Article
Agriculture, Multidisciplinary
Xinzhen Fu, Kun Chen, Zhi Li, Huaying Fan, Bo Xu, Ming Liu, Lin Guo, Zeping Xie, Ke Liu, Shumin Zhang, Lijuan Kou
Summary: In this paper, the pharmacokinetics and oral absolute bioavailability of Panax notoginseng saponins (PNS) were evaluated. It was found that Rb1 and Rd were the main ingredients of PNS, accounting for about 60% of PNS exposure. The total oral bioavailability of PNS was only 1.2%.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zongxi Sun, Huichao Wu, Yali Wu, Chenglong Wang, Yu Wang, Shaonan Hu, Shouying Du
Summary: The combined use of Panax notoginseng saponins (PNS) and aspirin (ASA) has shown superior efficacy in treating acute blood stasis, improving hemorheological indicators in rats. Untargeted metabolomics revealed that the combination therapy adjusts metabolites related to amino acid, lipid, and energy metabolism, bringing levels closer to normal than with single use. The findings support the scientific explanation for the effectiveness of PNS and ASA synergy in treating blood stasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wanying Hu, Yujie Zheng, Jianfen Zheng, Kaijing Yan, Zongsuo Liang, Pengguo Xia
Summary: This study investigated the regulatory mechanism of Panax notoginseng saponins (PNS) biosynthesis. Upstream promoters of PnSS and PnSE were cloned and analyzed, and their response to exogenous GA and ABA signals was verified. PnCOX11 and PnDCD, binding proteins that respond to peripheral hormones, were identified and their interaction with the promoters was confirmed. The structural analysis, subcellular localization, and expression of the recombinant proteins were also examined. This study provides fundamental information for the investigation of the transcription regulatory mechanism of PNS biosynthesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Yu Bai, Haijiao Liu, Jianying Pan, Shiyan Zhang, Yixin Guo, Yisha Xian, Zhirong Sun, Zilong Zhang
Summary: The removal of inflorescences in Panax notoginseng can enhance the biosynthesis pathway of saponins, activate molecular mechanisms, and improve the quality and yield of Panax notoginseng.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Urology & Nephrology
Jing Xie, Xin Ma, Yixuan Zheng, Nan Mao, Sichong Ren, Junming Fan
Summary: Panax notoginseng saponins may inhibit the development of inflammation and fibrosis in kidney tissue through the regulation of intestinal microorganisms and inhibition of pro-inflammatory and pro-fibrotic protein activation in the kidney.
Article
Plant Sciences
Yixuan Jiang, Hemei Li, Panling Huang, Shanliang Li, Bocun Li, Lini Huo, Jing Zhong, Ziyu Pan, Yuqing Li, Xing Xia
Summary: Panax notoginseng, also known as Burki, is a well-known traditional Chinese medicine with a long history of medicinal use. Studies have shown that it can alleviate mitochondrial damage caused by amyloid beta protein and protect cell viability by regulating autophagy. This mechanism may involve enhancing autophagy without depending on the PINK1 gene.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Dandan Wang, Linyan Lv, Yue Xu, Kai Jiang, Feng Chen, Jie Qian, Ming Chen, Guanping Liu, Yaozu Xiang
Summary: Panax Notoginseng saponins (PNS), the extract of Panax notoginseng, exerts cardioprotective effects in acute myocardial infarction by inducing cardiomyocyte autophagy, inhibiting platelet aggregation, enhancing endothelial cell migration and angiogenesis. PNS and its main constituents Rg1 and Rd also directly inhibit platelet aggregation in healthy subjects and enhance glucose deprivation-induced autophagy in cardiomyocytes. These findings provide insights for drug development from natural products against ischemic heart diseases and heart failure post myocardial infarction.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Zhu Cun, Hong -Min Wu, Jin-Yan Zhang, Sheng-Pu Shuang, Jie Hong, Tong-Xin An, Jun -Wen Chen
Summary: Nitrogen supply affects the morphological traits, N use efficiency, photosynthetic capacity, and saponins accumulation in Panax notoginseng. Increasing N supply reduces root biomass, enhances above-ground biomass, and increases N content. High N supply reduces NUE, NC, and Pn, while increasing SLN, Chl, and NL. Root biomass is positively correlated with NUE, yield, and Pn, while above-ground biomass is negatively correlated with PNUE. Saponins content is positively correlated with NUE and Pn. Overall, excess N reduces root and carbon-containing secondary metabolites (active ingredient) yield in P. notoginseng.
