Review
Environmental Sciences
Yujie Wei, Xiaona Guo, Lifeng Li, Wenhua Xue, Longhao Wang, Chengxin Chen, Shilong Sun, Yaqi Yang, Wu Yao, Wei Wang, Jie Zhao, Xiaoran Duan
Summary: Polycyclic aromatic hydrocarbons (PAHs) are environmental toxicants that can cause a range of toxic reactions in humans. Long-term exposure to PAHs is associated with an increased incidence of cancer. The N6-methyladenosine (m6A) modification affects RNA metabolism and is linked to the development of various diseases. Abnormal expression of m6A-binding proteins is implicated in the malignant proliferation and metastasis of cancers. Environmental toxicants, including PAHs, can impact m6A methylation and protein expression, thereby promoting the occurrence and development of cancers. m6A may serve as a biomarker for early environmental exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Neurosciences
Lin Zhang, Jian Xia
Summary: This review summarizes the relationship between m6A modification and cell apoptosis, particularly its role in the nervous system, and analyzes the limitations of current research.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Min Li, Xuan Zha, Shengjun Wang
Summary: The widely studied N6-methyladenosine (m6A) modification of mRNA has shown conflicting effects on tumor progression. In addition to its impact on tumor cells, m6A mRNA also plays a crucial role in stromal cells within the tumor microenvironment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Cell Biology
He Huang, Renhua Song, Justin J. -L. Wong, Victor Anggono, Jocelyn Widagdo
Summary: The aged brain experiences cognitive decline and increased vulnerability to neurodegenerative disorders. Molecular studies have shown various hallmarks associated with aging through transcriptomics and proteomic analysis. Recent epitranscriptomic analysis has focused on the role of RNA chemical modification, particularly N6-methyladenosine (m6A), in biological processes such as learning and memory. This study examines the m6A-transcriptomic landscape in the aging mouse hippocampus, revealing changes in methylation levels and their correlation with transcript expression. The findings suggest a co-transcriptional regulation of m6A with gene expression changes in the aged hippocampus.
Review
Biochemical Research Methods
Daoyu Duan, Wen Tang, Runshu Wang, Zhenxing Guo, Hao Feng
Summary: RNA methylation, including N6-methyladenosine (m(6)A), is a research domain for studying gene expression regulation. MeRIP-seq is a sequencing biotechnology that quantifies m(6)A levels and expands RNA epigenetics study. There are multiple statistical methods for identifying differentially methylated regions (DMRs), but a comprehensive evaluation is lacking. This study assesses eight existing methods for DMR calling and finds that TRESS and exomePeak2 perform the best in terms of precision, FDR, type I error control, and runtime, while DRME and exomePeak have high sensitivity but inflated FDR and type I error.
BRIEFINGS IN BIOINFORMATICS
(2023)
Review
Cell Biology
Lin Zhang, Jian Xia
Summary: Cell senescence is the growth arrest caused by the accumulation of irreparable cell damage, and m(6)A modification may affect cell senescence.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Ping Wu, Xing Fang, Yalan Liu, Yaoyun Tang, Wei Wang, Xin Li, Yuhua Fan
Summary: This study found that circRNA circCUX1 is upregulated in patients with HPSCC, mediates radiotherapy resistance through m6A methylation, and affects radiotherapy efficacy by inhibiting the release of inflammatory factors.
CELL DEATH & DISEASE
(2021)
Review
Genetics & Heredity
Qiang Liu
Summary: N6-methyladenosine (m6A) is a reversible post-transcriptional modification that alters gene expression, thereby regulating cell processes. Abnormal m6A methylation is directly related to tumor formation. The latest progress in m6A RNA methylation research has important implications for the occurrence and development of bladder cancer.
FRONTIERS IN GENETICS
(2022)
Article
Biology
Zhenkai Dai, Kayvan Etebari, Sassan Asgari
Summary: The analysis of m(6)A RNA modifications in the mosquito transcriptome and their changes during dengue virus infection provides insights into the role of epigenetics in regulating viral replication in mosquitoes.
COMMUNICATIONS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haiqing Yang, Yuting Li, Linying Huang, Miaochun Fang, Shun Xu
Summary: This review summarizes the critical role of N6-methyladenine (m6A) modification in glycolipid metabolism and glycolipid metabolic disease (GLMD), focusing on its effects and regulatory mechanisms on glucose and lipid metabolism as well as the development of GLMD.
