Journal
ORGANIC LETTERS
Volume 22, Issue 3, Pages 772-775Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b03904
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Funding
- National Key R&D Program of China [2017YFA020S400]
- Drug Innovation Major Project [2018ZX09711-001-00.5]
- CAMS Innovation Fund for Medical Sciences [2017-I2M-3011]
- Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences [2018PT35003, 2019 RC -HL-008]
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In this Letter, triazoles as carbene reagents were used for sulfonamide-directed C-H insertion carbenoid functionalization to construct benzylpyridine sulfonamide dual-pharmacophore compounds. This method is simple and efficient and can be used for the late-stage modification of sulfonamide drugs.
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