Article
Chemistry, Applied
Ji-Wu Huang, Yi-Qian Du, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Ying-Da Zang, Nai-Hong Chen, Dong-Ming Zhang
Summary: Two new triterpene saponins were isolated from Panax notoginseng leaves, with some compounds being able to inhibit cell damage and increase cell viability.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiaojuan Sun, Hongbo Deng, Tengyun Shu, Min Xu, Lihua Su, Haizhou Li
Summary: Panax notoginseng leaves contain various protopanaxadiol saponins and have significant pharmacological effects in tranquilizing, treating cancer, and nerve injury. Twenty-two saponins, including eight new compounds and fourteen known compounds, have been isolated and purified from P. notoginseng leaves. Among them, four compounds showed slight protective effects against L-glutamate-induced nerve cell injury.
Article
Biochemistry & Molecular Biology
Penghao Zhang, Ruimin Tang, Shilong Yang, Dengbang Jiang, Minglong Yuan, Hongli Li, Mingwei Yuan
Summary: This study aimed to promote the clinical application of Panax notoginseng saponins (PNS) by synthesizing drug-loaded microspheres. The results showed that mPEG(2k)-PLA (1:9) was the best carrier material, with stable release, good biocompatibility, and anti-inflammatory and antitumor activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Medicinal
Zhiheng Ning, Ziliang He, Guigui Yang, Yanting Wang, Guolin Zhang, Ashfaq-Ahmad Khan, Fu Li, Ji Zhang, Weicheng Hu
Summary: Three undescribed dammarane-type triterpene saponins were isolated from the roots of Panax notoginseng, along with seventeen known ones. The chemical structures of the new compounds were determined using HR-MS, NMR, and chemical methods. Compound 1, a fucose-containing triterpene saponin, was reported for the first time in the genus Panax. In addition, the isolated compounds were evaluated for their in vitro neuroprotective effects, and compounds 11-12 showed significant protective effects against 6-hydroxydopamine-induced PC12 cell injury.
Article
Plant Sciences
Pengguo Xia, Wanying Hu, Yujie Zheng, Yong Wang, Kaijing Yan, Zongsuo Liang
Summary: This study identified and characterized the interaction between PnMYB2 and key enzymes in Panax notoginseng. The study also confirmed the interaction between PnMYB2 and the upstream sequences of PnSS and PnSE1 promoters. The full-length cDNA sequence of PnMYB2 was isolated and its structure and phylogenetic analysis were conducted. The study showed that PnMYB2 is localized in the nucleus and can specifically bind to certain elements. This research provides a theoretical basis for the transcriptional regulation of saponin biosynthesis in Panax notoginseng.
