Journal
ORGANIC LETTERS
Volume 22, Issue 2, Pages 483-487Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b04239
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Funding
- National Natural Science Foundation of China [21901137, 21920102001]
- Swiss State Secretariat for Education, Research and Innovation, EPFL
- Thousand Young Talents Program
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Here we report an organocatalytic double Ugi reaction combining the enantioselective process and ee enhancement in a single operation to afford the chiral Ugi products with very high ee values. Both bisisocyanides and bisanilines tethered by carbonate and diester, respectively, were designed to accomplish this double multicomponent reaction that formed 10 new chemical bonds (4 C-N, 2 C-C, 2 C-O, and 2 N-H bonds). The strategy was further applied for the fast construction of an enantiomerically enriched macrocycle.
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