Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid

Imaging DNA Equilibrated onto Mica in Liquid Using Biochemically Relevant Deposition Conditions

(2019) Patrick R. Heenan et al.   ACS Nano

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

(2019) Nadezda A. Fursova et al.   MOLECULAR CELL

Direct visualization of the E. coli Sec translocase engaging precursor proteins in lipid bilayers

(2019) Raghavendar Reddy Sanganna Gari et al.   Science Advances

PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation

(2019) Evan Healy et al.   MOLECULAR CELL

Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits

(2018) Daniel T. Youmans et al.   GENES & DEVELOPMENT

Structures of human PRC2 with its cofactors AEBP2 and JARID2

(2018) Vignesh Kasinath et al.   SCIENCE

Studying protein-DNA interactions using atomic force microscopy

(2018) Emily C. Beckwitt et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines

(2017) Xueyin Wang et al.   MOLECULAR CELL

Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation

(2017) Sharmistha Kundu et al.   MOLECULAR CELL

Accurate nanoscale flexibility measurement of DNA and DNA–protein complexes by atomic force microscopy in liquid

(2017) Divakaran Murugesapillai et al.   Nanoscale

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

(2017) Jeongyoon Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Compaction and condensation of DNA mediated by the C-terminal domain of Hfq

(2017) Antoine Malabirade et al.   NUCLEIC ACIDS RESEARCH

Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity

(2017) Daniel Holoch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

(2017) Xueyin Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

(2017) Jeongyoon Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

(2017) Yicheng Long et al.   eLife

Atomic force microscopy of chromatin arrays reveal non-monotonic salt dependence of array compaction in solution

(2017) Katarzyna M. Krzemien et al.   PLoS One

The interaction of PRC2 with RNA or chromatin is mutually antagonistic

(2016) Manuel Beltran et al.   GENOME RESEARCH

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

(2016) Neil Justin et al.   Nature Communications

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

(2016) Alexei Brooun et al.   Nature Communications

Targeting Polycomb systems to regulate gene expression: modifications to a complex story

(2015) Neil P. Blackledge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging

(2015) Maria V. Sukhanova et al.   NUCLEIC ACIDS RESEARCH

Cryptic RNA-binding by PRC2 components EZH2 and SUZ12

(2015) Juan G Betancur et al.   RNA Biology

The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2

(2015) Chen Davidovich et al.   RNA

Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2

(2015) L. Jiao et al.   SCIENCE

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome

(2014) Simão Teixeira da Rocha et al.   MOLECULAR CELL

Interactions between JARID2 and Noncoding RNAs Regulate PRC2 Recruitment to Chromatin

(2014) Syuzo Kaneko et al.   MOLECULAR CELL

DNA bridging and looping by HMO1 provides a mechanism for stabilizing nucleosome-free chromatin

(2014) Divakaran Murugesapillai et al.   NUCLEIC ACIDS RESEARCH

A dimeric state for PRC2

(2014) Chen Davidovich et al.   NUCLEIC ACIDS RESEARCH

Single-Molecule Reconstruction of Oligonucleotide Secondary Structure by Atomic Force Microscopy

(2014) Alice Pyne et al.   Small

The central role of EED in the orchestration of polycomb group complexes

(2014) Qi Cao et al.   Nature Communications

Single molecular investigation of DNA looping and aggregation by restriction endonuclease BspMI

(2014) Yanwei Wang et al.   Scientific Reports

Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment

(2014) Sarah Cooper et al.   Cell Reports

Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put

(2013) Jeffrey A. Simon et al.   MOLECULAR CELL

Promiscuous RNA binding by Polycomb repressive complex 2

(2013) Chen Davidovich et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Using DNA as a Fiducial Marker To Study SMC Complex Interactions with the Atomic Force Microscope

(2012) M.E. Fuentes-Perez et al.   BIOPHYSICAL JOURNAL

RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3

(2012) Lígia Tavares et al.   CELL

Retrofitting an atomic force microscope with photothermal excitation for a clean cantilever response in low Q environments

(2012) Aleksander Labuda et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Single-step direct measurement of amyloid fibrils stiffness by peak force quantitative nanomechanical atomic force microscopy

(2011) Jozef Adamcik et al.   APPLIED PHYSICS LETTERS

Imaging of nucleic acids with atomic force microscopy

(2011) Yuri L. Lyubchenko et al.   METHODS

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

(2010) C. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

(2010) Eric M. Mendenhall et al.   PLoS Genetics

Dynamics of Nucleosomes Revealed by Time-Lapse Atomic Force Microscopy

(2009) Luda S. Shlyakhtenko et al.   BIOCHEMISTRY

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Mechanisms of Polycomb gene silencing: knowns and unknowns

(2009) Jeffrey A. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL