Article
Plant Sciences
Yuexin Zhang, Yapeng Fan, Cun Rui, Hong Zhang, Nan Xu, Maohua Dai, Xiugui Chen, Xuke Lu, Delong Wang, Junjuan Wang, Jing Wang, Qinqin Wang, Shuai Wang, Chao Chen, Lixue Guo, Lanjie Zhao, Wuwei Ye
Summary: The study showed that melatonin application can improve salt tolerance in cotton seedlings, with different levels of endogenous melatonin content in cotton varieties with varying salt tolerance. Inhibition of melatonin biosynthesis genes and endogenous melatonin content in cotton resulted in decreased antioxidant enzyme activity, Ca2+ content, and salt tolerance.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jia-Qi Wang, Ru-Hua Xiang, Zhong-Guang Li
Summary: This study investigated the crosstalk between hydrogen sulfide (H2S) and abscisic acid (ABA), as well as their role in inducing thermotolerance in maize seedlings. The results showed that H2S and ABA levels in maize seedlings could be induced by regulating their metabolic enzyme activity and gene expression. Additionally, H2S and ABA improved thermotolerance in maize seedlings by enhancing the ROS-scavenging system and reducing ROS levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Hongsheng Gao, Lunzeng Huang, Zijian Gong, Xueting Wang, Xuqiang Qiao, Fang Xiao, Yuting Yang, Bohui Yu, Xiaotong Guo, Chunyan Yu, Hongxia Zhang
Summary: Exogenous application of melatonin improves tobacco plant tolerance to high manganese stress by scavenging reactive oxygen species and regulating ion homeostasis.
PLANT GROWTH REGULATION
(2022)
Article
Plant Sciences
Vaseem Raja, Sami Ullah Qadir, Naveen Kumar, Abdulaziz Abdullah Alsahli, Joerg Rinklebe, Parvaiz Ahmad
Summary: Chromium is a hazardous metal contaminant that reduces crop production and poses a risk to human health. This study investigates the role of melatonin and strigolactones in mitigating Chromium toxicity in tomato plants.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Plant Sciences
Monica De Palma, Teresa Docimo, Gianpiero Guida, Maria Salzano, Rossella Albrizio, Pasquale Giorio, Michelina Ruocco, Marina Tucci
Summary: Trichoderma spp. can enhance plant performance under water stress by modulating transcription factors and genes related to photosynthesis, antioxidant defences, and maintenance of a juvenile state. The fungi specifically affected genes involved in stress damage mitigation, helping plants recover growth and photosynthesis levels after stress.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Genetics & Heredity
Sidra Habib, Yee Yee Lwin, Ning Li
Summary: The study demonstrates the significant role of tomato SlGRAS10 gene in plant growth and development under salt stress and drought. Down-regulation of SlGRAS10 through RNA interference resulted in dwarf plants with enhanced tolerance to abiotic stresses, increased flavonoid accumulation, and enhanced reactive oxygen species scavenging system.
Article
Biochemical Research Methods
Jia-Rong Wu, Rida Zohra, Ngoc Kieu Thi Duong, Ching-Hui Yeh, Chung-An Lu, Shaw-Jye Wu
Summary: In this study, a protein farnesylation system was developed in E. coli, and its applicability and practicality in producing farnesylated proteins from different plants were successfully demonstrated.
Review
Plant Sciences
Zongliang Chen, Mary Galli, Andrea Gallavotti
Summary: Temperature is a crucial environmental factor that affects crop development, and thermotolerance is an essential trait for the future of agriculture. This review examines recent findings on the regulation of plant growth by temperature, as well as the effects of heat on hormonal pathways, reactive oxygen species, and epigenetic regulation. Additionally, it highlights approaches and strategies that can be integrated to address the challenges of sustaining crop productivity in the coming decades.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Plant Sciences
Kai Chen, Chen Su, Wensi Tang, Yongbin Zhou, Zhaoshi Xu, Jun Chen, Haiyan Li, Ming Chen, Youzhi Ma
Summary: Drought stress increases ROS formation in plants, affecting soybean yield. Overexpression of GmNTF2B-1 improves drought tolerance by regulating ROS content, while the interaction between GmNTF2B-1 and GmOXR17 enhances nuclear ROS scavenging and drought resistance in soybeans.
