Article
Chemistry, Medicinal
Cong Lu, Zhen Wei, Ning Jiang, Ying Chen, Yongquan Wang, Shuying Li, Qiong Wang, Bei Fan, Xinmin Liu, Fengzhong Wang
Summary: Mounting evidence suggests a close association between chronic sleep deprivation (CSD) and cognitive deficits. This study investigated the effects of soy isoflavones (SI) on CSD-induced memory impairment. The results showed that SI administration improved cognitive performance, reduced oxidative stress, and suppressed inflammation in CSD-treated mice.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Bin Guo, Chan Chen, Lin Yang, Rong Zhu
Summary: The study aimed to evaluate the effects of DEX on the postoperative cognitive function of SD rats, and findings suggest that DEX can effectively alleviate postoperative hippocampal inflammation and improve cognitive function in SD rats. The mechanism may be related to the regulation of the Rac1/AKT/NF-κB pathway by DEX, leading to reduced oxidative stress in hippocampal neurons and restoration of damaged cells.
Article
Chemistry, Medicinal
Ning Jiang, Yiwen Zhang, Caihong Yao, Yupei Liu, Yuzhen Chen, Fang Chen, Yan Wang, Muhammad Iqbal Choudhary, Xinmin Liu
Summary: A compound called Tenuifolin (TEN) extracted from the Polygala tenuifolia Willd plant has been found to improve cognitive symptoms caused by sleep deprivation. It works by activating anti-inflammatory cells, improving antioxidant status, and restoring impaired neurogenesis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nutrition & Dietetics
Yadong Zheng, Luyan Zhang, Laura Bonfili, Luisa de Vivo, Anna Maria Eleuteri, Michele Bellesi
Summary: Insufficient sleep is a significant public health problem, leading to increased risk of chronic diseases and oxidative damage. Probiotics have antioxidant and anti-inflammatory properties and can counteract oxidative stress and inflammation caused by sleep loss.
Article
Food Science & Technology
Yujuan Li, Zheng Xie, Xiaoxiao Luo, Xuan Wang, Yue Wang, Mingke Guo, Zhiqiang Zhou, Rao Sun, Dongyu Hua, Ailin Luo, Shiyong Li
Summary: This study demonstrates that farnesol (FOL) can protect against cognitive impairment caused by sleep deprivation (SD) through activation of the Sirt1/Nrf2 signaling pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Behavioral Sciences
Yujie Hu, Jierong Yin, Guoshuai Yang
Summary: The purpose of this study is to investigate the mechanism of melatonin in regulating cognitive impairment caused by chronic sleep deprivation. A chronic sleep deprivation model was established and melatonin receptor agonist and inhibitor were administered. Results showed that melatonin can alleviate cognitive impairment by upregulating BMAL1 and reducing oxidative stress.
BRAIN AND BEHAVIOR
(2023)
Article
Medicine, Research & Experimental
M. A. Hamed, T. M. Akhigbe, R. E. Akhigbe, A. O. Aremu, P. A. Oyedokun, A. Gbadamos, P. E. Anifowose, M. A. Adewole, O. O. Aboyeji, H. O. Yisau, G. O. Tajudeen, M. M. Titiloye, N. F. Ayinla, A. F. Ajayi
Summary: Sleep deprivation has detrimental effects on male reproductive function, including reduced sperm quality and testicular injury. In addition, it leads to erectile dysfunction and decreased libido. Glutamine supplementation has been found to attenuate the negative effects of sleep deprivation on reproductive function.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Neurosciences
Zachary Zamore, Sigrid C. Veasey
Summary: Recent studies question the full recovery after chronic sleep disruption in both humans and animals. Human studies identify specific cognitive domains, such as sustained vigilance and episodic memory, that are particularly vulnerable to delayed or incomplete recovery. These findings guide animal model studies in examining the lasting impact of sleep loss on the brain. The article proposes common injury pathways in various forms of sleep disruption and discusses the implications of this injury in aging and neurodegenerative disorders.