JOURNAL OF PLANT PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Li Shao, Li Wang, Yong-Yan Shi, Wei Zhang, Li-Wen Tan, Jian-Bo Wan, Wei-Hua Huang
Summary: Saponins extracted from Panax notoginseng leaves can be used for insomniac patients due to their low bioavailability, which can be converted into potential bioactive products by gut microbiota. The metabolites and profiles of two saponin extracts were compared by incubation with gut microbiota from insomniac patients. The results showed significant differences in saponins between the methanol and water extracts, but similar metabolites were generated by gut microbiota. The study highlights the importance of gut microbiota biotransformation in the use of saponins for insomnia.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Lian Duan, Yongmei Liu, Jun Li, Yun Zhang, Yan Dong, Chao Liu, Jie Wang
Summary: Panax notoginseng saponins (PNS) may have an inhibitory effect against coronary artery disease (CAD), and the mechanism may be related to the methylation of miR-194. This study provides evidence through clinical trials and cell experiments to support the use of PNS for intervention in CAD by targeting the miR-194 promoter-miR-194-MAPK signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Letter
Rheumatology
Martin Sebastian Winkler, Peter Korsten, Claudia Binder, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Environmental Sciences
Luana Negris, Helisson N. Santos, Rochele S. Picoloto, Felipe E. A. Alves, Erico M. M. Flores, Maria F. P. Santos, Maristela A. Vicente
Summary: This study proposes the use of an ultrasound-assisted adsorption system to improve the removal of iron from groundwater. With optimized conditions, the method achieved nearly 100% iron removal efficiency for FeSO(4) solution, which was significantly higher than the efficiency without ultrasound.
ENVIRONMENTAL TECHNOLOGY
(2022)
Article
Ethnic Studies
Tais Freire Galvao, Gustavo Magno Baldin Tiguman, Bruno Vianei Real Antonio, Raquel Rodrigues Ferreira Rocha de Alencar, Leila Posenato Garcia, Marcus Tolentino Silva
Summary: This study examined the prevalence of perceived discrimination in health services and associated factors in the Manaus Metropolitan Region of Brazil. The results showed that women, individuals with brown skin color, people with hypertension, and frequent health service users were more likely to experience discrimination from health professionals.
ETHNICITY & HEALTH
(2022)
Article
Oncology
Yi Liao, Senmao Li, Hao Chen, Chunyu Chen, Jintuan Huang, Feng Lin, Jianping Wang, Zuli Yang
Summary: A risk prediction system combining FIT and risk factors was developed to improve the sensitivity of colonoscopy screening. The system effectively stratified participants into high risk and low risk groups, with better predictive ability for colorectal neoplasia compared to using FIT alone.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Luca Giraldi, Jovana Stojanovic, Dario Arzani, Roberto Persiani, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Carlo La Vecchia, Claudio Pelucchi, Nuno Lunet, Ana Ferro, Reza Malekzadeh, Joshua Muscat, David Zaridze, Dmitry Maximovich, Nuria Aragones, Vicente Martin, Jesus Vioque, Eva M. Navarrete-Munoz, Mohammadreza Pakseresht, Eva Negri, Matteo Rota, Farhad Pourfarzi, Lina Mu, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Roberta Pastorino, Stefania Boccia
Summary: This study aimed to examine the association between height and risk of gastric cancer. Through a large pooled analysis of case-control studies, the study found no significant association between adult height and gastric cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Maria A. Karalexi, Marina Servitzoglou, Vassilios Papadakis, Denis Kachanov, Maja Cesen Mazic, Margaret Baka, Maria Moschovi, Maria Kourti, Sofia Polychronopoulou, Eftichia Stiakaki, Emmanuel Hatzipantelis, Helen Dana, Kalliopi Stefanaki, Astero Malama, Marios S. Themistocleous, Katerina Strantzia, Tatyana Shamanskaya, Panagiota Bouka, Paraskevi Panagopoulou, Maria Kantzanou, Evangelia Ntzani, Nick Dessypris, Eleni Th. Petridou
Summary: The prognosis of children with neuroblastoma varies depending on the stage and biology of the tumor, and early-stage neuroblastoma has a better prognosis. Treatment with anti-GD2 antibody can improve the prognosis of high-risk patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Emergency Medicine
Luis Tallon-Aguilar, Virginia Maria Duran-Munoz-Cruzado, Isidro Martinez-Casas, Jose Manuel Aranda-Narvaez, Maria Dolores Perez-Diaz, Soledad Monton-Condon, Fernando Turegano-Fuentes, Felipe Pareja-Ciuro
