Article
Immunology
Kiersten Scott, Thien Trong Phan, Nabila Boukelmoune, Cobi J. Heijnen, Robert Dantzer
Summary: Chronic restraint stress affects the behavior of mice, specifically their voluntary wheel running but not working for food. This indicates a dissociation between energy demanding and energy procuring activities, possibly due to adaptive response to mitochondrial dysfunction caused by chronic restraint stress.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Keyin Shen, Xingran Liu, Dandan Chen, Jingru Chang, Ying Zhang, Xianjuan Kou
Summary: Autophagy is a crucial cellular process implicated in Alzheimer's disease and aging. miR-130a plays a key role in regulating brain autophagy and cell senescence, with exercise being able to reverse impaired autophagy resulted from aging. Overexpression of miR-130a can attenuate cell senescence and impaired autophagy, suggesting a potential therapeutic approach for brain aging.
BRAIN RESEARCH BULLETIN
(2021)
Article
Medicine, Research & Experimental
Yan Gao, Zhaoyun Yang, Kang He, Zeyu Wang, Tingyu Zhang, Jiang Yi, Lijing Zhao
Summary: This study found that exercise has anti-inflammatory and antioxidant effects on pulmonary fibrosis induced by paraquat, reducing the infiltration of inflammatory cells and fibrotic lesions. Furthermore, exercise also increased the expression of antioxidative distress proteins, improved the degree of epithelial-mesenchymal transition in alveolar epithelial cells, and ultimately alleviated paraquat-induced pulmonary fibrosis.
Article
Biochemistry & Molecular Biology
Laura Niiranen, Ville Stenback, Mikko Tulppo, Karl-Heinz Herzig, Kari A. Makela
Summary: Exercise has been proven to improve cognitive function, and studies on both humans and animals have shown this. Laboratory mice are often used as a model to study the effects of exercise, and running wheels provide a voluntary and stress-free form of exercise for mice. This study aimed to analyze the relationship between the cognitive state of a mouse and its wheel-running behavior. The results showed that high-runner mice exhibited enhanced learning capabilities and ate more compared to the other groups. Interestingly, individual mice had different reactions when introduced to running wheels, suggesting the importance of considering individual differences in voluntary endurance exercise studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Phillipe Huber, Brandon J. J. Ausk, K. Lionel Tukei, Steven D. D. Bain, Ted S. S. Gross, Sundar Srinivasan
Summary: The study developed a convolutional neural network model to accurately assess the running frequency of aged mice. The model achieved a 94% accuracy rate. This research method provides a higher resolution of information for studying the physiological effects of voluntary wheel running activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Neurosciences
Kyeong Jin Yoon, Suhong Park, Seung Hee Kwak, Hyo Youl Moon
Summary: Anxiety disorders are commonly diagnosed psychological conditions that are often treated with drugs, but these medications can have side effects. Exercise is an effective treatment for anxiety, and it has been found to release extracellular vesicles (EVs) that may help reduce anxiety. Research suggests that exercise-derived EVs may have anti-anxiety effects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Immunology
Kiersten S. Scott, Brandon Chelette, Chinenye Chidomere, A. Phillip West, Robert Dantzer
Summary: Cisplatin decreases energy-consuming activities but not energy-procuring activities unless they require a choice between options differing in their cost-benefit ratio. The physical dimension of fatigue is more likely to develop in cisplatin-treated individuals than the motivational dimension of fatigue.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Annika Reuser, Kristin Wenzel, Stephan B. Felix, Marcus Doerr, Martin Bahls, Stephanie Koenemann
Summary: This article introduces a method that combines radiotelemetry system and running wheels to determine spontaneous cage activity and voluntary exercise levels of individual animals in group-housed rodents. A software tool is developed for fast and reliable data analysis. This method can be used to study the benefits of physical activity and the impact of therapeutic interventions on animal behavior.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Yang Chen, Wei-jia Wu, Li-wei Xing, Xiao-juan Zhang, Jing Wang, Xiao-yan Xia, Rui Zhao, Rong Zhao
Summary: This study examined the correlations between mtDNA D-loop, its haplotypes, and PCOS in the Chinese population, and found that certain mtDNA D-loop mutations and haplotypes may confer protection against PCOS in Chinese women. In addition, elevated mtDNA copy number may serve as an indicator during early stages of PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Physiology
Olivia C. Eller, Xiaofang Yang, Isabella M. Fuentes, Angela N. Pierce, Brittni M. Jones, Aaron D. Brake, Ruipeng Wang, Gregory Dussor, Julie A. Christianson
Summary: This study investigated the susceptibility of female NMS mice to evoked migraine-like behaviors and the potential therapeutic effect of voluntary wheel running. The findings suggest that while exercise improved some measures associated with increased migraine susceptibility in NMS mice, behavioral outcomes were not impacted or even worsened by exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pediatrics
Hongfang Mei, Lin Yang, Tiantian Xiao, Sujuan Wang, Bingbing Wu, Huijun Wang, Yulan Lu, Xinran Dong, Hong Yang, Wenhao Zhou
Summary: This study explored the genetic spectrum of cerebral palsy in a Chinese pediatric cohort and identified genetic variants in approximately 35.9% of patients. Patients without clinical risk factors or with a family history were more likely to have genetic risk factors.
JOURNAL OF PEDIATRICS
(2022)
Article
Genetics & Heredity
Amanda K. Broz, Gus Waneka, Zhiqiang Wu, Matheus Fernandes Gyorfy, Daniel B. Sloan
Summary: The study used high-fidelity Duplex Sequencing technique to analyze mitochondrial mutations in multiple angiosperms from the genus Silene, revealing extreme variations in rates of mitochondrial sequence evolution among different species. While Silene latifolia maintained low variant frequencies, Silene conica showed higher variant frequencies and a biased mutational spectrum. This suggests historical fluctuations in mutation rates drive the extreme variation in plant mitochondrial sequence evolution.
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Biochemistry & Molecular Biology
Agnieszka Piotrowska-Nowak, Krzysztof Safranow, Jakub G. Adamczyk, Ireneusz Soltyszewski, Pawel Cieszczyk, Katarzyna Tonska, Cezary Zekanowski, Beata Borzemska
Summary: Energy efficiency is crucial for athletic performance. This study investigated the relationship between mitochondrial DNA (mtDNA) variants and athletic performance among Polish male athletes. The analysis revealed no correlation between mtDNA variants and athletic performance, but showed a lower mtDNA copy number in both power and endurance athletes compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Shenglong Kan, Xuezhu Liao, Zhiqiang Wu
Summary: There is a paradox in the evolution of plant mitochondrial genomes, with genic regions evolving slowly and intergenic regions evolving rapidly. This study identifies the mechanism behind this paradox and reveals interspecific variations in mitochondrial and plastid genomes. The findings suggest that mutation inputs are the same across different categories within the organelle genome, but the selection pressure varies. Copy number variations are also common in plant mitochondrial genomes.
Article
Neurosciences
Daniel A. Llano, Viswanath Devanarayan
Summary: The study suggests that serum lipid markers can differentiate AD from healthy controls and predict conversion from MCI to AD. Specifically, levels of PE and lyso-PE were found to be associated with faster progression from MCI to AD, indicating their potential as useful biomarkers for predicting disease conversion.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Neurosciences
Alexander Asilador, Daniel A. Llano
Summary: The article discusses the widespread acceptance that humans use contextual information to infer the meaning of ambiguous acoustic signals, as well as the current theories and models used to explain this phenomenon. It also highlights the importance of the corticofugal pathways in the brain in this process, and the predictive coding mechanisms that modulate perception of complex sounds.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Clinical Neurology
Jennifer M. Walters, Eung Chang Kim, Jiaren Zhang, Han Gil Jeong, Archit Bajaj, Brian C. Baculis, Gregory C. Tracy, Baher Ibrahim, Catherine A. Christian-Hinman, Daniel A. Llano, Graham R. Huesmann, Hee Jung Chung
Summary: This study is the first to demonstrate that the drug TC-2153 has inhibitory effects on hippocampal excitability and seizure severity in both sexes. TC-2153 can reduce seizure severity and decrease overall hippocampal excitability.
Article
Acoustics
Jihun Kim, Mathew R. Lowerison, Nathiya V. Chandra Sekaran, Zhengchang Kou, Zhijie Dong, Michael L. Oelze, Daniel A. Llano, Pengfei Song
Summary: Ultrasound localization microscopy (ULM) shows potential for visualizing tissue microvasculature at depth with high spatial resolution. A novel ULM imaging sequence based on MB uncoupling via transmit excitation (MUTE) is proposed, which silences MB signals to facilitate MB separation and localization, resulting in reduced data acquisition time and improved temporal resolution.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Multidisciplinary Sciences
Matthew R. Lowerison, Nathiya Chandra Sekaran, Wei Zhang, Zhijie Dong, Xi Chen, Daniel A. Llano, Pengfei Song
Summary: Aging-related cognitive decline is a health crisis, with no established mechanism identified. This study used super-resolution ultrasound localization microscopy to image the vasculature of aged mice and found decreased blood velocity, increased vascular tortuosity, and reduced blood volume in the cerebral cortex. These findings provide novel insights into subcortical microvascular dynamics in the aging brain.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Multidisciplinary
Susanna S. Kwok, Xuan-Mai T. Nguyen, Diana D. Wu, Raksha A. Mudar, Daniel A. Llano
Summary: The association between age-related hearing loss (ARHL) and Alzheimer's Disease (AD) is still poorly understood. A meta-analysis study revealed that AD patients have significantly impaired hearing compared to controls, with a greater effect seen at higher sound frequencies.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Lydia T. Nguyen, Elizabeth A. Lydon, Shraddha A. Shende, Daniel A. Llano, Raksha A. Mudar
Summary: Individuals with mild cognitive impairment (MCI) show impaired value-directed strategic processing compared to cognitively normal older adults, as evidenced by behavioral and neural differences.