TRENDS IN NEUROSCIENCES
(2022)
Article
Neurosciences
Boya Huang, Binhuang Sun, Rui Yang, Shihao Liang, Xinrui Li, Yi Guo, Qian Meng, Yaling Fu, Wenshuya Li, Penghui Zhao, Miao Gong, Yun Shi, Li Song, Sheng Wang, Fang Yuan, Haishui Shi
Summary: Sleep deprivation has long-term effects on cognitive function and social behavior in mice. It leads to cognitive impairment and decreased social dominance in adult male mice, while increasing food intake and weight. Levels of serum corticosterone, vasopressin and oxytocin are elevated, while neural dendritic spine density is reduced.
Article
Psychiatry
Man Yang, Jin Li, Haidong Yang, Linya Yan, Dongliang Liu, Lin Zhu, Xiaobin Zhang
Summary: This study found that abnormal plasma oxidative stress levels in patients with chronic schizophrenia are associated with cognitive impairment. The decreased plasma MDA levels and increased CAT activity may be related to the pathophysiology of schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Xiao-Chuan Zhao, Ke-Yan Han, Yuan-Yuan Gao, Na Li, Lan Wang, Lu-Lu Yu, Mei Song, Xue-Yi Wang
Summary: Shift work can lead to sleep disturbances and impaired cognitive function, especially in workers with lower educational levels, affecting aspects such as working memory performance.
PSYCHIATRY RESEARCH
(2021)
Article
Agriculture, Multidisciplinary
Qinchao Ding, Aiwen Pi, Liuyi Hao, Tiantian Xu, Qin Zhu, Long Shu, Xiaolong Yu, Weiguang Wang, Caijuan Si, Songtao Li
Summary: This study demonstrated that genistein has a protective role in acetaldehyde-induced liver injury in ALD. It ameliorates alcohol-induced hepatic steatosis, injury, and inflammation by reducing oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, and hepatocellular apoptosis. The restoration of heme oxygenase-1 (HO-1) levels and involvement of hepatic nuclear factor erythroid 2-related factor 2 (NRF2) were found to be the mechanisms behind genistein's protective effects.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Pinhong Chen, Dongmei Wang, Meihong Xiu, Dachun Chen, Blake Lackey, Hanjing E. Wu, Jin Zhou, Xiangyang Zhang
Summary: This study explores the association between the transferrin gene polymorphism rs3811655 and psychotic symptoms, cognition, and antioxidant enzymes in patients with schizophrenia. The results suggest that this polymorphism is involved in iron-induced oxidative stress and cognitive impairment in schizophrenia, deepening our understanding of the pathophysiology of the disorder.
Article
Cell Biology
Marcos Monico-Neto, Kil Sun Lee, Marcio Henrique Mello da Luz, Jessica Monteiro Volejnik Pino, Daniel Araki Ribeiro, Caroline Margonato Cardoso, Luciana Le Sueur-Maluf, Sergio Tufik, Hanna Karen Moreira Antunes
Summary: Previous studies have shown that muscle atrophy can be observed after sleep deprivation, but the exact mechanisms are not fully understood. Different types of muscle fibers exhibit variations in oxidative damage and histopathological changes. Muscle predominantly composed of type I fibers show greater oxidative damage and catabolic activity.
CELLULAR SIGNALLING
(2021)
Article
Neurosciences
Hui Gao, Yuxin Zhang, Danlei Luo, Jing Xu, Shuwen Tan, Ying Li, Wanling Qi, Qian Zhai, Qiang Wang
Summary: Sleep loss has become common in modern society and has a significant impact on cognitive abilities. Activation of the dopamine receptor D2 (DRD2) has been found to play a specific role in cognition, but the exact mechanism of how DRD2 affects cognition after sleep deprivation is still unclear. This study observed cognitive impairment and impaired synaptic plasticity in mice with chronic sleep restriction (CSR), including downregulation of synaptophysin and PSD95, decreased postsynaptic density thickness, neuron complexity, and spine density. The study also found downregulation of hippocampal DRD2 and Cryab expression in CSR mice, as well as neuroinflammation indicated by NF-κB translocation. However, treatment with the DRD2 agonist quinpirole effectively reversed these changes, both in vitro and in vivo, suggesting a potential anti-neuroinflammatory effect of Drd2/Cryab/NF-κB in CSR mice.
MOLECULAR NEUROBIOLOGY
(2023)