Article
Plant Sciences
Cong Sun, Sida Meng, Baofeng Wang, Siting Zhao, Yulong Liu, Mingfang Qi, Zhenqi Wang, Zepeng Yin, Tianlai Li
Summary: Heat stress inhibits photosynthetic electron transfer and increases ROS burst, causing damage to plant growth. However, exogenous melatonin improves photosynthetic efficiency and reduces oxidative damage by regulating electron transfer and antioxidant activities.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Plant Sciences
Si-Jia Yang, Bo Huang, Yu-Qing Zhao, Di Hu, Tao Chen, Chun-Bang Ding, Yang-Er Chen, Shu Yuan, Ming Yuan
Summary: The study found that exogenous melatonin can increase plant photosynthetic rate and protect photosynthetic proteins; mainly achieved by reducing the accumulation of reactive oxygen species, protecting the integrity of membrane and photosynthetic pigments, and reducing cell death.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Ziping Chen, Shijia Lin, Juan Li, Tingting Chen, Quan Gu, Tianyuan Yang, Zhaoliang Zhang
Summary: Salt stress increased the accumulation of various amino acids and theanine in tea plants, suggesting the induction of theanine biosynthesis. Applying theanine enhanced the salt stress tolerance and antioxidant activity in new shoots. The study indicated that theanine-induced salt stress tolerance is mediated by a CAT-dependent redox homeostasis pathway.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Sanober Gul, Kausar Nawaz Shah, Rashid Mehmood Rana, Muhammad Azam Khan, Ahmed M. El-Shehawi, Mona M. Elseehy
Summary: Heat shock proteins, specifically the Hsp100 gene family, are crucial for thermos-tolerance in plants. This study identified six SlHsp100 genes in tomato and investigated their evolutionary relationship and expression under heat stress. Sub-cellular localization of these genes showed distribution in chloroplast, mitochondria, and cytoplasm, while phylogenetic analysis revealed clustering among members of different kingdoms. Functional divergence between Hsp100 clusters demonstrated significant functional homology. Heat stress led to upregulation of the chloroplastic LeHSP110/ClpB gene, indicating the important role of this gene family in acquired thermo-tolerance.
Review
Chemistry, Multidisciplinary
Craig J. Neal, Elayaraja Kolanthai, Fei Wei, Melanie Coathup, Sudipta Seal
Summary: Reducible metal oxide nanozymes (rNZs) have attracted intense attention due to their catalytic nature, ease of synthesis, and complex surface character. Research has shown that the surface reactive sites of rNZs are highly sensitive to stresses, the physicochemical environment, and processing conditions. When administered in vivo, a protein corona binds to the surface, altering its biological identity and interactions within the biological system. The catalytic activities of rNZs impact protein corona formation, composition, and recognition by host cells. Understanding the principles that govern surface-biomolecule adsorption on rNZs is crucial for preventing corona formation or customizing protein coronas.
ADVANCED MATERIALS
(2023)
Article
Plant Sciences
Nikolaj Bjerring Jensen, Carl-Otto Ottosen, Rong Zhou
Summary: Understanding stomatal regulation in climate stress is crucial for resilient crops. This study investigates the effects of exogenous melatonin on stomatal conductance (g(s)) and its interactions with ABA or ROS signaling in combined heat and drought stress. It was found that in combined stress, stomata responded predominantly to heat at 50% soil moisture and to drought stress at 20% soil moisture. Melatonin treatment affected g(s) and ROS scavenging enzyme activity but had no effect on ABA levels. ABA metabolism and conjugation might play a role in stomatal opening towards high temperatures.
