Article
Oncology
Yangzhou Liu, Shankun Zhao, Jiamin Wang, Zhiguo Zhu, Lianmin Luo, Qian Xiang, Mingda Zhou, Yuxiang Ma, Zuomin Wang, Zhigang Zhao
Summary: The study revealed that miR-629-5p is upregulated in PCa tissues, promoting tumor cell proliferation, migration, and invasion, and plays an oncogenic role by targeting AKAP13, suggesting potential value for clinical diagnosis and treatment of PCa.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yaqian Niu, Fang Liu, Xiuyue Wang, Yuling Chang, Yanmei Song, Huiyuan Chu, Shisan Bao, Che Chen
Summary: The study found that miR-183-5p promotes migration and invasion of HepG2 cells by enhancing aerobic glycolysis, increasing glucose uptake and lactate generation, and regulating gene expression. It is suggested that miR-183-5p may promote HCC migration and invasion through targeting PTEN and activating the Akt/mTOR signaling pathway.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Kai Zhu, Jinlan Lin, Shengjia Chen, Qian Xu
Summary: The study revealed that miR-9-5p promotes LUAD cell progression by targeting ID4, potentially becoming a molecular target for LUAD.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Cell Biology
Min Liang, Wenxia Yao, Boyun Shi, Xiongjie Zhu, Rui Cai, Zhongjian Yu, Weihong Guo, Huaiming Wang, Zhijie Dong, Mingzhen Lin, Xinke Zhou, Yanfang Zheng
Summary: The study identified hsa_circ_0110389 as a novel upregulated circRNA in malignant-transformed gastric cancer cells, and found that it promotes gastric cancer progression via the miR-127-5p/miR-136-5p-SORT1 pathway. This circRNA may serve as a diagnostic/prognostic biomarker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Zekun Wang, Yaming Li, Jingwen Yang, Yiran Liang, Xiaolong Wang, Ning Zhang, Xiaoli Kong, Bing Chen, Lijuan Wang, Wenjing Zhao, Qifeng Yang
Summary: This study reveals that circ-TRIO plays a crucial role in TNBC and is associated with the recurrence and prognosis of TNBC patients. The findings demonstrate that knockdown of circ-TRIO inhibits the proliferation, migration, and invasion of TNBC cells, while overexpression of circ-TRIO has the opposite effects. Mechanistically, circ-TRIO interacts with miR-432-5p to regulate the expression of CCDC58.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Jun Bai, Hongli Li, Xinlu Chen, Lin Chen, Yaqiong Hu, Lu Liu, Yanqiao Zhao, Wei Zuo, Baogang Zhang, Chonggao Yin
Summary: LncRNA-AC009948.5 is upregulated in lung adenocarcinoma tissues and cells, and its increased expression is associated with tumor size, lymph nodes, distant metastasis, histological grade, and poor prognosis. Knockdown of LncRNA-AC009948.5 inhibits cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. Mechanistically, LncRNA-AC009948.5 directly binds to miR-186-5p and suppresses the expression of the target gene NCAPG2.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xiaoguang Gu, Jianan Zhang, Yajuan Ran, Hena Pan, JinHong Jia, Ying Zhao, Xijuan Zhao, Wendi Li, Shasha Song, Xiufeng Yu
Summary: The study revealed the role of hsa_circ_101555 in HCC, potentially acting as a competing endogenous RNA for miR-145-5p to upregulate CDCA3 expression. Silencing hsa_circ_101555 significantly suppressed cell proliferation, migration, and invasion of HCC cells.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Kaiyi Tao, JinShi Liu, JinXiao Liang, XiaoFang Xu, LiWei Xu, WeiMin Mao
Summary: The study investigated the molecular mechanism of lung adenocarcinoma (LUAD) progression and the communication between cancer cells and vascular endothelial cells. The findings demonstrated that miR-30a-5p could be delivered from vascular endothelial cells to LUAD cells via exosomes to inhibit tumor progression.
Article
Biotechnology & Applied Microbiology
Sijie Li, Hongyao Jia, Zhiru Zhang, Di Wu
Summary: The study demonstrated that DRAIC enhances SLBP expression by sponging miR-432-5p, promoting the malignant behaviors of breast cancer cells.
