Article
Rheumatology
Cosimo Bruni, Sebastian Heidenreich, Ashley Duenas, Anna-Maria Hoffmann-Vold, Armando Gabrielli, Yannick Allanore, Emmanuel Chatelus, Joerg H. W. Distler, Eric Hachulla, Vivien M. Hsu, Nicolas Hunzelmann, Dinesh Khanna, Marie-Elise Truchetet, Ulrich A. Walker, Margarida Alves, Nils Schoof, Lesley Ann Saketkoo, Oliver Distler
Summary: This is the first study to quantitatively elicit patients' preferences for treatment attributes in SSc-ILD. Patients showed willingness to make trade-offs, providing a firm basis for shared decision-making in clinical practice.
Article
Oncology
Karima Amaador, Pythia T. Nieuwkerk, Monique C. Minnema, Marie Jose Kersten, Josephine M. Vos
Summary: Treatment preferences of Waldenstrom's Macroglobulinemia (WM) patients were assessed using a discrete choice experiment. Results showed that 5-year progression-free survival and risk of secondary malignancies were the most important attributes for making treatment choices. Patients preferred fixed-duration treatment with IV/SC administration at the hospital over a continuous daily oral regimen at home. These findings can inform discussions with individual patients and help design clinical trials in WM.
Article
Oncology
Daneng Li, Ruoding Tan, Sairy Hernandez, Norelle Reilly, Cooper Bussberg, Carol Mansfield
Summary: In patients with advanced hepatocellular carcinoma (HCC), avoiding severe hand-foot syndrome and high blood pressure is more important than prolonging survival. 10 additional months of maintaining daily function is considered equally or more important than 10 additional months of survival. For some patients with advanced HCC, maintaining quality of life and avoiding severe side effects is prioritized over the survival benefit of a treatment.
Article
Dermatology
Suna Hoelker, Nadia Ninosu, Sylvia Buettner, Wiebke K. Peitsch, Marthe-Lisa Schaarschmidt
Summary: This study investigated the preferences of patients with psoriasis regarding topical treatments. The study found that the probabilities of 50% and 90% improvement were the most important factors for patients, followed by the risk of skin atrophy and treatment cost. Factors such as income, cardiovascular disease, number of visits, and current topical therapy influenced treatment preferences.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Clinical Neurology
S. K. Simblett, M. Pennington, M. Quaife, S. Siddi, F. Lombardini, J. M. Haro, M. T. Penarrubia-Maria, S. Bruce, R. Nica, S. Zorbas, A. Polhemus, J. Novak, E. Dawe-Lane, D. Morris, M. Mutepua, C. Odoi, E. Wilson, F. Matcham, K. M. White, M. Hotopfjk, T. Wykes
Summary: This study explores the preferences for adoption of mobile technologies among individuals with a history of depression. The findings suggest that accurate symptom detection is the most important factor for these individuals, followed by privacy and clinical support. However, there are some individuals who are willing to compromise on accuracy in order to gain more privacy and clinical support.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Gastroenterology & Hepatology
Nyantara Wickramasekera, Emily Strong, Philip Shackley, Tia Callaghan, Matthew Lee, Daniel Hind, Steven Brown
Summary: This study collected patient views on treatment preferences and values for pilonidal sinus disease (PSD) using an online survey and discrete choice experiment. The findings showed that low risk of infection/persistence was the most important factor in treatment decision-making, followed by shorter recovery time. Additionally, patients in different age groups had different trade-offs between treatment recovery time and risk of infection/persistence.
COLORECTAL DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Yuankai Huang, Qixiang Huang, Ailin Xu, Mengqing Lu, Xiaoyu Xi
Summary: This study investigated patient preferences for diabetes treatment-related attributes in China, finding that patients prioritize the number of days with controlled blood glucose levels and are willing to pay for improvements in treatment outcomes.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Yasuo Sugitani, Kyoko Ito, Shunsuke Ono
Summary: The study in Japan revealed that for lung cancer patients, overall survival was the most important chemotherapy attribute, followed by adverse events. Patient preferences varied depending on demographic characteristics and disease background. Pharmaceutical companies should consider patient preferences to develop drugs that meet segmented market needs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Development Studies
Michael Poku-Boansi, Nathan Tetteh, Kwasi Kwafo Adarkwa
Summary: With increasing demand for housing worldwide, rental housing is becoming a popular choice to meet the supply deficit. A study conducted in Koforidua, Ghana, using a discrete choice experimental approach, found that factors such as location outskirts, rent payment modality of two years' advance, electricity availability, access road quality, and monthly rent payable significantly influence housing renters' preferences. The study also revealed variations in preferences based on renters' age, gender, vehicle ownership, and employment status. Recommendations included improving access routes within built-up areas, promoting alternative energy sources, and enhancing neighborhood road infrastructure for sustainable rental housing provision.
