Journal
PHARMACEUTICAL CHEMISTRY JOURNAL
Volume 53, Issue 11, Pages 1059-1062Publisher
SPRINGER
DOI: 10.1007/s11094-020-02122-0
Keywords
hypoxia; brain; lipid peroxidation; flavonoids; Alchemilla vulgaris
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The infusion from the aerial part of common lady's mantle Alchemilla vulgaris L. injected preliminarily for 5 d exhibited neuroprotective properties by normalizing conditioned reflexes and orientational-exploratory behavior indicators of animals after hypoxic exposure. Infusion at a dose of 5 mL/kg was the most active. A. vulgaris infusion at a dose of 5 mL/kg with activation of lipid peroxidation after hypoxic action normalized the content of thiobarbiturate-reactive products in brain homogenate and reduced the concentration of antiradical antioxidants in the lipid extract.
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