Article
Neurosciences
David Perez-Gonzalez, Thomas G. Schreiner, Daniel A. Llano, Manuel S. Malmierca
Summary: Age-related hearing loss is a common condition among the elderly, impacting their communication and social participation. Recent studies suggest a possible link between hearing loss and the development of Alzheimer's disease, with changes in acetylcholine playing a role in both hearing deviance detection and Alzheimer's disease. Further research is needed to explore this association.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Elizabeth A. L. Stine-Morrow, Giavanna S. McCall, Ilber Manavbasi, Shukhan Ng, Daniel A. Llano, Aron K. K. Barbey
Summary: Considerable evidence suggests that language processing depends on memory processes vulnerable to aging declines. This study found that sustained literacy engagement, such as leisure reading, had positive effects on memory and cognition in older adults. The experimental group showed improved verbal working memory, episodic memory, and conceptual integration in sentence processing, regardless of personality characteristics.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Qi You, Joshua D. Trzasko, Matthew R. Lowerison, Xi Chen, Zhijie Dong, Nathiya Vaithiyalingam ChandraSekaran, Daniel A. Llano, Shigao Chen, Pengfei Song
Summary: This study introduces a curvelet transform-based sparsity promoting (CTSP) algorithm that improves the imaging speed of ultrasound localization microscopy (ULM) by recovering missing microbubble localization signal from data with very short acquisition times. The results demonstrate that CTSP can facilitate fast and robust ULM imaging, especially when microbubble localizations are inadequate.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Review
Behavioral Sciences
Silvio Macias, Daniel A. Llano
Summary: This study takes a comparative approach to understand the top-down modulation mechanisms in the mammalian and amphibian inferior colliculus (IC). The key question addressed is whether the thalamotectal projections in mammals and amphibians are homologous and how they interact with projections from the cerebral cortex. The behavioral significance of these descending pathways is also considered, particularly in anurans' ability to navigate complex acoustic landscapes without a corticocollicular projection.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2023)
Article
Neurosciences
Ashwini G. Naik, Robert Kenyon, Aynaz Taheri, Tanya Y. BergerWolf, Baher A. Ibrahim, Yoshitaka Shinagawa, Daniel A. Llano
Summary: Understanding the functional correlations between neuron populations is crucial for studying neuronal networks. V-NeuroStack is a novel network visualization tool that allows visualization of large-scale neuronal activity data. It offers both 3D and 2D visualization modes to explore correlations between neurons and examine specific time steps in detail. It can handle large datasets and potentially support future advancements in data capturing techniques.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Editorial Material
Behavioral Sciences
Peter M. Narins, Daniel A. Llano, Gunther K. H. Zupanc
Summary: This special issue of the Journal of Comparative Physiology A commemorates the life and work of Albert (Al) S. Feng, a pioneer in the field of neuroethology of auditory systems. It includes 15 articles written by friends, students, and colleagues, many of whom have become leading experts themselves in this field. Their contributions provide a comprehensive overview of bioacoustics in amphibians and mammals (including bats) and aim to inspire a new generation of scientists to advance our understanding of brain mechanisms of acoustic perception.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Daniel A. Llano, Priya Devanarayan, Viswanath Devanarayan
Summary: This study proposes a framework for classifying and combining biomarkers for Alzheimer's Disease (AD). The researchers found that low levels of VGF in cerebrospinal fluid (CSF) can serve as a strong predictor for the conversion from mild cognitive impairment (MCI) to AD.
NEUROBIOLOGY OF AGING
(2023)
Article
Medicine, General & Internal
Suzanna Kitten, Neel D. Jani, Daniel A. Llano
Summary: Functional neurological symptom disorder is a condition where neurological deficits cannot be explained by medical pathology, and auditory verbal agnosia is one of its manifestations. This case study demonstrates the effectiveness of a multi-pronged treatment approach in resolving conversion symptoms in a 19-year-old patient over several years.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)