Journal
NEUROSCIENCE RESEARCH
Volume 152, Issue -, Pages 66-77Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2019.12.018
Keywords
Optogenetics; Gene expression; Tet system; Gal4/UAS system; Cry2-CIB1
Categories
Funding
- USPS [15H05570, 15K18362, 17K14950, 15H01489, 16H01424, 16H06529]
- Ministry of Education, Culture, Sports, Science and the Technology ofJapan (MEXT)
- Japanese Science and Technology Agency UST) PRESTO program [JPMJPR14F3]
- CREST program [JPMJCR1752, UPMJCR1921 XII]
- Program for Technological Innovation of Regenerative Medicine [JP18bm0704020]
- Japanese Agency for Medical research and Development (AMED) [19dm0207090h0001]
- Leading Initiative for Excellent Young Researchers program of MEXT
- Waksman Foundation of Japan Inc
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Taking advantage of the recent development of genetically-defined photo-activatable actuator molecules, cellular functions, including gene expression, can be controlled by exposure to light. Such optogenetic strategies enable precise temporal and spatial manipulation of targeted single cells or groups of cells at a level hitherto impossible. In this review, we introduce light-controllable gene expression systems exploiting blue or red/far-red wavelengths and discuss their inherent properties potentially affecting induced downstream gene expression patterns. We also discuss recent advances in optical devices that will extend the application of optical gene expression control technologies into many different areas of biology and medicine. (C) 2020 The Authors.
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