Article
Biochemistry & Molecular Biology
Han Zheng, Haifeng Li, Jingyuan Zhang, Hanlu Fan, Lina Jia, Wenqiang Ma, Shuoqian Ma, Shenghong Wang, Hua You, Zhinan Yin, Xiangdong Li
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Oncology
Huijiao Liu, Mei Liu, Hua You, Xiru Li, Xiangdong Li
FRONTIERS IN ONCOLOGY
(2020)
Review
Oncology
Yuting Zhong, Huayu Hu, Ningning Min, Yufan Wei, Xiangdong Li, Xiru Li
Summary: Bleeding complications can lead to morbidities and mortalities, necessitating the development of fast, efficient, safe, and ready-to-use hemostatic materials. Understanding the coagulation process and mechanisms of different materials is essential to develop novel hemostatic agents. This review discusses the structural features of topical hemostatic materials, commercially available products, ongoing clinical trials, and recent studies on the development of different hemostatic materials.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Peng Li, Runjie Song, Fan Yin, Mei Liu, Huijiao Liu, Shuoqian Ma, Xiaomeng Jia, Xiaohui Lu, Yuting Zhong, Lei Yu, Xiru Li, Xiangdong Li
Summary: This study identifies circMRPS35 as a highly expressed circRNA in HCC and shows that its knockdown inhibits cell proliferation, migration, invasion, and colony formation, as well as tumor growth. circMRPS35 regulates PTEN expression and degradation through miR-148a and STX3. Additionally, the circMRPS35-encoded peptide circMRPS35-168aa promotes cisplatin resistance in HCC.
Article
Cell Biology
Kamila Pulawska, Donata Ponikwicka-Tyszko, Weronika Lebiedzinska, Peilan Guo, Piotr Bernaczyk, Agata Pilaszewicz-Puza, Xiangdong Li, Marcin Chrusciel, Oana Lupu, Sini Leskinen, Juho-Antti Makela, Jorma Toppari, Slawomir Wolczynski, Herjan J. T. Coelingh Bennink, Ilpo Huhtaniemi, Nafis A. Rahman
Summary: The study reveals unexpected ZP3 expression in the testis of healthy human and mouse, besides ovary, suggesting implications for the development of cancer immunotherapies and male immunocontraceptives targeting ZP3.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Yongli Qin, Lina Jia, Huijiao Liu, Wenqiang Ma, Xinmin Ren, Haifeng Li, Yuanwu Liu, Haiwen Li, Shuoqian Ma, Mei Liu, Pingping Li, Jinghua Yan, Jiyan Zhang, Yangdong Guo, Hua You, Yan Guo, Nafis A. Rahman, Slawomir Wolczynski, Adam Kretowski, Dangsheng Li, Xiru Li, Fazheng Ren, Xiangdong Li
Summary: The research shows that NOC4L is reduced in humans and mice with obesity, and its deficiency worsens inflammation and insulin resistance induced by a high-fat diet. NOC4L interacts with Toll-like receptor 4 to inhibit endocytosis, thereby blocking TLF4/TRIF inflammatory signaling.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Runjie Song, Yaqi Du, Peng Li, Lijun Zhou, Han Zheng, Xiaohui Lu, Shenghong Wang, Wenqiang Ma, Hua Zhang, Xiangdong Li
Summary: This study found that LETMD1 plays a crucial role in the thermogenesis and energy homeostasis of brown adipose tissue. By regulating mitochondrial structures and functions, LETMD1 can affect mitochondrial fission and the concentration of Ca2+, thereby influencing the thermogenesis of brown adipose tissue.