CANCER GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Wei Kang, Jinglin Zhang, Tingting Huang, Yuhang Zhou, Chi Chun Wong, Ronald C. K. Chan, Yujuan Dong, Feng Wu, Bin Zhang, William K. K. Wu, Michael W. Y. Chan, Alfred S. L. Cheng, Jun Yu, Nathalie Wong, Kwok Wai Lo, Ka Fai To
Summary: Aberrant activation of NOTCH3 has been linked to poor clinical outcomes in gastric cancer, partially attributed to the silencing of tumor suppressor miRNAs miR-491-5p and miR-875-5p. PHLDB2 was identified as a functional downstream modulator of NOTCH3 in gastric carcinogenesis, with positive correlation with NOTCH3 and negative correlation with miR-491-5p. The NOTCH3-PHLDB2-Akt cascade acts oncogenically in gastric carcinogenesis and may serve as a potential therapeutic target.
Article
Cell Biology
Renbo Guo, Benkui Zou, Yiran Liang, Jiasheng Bian, Jian Xu, Qian Zhou, Chao Zhang, Tao Chen, Mingshan Yang, Huansheng Wang, Fajun Pei, Zhonghua Xu
Summary: This study identified an uncharacterized and upregulated lncRNA RCAT1 in renal cell carcinoma, which played a key role in cell proliferation and metastasis by modulating the miR-214-5p/E2F2 axis, suggesting that lncRNA RCAT1 might be a new prognostic biomarker and potential therapeutic target for renal cell carcinoma.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Rossella Brandi, Marietta Fabiano, Corinna Giorgi, Ivan Arisi, Federico La Regina, Francesca Malerba, Sabrina Turturro, Andrea Ennio Storti, Flavia Ricevuti, Susanna Amadio, Cinzia Volonte, Simona Capsoni, Raffaella Scardigli, Mara D'Onofrio, Antonino Cattaneo
Summary: NGF regulates oligodendrogenesis and myelination by modulating miR-219a-5p levels, with NGF deprivation leading to increased expression of miR-219a-5p and enhanced oligodendrocyte differentiation.
Article
Cell Biology
Wei Jiang, Yaozhou He, Zijian Ma, Yu Zhang, Chengpeng Zhang, Nianpeng Zheng, Xing Tang
Summary: circ_0008234 in LUAC inhibits disease progression through a competitive endogenous RNA mechanism, potentially serving as a biomarker and therapeutic target for LUAC treatment.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Mo Liu, Qingwen Liu, Song Fan, Feng Su, Chun Jiang, Guanming Cai, Youyuan Wang, Guiqing Liao, Xinyuan Lei, Weixiong Chen, Junming Bi, Weiqi Cheng, LuoDan Zhao, Yi Ruan, Jinsong Li
Summary: Abnormal expression of long-noncoding RNA, LTSCCAT, is involved in the tumorigenesis and progression of tongue squamous cell carcinoma (TSCC). LTSCCAT promotes invasion and metastasis of TSCC by acting as a competitive endogenous RNA for miR-103a-2-5p to regulate metastasis-related genes.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jing Wang, Man Li, Meigui Wang, Jing Yang, Deguang Li, Yunxia Hao
Summary: Accumulating evidence suggests that miRNAs play a crucial role in lung adenocarcinoma. The specific contributions and mechanisms of miR-181c-5p in lung adenocarcinoma are not well understood. This study aimed to clarify the potential mechanism by which miR-181c-5p regulates the progression of lung adenocarcinoma. The results showed that miR-181c-5p was up-regulated in lung adenocarcinoma tissues and cells. Inhibition of miR-181c-5p suppressed the viability, migration, and invasion of lung adenocarcinoma cells. It was also found that miR-181c-5p targeted the PRKN gene and mediated its functions in lung adenocarcinoma progression. These findings suggest that miR-181c-5p could be a potential diagnostic and predictive marker for lung adenocarcinoma, offering new insights into the development of treatment strategies.
