Journal
BIOSENSORS & BIOELECTRONICS
Volume 63, Issue -, Pages 478-482Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.07.060
Keywords
Electrochemiluminescence; Peptide nanovesicles; Dopamine
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Funding
- National Basic Research Program of China [2011CBA00508]
- National Natural Science Foundation of China [21175009]
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The electrogenerated chemiluminescence (ECL) behavior of the bioinspired peptide nanovesicles (PNVs) was reported for the first time. The PNVs modified glassy carbon electrodes have shown a stable and efficient cathodic ECL signal with K2S2O8 as coreactant in aqueous solution. The possible ECL reaction mechanism was proposed. Dopamine (DA) was chosen as a model analyte to study the potential of the PNVs in the ECL analytical application. It was found that the ECL intensity of the PNVs was effectively increased by trace amounts of DA The limit of detection was estimated to be 3.15 pM (S/N=3). These results suggest that the PNVs could be a new class of promising materials for the ECL design and bioassays in the future due to their fascinating features, such as excellent biocompatibility, tunable composition as well as capability of molecular recognition. (C) 2014 Elsevier B.V. All rights reserved.
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