Journal
NUTRITIONAL NEUROSCIENCE
Volume 25, Issue 1, Pages 110-121Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1028415X.2020.1724452
Keywords
Cholesterol; hydroxy-methylglutaryl Coenzyme A reductase; mevalonate pathway; nerve growth factor; omega 3 fatty acids
Categories
Funding
- PRIN-MIUR [2015SHM58M_004, legge 232/2016, commi 314-337]
- Ministero dell'Istruzione, dell'Universita e della Ricerca
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This study aimed to evaluate the long-term impact of perinatal omega-3 fatty acid-enriched diet on the mevalonate/cholesterol pathway in the brain of male offspring. The results showed that the omega-3 enriched diet induced changes in the brain's 3-hydroxy 3-methylglutaryl Coenzyme A reductase, RhoA/CREB signaling, and nerve growth factor content.
Objective: We were aimed at evaluating the long-term impact of perinatal an omega-3 fatty acid-enriched diet on the mevalonate/cholesterol pathway in the brain of male offspring. Methods: Female rats were fed with standard or omega-3 fatty acid-enriched diet during pregnancy and lactation. Liver, brain and plasma were collected from infant, adolescent and adult male offspring for subsequent biochemical and morphological analyses. Results: The omega-3 enriched diet induced region-dependent changes of the 3-hydroxy 3-methylglutaryl Coenzyme A reductase in the brain and affected notably RhoA/CREB signaling and the nerve growth factor content in the hippocampus. Our data reveal a long-lasting impact of perinatal omega-3 fatty acid supplementation on hippocampal nerve growth factor levels mediated by reduced 3-hydroxy 3-methylglutaryl Coenzyme A reductase activation state and enhanced CREB signaling. Discussion: These data underline the importance of the perinatal omega-3 enriched diet for adult brain function and reveal a new pathway important for nerve growth factor regulation.
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