Molecular mechanism of curcumin action in signaling pathways: Review of the latest research

Effective electrochemotherapy with curcumin in MDA-MB-231-human, triple negative breast cancer cells: A global proteomics study

(2019) Lakshya Mittal et al.   BIOELECTROCHEMISTRY

Curcumin induces endoplasmic reticulum stress-associated apoptosis in human papillary thyroid carcinoma BCPAP cells via disruption of intracellular calcium homeostasis

(2018) Li Zhang et al.   MEDICINE

Inhibition of EV71 by curcumin in intestinal epithelial cells

(2018) Hsing-I Huang et al.   PLoS One

Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2

(2018) Sourav Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth

(2018) Yonika Arum Larasati et al.   Scientific Reports

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity

(2018) David Wang et al.   Cell Reports

Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition, and expression of differentiation genes in thyroid carcinoma cells

(2017) Suzan Schwertheim et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Curcumin attenuates blood-brain barrier disruption after subarachnoid hemorrhage in mice

(2017) Jichao Yuan et al.   JOURNAL OF SURGICAL RESEARCH

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11

(2017) Jing Li et al.   Nature Chemical Biology

Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance

(2017) Y Song et al.   ONCOGENE

Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway

(2017) An Hu et al.   Oncotarget

Intracellular Ca 2+ signaling and Ca 2+ microdomains in the control of cell survival, apoptosis and autophagy

(2016) Rita M.L. La Rovere et al.   CELL CALCIUM

Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance

(2016) Lulu Wang et al.   JOURNAL OF LIPID RESEARCH

Apoptotic activity and gene responses inDrosophila melanogasterS2 cells, induced by azadirachtin A

(2016) Lin Xu et al.   PEST MANAGEMENT SCIENCE

Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice

(2016) Hai-Mei Zhao et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

(2015) Ken Itoh et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects

(2015) Esther Parada et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis

(2015) Xing Guo et al.   NATURE CELL BIOLOGY

The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro

(2015) Xiang Li et al.   Viruses-Basel

Mitochondria as a Target in the Therapeutic Properties of Curcumin

(2014) Joyce Trujillo et al.   ARCHIV DER PHARMAZIE

Endoplasmic reticulum stress associated responses in cancer

(2014) Wen-An Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Apigenin Inhibits Enterovirus-71 Infection by Disrupting Viral RNA Association with trans-Acting Factors

(2014) Wei Zhang et al.   PLoS One

Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-Catenin Pathway

(2013) Shashi Kant Tiwari et al.   ACS Nano

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Curcumin, a component of turmeric: From farm to pharmacy

(2013) Subash C. Gupta et al.   BIOFACTORS

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

(2013) Hironori Satoh et al.   CANCER RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Activation of Nrf2-Antioxidant Response Element Mediated Glutamate Cysteine Ligase Expression in Hepatoma Cell line by Homocysteine

(2013) Monireh Mani et al.   Hepatitis Monthly

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway

(2013) Jingxian Wu et al.   PLoS One

bis-Dehydroxy-Curcumin Triggers Mitochondrial-Associated Cell Death in Human Colon Cancer Cells through ER-Stress Induced Autophagy

(2013) Valentina Basile et al.   PLoS One

Very long-term follow-up results of imatinib mesylate therapy in chronic phase chronic myeloid leukemia after failure of interferon alpha therapy

(2012) Hagop Kantarjian et al.   CANCER

Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2

(2012) Peter H. Killian et al.   CARCINOGENESIS

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

Multitargeting by turmeric, the golden spice: From kitchen to clinic

(2012) Subash C. Gupta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Early cytogenetic and molecular response during first-line treatment of chronic myeloid leukemia in chronic phase

(2011) Alfonso Quintás-Cardama et al.   CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Kaempferol inhibits enterovirus 71 replication and internal ribosome entry site (IRES) activity through FUBP and HNRP proteins

(2011) Fuu-Jen Tsai et al.   FOOD CHEMISTRY

Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF  treatment

(2011) C. Veltkamp et al.   GUT

Curcumin and its nano-formulation: The kinetics of tissue distribution and blood–brain barrier penetration

(2011) Yin-Meng Tsai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat

(2010) Diego Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity

(2010) A. Bielak-Zmijewska et al.   CELL PROLIFERATION

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

(2010) Gerasimos P Sykiotis et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial

(2010) François-Xavier Mahon et al.   LANCET ONCOLOGY

Microglia and neuroprotection: From in vitro studies to therapeutic applications

(2010) Elisabetta Polazzi et al.   PROGRESS IN NEUROBIOLOGY

Chromatin remodeling complex in Treg function

(2009) Anant Jani et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting the ubiquitin system in cancer therapy

(2009) Daniela Hoeller et al.   NATURE

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

(2008) Preetha Anand et al.   BIOCHEMICAL PHARMACOLOGY

Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells

(2008) A. Kunwar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner

(2008) Jane L. Watson et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

(2008) Hwan-Ching Tai et al.   NATURE REVIEWS NEUROSCIENCE

Anti cancer effects of curcumin: cycle of life and death

(2008) Gaurisankar Sa et al.   Cell Division