HABITAT INTERNATIONAL
(2023)
Article
Economics
Tommi Tervonen, Ashley Duenas, Hannah Collacott, Annette Lam, Katharine S. Gries, Robin Carson, Nicola Trevor, Nicolas Krucien, Jianming He
Summary: This study investigated the influence of disease status and current health state on treatment preferences of patients with multiple myeloma (MM). The results showed that pain, fatigue, and increased life expectancy were the most important factors. Participants were willing to trade an additional 2.7 years of life expectancy to tolerate extreme pain and an additional 2.0 years to tolerate constant fatigue. Current health state had a greater impact on treatment preferences than disease status.
Article
Endocrinology & Metabolism
C. Beaudart, A. Boonen, N. Li, S. Bours, S. Goemaere, J-Y Reginster, C. Roux, B. McGowan, A. Diez-Perez, R. Rizzoli, C. Cooper, M. Hiligsmann
Summary: Using a discrete choice experiment, this study aimed to assess patients' preferences for adopting lifestyle behaviors to prevent osteoporotic fractures. The results showed that most patients were favorable towards adopting certain lifestyle behaviors to prevent osteoporotic fractures.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Environmental Sciences
Edel Doherty, Sinead Mellett, Daniel Norton, Thomas K. J. McDermott, Denis O' Hora, Mary Ryan
Summary: Agriculture is highly vulnerable to climate change, with insurance seen as an efficient means of financial security but potentially leading to negative impacts. Irish farmers prefer multi-annual insurance, weather-indexed insurance, and affordable coverage.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Economics
Niranjan Poudel, Patrick A. Singleton
Summary: This study investigates the preferences of US adult bicyclists for roundabouts with different design and operational characteristics. The findings suggest that US bicyclists generally prefer roundabouts with smaller central islands, fewer travel lanes, lower traffic volumes, lower speed limits, and separated bicycle lanes.
TRANSPORTATION RESEARCH PART A-POLICY AND PRACTICE
(2022)
Article
Clinical Neurology
Pravesh S. Gadjradj, Nicholas V. R. Smeele, Mandy de Jong, Paul R. A. M. Depauw, Maurits W. van Tulder, Esther W. de Bekker-Grob, Biswadjiet S. Harhangi
Summary: Lumbar discectomy is a commonly performed procedure for treating sciatica. This study aims to determine patient preference weights for different attributes of the surgery, examine whether patient preferences change after surgery, identify preference heterogeneity in choosing surgery for sciatica, and calculate patient willingness to pay for other attributes.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Article
Health Care Sciences & Services
Simon Fifer, Brittany Keen, Polo Guilbert-Wright, Kaoru Yamabe, Dale J. Murdoch
Summary: This study aimed to understand how patients with heart valve disease (HVD) weigh the benefits and risks of different treatment procedures, as well as their preferences and the importance they place on various treatment attributes. The results showed that HVD patients prefer minimally invasive procedures over invasive ones, and the durability of the valve and faster recovery were the most important attributes influencing their treatment preferences.