BIOCHEMICAL GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Huijie Guo, Mei Pu, Yusi Tai, Yuxiang Chen, Henglei Lu, Junwen Qiao, Guanghui Wang, Jing Chen, Xinming Qi, Ruimin Huang, Zhouteng Tao, Jin Ren
Summary: The study revealed that miR-30b-5p can inhibit TFEB-dependent gene transcription by binding to CLEAR elements in the nucleus, thus affecting lysosomal biogenesis and autophagy. Knocking out miR-30b-5p increases TFEB transactivation, leading to increased expression of autophagy and lysosomal biogenesis-related genes.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Endocrinology & Metabolism
Xin-Yi Liu, Xue-Jiao Chen, Miao Zhao, Zhi-qiang Wang, Hai-zhu Chen, Hong-Fu Li, Chen-Ji Wang, Shi-Fei Wu, Chao Peng, Yue Yin, Hong-Xia Fu, Min-Ting Lin, Long Yu, Zhi-Qi Xiong, Zhi-Ying Wu, Ning Wang
Summary: Late-onset MADD may be associated with mutations in the ETFDH gene, leading to instability and degradation of ETF:QO proteins. The study found that CHIP-dependent ubiquitin-proteasome pathway degradation may play a key role in the degradation of mutant ETF:QO proteins.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Engineering, Biomedical
Fanyan Deng, Wanyin Zhai, Yue Yin, Chao Peng, Congqin Ning
Summary: Silicate bioceramics, particularly CPS, exhibit excellent cytocompatibility and osteogenic activity. Through proteomics technology, it was shown that CPS adsorbed a greater variety and quantity of serum proteins compared to HA, leading to enhanced cell adhesion and bone regeneration. Further analysis revealed the mechanistic insights into how these absorbed proteins mediate cellular behavior and promote osteogenic activity.
BIOACTIVE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Jinhuan Chen, Yifan Wang, Cong Xu, Kaijian Chen, Qiaoyu Zhao, Shutian Wang, Yue Yin, Chao Peng, Zhanyu Ding, Yao Cong
Summary: Cryo-EM structures of the mammalian PA28 alpha beta-iCP immunoproteasome and free iCP, combined with cross-linking data, reveal the complex architecture and suggest a distinct immunoproteasome activation mechanism.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Yanping Wang, Jie Xiong, Yanmei Yuan, Chao Peng, Ping Wu, Yibing Wang, Junxi Lu, Yue Yin, Junting Xu, Suzhen Chen, Junli Liu
Summary: This study uncovers the role of RIP1 in obesity-induced insulin resistance. Inhibition of RIP1 activity improves hepatic insulin resistance caused by palmitic acid or high-fat diet. A novel phosphorylation site S415 on RIP1 is identified as a critical factor influencing RIP1-mediated insulin resistance.
Article
Multidisciplinary Sciences
Hao Liu, Jianqun Zheng, Lei Zhu, Lele Xie, Yawen Chen, Yirong Zhang, Wei Zhang, Yue Yin, Chao Peng, Jun Zhou, Xueliang Zhu, Xiumin Yan
Summary: The formation of axonemal central pair microtubules in mammals requires the cooperative action of Wdr47, Camsaps, and Katanin. These proteins work together to ensure the initiation and proper positioning of central microtubules, with deficiencies leading to ciliary dysfunctions.
