Journal
POLYMER DEGRADATION AND STABILITY
Volume 175, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymdegradstab.2020.109128
Keywords
Copolymerization; Trimethylene carbonate; 2,2 '-dimethyltrimethylene carbonate; In vitro enzymatic degradation; Molecular weight
Categories
Funding
- National Key Research and Development Program of China [2016YFC1000902]
- National Natural Science Foundation of China [31560268]
- Liaoning Revitalization Talents Program [XLYC1807142]
- Department of Science and Technology of Liaoning Province [2018225079, 20180037]
- Educational Department of Liaoning Province [ZF2019040]
- Shenyang Science and Technology Bureau [RC190426]
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A series of copolymers [P (TMC-co-DTC)] with different molecular weights based on trimethylene carbonate (TMC) and 2, 2-dimethyltrimethylene carbonate (DTC) were synthesized via ring-opening copolymerization, by adjusting the amount of Sn(Oct)(2). The thermal performance showed that the T-g and T-d of the obtained amorphous copolymer rose with the increase of molecular weight from 118 to 213 kDa. Then the in vitro enzymatic experiment was carried out in lipase solutions, it could be concluded that the higher the molecular weight, the faster the degradation rate of the P (TMC-co-DTC), which may be related to the stronger hydrophobicity of the high molecular weight sample. Furthermore, the degradation mechanism of P (TMC-co-DTC) was determined to be the surface erosion, due to the result of the unchanged molecular weight during the degradation period. The fact that polycarbonate copolymer produces no acidic compounds in the process of enzymatic degradation had also been confirmed. This study provides confirmation for adjusting the degradation behavior performance of polycarbonate materials by molecular weight to meet the needs of more abundant clinical applications. (C) 2020 Elsevier Ltd. All rights reserved.
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