HEALTH EXPECTATIONS
(2023)
Letter
Gastroenterology & Hepatology
Joshua Quan, Christopher Ma, Remo Panaccione, Lindsay Hracs, Nastaran Sharifi, Michelle Herauf, Ante Makovinovic, Stephanie Coward, Joseph W. Windsor, Lea Caplan, Richard J. M. Ingram, Jamil N. Kanji, Graham Tipples, Jessalyn K. Holodinsky, Charles N. Bernstein, Douglas J. Mahoney, Sasha Bernatsky, Eric Benchimol, Gilaad G. Kaplan
Article
Urology & Nephrology
N. Timilshina, S. M. H. Alibhai, G. Tomlinson, B. Sander, D. C. Cheung, A. Finelli
Summary: This study aimed to determine the long-term population-level oncological outcomes in active surveillance patients and examine the discontinuation rate. The results showed that active surveillance was associated with excellent long-term metastasis-free survival and overall survival, but slightly inferior cancer-specific survival.
JOURNAL OF UROLOGY
(2023)
Article
Surgery
Lusine Abrahamyan, George Tomlinson, Jeannie Callum, Steven Carcone, Deep Grewal, Justyna Bartoszko, Murray Krahn, Keyvan Karkouti
Summary: This study compared the cost-effectiveness of fibrinogen concentrate and cryoprecipitate in managing excessive bleeding after cardiac surgery. The results showed that fibrinogen concentrate is cost-effective in most adult patients who require fibrinogen replacement.
Article
Gastroenterology & Hepatology
Marietta Iacucci, Tommaso Lorenzo Parigi, Rocio Del Amor, Pablo Meseguer, Giulio Mandelli, Anna Bozzola, Alina Bazarova, Pradeep Bhandari, Raf Bisschops, Silvio Danese, Gert De Hertogh, Jose G. Ferraz, Martin Goetz, Enrico Grisan, Xianyong Gui, Bu Hayee, Ralf Kiesslich, Mark Lazarey, Remo Panaccione, Adolfo Parra-Blanco, Luca Pastorelli, Timo Rath, Elin S. Royset, Gian Eugenio Tontini, Michael Vieth, Davide Zardo, Subrata Ghosh, Valery Naranjo, Vincenzo Villanacci
Summary: An artificial intelligence computer-aided diagnosis system was developed and validated to evaluate UC biopsies and predict prognosis. The system showed high accuracy and sensitivity in assessing biopsy results and predicting outcomes.
Review
Rheumatology
Gurjeet Bhangu, Nicole M. S. Hartfeld, Diane Lacaille, Elena Lopatina, Alison M. Hoens, Megan R. W. Barber, Karen L. Then, Saania Zafar, Aurore Fifi -Mah, Glen Hazlewood, Claire E. H. Barber
Summary: Shared care models with patient-initiated follow-up show comparable outcomes for rheumatoid arthritis, including disease activity, radiographic damage, and quality of life. However, further research is needed to understand patient preferences, health equity considerations, and long-term outcomes for such models of care.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Oncology
Valerie S. Kim, Helen Yang, Narhari Timilshina, Henriette Breunis, Urban Emmenegger, Richard Gregg, Aaron R. Hansen, George Tomlinson, Shabbir M. H. Alibhai
Summary: As treatment options for metastatic castration-resistant prostate cancer (mCRPC) expand and its patient population ages, consideration of frailty is increasingly relevant. Using a novel frailty index (FI) and two common frailty screening tools, we examined quality of life (QoL) and physical function (PF) in frail versus nonfrail men receiving treatment for mCRPC.