Article
Biochemistry & Molecular Biology
Peng Li, Runjie Song, Yaqi Du, Huijiao Liu, Xiangdong Li
Summary: Brown and beige adipose tissues play a crucial role in maintaining body temperature and their impaired function can lead to metabolic diseases. This study identified a functional thermogenic regulator, Adtrp, which was significantly overexpressed in mature brown/beige adipocytes and played a key role in thermogenesis and metabolism.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medical Laboratory Technology
Shanshan Zhang, Yajing Liu, Mingming Wang, Donata Ponikwicka-Tyszko, Wenqiang Ma, Anna Krentowska, Irina Kowalska, Ilpo Huhtaniemi, Slawomir Wolczynski, Nafis A. Rahman, Xiangdong Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, but its etiology and targeted therapy options are still unknown. The reduced expression of miR-335-5p in PCOS patients suggests its potential as a diagnostic biomarker and therapeutic target for PCOS. Further studies revealed the mechanistic pathway of miR-335-5p in the etiopathogenesis of PCOS, making it a promising candidate for further research and development.
TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaomeng Jia, Huijiao Liu, Xinmin Ren, Peng Li, Runjie Song, Xiru Li, Yangdong Guo, Xiangdong Li
Summary: This study identified a novel SIRT1 regulatory protein, NOC4L, that binds to and inhibits the deacetylation of p53 mediated by SIRT1. Overexpression of NOC4L increases p53 acetylation and promotes cell apoptosis, while inhibiting tumor cell proliferation and tumor growth in a p53-dependent manner.
Article
Biochemistry & Molecular Biology
Runjie Song, Shuoqian Ma, Jiajia Xu, Xin Ren, Peilan Guo, Huijiao Liu, Peng Li, Fan Yin, Mei Liu, Qiang Wang, Lei Yu, Jiali Liu, Binwei Duan, Nafis A. Rahman, Slawomir Wolczynski, Guangming Li, Xiangdong Li
Summary: This study aims to elucidate the potential role and molecular mechanism of circZKSaa in the regulation of hepatocellular carcinoma (HCC) progression. Through a series of experiments, it was found that circZKSaa inhibited HCC progression and sensitized HCC cells to sorafenib. Furthermore, the high expression of cicZKSCAN1 in sorafenib-treated HCC cells was regulated by QKI-5. These findings demonstrate that circZKSaa has the potential to serve as a therapeutic target and biomarker for HCC treatment.
Article
Medical Laboratory Technology
Yajing Liu, Shanshan Zhang, Li Chen, Xuan Huang, Mingming Wang, Donata Ponikwicka-Tyszko, Nafis A. Rahman, Slawomir Wolczynski, Bing Yao, Xiangdong Li
Summary: The study found that miR-96-5p plays a crucial role in the pathogenesis of PCOS and may serve as a novel diagnostic biomarker and therapeutic target for PCOS.
TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Runjie Song, Peilan Guo, Xin Ren, Lijun Zhou, Peng Li, Nafis A. Rahman, Slawomir Wolczynski, Xiru Li, Yanjun Zhang, Mei Liu, Jiali Liu, Xiangdong Li
Summary: This study reanalyzed the circRNA expression data of TNBC and identified circCAPG as a potential biomarker in TNBC. Further experiments showed that circCAPG could encode a novel polypeptide, CAPG-171aa, which promoted the proliferation and metastasis of TNBC cells. Additionally, SLU7 was found to be involved in the formation of circCAPG. These findings provide new insights into the role of circCAPG in TNBC and its potential as a therapeutic target and prognostic biomarker.
Article
Medicine, Research & Experimental
Xiaohui Lu, Jingyuan Zhang, Huijiao Liu, Wenqiang Ma, Leo Yu, Xin Tan, Shubin Wang, Fazheng Ren, Xiru Li, Xiangdong Li
Summary: CBD has shown promising effects in reversing pathological changes, inhibiting proliferation of PASMCs, reducing inflammation and oxidative stress levels, and alleviating pulmonary arterial hypertension in rodent models by improving mitochondrial energy metabolism and reducing lactate accumulation.
Article
Oncology
Donata Ponikwicka-Tyszko, Marcin Chrusciel, Kamila Pulawska, Piotr Bernaczyk, Maria Sztachelska, Peilan Guo, Xiangdong Li, Jorma Toppari, Ilpo T. Huhtaniemi, Slawomir Wolczynski, Nafis A. Rahman