Review
Biochemistry & Molecular Biology
Rhiane Moody, Kirsty Wilson, Katie L. Flanagan, Anthony Jaworowski, Magdalena Plebanski
Summary: COVID-19, primarily a respiratory infection, can lead to complications affecting multiple organs. Immune responses can both protect against and exacerbate the disease. Viral infections have been linked to autoimmune diseases like multiple sclerosis and lupus, with reports of new onset autoimmune-like diseases in COVID-19 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Douglas Johnson, Wei Jiang
Summary: Infections can trigger autoimmune diseases in humans and animals, through mechanisms such as antigen mimicry, bystander polyclonal activation, and epitope spreading. This review highlights recent research on infection-mediated autoimmune responses and discusses the underlying mechanisms.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Kristina Elizabeth Neergaard Clark, Shiwen Xu, Moustafa Attah, Voon H. Ong, Christopher Dominic Buckley, Christopher P. Denton
Summary: This study investigated cellular differences in diffuse cutaneous systemic sclerosis (dcSSc) patients compared with healthy controls (HCs), and found differences in cell clusters between the ARA+ and ATA+ subsets, highlighting the importance of considering antibodies and disease stage in the management and trial design of dcSSc.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Burcu Ayoglu, Michele Donato, Daniel E. Furst, Leslie J. Crofford, Ellen Goldmuntz, Lynette Keyes-Elstein, Judith James, Susan Macwana, Maureen D. Mayes, Peter McSweeney, Richard A. Nash, Keith M. Sullivan, Beverly Welch, Ashley Pinckney, Rong Mao, Lorinda Chung, Purvesh Khatri, Paul J. Utz
Summary: Results from the SCOT clinical trial showed that HSCT had significant benefits over CTX in patients with systemic sclerosis. The objective of this study was to test the hypothesis that transplantation stabilizes the autoantibody repertoire in patients with favorable clinical outcomes. Analysis of autoantibody profiles revealed significant differences between HSCT and CTX-treated patients, suggesting that HSCT alters the autoantibody repertoire while CTX treatment does not.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Brittany L. Adler, Francesco Boin, Paul J. Wolters, Clifton O. Bingham, Ami A. Shah, Carol Greider, Livia Casciola-Rosen, Antony Rosen
Summary: Autoantibodies targeting telomere-associated proteins are found in a subset of patients with systemic sclerosis (SSc), and are associated with short lymphocyte telomere length and lung disease. These autoantibodies are rarely present in rheumatoid arthritis, myositis, and healthy controls, suggesting a specificity for SSc and idiopathic pulmonary fibrosis (IPF).
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Sophie I. E. Liem, Sam Neppelenbroek, Cynthia M. Fehres, Brigitte A. Wevers, Rene E. M. Toes, Cornelia F. Allaart, Tom W. J. Huizinga, Hans Ulrich Scherer, Jeska K. De Vries-Bouwstra
Summary: Early diagnosis of systemic sclerosis (SSc) is important. The most frequent SSc-specific autoantibodies are anti-centromere antibodies (ACA) and anti-topoisomerase I antibodies (ATA). ATA is associated with severe disease course. More detailed characterisation of the ATA-response in SSc might improve prognostication.
Article
Immunology
Arad Dotan, Sylviane Muller, Darja Kanduc, Paula David, Gilad Halpert, Yehuda Shoenfeld
Summary: This article emphasizes the association between COVID-19 and the development of multiple types of autoantibodies and autoimmune diseases in patients. It highlights the potential molecular resemblance between SARS-CoV-2 and host self-components, leading to hyper-stimulation of the immune system. Recognizing autoimmune manifestations of COVID-19 is crucial for managing the ongoing pandemic and its long-term consequences.
AUTOIMMUNITY REVIEWS
(2021)
Article
Immunology
Ahreum Lee, Duck Kyun Yoo, Yonghee Lee, Sumin Jeon, Suhan Jung, Jinsung Noh, Soyeon Ju, Siwon Hwang, Hong Hee Kim, Sunghoon Kwon, Junho Chung, Youngnim Choi
Summary: Sjogren's syndrome is an autoimmune disease characterized by dryness of the mouth and eyes. A new model has been developed to investigate the role of anti-AQP5 autoantibodies in glandular dysfunction in SS and test new therapeutics targeting autoantibody production.
Review
Immunology
A. Starshinova, A. Malkova, I Kudryavtsev, D. Kudlay, Yu Zinchenko, P. Yablonskiy
Summary: Despite the proven infectious nature of tuberculosis, new data has emerged on the autoimmune component associated with tuberculosis infection. This chapter explores the signs of autoimmune inflammation in tuberculosis infection, including clinical and immunological manifestations. Considering the potential triggering effect of M. tuberculosis on the development of autoimmune processes, addressing these autoimmune complications is crucial in prescribing therapy and predicting the effectiveness of disease treatment.
