Review
Immunology
Consolato M. Sergi, Elka Miller, Dina El Demellawy, Fan Shen, Mingyong Zhang
Summary: Chronic recurrent and multifocal osteomyelitis (CRMO) is a continuous autoinflammatory disorder commonly found in children and adolescents. Whole-body MRI plays a crucial role in diagnosing and monitoring the progression of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Bridget A. Rafferty, Pooja Thakrar
Summary: CNO/CRMO is an underrecognized autoinflammatory disorder of the skeletal system resulting from immune dysregulation. Diagnosis is often delayed due to vague symptoms and the lack of accepted diagnostic criteria or specific biomarkers. Untreated CRMO can lead to chronic skeletal deformities, arthritis, and chronic pain. Diagnosis requires MRI and WB-MRI. Treatment primarily involves antiinflammatory medications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Andressa Guariento, Parth Sharma, Savvas Andronikou
Summary: This study characterized the MR imaging features and patterns of pediatric spinal CRMO/CNO. The results showed that CRMO/CNO typically involves the thoracic spine, vertebral body edema is often focal at the superior vertebral body, and kyphosis and scoliosis occur in about a quarter of children at spinal disease recognition, with vertebral height loss in about a third.
PEDIATRIC RADIOLOGY
(2023)
Article
Pediatrics
Sarah J. Menashe, Ramesh S. Iyer, Anh-Vu Ngo, Natalie L. Rosenwasser, Yongdong Zhao, Ezekiel Maloney
Summary: This study retrospectively analyzed whole-body MRI results of CRMO patients and correlated them with clinical disease severity at initial rheumatology presentation. The results showed that CRMO lesions were mainly distributed in the pelvis and lower extremities, and the number of lesions detected on MRI at initial presentation had a significant correlation with disease severity. However, other MRI parameters did not correlate with disease severity.
PEDIATRIC RADIOLOGY
(2022)
Review
Pediatrics
Fernando Moreno-Mateo, Sofia Hidalgo Perea, Karen Brandt Onel
Summary: Recent advancements in MRI imaging and understanding of pathophysiology have improved the diagnosis and treatment of CRMO, with TNF-alpha inhibitors and bisphosphonates showing promising results for symptomatic relief and normalization of bone morphology. Better knowledge of genetic and molecular factors may lead to early diagnosis and development of more effective individualized treatments in the future.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Rheumatology
Marie Robert, Anna Giolito, Heloise Reumaux, Linda Rossi-Semerano, Claire Guillemin, Louis Biarrotte, Damia Leguevaques, Alexandre Belot, Agnes Duquesne, Cecile Frachette, Audrey Laurent, Marine Desjonqueres, Jean-Paul Larbre, Caroline Galeotti, Isabelle Kone-Paut, Perrine Dusser
Summary: This study aimed to investigate the frequency, characteristics and treatment of extra-osseous (EO) manifestations in chronic recurrent multifocal osteomyelitis (CRMO) and whether different phenotypes can benefit from special management. The study included 133 CRMO patients and found that 67.7% of them had EO manifestations, primarily skin lesions, sacroiliitis, enthesitis, arthritis, and gastrointestinal manifestations. Patients with EO manifestations were more likely to be treated with biologics, and a significant number of them achieved complete remission under this treatment.
Article
Pediatrics
Michal Kopec, Magdalena Braszewska, Mariusz Jarosz, Katarzyna Dylewska, Andrzej Kurylak
Summary: This single-center observational study analyzed the imaging studies on 10 patients with CRMO, showing the pivotal role of MRI in diagnosis and treatment observation. While 40% of the patients saw complete resolution of symptoms, 50% showed partial regression in clinical and radiological manifestations.
Review
Radiology, Nuclear Medicine & Medical Imaging
Marcelo Astolfi Caetano Nico, Flavia Ferreira Araujo, Julio Brandao Guimaraes, Isabela Azevedo Nicodemos da Cruz, Flavio Duarte Silva, Bruno Cerretti Carneiro, Alipio Gomes Ormond Filho
Summary: Chronic nonbacterial osteomyelitis is a common noninfectious autoinflammatory bone marrow disease in children and adolescents. Whole-body magnetic resonance imaging can assist in the diagnosis and assessment of disease severity, and early treatment can prevent permanent damage to the skeletal system.
INSIGHTS INTO IMAGING
(2022)
Article
Medicine, General & Internal
Akshay Waghmode, Nikhith Soman, Aryan Gupta
Summary: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoimmune inflammatory condition that mainly affects children and young adults. Its typical features include recurrent severe bone pain and imaging findings suggestive of osteomyelitis or malignancy. Diagnosis of CRMO requires excluding other possibilities and considering various diagnostic criteria.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pediatrics
Dita Cebecauerova, Hana Malcova, Veronika Koukolska, Zuzana Kvicalova, Ondrej Soucek, Lukas Wagenknecht, Jiri Bronsky, Zdenek Sumnik, Martin Kyncl, Marek Cebecauer, Rudolf Horvath
Summary: Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an autoinflammatory bone disorder predominantly affecting children, with associated extraosseous conditions such as psoriasis, inflammatory bowel disease, and arthritis. This study found that CRMO without extraosseous manifestations had a milder course compared to complex CRMO, which was more likely to require escalation to advanced therapy.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Min Cheol Kim, Kyeong Ok Kim, Min Kyu Kang, Byung Ik Jang
Summary: CRMO is a rare condition characterized by chronic relapsing noninfectious bone inflammation, with most cases associated with Crohn's disease and very few associated with ulcerative colitis. In this case, a 21-year-old UC patient with recurrent left thigh pain was diagnosed with CRMO associated with UC, which was well controlled with azathioprine treatment.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Rheumatology
Philipp Rausch, Meike Hartmann, John F. Baines, Philipp von Bismarck
Summary: This study investigates the differences in oral and fecal microbial communities between children with and without chronic recurrent multifocal osteomyelitis (CRMO) using bacterial 16S rRNA gene profiling. The results suggest that the absence of potential probiotic bacteria in fecal communities and the presence of known pathobionts in oral microbial communities may serve as indicators of underlying susceptibility to CRMO. Furthermore, the gut bacterial communities appear to reflect altered host physiology more strongly than the oral community, indicating an oral disease origin followed by systemic propagation or responses.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Mohamad Ali Tahririan, Seyed Mohamad Hossein Tabatabaei Nodushan, Mehrdad Farrokhi
Summary: This is a rare case of multifocal bone disorder, where the patient was ultimately diagnosed with chronic recurrent multifocal osteomyelitis (CRMO) and showed significant improvement after a 5-month treatment with nonsteroidal anti-inflammatory drugs.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sarah J. Menashe, Hassan Aboughalia, Yongdong Zhao, Anh-Vu Ngo, Jeffrey P. Otjen, Mahesh M. Thapa, Ramesh S. Iyer
Summary: CRMO is an autoinflammatory bone disease of childhood and adolescence characterized by episodic bone pain. Diagnosis relies heavily on whole-body MRI and differentiates the disease by excluding other disorders with overlapping imaging features.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Rheumatology
Shima Yasin, T. Shawn Sato, Polly Ferguson
Summary: Advances in understanding the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO) in children have influenced therapeutic strategies. The use of whole-body MRI (WBMRI) and increased awareness of CRMO have led to higher rates and timeliness of CRMO diagnoses. This review highlights recent findings from CRMO cohorts and discusses the course, complications, and long-term sequelae of the disease. It is important for clinicians to be aware of the potential for long-term sequelae in order to optimize therapy and prevent complications.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Clinical Neurology
J. Uthoff, F. A. De Stefano, K. Panzer, B. W. Darbro, T. S. Sato, R. Khanna, D. E. Quelle, D. K. Meyerholz, J. Weimer, J. C. Sieren
JOURNAL OF NEURORADIOLOGY
(2019)
Article
Rheumatology
Yongdong Zhao, T. Shawn Sato, Sabrina M. Nielsen, Meinrad Beer, Mingqian Huang, Ramesh S. Iyer, Michael McGuire, Anh-Vu Ngo, Jeffrey P. Otjen, Jyoti Panwar, Jennifer Stimec, Mahesh Thapa, Paolo Toma, Angela Taneja, Nancy E. Gove, Polly J. Ferguson
JOURNAL OF RHEUMATOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
T. Shawn Sato, Atsuhiko Handa, Sarv Priya, Pankaj Watal, Robert M. Becker, Yutaka Sato
Article
Multidisciplinary Sciences
Johanna Uthoff, Jared Larson, Takashi S. Sato, Emily Hammond, Kimberly E. Schroeder, Frank Rohret, Christopher S. Rogers, Dawn E. Quelle, Benjamin W. Darbro, Rajesh Khanna, Jill M. Weimer, David K. Meyerholz, Jessica C. Sieren
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Amber M. Goedken, Joshua A. Samuels, Takashi S. Sato, Lyndsay A. Harshman
Summary: The study examined the frequency of kidney imaging in TSC patients with commercial insurance in the US, finding that a significant percentage of patients lack kidney imaging surveillance, potentially leading to delayed detection of kidney manifestations.
PEDIATRIC NEUROLOGY
(2021)
Editorial Material
Rheumatology
Takashi Shawn Sato, Polly J. Ferguson
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Clinical Neurology
Sedat Giray Kandemirli, Burak Kocak, Shotaro Naganawa, Kerem Ozturk, Stephen S. F. Yip, Saurav Chopra, Luciano Rivetti, Amro Saad Aldine, Karra Jones, Zuzan Cayci, Toshio Moritani, Takashi Shawn Sato
Summary: The study developed an MRI radiomic model using machine learning techniques to predict H3K27M mutation in midline gliomas, demonstrating promising accuracy and sensitivity in identifying the mutation status.
WORLD NEUROSURGERY
(2021)
Review
Rheumatology
Shima Yasin, T. Shawn Sato, Polly Ferguson
Summary: Advances in understanding the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO) in children have influenced therapeutic strategies. The use of whole-body MRI (WBMRI) and increased awareness of CRMO have led to higher rates and timeliness of CRMO diagnoses. This review highlights recent findings from CRMO cohorts and discusses the course, complications, and long-term sequelae of the disease. It is important for clinicians to be aware of the potential for long-term sequelae in order to optimize therapy and prevent complications.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Oncology
Moon Ley Tung, Bharatendu Chandra, Kyle Dillahunt, Matthew D. Gosse, T. Shawn Sato, Alpa Sidhu
Summary: Von Hippel-Lindau (VHL) syndrome and paraganglioma, pheochromocytoma, etc. are associated with mutations in two genes, VHL and SDHA. We report the co-occurrence of pathogenic mutations in both genes in a patient with pancreatic neuroendocrine tumor. Further studies are needed to determine the significance of this co-occurrence in relation to tumor penetrance, disease severity, treatment response, and clinical outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takashi Shawn Sato, Travis S. Henry
Summary: As modern learners' expectations evolve, educators need to adapt to meet these changes. Quick Response codes offer a simple way to distribute web-based information to audiences, and can be effectively incorporated into radiology lectures to increase audience engagement.
CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY
(2021)
Review
Medicine, General & Internal
Elizabeth Pernicone, Pankaj Watal, Deeksha Dhar, Laura L. Hayes, Tushar Chandra
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Priya Sarv, Watal Pankaj, Staron Michelle, Sato Shawn
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2019)