NATURE COMMUNICATIONS
(2021)
Article
Toxicology
Weiqian Wang, Yan Chen, Yue Yin, Xunjiang Wang, Xuanling Ye, Kaiyuan Jiang, Yi Zhang, Jiwei Zhang, Wei Zhang, Yuzheng Zhuge, Li Chen, Chao Peng, Aizhen Xiong, Li Yang, Zhengtao Wang
Summary: Hepatic sinusoidal obstruction disease (HSOS) is a rare but life-threatening liver disease with unknown underlying mechanism and molecular changes. This study reveals that hepatic sinusoidal endothelial cells (HSECs) are the primary target of HSOS, and TSP1 overexpression plays a crucial role in its development.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiao-Ru Ma, Xudong Zhu, Yujie Xiao, Hui-Min Gu, Shuang-Shuang Zheng, Liang Li, Fan Wang, Zhao-Jun Dong, Di-Xian Wang, Yang Wu, Chenyu Yang, Wenhong Jiang, Ke Yao, Yue Yin, Yang Zhang, Chao Peng, Lixia Gao, Zhuoxian Meng, Zeping Hu, Chong Liu, Li Li, Hou-Zao Chen, Yousheng Shu, Zhenyu Ju, Jing-Wei Zhao
Summary: Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). The authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. beta-nicotinamide mononucleotide (beta-NMN) supplement delays myelin aging and enhances remyelination in the aged mice.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Mohan Zhao, Na Wang, Yaoting Guo, Jingwen Li, Yue Yin, Yan Dong, Jiabin Zhu, Chao Peng, Tingting Xu, Jinsong Liu
Summary: Orphan nuclear receptor Nurr1 plays important roles in various diseases, and this study reveals its structural flexibility and molecular mechanisms for transcriptional activity regulation through analyzing its binding structure with DNA and RXRα.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Letter
Cell Biology
Yuzhu Zhang, Changping Yin, Yue Yin, Mengqi Wei, Wei Jing, Chao Peng, Zhengjun Chen, Jing Huang
Article
Multidisciplinary Sciences
Wenyu Han, Mingliang Jin, Caixuan Liu, Qiaoyu Zhao, Shutian Wang, Yifan Wang, Yue Yin, Chao Peng, Yanxing Wang, Yao Cong
Summary: Using cryo-electron microscopy, we investigated the folding mechanism of tubulin/actin under the assistance of the chaperonin TRiC and its co-chaperone plp2. Our findings revealed the interaction between plp2 and tubulin/actin in different chambers of TRiC, and provided insights into the folding mechanism of these cytoskeletal proteins. These findings enhance our understanding of cytoskeletal proteostasis and its relevance to human diseases.
Article
Multidisciplinary Sciences
Xiaolong Xu, Yaru Wang, Yan Zhang, Yingli Wang, Yue Yin, Chao Peng, Xinyu Gong, Miao Li, Yuchao Zhang, Mingfang Zhang, Yubin Tang, Xindi Zhou, Haobo Liu, Lifeng Pan
Summary: This study reports the crystal structure of the catalytic core region of HOIL-1L and uncovers the key catalytic triad residues of HOIL-1L. It also discovered that HOIL-1L contains two distinct linear di-ubiquitin binding sites and the binding of HOIL-1L with linear tetra-ubiquitin can enhance its E3 activity.
Article
Cell Biology
Shichen Su, Shanshan Li, Ting Deng, Minsong Gao, Yue Yin, Baixing Wu, Chao Peng, Jianzhao Liu, Jinbiao Ma, Kaiming Zhang
Summary: This study reveals the structure and function of the m(6)A writer complex. Cryo-EM and other experimental methods were used to uncover the structure of MACOM and its interaction with MAC.
Article
Medicine, Research & Experimental
Wenjing Zhang, Yu Sun, Lu Bai, Lili Zhi, Yun Yang, Qingzhi Zhao, Chaoqun Chen, Yangfan Qi, Wenting Gao, Wenxia He, Luning Wang, Dan Chen, Shujun Fan, Huan Chen, Hai-Long Piao, Qinglong Qiao, Zhaochao Xu, Jinrui Zhang, Jinyao Zhao, Sirui Zhang, Yue Yin, Chao Peng, Xiaoling Li, Quentin Liu, Han Liu, Yang Wang
Summary: RBMS1 is a key regulator of ferroptosis in lung cancer development and its high expression is associated with reduced patient survival. Depletion or inhibition of RBMS1 can promote ferroptosis and sensitize radioresistant lung cancer cells to radiotherapy. RBMS1 interacts with eIF3d to regulate translation of SLC7A11, playing a critical role in ferroptosis evasion during lung cancer progression.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Jingjiao Li, Mingquan Guo, Xiaoxu Tian, Xin Wang, Xing Yang, Ping Wu, Chengrong Liu, Zixuan Xiao, Yafei Qu, Yue Yin, Chunxia Wang, Yucai Zhang, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, Tongyu Zhu, Qiming Liang
Summary: This study provides insights into the molecular mechanisms of SARS-CoV-2 pathogenesis by identifying host proteins targeted by the virus and perturbed in COVID-19 patients. The findings suggest a potential link between the upregulation of cellular proteins related to neutrophil activation, blood coagulation, and downregulation of proteins mediating T cell receptor signaling in severe COVID-19 patients. The interactome analysis further reveals the potential mechanisms by which SARS-CoV-2 triggers cytokine storms through the induction of interleukin-8 and the facilitation of neutrophil chemotaxis.