressor.
Article
Behavioral Sciences
Paulina Cieslik, Joanna M. Wieronaka
Summary: The mGlu7 receptor is highly expressed in the brain and may be involved in the pathophysiology of schizophrenia, serving as a potential target for antipsychotic drug discovery. Ligands of this receptor show promise in animal models of schizophrenia, particularly negative allosteric modulators (NAMs), suggesting that inhibiting the receptor could be a promising approach in developing novel treatments. The expression of the receptor in the CNS and potential mechanisms by which its inhibition may contribute to the treatment of schizophrenia, along with genetic polymorphisms in schizophrenic patients, are also discussed in this review.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Review
Biochemistry & Molecular Biology
Michela Matteoli, Davide Pozzi, Matteo Fossati, Elisabetta Menna
Summary: In the last two decades, the concept of synaptopathy has been widely used to emphasize that impairments of synaptic structure and function are the main determinant of brain disorders, including neurodevelopmental disorders. The understanding of the genetic architecture of these disorders has highlighted the convergence of genetic risk factors on synapse-related molecular pathways. However, the involvement of environmental factors and inflammation has also been recognized, with immune molecules contributing to synaptic dysfunction. This review discusses the concept of immune-synaptopathy and recent evidence suggesting a bidirectional link between genetic architecture and maternal immune system activation in modulating brain development.
Article
Pharmacology & Pharmacy
F. Markus Leweke, Cathrin Rohleder, Christoph W. Gerth, Martin Hellmich, Ralf Pukrop, Dagmar Koethe
Summary: CBD and AMI show comparable efficacy in improving neurocognitive functioning in young and acutely ill schizophrenia patients, with CBD also enhancing sustained attention and visuomotor coordination.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Flavia S. Mueller, Joseph Scarborough, Sina M. Schalbetter, Juliet Richetto, Eugene Kim, Amalie Couch, Yohan Yee, Jason P. Lerch, Anthony C. Vernon, Ulrike Weber-Stadlbauer, Urs Meyer
Summary: Research has shown that offspring exposed to the same MIA can be divided into different subgroups with significant differences in behavior, transcription, brain networks, and immune spectra. Offspring with a high innate inflammatory cytokine status displayed impairments in social approach and sensorimotor gating in adulthood.
MOLECULAR PSYCHIATRY
(2021)
Article
Immunology
Michele Santoni, Claudia Sagheddu, Valeria Serra, Rafaela Mostallino, Maria Paola Castelli, Francesco Pisano, Maria Scherma, Paola Fadda, Anna Lisa Muntoni, Erica Zamberletti, Tiziana Rubino, Miriam Melis, Marco Pistis
Summary: Prenatal infections, when combined with other postnatal insults, can increase the risk of developing psychiatric disorders such as schizophrenia in the offspring. In a rat model, maternal immune activation (MIA) was found to affect the endocannabinoid system and endocannabinoid-mediated modulation of dopamine functions. MIA offspring showed altered locomotor activity, abnormal response to THC, and dysregulation of neuroinflammatory markers and synaptic plasticity, which contribute to psychotic-like symptoms in adulthood.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Psychiatry
S. Andrea Wijtenburg, Min Wang, Stephanie A. Korenic, Shuo Chen, Peter B. Barker, Laura M. Rowland
Summary: Proton magnetic resonance spectroscopy (MRS) studies in schizophrenia have revealed altered GABAergic, glutamatergic, and bioenergetic pathways, with multi-region differences observed between subjects with schizophrenia, first-degree relatives, and healthy controls using 7T MRS. These differences suggest potential genetic vulnerability and evolution with illness duration, not solely attributed to antipsychotic interventions.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Behavioral Sciences
Bradley J. Dixon, Jyothika Kumar, Claudia Danielmeier
Summary: This systematic review explores the differences in cognitive control functions and neurometabolite levels between schizophrenia patients and healthy controls. The study finds that chronic patients show decreased GABA and glutamate concentrations, while the results for first-episode patients are mixed. The review also suggests that working memory and processing speed are associated with GABA and glutamate levels, but the relationship between metabolites and negative symptoms is inconsistent.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Cell Biology
Wei Sun, Yazi Mei, Xiaoliang Li, Yang Yang, Lei An
Summary: Prenatal exposure to maternal infection may impact learning and memory through altering proBDNF expression, resulting in contextual memory deficits.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Psychiatry
Tasnim Rahman, Tertia Purves-Tyson, Amy E. Geddes, Xu-Feng Huang, Kelly A. Newell, Cynthia Shannon Weickert
Summary: Lower levels of N-methyl-D-aspartate receptor (NMDAR) GluN1 subunit and heightened neuroinflammation are found in the cortex in schizophrenia. Changes in NMDAR composition, specifically the ratios of GluN2A:GluN2B binding and GRIN2A:GRIN2B mRNA, are associated with inflammation in schizophrenia cases.
SCHIZOPHRENIA RESEARCH
(2022)
Review
Psychiatry
Noor S. Jarbou, Kelly A. Newell
Summary: This review examines the impact of exercise during pregnancy on depressive and associated symptoms. The evidence suggests that exercise of various types can reduce depressive and/or anxiety symptoms in the perinatal period, particularly in women with antenatal depression who undergo yoga-based interventions.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Article
Psychiatry
Samara J. Brown, Amelia M. Brown, Tertia D. Purves-Tyson, Xu-Feng Huang, Kelly A. Newell, Cynthia Shannon Weickert
Summary: This study suggests that alterations in the kynurenine pathway may contribute to the development of depression. The increased gene expression of enzymes in the kynurenine pathway indicates an activation of the kynurenic acid arm, possibly related to astrocyte response in depression. These findings point to dysfunction of the kynurenine pathway and its potential role in glutamate dysfunction in depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Jeremy S. Lum, Tracey Berg, Christen G. Chisholm, Michele Vendruscolo, Justin J. Yerbury
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron loss and paralysis. Synaptic alterations and protein homeostasis disturbances in the motor neuron presynaptic terminal may contribute to the synaptic dysfunction observed in ALS.
NEUROSCIENCE LETTERS
(2022)
Article
Geriatrics & Gerontology
Zhizhen Wang, Peng Zheng, Xi Chen, Yuanyi Xie, Katrina Weston-Green, Nadia Solowij, Yee Lian Chew, Xu-Feng Huang
Summary: CBD treatment can extend lifespan and rescue age-associated physiological declines in C. elegans by promoting autophagy and improving neuronal health. These findings highlight the potential anti-aging benefits of CBD in both in vitro and in vivo models.
Article
Chemistry, Analytical
Neville S. Ng, Simon Maksour, Jeremy S. Lum, Michelle Newbery, Victoria Shephard, Lezanne Ooi
Summary: This study aimed to optimize and apply a cost-effective protocol for direct sampling of gene expression data from microplate cell cultures, overcoming the limitations of routine RT-qPCR analysis. The optimized protocol involves direct lysis of microplate well population followed by a reduced thermocycler reaction time one-step RT-qPCR assay. The protocol provides quick and cost-comparable microplate gene expression results, which can be utilized in various cell-based applications.
Article
Biochemistry & Molecular Biology
Mikayla L. Brown, Luke McAlary, Jeremy S. Lum, Natalie E. Farrawell, Justin J. Yerbury
Summary: CuATSM has shown therapeutic effectiveness in ALS mouse models, but only for wild-type-like SOD1 mutants. It has genotype-specific effects and can cause adverse events at high doses. The therapeutic window of CuATSM depends on the specific variant of the SOD1 mutant and the availability of copper-depleted SOD1.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Psychiatry
Katrina Weston-Green
Summary: Schizophrenia is a complex disorder with varied symptoms, and there is a need for improved treatment options. By understanding the basic science and pharmacological mechanisms of new drugs, it is possible to target specific sub-populations of patients for more effective treatment. This approach to schizophrenia treatment may be more achievable and beneficial than treating it as a homogeneous disorder.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Gabriela Visini, Samara Brown, Katrina Weston-Green, Cynthia Shannon Weickert, Rose Chesworth, Tim Karl
Summary: This study aimed to investigate the effect of CBD given during adolescence on the development of schizophrenia-relevant phenotypes and sensitivity to THC. The results showed that CBD increased locomotion and had anxiolytic effects, while also enhancing social behavior in response to THC. However, CBD did not alleviate schizophrenia-relevant phenotypes in mutant mice and increased vulnerability to THC-induced behaviors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Jeremy S. Lum, Justin J. Yerbury
Summary: Protein homeostasis plays a crucial role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Pathological accumulation of ALS-associated proteins occurs within the axo-synaptic compartment of motor neurons, leading to synaptic dysfunction. The earliest pathological alterations in ALS occur at the synapse, prior to motor neuron loss.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Psychiatry
Samara J. Brown, Amelia M. Brown, Tertia D. Purves-Tyson, Xu-Feng Huang, Cynthia Shannon Weickert, Kelly A. Newell
Summary: This study found that the glutamatergic system may play a central role in the neurobiology and treatment of major depressive disorder (MDD) and psychosis. Gene expression measurement showed increased levels of GRIN2B mRNA and a trend increase in GRIN1 mRNA in MDD subjects, suggesting dysfunction of the glutamatergic system in MDD. Additionally, a significant decrease in the GRIN2A:GRIN2B mRNA ratio was observed in MDD subjects with psychosis.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Samara J. Brown, Katerina Christofides, Christin Weissleder, Xu-Feng Huang, Cynthia Shannon Weickert, Chai K. Lim, Kelly A. Newell
Summary: This study found that the kynurenine pathway (KP) in the brains of individuals with major depressive disorder (MDD) undergoes changes, with decreased KYNA levels in female patients. In addition, suicide victims with MDD also had significantly decreased KYNA levels, which may be related to increased KYAT2 mRNA.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jessica G. Bartschi, Lisa-Marie Greenwood, Amy Montgomery, Lon Dortants, Katrina Weston-Green, Xu-Feng Huang, Nagesh Pai, Jan Potter, Mark M. Schira, Rodney Croft, Nadia Solowij
Summary: This trial aims to investigate the effects of CBD on neuroanatomical and psychological outcomes in individuals with early-stage dementia, with the potential to provide a novel and accessible treatment approach for this condition.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)