Review
Cell Biology
Peipei Li, Yuntao Wang, Yiwen Sun, Sanjie Jiang, Jingjing Li
Summary: N-6-methyladenosine (m(6)A) RNA methylation plays a crucial role in various RNA metabolism pathways, ultimately affecting pathological processes, especially oncogenic and tumor-suppressing activities. Recent studies also suggest its involvement in immune cells and tumor immunity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Dermatology
Gaofeng Wang, Dongqiang Zeng, Evan Sweren, Yong Miao, Ruosi Chen, Junjun Chen, Jin Wang, Wangjun Liao, Zhiqi Hu, Sewon Kang, Luis A. Garza
Summary: RNA methylation inhibits self-recognition and immunogenicity of RNA. N6-methyladenosine (m6A) affects prognosis and treatment response in melanoma. The m6A modification patterns were correlated with immune cell infiltration and survival. Low m6Ascores were associated with an immune-inflamed phenotype and better treatment response, while high m6Ascores correlated with an immune-excluded phenotype and poor survival. The m6Ascore reflects melanoma progression, immune exhaustion, and resistance to immunotherapy.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuru Wang, Zijie Zhang, Caraline Sepich-Poore, Lisheng Zhang, Yu Xiao, Chuan He
Summary: The study introduces a new method, LEAD-m(6)A-seq, which significantly improves the efficiency of locus-specific analysis of m(6)A modification by coupling it to next generation sequencing technology. This strategy allows for high-throughput validation and detection of m(6)A modification at selected sites, with high reproducibility in evaluating differential methylation levels.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Cell Biology
Shuai Liu, Yongfeng Lao, Yanan Wang, Rongxin Li, Xuefeng Fang, Yunchang Wang, Xiaolong Gao, Zhilong Dong
Summary: Epigenetic alterations, especially RNA methylation, play a crucial role in various diseases, particularly in male infertility and genital system tumors. The biological effects of RNA m6A modification are dynamically regulated by methyltransferases, demethylases, and m6A binding proteins.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zhaolin Chen, Ying Hu, Le Jin, Fan Yang, Haiwen Ding, Lei Zhang, Lili Li, Tingting Pan
Summary: N6-methyladenosine (m(6)A) RNA methylation plays a crucial role in human tumorigenesis and can be a potential therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Ye, Shiqiang Cheng, Xiaomeng Chu, Yan Wen, Bolun Cheng, Li Liu, Chujun Liang, Om Prakash Kafle, Yumeng Jia, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Feng Zhang
Summary: The study found significant associations between electronic devices use and mental traits in the UK Biobank cohort, with TV watching associated with depression score, anxiety score, and alcohol drinking; computer using associated with cigarette smoking; and computer playing associated with depression score. Gene-environment interaction study identified genetic loci interacting with electronic devices use on various mental traits.
Article
Neuroimaging
Huijie Zhang, Li Liu, Shiqiang Cheng, Yumeng Jia, Yan Wen, Xuena Yang, Peilin Meng, Chun'e Li, Chuyu Pan, Yujing Chen, Zhen Zhang, Jingxi Zhang, Feng Zhang
Summary: This study aims to explore the potential interaction effects of brain aging and gut microbiota on sleep, anxiety, and depression disorders. The findings reveal the significant impacts of brain aging and gut microbiota on the development of these disorders. The study provides new insights for understanding the pathogenesis of sleep, anxiety, and depression disorders.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Cell Biology
Ping Li, Shiqiang Cheng, Yan Wen, Bolun Cheng, Li Liu, Xiuhua Wu, Xiang Ao, Zucheng Huang, Congrui Liao, Shaen Li, Feng Zhang, Zhongmin Zhang
Summary: This study aimed to identify novel candidate genes related to ALS. Through a transcriptome-wide association study, 761 significant genes, 627 gene ontology terms, and 8 Kyoto Encyclopedia of Genes and Genomes pathways for ALS were identified. Furthermore, 107 common genes, 4 KEGG pathways, and 41 GO terms were detected by integrating the mRNA expression profiles.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Psychology, Clinical
Yao Yao, Xin Qi, Yumeng Jia, Jing Ye, Xiaomeng Chu, Yan Wen, Bolun Cheng, Shiqiang Cheng, Li Liu, Chujun Liang, Cuiyan Wu, Xi Wang, Yujie Ning, Sen Wang, Feng Zhang
Summary: This study used polygenic risk scores to analyze the interactions between gut microbiome and dietary habits in relation to depression and anxiety. The findings identified common interactions between specific diet choices and gut microbiome composition that were associated with depression and anxiety. This study expands our understanding of the complex relationship between diet, gut microbiome, and mental health.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Peilin Meng, Jing Ye, Xiaomeng Chu, Bolun Cheng, Shiqiang Cheng, Li Liu, Xuena Yang, Chujun Liang, Feng Zhang
Summary: This study used time-to-event data analysis to identify susceptibility genetic variants associated with mental disorders (MD) and investigated the role of environmental factors in these associations. Multiple novel loci associated with MD were identified, and the study also found that multiple environmental factors could influence the associations between these loci and MD.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Yao Yao, Yumeng Jia, Yan Wen, Bolun Cheng, Shiqiang Cheng, Li Liu, Xuena Yang, Peilin Meng, Yujing Chen, Chun'e Li, Jingxi Zhang, Zhen Zhang, Chuyu Pan, Huijie Zhang, Cuiyan Wu, Xi Wang, Yujie Ning, Sen Wang, Feng Zhang
Summary: This study aimed to comprehensively analyze the genetic factors of sleep behaviors, identify candidate genes and biomarkers associated with sleep health score, and explore the genetic correlations between sleep health score and other traits and diseases.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Nutrition & Dietetics
Xin Qi, Jing Ye, Yan Wen, Li Liu, Bolun Cheng, Shiqiang Cheng, Yao Yao, Feng Zhang
Summary: This study used data from the UK Biobank cohort and found genetic correlations and interactions between diet habits and gut microbiota that are associated with sleep. Multiple diet-gut microbiota interactions associated with sleep were identified, providing new insights into the mechanisms of how diet and gut microbiota affect sleep.
Article
Psychology, Clinical
Chuyu Pan, Xin Qi, Shiqiang Cheng, Yujing Chen, Chun'e Li, Huijie Zhang, Jingxi Zhang, Zhen Zhang, Xuena Yang, Peilin Meng, Yao Yao, Yan Wen, Yumeng Jia, Feng Zhang
Summary: This study investigates the impact of socioeconomic deprivation on smoking behaviors and biological mechanisms. Through research on the UK Biobank cohort, it was found that higher levels of poverty were associated with increased smoking frequency and risk. The study also reveals the associations between Index of Multiple Deprivation (IMD) and its subdomains with smoking behaviors, as well as the interaction effects between socioeconomic deprivation and genetic factors on smoking behaviors.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2022)
Review
Behavioral Sciences
Xin Qi, Yumeng Jia, Chuyu Pan, Chune Li, Yan Wen, Jingcan Hao, Li Liu, Bolun Cheng, Shiqiang Cheng, Yao Yao, Feng Zhang
Summary: This study explores the interaction effects of social environmental and genetic factors on the risks of common psychiatric disorders. The higher levels of deprivation index are significantly associated with higher risks of bipolar disorder, depression, and anxiety. Additionally, multiple candidate genetic loci interacting with the deprivation index were identified.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychiatry
Li Liu, Shiqiang Cheng, Xin Qi, Peilin Meng, Xuena Yang, Chuyu Pan, Yujing Chen, Huijie Zhang, Zhen Zhang, Jingxi Zhang, Chune Li, Yan Wen, Yumeng Jia, Bolun Cheng, Feng Zhang
Summary: The aim of this study was to investigate the interaction effects of mitochondrial dysfunction and inflammatory cytokines on the risks of anxiety and depression. The researchers utilized the UK Biobank as the sample for the study and performed a mitochondria-wide association (MiWAS) and interaction analysis. Significant associations and interactions were found between mitochondrial DNA (mtDNA), C-reactive protein (CRP), self-reported anxiety, general anxiety disorder (GAD-7) scores, self-reported depression, and Patient Health Questionnaire (PHQ-9) scores. The findings suggest the important role of mitochondrial function and CRP in the risks of anxiety and depression.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Cell & Tissue Engineering
Y. Jia, X. Qi, M. Ma, S. Cheng, B. Cheng, C. Liang, X. Guo, F. Zhang
Summary: This study aimed to explore novel regulatory genetic variants associated with bone mineral density (BMD). Through an integrative analysis of BMD genome-wide association study and regulatory single nucleotide polymorphism (rSNP) annotation information, we identified 36 common genes associated with BMD, such as FAM3C, CCDC170, and SOX6. Additionally, multiple gene ontology terms related to BMD were detected. These findings support the implication of regulatory genetic variants in the development of osteoporosis.
BONE & JOINT RESEARCH
(2023)
Article
Clinical Neurology
Peilin Meng, Bolun Cheng, Chuyu Pan, Li Liu, Shiqiang Cheng, Xuena Yang, Yujing Chen, Chun'e Li, Huijie Zhang, Zhen Zhang, Jingxi Zhang, Dan He, Sirong Shi, Xiaoge Chu, Qingqing Cai, Na Zhang, Xiaoyue Qin, Yijing Zhao, Wenming Wei, Yumeng Jia, Yan Wen, Feng Zhang
Summary: Meng et al. conducted mediation analyses to identify the partly mediating role of anxiety in the association between irritable bowel syndrome and brain volumes, promoting our understanding of the mechanisms of irritable bowel syndrome and related psychosocial factors.
BRAIN COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Li Liu, Xin Qi, Shiqiang Cheng, Peilin Meng, Xuena Yang, Chuyu Pan, Na Zhang, Yujing Chen, Chune Li, Huijie Zhang, Zhen Zhang, Jingxi Zhang, Bolun Cheng, Yan Wen, Yumeng Jia, Huan Liu, Feng Zhang
Summary: By studying the epigenetic brain aging of individuals with autism spectrum disorder (ASD) and schizophrenia (SCZ), it was found that there are aberrant aging patterns in the cerebellum of older adults with these disorders. However, further studies with larger cohorts are needed to confirm these findings.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Bolun Cheng, Peilin Meng, Xuena Yang, Shiqiang Cheng, Li Liu, Yumeng Jia, Yan Wen, Feng Zhang
Summary: Cheng et al. performed proteome-wide association studies to identify genes whose cis-regulated protein abundance changes in the human brain were associated with vertigo, followed by chemical-related gene set enrichment analysis. They provide novel genes (MTERFD2, MGST1, and RAB3B) into the pathogenesis of vertigo and highlight promising chemicals for further therapeutics research.
BRAIN COMMUNICATIONS
(2022)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)