TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex

Why Malformations of Cortical Development Cause Epilepsy

(2019) Alfonso Represa   Frontiers in Neuroscience

New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives

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The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

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Epilepsy

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mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis

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Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway

(2017) Bai-bing Zhang et al.   NEURON

Molecular neurobiology of mTOR

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Anxiety and Nicotine Dependence: Emerging Role of the Habenulo-Interpeduncular Axis

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The genomic landscape of tuberous sclerosis complex

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Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala

(2017) Aniruddha Das et al.   Scientific Reports

White matter disruption is associated with persistent seizures in tuberous sclerosis complex

(2016) Romina Moavero et al.   EPILEPSY & BEHAVIOR

Tuberous sclerosis complex: From molecular biology to novel therapeutic approaches

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Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity

(2016) Nathan G. Hedrick et al.   NATURE

Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease)

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Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits

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Neurological and neuropsychiatric aspects of tuberous sclerosis complex

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Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems

(2015) Zhong L. Hua et al.   Neural Development

Neuronal morphometry directly from bitmap images

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Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

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The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function

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Loss of White Matter Microstructural Integrity Is Associated with Adverse Neurological Outcome in Tuberous Sclerosis Complex

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Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions

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Fear, anxiety, and control in the zebrafish

(2011) Suresh Jesuthasan   Developmental Neurobiology

Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice

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Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

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Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

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Imaging escape and avoidance behavior in zebrafish larvae

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Circuit Neuroscience in Zebrafish

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Brain-derived neurotrophic factor and the development of structural neuronal connectivity

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Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin

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The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

Diffusion Features of White Matter in Tuberous Sclerosis With Tractography

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Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse

(2009) S. W. Way et al.   HUMAN MOLECULAR GENETICS

A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles

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Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation

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Tuberous sclerosis complex proteins control axon formation

(2008) Y.-J. Choi et al.   GENES & DEVELOPMENT

Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs

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Prenatal diagnosis of cerebral lesions in Tuberous sclerosis complex (TSC). Case report and review of the literature

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