Journal
PHYTOCHEMISTRY
Volume 168, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2019.112127
Keywords
Epigynum cochinchinensis (Apocynaceae); Epigycoside E; Pregnane glycosides; Immunosuppressive; Cytokines
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Funding
- National Natural Science Foundation of China [31600274, 31960094, 31460083]
- Applied Basic Research Project of Yunnan Province [2018FB036]
- Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Traditional Chinese Pharmacology), Zhejiang Chinese Medical University [ZYAOX2018031]
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Five undescribed C-21 pregnane glycosides, epigycosides D - H, together with four known analogues, two lignans, and a flavonoid have been isolated from the stems of Epigynum cochinchinensis. The structures of pregnane glycosides were elucidated using spectroscopic techniques and acid hydrolysis. The in vitro immunological activities were assessed against Con A-stimulated proliferation of mice splenocytes. The C-21 pregnane glycosides showed immunosuppressive activity in a concentration-dependent manner. Moreover, epigycoside E exhibited a potent immunosuppressive effect, and the IC50 value on Con A-stimulated mice splenocytes was 22.1 +/- 6.4 mu M. Epigycoside E also caused G(0)/G(1) arrest, and inhibited TNF-alpha and IL-2 production.
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