Journal
ORGANIC LETTERS
Volume 22, Issue 2, Pages 468-473Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04232
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Funding
- Science and Engineering Research Board, India [EMR/2016/006344]
- IACS, CSIR
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Herein, we describe a method for the catalytic enantioselective alpha-amination of alpha-substituted acyclic 1,3-ketoamides and 1,3-amidoesters that affords the products possessing N-substituted quaternary stereocenters with a chiral N-heterocyclic carbene (NHC). The reaction is based on the utilization of an intrinsic Bronsted base characteristic of NHC that enables the catalytic formation of a chiral ion pair comprising the enolate and the azolium ion. A series of challenging open-chain alpha-substituted 1,3-dicarbonyls are aminated via this method with ee's of <= 99%.
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