Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments

Sex and Mitonuclear Adaptation in Experimental Caenorhabditis elegans Populations

(2019) Riana I. Wernick et al.   GENETICS

When a common biological role does not imply common disease outcomes: Disparate pathology linked to human mitochondrial aminoacyl-tRNA synthetases

(2019) Ligia Elena González-Serrano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic scans reveal multiple mito-nuclear incompatibilities in population crosses of the copepod Tigriopus californicus

(2019) Thiago G. Lima et al.   EVOLUTION

Interactions Between Mitochondrial Haplotype and Dietary Macronutrient Ratios Confer Sex-Specific Effects on Longevity in Drosophila melanogaster

(2019) Venkatesh Nagarajan-Radha et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Germline selection shapes human mitochondrial DNA diversity

(2019) Wei Wei et al.   SCIENCE

Sexual conflict through mother’s curse and father’s curse

(2019) J. Arvid Ågren et al.   THEORETICAL POPULATION BIOLOGY

Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla

(2019) Paméla Dakik et al.   Frontiers in Physiology

Mitochondrial Recombination Reveals Mito–Mito Epistasis in Yeast

(2018) John F. Wolters et al.   GENETICS

The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases

(2018) Hyon-Seung Yi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Coadaptation of mitochondrial and nuclear genes, and the cost of mother's curse

(2018) Tim Connallon et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mitochondrial Recombination Reveals Mito–Mito Epistasis in Yeast

(2018) John F. Wolters et al.   GENETICS

Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy

(2018) Meagan J. McManus et al.   Cell Metabolism

Assessing the fitness consequences of mitonuclear interactions in natural populations

(2018) Geoffrey E. Hill et al.   BIOLOGICAL REVIEWS

Mitonuclear epistasis, genotype-by-environment interactions, and personalized genomics of complex traits in Drosophila

(2018) David M. Rand et al.   IUBMB LIFE

Evolution in the light of fitness landscape theory

(2018) Inês Fragata et al.   TRENDS IN ECOLOGY & EVOLUTION

Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness

(2018) Wen C. Aw et al.   PLoS Genetics

The Genetic Architecture of Intra-Species Hybrid Mito-Nuclear Epistasis

(2018) Rania Haddad et al.   Frontiers in Genetics

Mitotype Interacts With Diet to Influence Longevity, Fitness, and Mitochondrial Functions in Adult Female Drosophila

(2018) Samuel G. Towarnicki et al.   Frontiers in Genetics

Mitochondrial Replacement Therapy: Are Mito-nuclear Interactions Likely To Be a Problem?

(2017) Adam Eyre-Walker   GENETICS

MiSynPat: An integrated knowledge base linking clinical, genetic, and structural data for disease-causing mutations in human mitochondrial aminoacyl-tRNA synthetases

(2017) Luc Moulinier et al.   HUMAN MUTATION

SmithRNAs: Could Mitochondria “Bend” Nuclear Regulation?

(2017) Andrea Pozzi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits

(2017) Lorin Crawford et al.   PLoS Genetics

Mitochondrial Replacement Therapy: Are Mito-nuclear Interactions Likely To Be a Problem?

(2017) Adam Eyre-Walker   GENETICS

Mother’s curse neutralizes natural selection against a human genetic disease over three centuries

(2017) Emmanuel Milot et al.   Nature Ecology & Evolution

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Sex-specific mitonuclear epistasis and the evolution of mitochondrial bioenergetics, ageing, and life history in seed beetles

(2016) Mirko Đorđević et al.   EVOLUTION

Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila

(2016) J. A. Mossman et al.   GENETICS

Mitonuclear Epistasis for Development Time and Its Modification by Diet in Drosophila

(2016) Jim A. Mossman et al.   GENETICS

Selfish drive can trump function when animal mitochondrial genomes compete

(2016) Hansong Ma et al.   NATURE GENETICS

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear-mitochondrial epistasis: a gene's eye view of genomic conflict

(2016) Michael J. Wade et al.   Ecology and Evolution

Mitonuclear Epistasis for Development Time and Its Modification by Diet in Drosophila

(2016) Jim A. Mossman et al.   GENETICS

The impact of mitochondrial endosymbiosis on the evolution of calcium signaling

(2015) Neil W. Blackstone   CELL CALCIUM

A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase

(2015) M. A. Holmbeck et al.   Disease Models & Mechanisms

Conflict and cooperation in eukaryogenesis: implications for the timing of endosymbiosis and the evolution of sex

(2015) Arunas L. Radzvilavicius et al.   Journal of the Royal Society Interface

Behavioral idiosyncrasy reveals genetic control of phenotypic variability

(2015) Julien F. Ayroles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems Genomics of Metabolic Phenotypes in Wild-Type Drosophila melanogaster

(2014) Laura K. Reed et al.   GENETICS

Mitochondrial-Nuclear Epistasis Contributes to Phenotypic Variation and Coadaptation in Natural Isolates of Saccharomyces cerevisiae

(2014) S. Paliwal et al.   GENETICS

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

(2014) W. Huang et al.   GENOME RESEARCH

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Detecting epistasis in human complex traits

