Article
Biochemistry & Molecular Biology
Xia Zou, Jishun Lu, Yao Deng, Qiannan Liu, Xialin Yan, Yalu Cui, Xiao Xiao, Meng Fang, Fang Yang, Hiromichi Sawaki, Takashi Sato, Binbin Tan, Xiaoyan Lu, Bo Feng, Atsushi Kuno, Hisashi Narimatsu, Chunfang Gao, Yan Zhang
Summary: This study revealed that ST6GAL1 and alpha 2,6 sialylation are negatively correlated with HCC cell metastasis. ST6GAL1 overexpression inhibits HCC cell migration and invasion in vitro and suppresses HCC metastasis in vivo, possibly through regulating MCAM expression.
Review
Biochemistry & Molecular Biology
Xinyu Chang, Uchechukwu Edna Obianwuna, Jing Wang, Haijun Zhang, Guanghai Qi, Kai Qiu, Shugeng Wu
Summary: Conventional cancer management based on tumor type and stage leads to poor outcomes in young women. Early detection of proteins in the serum could improve survival rates of breast cancer patients. This review highlights the impact of aberrant glycosylation on breast cancer development and progression, suggesting the potential for new serum biomarkers in diagnosis and treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Xin Nie, Li Fu, Yanfen Cheng, Xiaoping Wu, Kongpeng Lv, Renkai Li, Yihan Wu, George Pak-Heng Leung, Chaomei Fu, Simon Ming-Yuen Lee, Sai-Wang Seto, Jinming Zhang, Jingjing Li
Summary: Garicinone E (GE) effectively inhibits M2-like macrophage polarization and suppresses breast cancer growth and pulmonary metastasis. GE regulates the expression of M2 macrophage specific genes, impairs breast cancer cell proliferation, migration, and angiogenesis, and reduces the proportion of M2-like TAMs while increasing the proportion of M1-like TAMs. These findings suggest that GE may serve as a potential therapeutic agent for metastatic breast cancer.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hui Shen, Xingsen Zhao, Junchen Chen, Wenzheng Qu, Xiaoli Huang, Mengxuan Wang, Zhiyong Shao, Qiang Shu, Xuekun Li
Summary: Ogt-mediated O-GlcNAcylation plays essential roles in regulating mammalian neuronal development by controlling neural stem cell proliferation, neuron migration, and maturation. Ogt depletion leads to decreased Wnt/β-catenin signaling activity, which affects neuronal development.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Cancan Lyu, Aarzoo K. Bhimani, William T. Draus, Ronald Weigel, Songhai Chen
Summary: This study uncovers a critical role of Gα(i/o) signaling in accelerating breast cancer metastasis through the c-Src pathway.
MOLECULAR AND CELLULAR BIOLOGY
(2023)
Article
Cell Biology
Huang Huang, Qiong Wu, Xinyi Guo, Tianmiao Huang, Xueqin Xie, Lingyan Wang, Yangzhi Liu, Lin Shi, Wenli Li, Jianing Zhang, Yubo Liu
Summary: This study demonstrates that FOXA2 is O-GlcNAcylated by OGT and regulates migration and invasion of HCC cells, with reduced levels of FOXA2 associated with poor prognosis in HCC patients. O-GlcNAcylation decreases transcription of E-cadherin by FOXA2 and ultimately promotes HCC cell migration and invasion. Understanding the role of O-GlcNAcylation in regulating FOXA2 activity provides important insights into HCC metastasis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Cell Biology
Gabriele Antonarelli, Valentina Pieri, Francesca Maria Porta, Nicola Fusco, Gaetano Finocchiaro, Giuseppe Curigliano, Carmen Criscitiello
Summary: Various tumors rely on post-translational modifications to promote invasiveness, angiogenesis, and reprogram cellular energetics. Fucosylation, a type of glycosylation, has been linked to immune and hormonal functions as well as tumor development. In breast cancer, fucosylation of the glycan core is associated with poor prognosis and increased metastatic potential. Pre-clinical studies have investigated the molecular mechanisms of core-fucosylation in breast cancer models and its potential as a biomarker for predicting cancer outcomes.
Article
Cell Biology
Ruijun Li, Xichen Dong, Shibin Chen, Jingyu Tan, Xiangyu Chen, Jian Liu, Tao Wen, Xiaoli Ru
Summary: Breast cancer is a serious and deadly disease. The Tn antigen, a carbohydrate antigen, is frequently found in breast cancer cells, but its role in metastasis is not well understood. This study found that Tn-expressing breast cancer cells promoted metastasis through induction of EMT. The downregulation of heavily O-glycosylated protein CASC4 was identified as a mechanism underlying Tn-induced metastasis. These findings highlight the importance of aberrant O-glycosylation in breast cancer metastasis.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Melanie R. Walker, Hira Lal Goel, Dimpi Mukhopadhyay, Peter Chhoy, Emmet R. Karner, Jennifer L. Clark, Haibo Liu, Rui Li, Julie Lihua Zhu, Shuhui Chen, Lara K. Mahal, Barbara A. Bensing, Arthur M. Mercurio
Summary: Specific glycans can be used to distinguish breast cancer stem cells and influence their function. The expression of certain glycans plays a role in the enrichment and fate of breast cancer stem cells.
Article
Immunology
Yun Zhang, Maihuan Wang, Kebin Zhang, Junze Zhang, Xinpu Yuan, Guijun Zou, Zhen Cao, Chaojun Zhang
Summary: Chronic gastritis, a common digestive system disease, is mainly caused by Helicobacter pylori (H. pylori) infection. This study found that 6'-O-Galloylpaeoniflorin (GPF) can reduce H. pylori-induced gastric mucosal injury by activating the Nrf2 signaling pathway, and it has antioxidant and anti-inflammatory effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Shuang Liu, Shaoping Tian, Tianyu Lin, Xin He, Justin Eze Ideozu, Rui Wang, Yong Wang, Dan Yue, Hua Geng
Summary: G3BP1 plays multiple roles in breast cancer cell proliferation and metastasis, and it may regulate the activation of PKC zeta.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Multidisciplinary
Yongliang Wei, Benjamin Ben-zvi, Tianning Diao
Summary: C-aryl glycosyl compounds offer improved in vivo stability compared to O- and N-glycoside analogues, making them attractive candidates for drug development and chemical biology studies. A new cross-coupling method has been developed for the preparation of C-aryl and heteroaryl glycosides, including nucleosides and 2-deoxysugars, from easily accessible glycosyl esters and bromoarenes, demonstrating the potential of this method in medicinal chemistry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Jaggaiah N. Gorantla, Maniganda Santhi, Yanling Hua, James R. Ketudat Cairns
Summary: This study discovered an acyl migration-dependent method for synthesis by using appropriate blocking groups, which turns acyl migration into a tool for synthesis rather than an impediment.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Junfeng Ke, Wenzhao Han, Fanwei Meng, Feng Guo, Yuhong Wang, Liping Wang
Summary: Studies have shown that CTI-2 inhibits the activation of the MAPK signaling pathway, reduces the expression of E-cadherin, N-cadherin, and vimentin, thus preventing the metastasis of breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kexin Wang, Qiuzi Li, Yufeng Fan, Pingping Fang, Haibing Zhou, Jian Huang
Summary: Abnormal glycometabolism has become a fundamental research topic in tumor biology due to the poor metabolic conditions promoting the emergence of the Warburg effect (WE) phenotype. This study investigated the potential of Oxabicycloheptene sulfonate (OBHS), a selective estrogen receptor modulator, in targeting breast cancer glycometabolism. The results revealed that OBHS inhibits the expression of glucose transporter 1 (GLUT1) via the PI3K/Akt signaling pathway, leading to the suppression of breast cancer progression and proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yu Zhao, Hang Li, Yingyi Zhang, Leilei Li, Runping Fang, Yinghui Li, Qian Liu, Weiying Zhang, Liyan Qiu, Fabao Liu, Xiaodong Zhang, Lihong Ye
Article
Multidisciplinary Sciences
Qing Wei, Yingyi Zhang, Clementine Schouteden, Yuxia Zhang, Qing Zhang, Jinhong Dong, Veronika Wonesch, Kun Ling, Alexander Dammermann, Jinghua Hu
NATURE COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
Yingyi Zhang, Yu Zhao, Leilei Li, Yu Shen, Xiaoli Cai, Xiaodong Zhang, Lihong Ye
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2013)
Article
Oncology
Lin Yue, Leilei Li, Fangfang Liu, Nan Hu, Weiying Zhang, Xiao Bai, Yinghui Li, Yingyi Zhang, Li Fu, Xiaodong Zhang, Lihong Ye
Article
Biochemistry & Molecular Biology
Wenjing Cui, Yu Zhao, Changliang Shan, Guangyao Kong, Nan Hu, Yiwen Zhang, Shuai Zhang, Weiying Zhang, Yingyi Zhang, Xiaodong Zhang, Lihong Ye
Article
Oncology
Qian Liu, Xiao Bai, Hang Li, Yingyi Zhang, Yu Zhao, Xiaodong Zhang, Lihong Ye
INTERNATIONAL JOURNAL OF CANCER
(2013)
Article
Biochemistry & Molecular Biology
Shuangping Liu, Leilei Li, Yingyi Zhang, Yiwen Zhang, Yu Zhao, Xiaona You, Zhenhua Lin, Xiaodong Zhang, Lihong Ye
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Yingyi Zhang, Yu Zhao, Hang Li, Yinghui Li, Xiaoli Cai, Yu Shen, Hui Shi, Leilei Li, Qian Liu, Xiaodong Zhang, Lihong Ye
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Cell Biology
Yingyi Zhang, Jielu Hao, Mariana G. Tarrago, Gina M. Warner, Nino Giorgadze, Qing Wei, Yan Huang, Kai He, Chuan Chen, Thais R. Peclat, Thomas A. White, Kun Ling, Tamar Tchkonia, James L. Kirkland, Eduardo N. Chini, Jinghua Hu
Summary: Primary cilia play a central role in the determination of preadipocyte fate and the generation of metabolically healthy fat tissue by controlling transition fiber processes and signaling pathways, impacting adipocyte differentiation, obesity, and metabolic health.
Article
Genetics & Heredity
Hui Hong, Huicheng Chen, Yuxia Zhang, Zhimao Wu, Yingying Zhang, Yingyi Zhang, Zeng Hu, Jian V. Zhang, Kun Ling, Jinghua Hu, Qing Wei
Summary: Coordination of neurite extension with surrounding glia development is crucial for neuronal function. DYF-4, a glia-secreted protein, functions as a regulator for DAF-6 to control sensory compartment formation, indirectly affecting neurite extension and ciliogenesis.
Article
Medicine, Research & Experimental
Yu Zhao, Simeng Wen, Hang Li, Chun-Wu Pan, Yulei Wei, Ting Huang, Zhaochen Li, Yinhui Yang, Saijun Fan, Yingyi Zhang
Summary: This study identified bone-specific m6A-modified eRNA as a novel predictor for radiotherapy resistance in bone metastatic prostate cancer (mPCa). The RNA-binding protein KHSRP was found to play a functional role in inhibiting RNA degradation, thus contributing to radiotherapy resistance. Inhibition of the MLXIPe/KHSRP/PSMD9 regulatory complex was shown to suppress tumor growth and sensitize mPCa to radiotherapy.
Article
Multidisciplinary Sciences
Xiaoyu Ma, Yingyi Zhang, Yuanyuan Zhang, Xu Zhang, Yan Huang, Kai He, Chuan Chen, Jielu Hao, Debiao Zhao, Nathan K. LeBrasseur, James L. L. Kirkland, Eduardo N. N. Chini, Qing Wei, Kun Ling, Jinghua Hu
Summary: Exposure to irreparable stresses induces transient ciliogenesis, enabling communication with PML-NBs via a FBF1 pathway to trigger senescence in mammalian cells. Fbf1 ablation reduces senescence and associated health decline in mice, highlighting cilia as a promising senotherapy target.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Yinghui Li, Chaoqun Wang, Huier Gao, Jiali Gu, Yiran Zhang, Yingyi Zhang, Min Xie, Xuelian Cheng, Ming Yang, Wenshan Zhang, Yafang Li, Mei He, Hui Xu, Hexiao Zhang, Qing Ji, Tianhua Ma, Sheng Ding, Yu Zhao, Yingdai Gao
Summary: This study identified a specific KDM4 inhibitor, SD49-7, for resistant leukemia therapy, demonstrating its ability to inhibit the progression of leukemia stem cells (LSCs) and overcome resistance to traditional treatments.