Journal
POLYHEDRON
Volume 178, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2019.114340
Keywords
Boehmite; Acidic heterogeneous nano-catalysts; Biginelli reaction; 1,4-Dihydropyridines
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Funding
- Razi University of Kermanshah
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Heterocyclic compounds with biological and pharmacological activates like 3,4-dihydropyrimidin-2(1H)-ones and 1,4-dihydropyridines have attracted great interest. Boehmite nanoparticles functionalized with silylpropyl sulfamic acid (BNPs@SiO2(CH2)(3)NHSO3H) as a metal free and environmentally friendly catalyst has been found to be effective for the one pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones and the preparation of 1,4-dihydropyridines derivatives. Some features of this protocol are low cost and available materials, short reaction times, convenient catalyst separation, and no need for a neutral atmosphere. Moreover, the catalyst can be reused for at least five times with only a 7% reduction in yield. This study also shows that BNPs@SiO2(CH2)(3)NHSO3H is a sustainable, recoverable and effective heterogeneous catalyst for multicomponent reactions. (C) 2020 Elsevier Ltd. All rights reserved.
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