Summary: Most Spanish surgeons work in the emergency department, but only 40% have received specific training in definitive surgical management of severe trauma. While the majority believe that the ATLS course should be compulsory during residency, many have a poor perception of severe trauma care in their hospital.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Emergency Medicine
Markus Laubach, Miguel Pishnamaz, Matti Scholz, Ulrich Spiegl, Richard Martin Sellei, Christian Herren, Frank Hildebrand, Philipp Kobbe
Summary: This study investigated the interobserver reliability of the Gehweiler classification for C1 fractures and found a moderate reliability. There were diverging treatment strategies for type 3b fractures, emphasizing the need for further research to determine the optimal treatment for unstable C1 fractures.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Zoya Khalid, Hammad Naveed
Summary: COVID-19, caused by a novel coronavirus, has become a global pandemic. This study used a bioinformatics approach to analyze the interaction between spike glycoprotein and ACE2 receptor protein, and identified mutations that may disrupt the structure of the complex, potentially blocking the virus from entering host cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Surgery
Triantafyllos Doulias, Gaetano Gallo, Ines Rubio-Perez, Stephanie O. Breukink, Dieter Hahnloser
Summary: The impact of COVID-19 on surgical training has been significant, with surgical trainees being redeployed and teaching activities and research being postponed. The pandemic has forced educational bodies to reexamine training curriculums and come up with innovative strategies to maintain rigorous standards of education and training in the post-COVID-19 era.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Otorhinolaryngology
Maria Stella Arantes do Amaral, Francine Raquel dos Santos, Fabiana Danieli, Eduardo T. Massuda, Ana Claudia Mirandola Barbosa Reis, Miguel Angelo Hyppolito
Summary: The bone-anchored hearing system is an effective treatment option for patients with hearing loss. This study compared the surgical and audiological outcomes between the minimally invasive Ponto surgery and a linear incision technique. The results showed no differences in audiological outcomes between the two surgical techniques, but the minimally invasive Ponto surgery had a shorter surgical time and better cosmetic outcomes.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Pharmacology & Pharmacy
Piera Polidori, Daniele Leonardi Vinci, Silvia Adami, Stefano Bianchi, Maria Ernestina Faggiano, Alessio Provenzani
Summary: The inappropriate use of antimicrobial agents is contributing to bacterial resistance. This study conducted in six Italian hospitals aimed to create a training manual on antibiotic stewardship to introduce the role of pharmacists with infection disease skills in the healthcare system. The results showed that the pharmacist's interventions led to improvements in patient care quality and resource efficiency.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2022)
Review
Clinical Neurology
Christoph Eckhard Heyde, Ulrich Josef Albert Spiegl, Anna Voelker, Nicolas von der Hoeh, Jeanette Henkelmann
Summary: The prevalence of nonspecific pyogenic spondylodiskitis has increased, causing high morbidity and mortality. The diagnosis is often delayed due to nonspecific clinical manifestations at the early stage. CT can assess the bony condition, while MRI is still the gold standard for diagnosis.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Pharmacology & Pharmacy
Yan Li, Xueyan Liang, Huijuan Li, Tong Yang, Sitong Guo, Xiaoyu Chen
Summary: This study evaluated the cost-effectiveness of nivolumab and sorafenib in the treatment of advanced hepatocellular carcinoma (aHCC). It found that nivolumab improved overall survival and quality-adjusted life-years compared to sorafenib, but at a higher cost.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Paula Remoaldo, Olga Matos, Isabel Freitas, Ricardo Goja, Juliana Araujo Alves, Vitor Ribeiro, Miguel Pereira, Carla Xavier
Summary: This article discusses the transition from mass cultural tourism to creative tourism and focuses on the implementation and research in urban areas. It evaluates the differences between rural and urban institutions in terms of creative tourism practices and offerings.
JOURNAL OF HOSPITALITY & TOURISM RESEARCH
(2022)