Article
Biochemistry & Molecular Biology
Michael Quagliata, Francesca Nuti, Feliciana Real-Fernandez, Kalina Kirilova Kirilova, Federica Santoro, Alfonso Carotenuto, Anna Maria Papini, Paolo Rovero
Summary: Multiple sclerosis (MS) is an inflammatory and autoimmune disorder characterized by antibody-mediated demyelination. Glucosylated peptides derived from human myelin proteins, OMGp and RTN4R, were recognized by antibodies in the sera of MS patients, indicating an immunological association between human and bacterial protein antigens. These findings support the hypothesis of molecular mimicry triggering self-tolerance breakdown in MS, suggesting RTN4R and OMGp as autoantigens.
JOURNAL OF PEPTIDE SCIENCE
(2023)
Article
Multidisciplinary Sciences
Andres Sanchez Caraballo, Yenny Guzman, Jorge Sanchez, Marlon Munera, Elizabeth Garcia, Deyanira Gonzalez-Devia
Summary: Research suggests a potential correlation between Helicobacter pylori and chronic urticaria and type 1 gastric neuroendocrine tumors. Shared antigens and molecular mimicry may explain this relationship.
Review
Immunology
Claire F. Beesley, Nina R. Goldman, Taher E. Taher, Christopher P. Denton, David J. Abraham, Rizgar A. Mageed, Voon H. Ong
Summary: Systemic sclerosis (SSc) is an immune-mediated rheumatic disease characterized by excessive extracellular matrix deposition. B cells play a fundamental role in the pathogenesis and development of SSc, as they infiltrate lesional sites and produce profibrotic cytokines. B cell counts are increased in SSc patients and show differences in various B cell compartments. B cell signaling is impaired in SSc patients, and B cell depletion therapy has shown therapeutic benefits.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Viktoryia Laurynenka, Lili Ding, Kenneth M. Kaufman, Judith A. James, John B. Harley
Summary: The association between EBV infection and SLE is reconfirmed, and the presence of anti-EBNA1 antibodies in SLE cases is more frequent than in EBV-infected controls, supporting the hypothesis that anti-EBNA1 contributes to SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Xiaoyang Yue, Junping Yin, Xiaoqing Wang, Harald Heidecke, Alexander Maximilian Hackel, Xiaoru Dong, Brigitte Kasper, Lifang Wen, Liang Zhang, Kai Schulze-Forster, Juliane Junker, Hanna Grasshoff, Antje Mueller, Gerd Wallukat, Ingolf Schimke, Julian Zeiner, Lisa Marie Deckstein, Nicole Mertens, Anja Kerstein-Staehle, Jennifer Elisabeth Hundt, Evi Kostenis, Xinhua Yu, Gabriela Riemekasten, Frank Petersen
Summary: This study successfully induced AT1R antibodies using an immunization strategy and found that these antibodies activate the AT1R, leading to inflammation and fibrosis. These findings suggest that AT1R antibodies could be potential targets for therapies of systemic sclerosis (SSc) and other AT1R antibody-related diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Pawel Zebryk, Piotr Przymuszala, Jan Krzysztof Nowak, Tomasz Piorunek, Tatiana Mularek-Kubzdela, Mariusz Puszczewicz
Summary: This study evaluated the prevalence and clinical significance of SSc-related autoantibodies and compared the sensitivity of two line immunoblot assays. The findings indicate that different autoantibodies are associated with specific characteristics of SSc.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Monica Yang, Vivien Goh, Jungwha Lee, Monica Espinoza, Yiwei Yuan, Mary Carns, Kathleen Aren, Lorinda Chung, Dinesh Khanna, Zsuzsanna H. McMahan, Rishi Agrawal, Lauren Beussink Nelson, Sanjiv J. Shah, Michael L. Whitfield, Monique Hinchcliff
Summary: The classification of systemic sclerosis (SSc) patients based on skin gene expression can identify different clinical phenotypes and provide additional clinically useful information to current SSc classification systems.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Burcu Ayoglu, Michele Donato, Daniel E. Furst, Leslie J. Crofford, Ellen Goldmuntz, Lynette Keyes-Elstein, Judith James, Susan Macwana, Maureen D. Mayes, Peter McSweeney, Richard A. Nash, Keith M. Sullivan, Beverly Welch, Ashley Pinckney, Rong Mao, Lorinda Chung, Purvesh Khatri, Paul J. Utz
