Article
Cardiac & Cardiovascular Systems
Emily S. Lau, Elizabeth Liu, Samantha M. Paniagua, Amy A. Sarma, Giovanna Zampierollo, Begona Lopez, Javier Diez, Thomas J. Wang, Jennifer E. Ho
Summary: In this trial, higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, but treatment with modified citrus pectin did not change collagen markers. Further investigation is needed for the effect of Gal-3 inhibition among individuals with heart failure.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Article
Chemistry, Applied
Tao Zhang, Guoqing Sun, Ming Shuai, Jingyu Ye, Jian Huang, Xiaodong Yao, Chengxin Sun, Xun Min
Summary: This study isolated five fractions from modified citrus pectin (MCP) and studied their structures, ability to inhibit galectin-3, and antiproliferation activities on MCF-7 and A549 cell lines. One of the fractions, EMCP-3p, showed strong inhibition of galectin-3 and significant cytotoxicity against MCF-7 and A549 cell lines. These results offer new insights into the structure-function relationships of polysaccharides derived from MCP.
Review
Cell Biology
Devaraj Ezhilarasan
Summary: Galectin-3 is a soluble protein that specifically binds to beta-galactoside carbohydrates and plays a key role in various pathophysiological processes. It has been implicated in liver diseases, including fatty liver diseases, inflammation, fibrosis, and hepatocellular carcinoma. Galectin-3 activates immune responses and promotes fibrogenesis in injured liver cells and stromal microenvironment, and it also affects cancer cell behavior. In clinical studies, increased levels of Galectin-3 have been observed in patients with liver diseases. This review focuses on the pathological role of Galectin-3 in the progression of chronic liver diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Alison C. Mackinnon, Dimitar Tonev, Brian Jacoby, Massimo Pinzani, Robert J. Slack
Summary: The incidence of liver diseases is increasing worldwide, but there are limited therapeutic options for managing chronic inflammation and fibrosis, which are the main causes of morbidity and mortality in liver diseases. Galectin 3 (Gal-3) is a protein involved in fibrosis in multiple organs, and several Gal-3 inhibitors are currently being developed for clinical use.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Food Science & Technology
Miao-Miao Wang, Fan Wang, Gen Li, Meng-Ting Tang, Chong Wang, Qing-Qing Zhou, Tao Zhou, Qing Gu
Summary: This study investigated the antioxidant and hypolipidemic activities of pectin extracted from citrus fruit canning processing water. The pectins showed significant ability to scavenge free radicals and bind bile acids, effectively reducing oxidative stress and blood lipid levels. Furthermore, they down-regulated the expression of relevant genes associated with lipid metabolism. Therefore, these citrus pectins have potential as ingredients for functional foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Yiyun Zhang, Danning Su, Yimeng Wang, Ziqiang Wang, Ying Ren, Rui Liu, Bo Du, Ruiping Duan, Yanping Shi, Lingrong Liu, Xuemin Li, Qiqing Zhang
Summary: A collagen membrane-based modified citrus pectin (MCP) delivery system (MCP-C) was developed in this study to simultaneously modulate regenerative and inflammatory responses by targeting galectin-3 (Gal-3), enhancing the repair of articular cartilage (AC) defects.
Article
Chemistry, Medicinal
David Vrbata, Marcela Filipova, Marina R. Tavares, Jakub Cerveny, Miluse Vlachova, Milada Sirova, Helena Pelantova, Lucie Petraskova, Ladislav Bumba, Rafal Konefal, Tomas Etrych, Vladimir Kren, Petr Chytil, Pavla Bojarova
Summary: Galectin-3 plays a role in cancer-related metabolic processes. Inhibiting overexpressed Galectin-3, such as with beta-galactoside-based inhibitors, holds promise for cancer treatment. A library of inhibitors was synthesized and displayed on a suitable biocompatible carrier to enhance affinity for Gal-3. One of the candidates exhibited strong inhibitory effects in cancer cells and shows potential for Gal-3-associated cancer therapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Carolin Pozder geb Gehlken, A. Rogier van der Velde, Wouter C. Meijers, Herman H. W. Sillje, Pieter Muntendam, Martin M. Dokter, Wiek H. van Gilst, Henk A. Schols, Rudolf A. de Boer
Summary: The study aimed to find a therapy for cardiac fibrosis and identified rhubarb pectin as a potent inhibitor of galectin-3. The effectiveness of rhubarb pectin was validated in a mouse model of myocardial fibrosis, showing significant reduction of fibrosis and preserved cardiac function.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Applied
Na Liu, Wenna Yang, Xia Li, Ping Zhao, Yu Liu, Lanping Guo, Luqi Huang, Wenyuan Gao
Summary: The properties of citrus peel pectins (CPPs) obtained from different cultivars and growth regions were compared. The physicochemical features of CPPs were investigated, including molecular weight distribution, monosaccharide composition, thermal behaviors and flow behaviors. It was found that different cultivars and growing areas had significant effects on CPPs. Some CPPs exhibited superior antioxidant activity, while others showed excellent functional properties. The study also identified the factors that contributed to the thermal stability and viscosity of CPPs, as well as their antioxidant activity.
Article
Gastroenterology & Hepatology
Dor Yoeli, Cara L. Mack, Yuhuan Luo, Alexander Chaidez, Nathaly Limon de la Rosa, Zhaohui Wang, Eduardo Cervantes-Alvarez, Christene A. Huang, Nalu Navarro-Alvarez
Summary: This study found that circulating Galectin-3 levels increase with disease progression in children with biliary atresia (BA), and are associated with markers of disease severity and inflammation. Late-stage BA is characterized by an elevated number of Galectin-3 expressing M2 macrophages, which is related to activated hepatic stellate cells and bile duct proliferation.
HEPATOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Gallo, Domenico Zannini, Barbara Immirzi, Alessandra De Bruno, Gabriella Fiorentino, Giovanni Dal Poggetto
Summary: The aim of this study was to extract antioxidant molecules from the pectin purification process of citrus lemon waste and encapsulate them in stable pectin films for a green and circular economy process. Seven molecules were recovered, identified, and quantified, and their antioxidant power and stability over time were evaluated. The stability and thermal properties of the bioactive fraction were improved by complexing it with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD). The most promising complexes showed increased stability over time compared to uncomplexed antioxidants when incorporated into a pectin film, demonstrating potential for the delivery of antioxidant molecules.
Article
Chemistry, Applied
Zhongcan Peng, Shurong Tian, Hailing Li, Longping Zhu, Zhimin Zhao, Guodong Zheng, Qiyin Wen, Hongru Tian, Depo Yang
Summary: The cell wall polysaccharides of Citrus reticulata cv. Chachiensis were extracted and characterized in terms of composition, structure, thermal, rheological, and antioxidant properties. The pectin fractions exhibited high methoxy pectin characteristics and high thermal stability. The water-soluble pectin showed the highest radical scavenging activity.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Marzieh Rashidipour, Bahram Rasoulian, Afshin Maleki, Behroz Davari, Naser Pajouhi, Ebrahim Mohammadi
Summary: In this study, it was found that encapsulation of paraquat in PEC/CS/TPP nanoparticles significantly reduced lung injury and fibrosis in a rat model of inhalation toxicity. Nanoencapsulation also led to lower apoptosis, oxidative stress, and alpha-SMA expression in lung tissue.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Review
Genetics & Heredity
Grzegorz Procyk, Aleksandra Czapla, Kamila Jalocha, Agata Tyminska, Marcin Grabowski, Aleksandra Gasecka
Summary: Galectin-3 shows potential as a diagnostic, prognostic, and predictive biomarker in atrial fibrillation (AF). Patients with AF have increased levels of galectin-3, and the concentration differs between different types of AF. Galectin-3 has the potential to predict the outcome of AF ablation therapy, with higher levels indicating a higher risk of AF recurrence.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Medicine, Research & Experimental
Diego D. Santos, Gisela R. S. Sasso, Nycole M. Belote, Rafael Andre da Silva, Izabella Lice, Rebeca D. Correia-Silva, Fernanda T. Borges, Adriana A. F. Carbonel, Cristiane D. Gil
Summary: The role of galectin-3 in liver was evaluated using an acute model of cisplatin-induced toxicity. Treatment with modified citrus pectin (MCP) was used to inhibit galectin-3. The study showed that reducing the levels of galectin-3 in hepatocytes promotes cell death and increases oxidative stress.
Article
Surgery
Abdulaziz Itlaybah, Hosam Elbanna, Sameh Emile, Waleed Thabet, Wagdi Elkashef, Noha Abdelsalam, Ahmed AbdelMawla, Haitham Elkaffas
Article
Pharmacology & Pharmacy
Mohammed M. Heikal, Ahmed A. Shaaban, Wagdi F. Elkashef, Tarek M. Ibrahim
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Nashwa Abu-Elsaad, Amr El-Karef
PHARMACOLOGICAL REPORTS
(2019)
Article
Gastroenterology & Hepatology
Tarek Besheer, Hatem Elalfy, Mohamed Abd El-Maksoud, Ahmed Abd El-Razek, Saher Taman, Khaled Zalata, Wagdy Elkashef, Hossam Zaghloul, Heba Elshahawy, Doaa Raafat, Wafaa Elemshaty, Eman Elsayed, Abdel-Hady El-Gilany, Mahmoud El-Bendary
WORLD JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Immunology
Mahmoud Elshal, Nashwa Abu-Elsaad, Amr El-Karef, Tarek Ibrahim
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Surgery
Sameh H. Emile, Ayman Elshobaky, Hosam G. Elbanna, Wagdi Elkashef, Mohamed A. Abdel-Razik
Article
Multidisciplinary Sciences
Ahmed M. Awad, Mohamed A. Saleh, Nashwa M. Abu-Elsaad, Tarek M. Ibrahim
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Medicinal
Mohamed A. Saleh, Ahmed M. Awad, Tarek M. Ibrahim, Nashwa M. Abu-Elsaad
Article
Cell Biology
Hassan Reda Hassan Elsayed, Mohammad El-Nablaway, Basma Adel Khattab, Rania N. Sherif, Wagdi Fawzy Elkashef, Asim Mohammed Abdalla, Eman Mohammad El Nashar, Mostafa Mohammed Abd-Elmonem, Randa El-Gamal
Summary: This study aimed to evaluate the therapeutic effect of alternate-day fasting (ADF) on non-alcoholic steatohepatitis (NASH), and found that ADF could improve HFF-induced NASH, reduce lipogenesis, apoptosis, and hepatic inflammation. The research also indicated that ADF could treat NASH by improving hepatic steatosis, inflammation, ballooning, and fibrosis.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Mohamed S. Elsayed, Nashwa M. Abu-Elsaad, Manar A. Nader
Summary: The study demonstrated that DAPA improves renal tissue integrity, reduces levels of kidney function biomarkers, and exerts its effects by inhibiting inflammatory molecules as well as proliferation and autophagy markers.
Review
Oncology
Waleed Elnahas, Islam H. Metwally, Wagdi Elkashef
Summary: Colorectal cancer commonly presents with distant metastasis, with thyroid metastasis being rarely reported. Metachronous thyroid metastasis from CRC, often originating from colon cancer, is associated with good survival rates. Further research comparing survival rates of thyroid metastasis patients with other metastatic sites is recommended.
MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Dina Eskandere, Hazem Hakim, Magdy Attwa, Wagdi Elkashef, Ahmed Youssef Altonbary
Summary: EUS-FNA is a safe and effective technique for determining the nature of PVT in patients with liver cirrhosis and/or HCC. This method plays an important role in the diagnosis of HCC.
CLINICAL ENDOSCOPY
(2021)
Article
Chemistry, Medicinal
Faten Shafeek, Dalia H. El-Kashef, Nashwa Abu-Elsaad, Tarek Ibrahim
Summary: Recently, recurrent heat stress and dehydration have caused a kidney disease epidemic in hot regions. This study investigated the potential renoprotective effect of dexamethasone and epigallocatechin-3-gallate on heat stress-induced nephropathy. The results showed that combination treatment with EGCG and Dexa significantly reduced kidney injury and inflammatory and oxidative stress responses.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Ahmed Atef, Khaled Gaballa, Mohammad Zuhdy, Khalid Atallah, Wagdi Elkashef, Shadi Awny, Basma Gadelhak, Basel Refky
JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE
(2019)
Article
Gastroenterology & Hepatology
Hassan E. Elbatee, Mohamed H. Emara, Mariam S. Zaghloul, Mohammed H. Ahmed, Mohamed I. Radwan, Ahmed S. Seif, Magdy B. Elmoghazy, Wagdi F. Elkashef