Article
Ophthalmology
Alessandro Marchese, Chiara Giuffre, Elisabetta Miserocchi, Maria Vittoria Cicinelli, Francesco Bandello, Giulio Modorati
Summary: This case report describes a 44-year-old female patient with Hodgkin lymphoma who developed anterior uveitis complicated by ocular hypotony. Treatment with ibopamine 2% eye drops was safe and effective in resolving ocular hypotony and improving vision in this patient.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Medicine, General & Internal
Yan Li
Summary: This is a case report of bilateral cataracts following hypoparathyroidism. The patient, a 27-year-old man, presented with painless and progressive visual impairment in both eyes over two years.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Biology
Sarah Kunze, Alexander Cecil, Cornelia Prehn, Gabriele Moeller, Andreas Ohlmann, Gerhild Wildner, Stephan Thurau, Kristian Unger, Ute Roessler, Sabine M. Hoelter, Soile Tapio, Florian Wagner, Andreas Beyerlein, Fabian Theis, Horst Zitzelsberger, Ulrike Kulka, Jerzy Adamski, Jochen Graw, Claudia Dalke
Summary: The long-term effects of low and moderate doses of ionizing radiation on the lens remain debated, with a study on B6C3F1 mice revealing no significant increase in posterior subcapsular cataracts (PSCs) after exposure to doses below 0.5 Gy. Factors such as sex and aging had a clearer effect on the lenses compared to radiation and genotype. Metabolomics analyses showed a sex effect in plasma samples, suggesting a complex interplay of factors in the development of PSCs.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Immunology
Eveline Daetwyler, Alfred Zippelius, Peter Meyer, Heinz Laubli
Summary: This article reports a case of optic neuropathy caused by pembrolizumab. Prompt treatment with high-dose steroids is necessary to prevent persistent loss of visual acuity. Combination therapy with steroids and mycophenolate mofetil showed significant success in treating steroid-refractory optic neuropathy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ophthalmology
Brad Guo, Matthew Little
Summary: This case report describes a patient with severe, recurrent bilateral panuveitis secondary to primary progressive multiple sclerosis who had a good response to ocrelizumab infusions.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Calvin L. McNelly, Asghar A. Haider, Robert C. Wann, Jason N. Crosson, John O. Mason
Summary: A case of painless posterior scleritis presenting as a choroidal nodule in a patient treated with pembrolizumab was reported. The findings were analyzed and a literature review was performed. It was concluded that clinicians should be aware of this ocular complication associated with the use of pembrolizumab.
JOURNAL OF VITREORETINAL DISEASES
(2023)
Article
Immunology
Kazuhiro Nishiyama, Kei Morikawa, Yusuke Shinozaki, Junko Ueno, Satoshi Tanaka, Hajime Tsuruoka, Shinya Azagami, Atsuko Ishida, Nobuyuki Yanagisawa, Yoshihiro J. J. Akashi, Masamichi Mineshita
Summary: ICI-induced myocarditis is rare but fatal, and its clinical course can be understood through case reports. We report a case of pembrolizumab-induced myocarditis and document the electrocardiographic changes from onset to death. The patient was admitted with pericardial effusion and was diagnosed with mild COVID-19. Despite treatment, she developed polymorphic ventricular tachycardia and died.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xiaoyan Zhang, Dongjiang Sui, Dong Wang, Lina Zhang, Ruiyan Wang
Summary: This case describes a rare occurrence of bullous pemphigoid associated with pembrolizumab, an immune checkpoint inhibitor used in the treatment of various malignant tumors. The patient developed severe skin reactions which were alleviated with glucocorticoid treatment. Increased awareness and early identification of cutaneous adverse effects of immunotherapy are essential to manage the toxicity effectively.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Amgad El Nokrashy, Eman El Hefny, Amani E. Badawi, Magda A. Torky, Ashraf Sewelam, Aya M. Hashish
Summary: This study outlines the posterior segment characteristics of presumed-trematode induced granulomatous uveitis. The findings show that involvement of the posterior segment structures may also threaten vision.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Medicine, General & Internal
Da Woon Kim, Hakeong Jeon, Sungmi Kim, Wanhee Lee, Hyo Jin Kim, Harin Rhee, Sang Heon Song, Eun Young Seong
Summary: FSGS is a common primary glomerular disorder that can be caused by pembrolizumab, an immune checkpoint inhibitor used for advanced melanoma. This case study highlights the importance of monitoring renal function and considering kidney biopsy in patients treated with PD-1 inhibitors who develop renal injury or unexplained proteinuria. Treatment based on guidelines can lead to resolution of nephrotic syndrome in such cases.
Article
Medicine, General & Internal
Xinyu Zhang, Zhibin Fu, Chaoguang Yan
Summary: This article reports a case of two episodes of cytokine release syndrome (CRS) and delirium caused by pembrolizumab. The occurrence of this case helps clinicians to better understand CRS and improve the diagnosis and treatment of immune-related adverse events.
Article
Infectious Diseases
Xiang Zhao, Junfang Huang, Lina Wang, Cuiyan Guo, JiTing Di, Yan Xiong, Weiming Huang, Jing Ma, Guangfa Wang
Summary: Pulmonary actinomycosis (PA) is a rare, asymptomatic, and often misdiagnosed pulmonary infectious disease. Despite extensive regular and invasive testing, significant intermittent hemoptysis, and repeated bronchial artery embolization, our patient remained undiagnosed. A left lower lobectomy was performed via video-assisted thoracoscopic surgery, and histopathological examination revealed an actinomycete infection.
INFECTION AND DRUG RESISTANCE
(2023)
Letter
Ophthalmology
Ploysai Rujkorakarn, Avery Zhou, Fatima Babiker, Peter Y. Y. Chang
Summary: We report the first case of SCS-TA used in the treatment of posterior scleritis, which resulted in pain relief and improved visual acuity. SCS-TA may be an effective treatment for posterior scleritis, but further studies are needed to establish its long-term efficacy and safety.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Yilin Sun, Jia Li, Li Yu, Yajuan Zheng
Summary: This case report highlights the clinical presentation of a patient with PPRCA, emphasizing the similarities with RP and proposing a potential genetic basis for the two conditions.
Article
Oncology
Waleed Kian, Melanie Zemel, Firas Elobra, Adam A. Sharb, Dina Levitas, Yarden Assabag, Farouq Alguayn, Alexander Yakobson, Keren Rouvinov, Lior Fuchs
Summary: This article reports a case of toxic epidermal necrolysis in a patient with non-small cell lung cancer following the use of pembrolizumab, which was completely resolved through the use of intravenous immunoglobulin.