(2014) Wen-Hua Wei et al.   NATURE REVIEWS GENETICS

Cryptic genetic variation: evolution's hidden substrate

(2014) Annalise B. Paaby et al.   NATURE REVIEWS GENETICS

Mitochondrial pathology: stress signals from the energy factory

(2014) Nuno Raimundo   TRENDS IN MOLECULAR MEDICINE

Why epistasis is important for tackling complex human disease genetics

(2014) Trudy FC Mackay et al.   Genome Medicine

In vivo male fertility is affected by naturally occurring mitochondrial haplotypes

(2013) Winston K.W. Yee et al.   CURRENT BIOLOGY

Calcium signalling and calcium channels: Evolution and general principles

(2013) Alexei Verkhratsky et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pleiotropic Effects of a Mitochondrial–Nuclear Incompatibility Depend upon the Accelerating Effect of Temperature in Drosophila

(2013) Luke A. Hoekstra et al.   GENETICS

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Genetic incompatibilities are widespread within species

(2013) Russell B. Corbett-Detig et al.   NATURE

Integrating protein-protein interaction networks with phenotypes reveals signs of interactions

(2013) Arunachalam Vinayagam et al.   NATURE METHODS

Epistasis and quantitative traits: using model organisms to study gene–gene interactions

(2013) Trudy F. C. Mackay   NATURE REVIEWS GENETICS

Genotype to phenotype: lessons from model organisms for human genetics

(2013) Ben Lehner   NATURE REVIEWS GENETICS

Why did eukaryotes evolve only once? Genetic and energetic aspects of conflict and conflict mediation

(2013) N. W. Blackstone   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila

(2013) Colin D. Meiklejohn et al.   PLoS Genetics

Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

(2012) Mark S. Sharpley et al.   CELL

Mitochondria, Maternal Inheritance, and Male Aging

(2012) M. Florencia Camus et al.   CURRENT BIOLOGY

The neglected genome

(2012) Graziano Pesole et al.   EMBO REPORTS

Beyond genotype to phenotype: why the phenotype of an individual cannot always be predicted from their genome sequence and the environment that they experience

(2012) Alejandro Burga et al.   FEBS Journal

Epistasis dominates the genetic architecture of Drosophila quantitative traits

(2012) W. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Predictive Capacity of Personal Genome Sequencing

(2012) N. J. Roberts et al.   Science Translational Medicine

Adenine nucleotide transporters in organelles: novel genes and functions

(2011) Javier Traba et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

REVERSING MOTHER'S CURSE REVISITED

(2011) Philip W. Hedrick   EVOLUTION

Predicting phenotypic variation in yeast from individual genome sequences

(2011) Rob Jelier et al.   NATURE GENETICS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans

(2011) M. O. Casanueva et al.   SCIENCE

Molecular mechanisms of epistasis within and between genes

(2011) Ben Lehner   TRENDS IN GENETICS

MITOCHONDRIAL-NUCLEAR EPISTASIS AFFECTS FITNESS WITHIN SPECIES BUT DOES NOT CONTRIBUTE TO FIXED INCOMPATIBILITIES BETWEEN SPECIES OF DROSOPHILA

(2010) Kristi L. Montooth et al.   EVOLUTION

GENETIC ARCHITECTURE OF METABOLIC RATE: ENVIRONMENT SPECIFIC EPISTASIS BETWEEN MITOCHONDRIAL AND NUCLEAR GENES IN AN INSECT

(2010) Göran Arnqvist et al.   EVOLUTION

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

The energetics of genome complexity

(2010) Nick Lane et al.   NATURE

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Multiple Molecular Mechanisms Cause Reproductive Isolation between Three Yeast Species

(2010) Jui-Yu Chou et al.   PLOS BIOLOGY

REVERSING MOTHER'S CURSE: SELECTION ON MALE MITOCHONDRIAL FITNESS EFFECTS

(2009) Michael J. Wade et al.   EVOLUTION

Comparative Genomics of Drosophila mtDNA: Novel Features of Conservation and Change Across Functional Domains and Lineages

(2009) Kristi L. Montooth et al.   JOURNAL OF MOLECULAR EVOLUTION

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Detecting gene–gene interactions that underlie human diseases

(2009) Heather J Cordell   NATURE REVIEWS GENETICS

Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

(2009) David G. Clayton   PLoS Genetics

Incompatibility of Nuclear and Mitochondrial Genomes Causes Hybrid Sterility between Two Yeast Species

(2008) Hsin-Yi Lee et al.   CELL

Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T

(2008) Taku Amo et al.   GENE

Mitochondrial DNA background modulates the assembly kinetics of OXPHOS complexes in a cellular model of mitochondrial disease

(2008) Rosa Pello et al.   HUMAN MOLECULAR GENETICS

Hybrid breakdown and mitochondrial dysfunction in hybrids of Nasonia parasitoid wasps

(2008) C. K. ELLISON et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Genotype-dependent variation of mitochondrial transcriptional profiles in interpopulation hybrids

(2008) C. K. Ellison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA