Review
Cardiac & Cardiovascular Systems
Dating Sun, Hui Xiang, Jiangtao Yan, Liqun He
Summary: Intestinal microbiota and its metabolites play an important role in the development of hypertension, and the limitations and challenges in this field provide directions for future research. Modulating intestinal microbes and metabolites can lead to the development of accurate and personalized preventive and therapeutic strategies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Adela Danau, Laura Dumitrescu, Antonia Lefter, Delia Tulba, Bogdan Ovidiu Popescu
Summary: There is a close connection between the gut microbiota and the brain via the gut-brain axis, with Small Intestinal Bacterial Overgrowth (SIBO) potentially playing a role in the progression of Parkinson's disease (PD). SIBO can be eradicated with antibiotics, but may reappear if predisposing factors persist, highlighting its potential impact on the development of PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Ting Zhang, Jin-ke Cheng, Yao-min Hu
Summary: Sarcopenia, a progressive loss of skeletal muscle mass and function with aging, has been shown to be closely related to gut microbiota. Strategies such as probiotics and fecal microbiota transplantation have shown potential in ameliorating muscle loss.
AGEING RESEARCH REVIEWS
(2022)
Review
Medicine, Research & Experimental
Weifang Huang, Desong Kong
Summary: Liver diseases such as NAFLD and ALD are on the rise globally, with a close relationship to the intestinal microbiota. Understanding the role of intestinal microbiota and the gut-liver axis may lead to novel therapeutic approaches for these diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Neha, Mohd Salman, Suhel Parvez
Summary: Globally, ischemic stroke (IS) has emerged as a major cause of death and disability, with the process characterized by the formation of blood clots in the brain due to blockages in blood vessels. This triggers various signaling pathways, leading to excitotoxicity, acidosis, ionic imbalance, inflammation, oxidative stress, and ultimately cell apoptosis. The current FDA-approved tissue plasminogen activator therapy has limitations, prompting research into potential candidates like ASICs and VDCCs inhibitors for IS treatment. Animal toxins have provided neuroprotective insights into the pathophysiology of IS by inhibiting these channels.
Review
Pharmacology & Pharmacy
Xiaoli Zhang, Yiming Ma, Guoqing Lv, Hongying Wang
Summary: Ferroptosis is a type of programmed cell death that depends on iron and is characterized by lipid peroxidation induced by reactive oxygen species and resulting membrane damage. Recent research has revealed its mechanism and explored its connection to various diseases, including degenerative diseases, cancer, and inflammation. Inflammation-related intestinal diseases such as colitis and colitis-associated cancer are associated with ferroptosis. Understanding the role of ferroptosis in the pathogenesis of these diseases has led to the identification of potential therapeutic targets. This review summarizes the current knowledge on the molecular mechanisms of ferroptosis and discusses its emerging role and therapeutic potential in inflammation-related intestinal diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Manlian Zhu, Xia Liu, Yiru Ye, Xiumei Yan, Yiwen Cheng, Longyou Zhao, Feng Chen, Zongxin Ling
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor dysfunction. Gut dysbiosis is involved in the development and progression of PD, and the gut microbiota can be considered as a potential diagnostic and therapeutic target. Gut dysbiosis influences the progression and onset of PD by increasing intestinal permeability, aggravating neuroinflammation, aggregating abnormal levels of alpha-synuclein fibrils, increasing oxidative stress, and decreasing neurotransmitter production.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaoyu Ji, Yang Zeng, Jie Wu
Summary: Epilepsy is characterized by repeated bursts of neuronal hyperactivity and synchronization in the central nervous system. Developing new drugs to manage and control refractory epilepsy, including cannabinoid ligands as novel candidates, is urgently needed. Cannabinoid ligands have shown significant benefits in controlling seizure activity in various animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Alexander F. Flynn, Rebekah T. Taylor, Marzena E. Pazgier, Sasisekhar Bennuru, Alyssa R. Lindrose, Spencer L. Sterling, C. Paul Morris, Brynna Gleeson, Tim K. Maugel, Thomas B. Nutman, Edward Mitre
Summary: Lymphatic filariasis is a global disease caused by parasitic nematodes that affect millions of people. Identifying new drug and vaccine targets in adult filariae could aid elimination efforts. Bma-LAD-2 was identified as an essential protein for adult Brugia malayi, making it a potential therapeutic target.
Review
Immunology
Mengling Yang, Yang Yang, Qingnan He, Ping Zhu, Mengqi Liu, Jiahao Xu, Mingyi Zhao
Summary: The intestinal microbiota plays a crucial role in antiviral immunity, with different components potentially promoting or inhibiting viral invasion through immune response modulation and interaction with viruses. Current therapeutic strategies for regulating intestinal microbiota balance, such as oral probiotics, FMT, and antibiotics, have shown limited efficacy in clinical trials, indicating a need for further research into more efficient and safer methods of modulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Neurosciences
Nihan carcak, Filiz Onat, Evgenia Sitnikova
Summary: Astrocytes are specialized glial cells in the central nervous system that contribute to neuronal excitability and synaptic transmission. They play a key role in epileptogenesis and seizure generation. Targeting astrocytic functions and developing novel therapeutic strategies focusing on astroglial cells show promise for treating epilepsy.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Kailu Wei, Fei Gong, Jie Wu, Wei Tang, Fan Liao, Zhihui Han, Zifan Pei, Huali Lei, Li Wang, Mingwang Shao, Zhuang Liu, Liang Cheng
Summary: This study developed silicon hydrogen nanoparticles with reactive oxygen species-scavenging ability for the treatment of inflammatory bowel diseases. The nanoparticles showed stability in gastric and intestinal fluids and efficiently cleared excess reactive oxygen species, protecting cells from oxidative stress-induced death. Through oral delivery, the nanoparticles targeted the inflamed colon and exhibited significant preventive and therapeutic effects.
Review
Toxicology
Ping Guo, Yufeng Liu, Jingrong Feng, Shihang Tang, Fanyan Wei, Jian Feng
Summary: In this review, the importance of PAK1 in cardiac diseases, especially in the regulation of programmed cell death, oxidative stress, and inflammatory responses of cardiomyocytes, is discussed. The association of PAK1 with the gut microbiome and microRNAs in cardiotoxicity is also introduced.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Fengjie Ji, Huansheng Yang, Qiye Wang, Jianzhong Li, Hanlin Zhou, Shengmin Liu
Summary: This study aimed to investigate the efficacy of porcine intestinal antimicrobial peptide (PIAP) as an alternative to in-feed antibiotics for growth performance, intestinal morphology, digestive enzymes, immunity, and microbiota community of post-weaning piglets. The results showed that dietary supplementation with a relatively low dose of PIAP demonstrated beneficial effects on intestinal morphology, digestive enzymes, immunity, and permeability by shaping the gut microbiota composition in weaned piglets. This study provides valuable reference for using PIAP as an in-feed antibiotic alternative in swine production.
Article
Cell Biology
Jie Yin, Ziming Zhao, Jianzheng Huang, Yang Xiao, Mewlude Rehmutulla, Biqiong Zhang, Zijun Zhang, Ming Xiang, Qingyi Tong, Yonghui Zhang
Summary: Acute liver failure (ALF) is a severe and life-threatening disease associated with gut-liver axis disorder. In this study, a mouse ALF intestinal cellular atlas was defined using a D-GALN/LPS (D/L)-induced ALF model, and the cellular characteristics and therapeutic targets were analyzed. Unique intestinal immune cells were found to be responsive to ALF, and the transcriptional profiles of these subsets were identified. The heterogeneity of intestinal epithelial cells (IECs) was also delineated, and ALF-induced cell cycle arrest and activation of specific enterocyte and goblet cell clusters were observed. Ep300 was identified as a novel therapeutic target in ALF, and its inhibition alleviated inflammation and oxidative stress, corrected intestinal ecology, and protected IECs.