Summary: Results from the SCOT clinical trial showed that HSCT had significant benefits over CTX in patients with systemic sclerosis. The objective of this study was to test the hypothesis that transplantation stabilizes the autoantibody repertoire in patients with favorable clinical outcomes. Analysis of autoantibody profiles revealed significant differences between HSCT and CTX-treated patients, suggesting that HSCT alters the autoantibody repertoire while CTX treatment does not.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ana E. E. Tucker, Jamie Perin, Elizabeth R. R. Volkmann, Tsion Abdi, Ami A. A. Shah, John Pandolfino, Richard M. M. Silver, Zsuzsanna H. H. McMahan
Summary: This study aimed to investigate whether patterns of esophageal dysfunction in patients with systemic sclerosis (SSc) are associated with specific clinical phenotypes. The results showed that absent contractility (AC) is closely associated with the clinical manifestations of SSc, while ineffective esophageal motility (IEM) may be associated with a milder phenotype.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ilya Andreev, Kamilla M. E. Laidlaw, Simone M. Giovanetti, Guillaume Urtecho, Daniel Shriner, Joshua S. Bloom, Chris MacDonald, Meru J. Sadhu
Summary: Secreted protein toxins play important roles in conflicts between organisms. Understanding how organisms genetically adapt to defend themselves against these toxins is crucial for understanding the coevolutionary dynamics of competing organisms. This study discovered a novel defense factor, KTD1, which is critical in resisting the killer toxin K28.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Rheumatology
Lesley Ann Saketkoo, Jessica K. Gordon, Kim Fligelstone, Anne Mawdsley, Humza A. Chaudhry, Antonia Valenzuela, Angela Christensen, Samara M. Khalique, Kelly Jensen, Sophia C. Weinmann, Evan Busman, Lorinda Chung, Vivien M. Hsu, Anne-Marie Russell, Virginia D. Steen
Summary: The patient experience of SSc-calcinosis was analyzed in an international cohort, leading to a better understanding of the pervasive disability, frustration, symptom distress, and uncertainty associated with daily living with the condition. Patient observations and self-management behavior offer opportunities for education of clinicians and patients, with a need for self-management guidance. The findings informed the development of a novel PROM, the MCQ, for assessing the severity and impact of SSc-calcinosis in clinical studies and practice.
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2023)
Article
Rheumatology
Cecilia Varju, John D. Pauling, Lesley Ann Saketkoo
Summary: The article introduces a philosophic approach that prioritizes the importance of biophysical elements in improving quality of life. While the level of care and vigilance of clinicians regarding biophysical aspects may remain unchanged, this patient-centered approach helps to emphasize shared decision-making, empowering patients with anticipatory guidance and counseling, and integrating the experience of living with SSc into clinical decision-making more readily and proactively.
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
(2023)
Article
Rheumatology
Didem Saygin, Hanna Kim, Christian Douglas, Brian Erman, Jesse Wilkerson, John A. McGrath, Chester Oddis, Ingrid E. Lundberg, Anthony A. Amato, Ignacio Garcia-De La Torre, Hector Chinoy, David Fiorentino, Lorinda Chung, Yeong-Wook Song, Frederick W. Miller, Nicolino Ruperto, Jiri Vencovsky, Rohit Aggarwal, Lisa G. Rider
Summary: This study further validated the ACR-EULAR Myositis Response Criteria (MRC) by assessing the contribution of each core set measure, the frequency of improvement in strength vs extramuscular activity, the representation of patient-reported outcome measures (PROM), and the frequency of core set measure worsening. The results showed that improvement in strength was the main contributing factor, and the majority of patients also had improvement in PROM.
Article
Rheumatology
Sarah Luebker, Tracy M. Frech, Shervin Assassi, Brian Skaug, Jessica K. Gordon, Kimberly Lakin, Elana J. Bernstein, Yiming Luo, Virginia D. Steen, Ami A. Shah, Laura K. Hummers, Carrie Richardson, Duncan F. Moore, Dinesh Khanna, Flavia Castelino, Lorinda Chung, Puneet Kapoor, Faye N. Hant, Victoria K. Shanmugam, John M. VanBuren, Jessica Alvey, Monica Harding, Ankoor Shah, Ashima Makol, Dorota Lebiedz-Odrobina, Julie K. Thomas, Elizabeth R. Volkmann, Jerry A. Molitor, Nora Sandorfi
Summary: The study conducted by the CONQUER collaborative revealed that severe gastrointestinal symptoms in SSc patients lead to increased healthcare resource utilization. Understanding the pattern of resource utilization, especially in early disease stages, is crucial for managing the health-related costs of SSc.
Review
Rheumatology
Laura Ross, Nancy Maltez, Michael Hughes, Jan W. Schoones, Murray Baron, Lorinda Chung, Dilia Giuggioli, Pia Moinzadeh, Yossra A. Suliman, Corrado Campochiaro, Yannick Allanore, Christopher P. Denton, Oliver Distler, Tracy Frech, Daniel E. Furst, Dinesh Khanna, Thomas Krieg, Masataka Kuwana, Marco Matucci-Cerinic, Janet Pope, Alessia Alunno
Summary: A systematic literature review found that intravenous iloprost, phosphodiesterase-5 inhibitors, and atorvastatin are effective for the treatment of SSc digital ulcers. Bosentan can reduce the occurrence of future ulcers. Limited evidence supports the effectiveness of Janus kinase inhibitors, while immunosuppression or anti-platelet agents have insufficient data to support their use. Further research is needed to define the optimal treatment regimen.
Article
Rheumatology
Christopher A. Mecoli, Brant Chee, Mengkun Chen, XingYao Wang, Jemima Albayda, Julie J. Paik, Eleni Tiniakou, Brittany Adler, Will Kelly, Andrew L. Mammen, Elizabeth A. Platz, Livia Casciola-Rosen, Lisa Christopher-Stine, Ami A. Shah
Summary: This study evaluated the diagnostic yield of computed tomography (CT) imaging for cancer screening/surveillance in patients with idiopathic inflammatory myopathy (IIM). The results showed that dermatomyositis patients had the highest diagnostic yields on CT scans of the chest and abdomen/pelvis, while patients under 40 years old had lower diagnostic yields.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
David Fiorentino, Christopher A. Mecoli, Tak Igusa, Jemima Albayda, Julie J. Paik, Eleni Tiniakou, Brittany Adler, Andrew L. Mammen, Ami A. Shah, Antony Rosen, Lisa Christopher-Stine, Livia Casciola-Rosen
Summary: This study demonstrates the disease specificity and clinical significance of anti-CCAR1 autoantibodies in dermatomyositis (DM) patients. It also reveals a lower risk of cancer in DM patients with anti-TIF1 gamma positive and anti-CCAR1 positive status.
ARTHRITIS & RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Lesley Ann Saketkoo, Antonia Valenzuela, Susan Kim, Liza J. McCann, Christian Lood, Dawn M. Wahezi, Victoria P. Werth, Belina Yi, Helene Alexanderson, Susan Maillard, Clarissa Pilkington, Kim Fligelstone, Barbara Limbach, Amir B. Orandi, Malin Regardt, Anne-Marie Russell, Srijana Davuluri, Ingrid deGroot, Floranne Ernste, Julie J. Paik, Carlos A. von Muhlen, Mazen M. Dimachkie, Pedro M. Machado, Elie Naddaf, Barbara M. Shafranski, Latika Gupta, Francesco Zulian, Lorinda Chung
Article
Rheumatology
Matthew R. Lammi, Kathleen D. Kolstad, Lesley Ann Saketkoo, Avani Khatri, Paul J. Utz, Virginia D. Steen, Lorinda Chung
Summary: The study shows that certain endothelial biomarkers (ADMA, sEng, and PTX-3) can determine the risk of SSc-PH and differentiate between SSc-PH subgroups. PTX-3 is a promising biomarker for PH risk and a possible marker for precapillary PH, but ADMA and sEng do not show significant differences in this regard.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Robert Spiera, Masataka Kuwana, Dinesh Khanna, Laura M. Hummers, Tracy Frech, Wendy Stevens, Marco Matucci-Cerinic, Suzanne Kafaja, Oliver Distler, Jae-Bum Jun, Yair Levy, Piotr Leszcyznski, Jessica Gordon, Virginia Steen, Eun Bong Lee, Tomasz Jankowski, Irena Litinsky, Lorina Chung, Vivien Hsu, Maureen Mayes, Nora W. Sandorfi, Robert Simms, Stephanie Finzel, Jeska de Vries-Bouwstra, Scott Constantine, Nancy Dgetluck, Quinn J. Dinh, Bradley E. Bloom, Daniel Furst, Barbara P. White, Christopher Denton
Summary: The efficacy and safety of lenabasum in dcSSc patients were investigated. The study failed to demonstrate a benefit of lenabasum in dcSSc, but showed better outcomes in patients treated with background IST, particularly mycophenolate mofetil.
ARTHRITIS & RHEUMATOLOGY
(2023)