JOURNAL OF GERIATRIC ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Simon Travis, Alison Potts Bleakman, Marla C. Dubinsky, Stefan Schreiber, Remo Panaccione, Toshifumi Hibi, Theresa Hunter Gibble, Cem Kayhan, Christian Atkinson, Christophe Sapin, Eoin J. Flynn, David T. Rubin
Summary: Bowel urgency has a significant impact on the lives of patients from the United States and Europe, and there are disparities between patient and healthcare professional perceptions on the experience and impact of ulcerative colitis symptoms. The CONFIDE study aimed to evaluate these symptoms and communication gaps between patients and healthcare professionals in the US and Europe.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Sangmin Lee, Cynthia H. Seow, Kara Nerenberg, Stefania Bertazzon, Yvette Leung, Vivian Huang, Tara Whitten, Stephanie Coward, Remo Panaccione, Gilaad G. Kaplan, Amy Metcalfe
Summary: Attendance at a dedicated IBD-pregnancy clinic improves disease-specific pregnancy knowledge and does not affect perinatal outcomes in pregnant women with IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Health Care Sciences & Services
Omar Dewidar, Mostafa Bondok, Leenah Abdelrazeq, Khadija Aliyeva, Karla Solo, Vivian Welch, Romina Brignardello-Petersen, Joseph L. Mathew, Glen Hazlewood, Kevin Pottie, Lisa Hartling, Dina Sami Khalifa, Stephanie Duda, Maicon Falavigna, Joanne Khabsa, Tamara Lotfi, Jennifer Petkovic, Sarah Elliot, Yuan Chi, Roses Parker, Elizabeth Kristjansson, Alison Riddle, Andrea J. Darzi, Olivia Magwood, Ammar Saad, Gabriel Radav, Ignacio Neumann, Mark Loeb, Ludovic Reveiz, Dominik Mertz, Thomas Piggott, Alexis F. Turgeon, Holger Schunemann, Peter Tugwell
Summary: Equity issues were rarely explicitly considered in the development of COVID-19 formal recommendations focused on specific disadvantaged populations. Guidance is needed to support the consideration of health equity in guideline development.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Letter
Rheumatology
Glen S. Hazlewood, Pooneh Akhavan, Jordi Pardo Pardo, Arnav Agarwal, Orit Schieir, Claire E. H. Barber, Laurie Proulx, Dawn P. Richards, Claire Bombardier, Janet E. Pope, Cheryl Barnabe, Peter Tugwell, Shahin Jamal, J. Carter Thorne, Roko P. A. Nikolic, Majed Khraishi, Nick Bansback, Alexandra Legge, Vivian Bykerk, Regina Taylor-Gjevre
JOURNAL OF RHEUMATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
R. Atreya, P. Irving, M. Fujiya, J. F. Colombel, S. Danese, L. Peyrin-Biroulet, T. Bessissow, R. Panaccione, G. D'Haens, S. van Haaren, E. Neimark, J. Zambrano, Y. Zhang, K. Kligys, M. Ferrante
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Audiology & Speech-Language Pathology
Peter R. Dixon, Justin Shapiro, George Tomlinson, Justin Cottrell, Justin T. Lui, Lindsey Falk, Joseph M. Chen
Summary: The cost-effectiveness of bilateral cochlear implants in adults is uncertain. This study aimed to review and synthesize published data on health state utility value (HSUV) associated with cochlear implants in adults. The results showed that the change in HSUV for unilateral cochlear implants compared to preimplant was small, while the change for bilateral cochlear implants was slightly larger, but there was no significant difference in HSUV between bilateral and unilateral cochlear implants.
Article
Critical Care Medicine
Christopher J. J. Yarnell, Federico Angriman, Bruno L. L. Ferreyro, Kuan Liu, Harm Jan De Grooth, Lisa Burry, Laveena Munshi, Sangeeta Mehta, Leo Celi, Paul Elbers, Patrick Thoral, Laurent Brochard, Hannah Wunsch, Robert A. A. Fowler, Lillian Sung, George Tomlinson
Summary: This study compared the effect of different hypoxemia severity thresholds on initiating invasive ventilation. The results showed that lower hypoxemia severity thresholds increased the rate of invasive ventilation and could either increase or decrease the expected mortality, depending on baseline mortality risk and clinical context.
Review
Health Policy & Services
Keiwan Wind, Blake Poland, Farimah HakemZadeh, Suzanne Jackson, George Tomlinson, Alejandro Jadad
Summary: This scoping review examines the association between social determinants of health (SDH) and self-reported health (SRH), identifies gaps in the literature, and proposes hypotheses for further exploration of the role of SDH in improving SRH.
HEALTH PROMOTION INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Sudheer K. Vuyyuru, Virginia Solitano, Neeraj Narula, Matthew J. Lee, John K. Macdonald, Jeffrey D. Mccurdy, Siddharth Singh, Christopher Ma, Vipul Jairath
Summary: The study aimed to evaluate the efficacy of medical therapies for fistulizing Crohn's disease. The results showed that anti-tumor necrosis factor agents, oral small molecules, ustekinumab, and mesenchymal stem cell therapy were effective for perianal fistulizing Crohn's disease.
JOURNAL OF CROHNS & COLITIS
(2023)