Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Review
Geriatrics & Gerontology
Felix Bermejo-Pareja, Israel Contador, Teodoro del Ser, Javier Olazaran, Sara Llamas-Velasco, Saturio Vega, Julian Benito-Leon
Summary: MCI is the most commonly mentioned predementia entity, recognized as a harbinger of dementia caused by various etiologies, mainly MCI due to Alzheimer's disease. The operational definition of MCI has shortcomings, as does the recent miNCD construct. Current data suggest that miNCD is a stricter predementia condition with lower prevalence than MCI, less sensitivity to cognitive decline, and possibly a higher conversion rate to dementia.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Mark Sanderson-Cimino, Jeremy A. Elman, Xin M. Tu, Alden L. Gross, Matthew S. Panizzon, Daniel E. Gustavson, Mark W. Bondi, Emily C. Edmonds, Joel S. Eppig, Carol E. Franz, Amy J. Jak, Michael J. Lyons, Kelsey R. Thomas, McKenna E. Williams, William S. Kremen
Summary: Cognitive practice effects (PEs) can impact the diagnosis and progression prediction of MCI, increasing prevalence, reducing reversion rates, and increasing the risk of dementia. Accounting for PEs can improve diagnostic accuracy and the prediction ability of dementia in MCI diagnoses.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Alexa Pichet Binette, Sebastian Palmqvist, Divya Bali, Gill Farrar, Christopher J. Buckley, David A. Wolk, Henrik Zetterberg, Kaj Blennow, Shorena Janelidze, Oskar Hansson
Summary: This study found that the combination of plasma p-tau217 and a brief cognitive composite score is strongly associated with the risk of progression to AD dementia in MCI patients. These findings suggest that these measures could be key components of future prognostic algorithms for early AD.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Catarina Bernardes, Marisa Lima, Diana Duro, Anuschka Silva-Spinola, Joao Duraes, Miguel Tabuas-Pereira, Ines Baldeiras, Sandra Freitas, Isabel Santana
Summary: This study confirms the role of cerebrospinal fluid Alzheimer's disease biomarkers in predicting conversion from mild cognitive impairment to dementia and suggests the utility of Montreal Cognitive Assessment in predicting conversion in highly educated subjects, supporting its use in the evaluation of MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Felipe Botero-Rodriguez, Ana Melisa Cordoba Sastoque, Jose Manuel Santacruz Escudero, Hernando Santamaria-Garcia
Summary: This study aims to evaluate the impact of early and chronic neuropsychiatric symptoms (NPS) on cognition and functionality in patients with neurocognitive disorders (NCD). The results demonstrate an association between early NPS and cognitive and functional outcomes in mild NCD, while chronic NPS are negatively correlated with cognition and functionality in severe NCD. Therefore, NPS could serve as a pathological marker of the clinical course of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Marina Botello-Marabotto, M. Carmen Martinez-Bisbal, Miguel Calero, Andrea Bernardos, Ana B. Pastor, Miguel Medina, Ramon Martinez-Manez
Summary: This study employed 1H NMR spectroscopy to conduct a metabolomic study in serum samples from patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls (HC). The aim was to search for potential metabolite biomarkers. The results highlight the potential of 1H NMR metabolomics to support the diagnosis of dementia in a less invasive way, and provide a starting point for the study of potential biomarkers to identify MCI or HC subjects at risk of developing AD in the future.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Andrea M. Weinstein, Swathi Gujral, Meryl A. Butters, Christopher R. Bowie, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, James L. Kennedy, Linda Mah, Shima Ovaysikia, Bruce G. Pollock, Tarek K. Rajji, Benoit H. Mulsant
Summary: This study compared diagnostic rates and clinical predictors between NIA-AA criteria and DSM-5 criteria, finding that discrepancies were more likely in individuals with a history of MDD or carrying at least one ApoE4 allele. Detailed neuropsychological testing and NIA-AA criteria identified a greater prevalence of cognitive impairment compared to DSM-5 criteria and the Montreal Cognitive Assessment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Woori Moon, Ji Won Han, Jong Bin Bae, Seung Wan Suh, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: This study investigated the disease burden of various dementias and mild cognitive impairment in a representative South Korean population, predicting a significant increase in disability-adjusted life-years and years lived with disability due to these conditions by 2065.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Clinical Neurology
Tommy Kwan Hin Fong, Teris Cheung, Sze Ting Joanna Ngan, Kelvin Tong, Wai Yan Vivian Lui, Wai Chi Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng
Summary: This study aimed to assess the effectiveness and tolerability of transcranial pulse stimulation (TPS) with neuro-navigation in older adults with mild neurocognitive disorder (NCD). The results showed a significant improvement in cognition of elderly with mild NCD after receiving TPS intervention. This study provides valuable information for the long-term effect of TPS in cognition in older adults.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Pedro Lopes das Nevesa, Joao Duraes, Anuschka Silva-Spinola, Marisa Lima, Maria Joao Leitao, Miguel Tabuas-Pereira, Isabel Santana, Ines Baldeiras
Summary: Serum light-chain neurofilaments (sNfL) could serve as a potential minimally invasive biomarker for the diagnosis of patients with cognitive symptoms, showing a strong correlation with cerebrospinal fluid (CSF) biomarkers.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Jasmin E. Guevara, Natalie E. Kurniadi, Kevin Duff
Summary: This study quantifies cognitive change in patients with mild cognitive impairment (MCI) using standardized regression-based (SRB) z-scores. The findings show a significant decline in cognitive function over time, especially in learning and memory. Patients who progressed to dementia (MCI-Decline) showed more decline compared to those who remained stable (MCI-Stable). The study highlights the value of SRB in quantifying cognitive decline and identifying individuals at higher risk for MCI progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Sara Bernini, Silvia Panzarasa, Elena Sinforiani, Silvana Quaglini, Stefano F. Cappa, Chiara Cerami, Cristina Tassorelli, Tomaso Vecchi, Sara Bottiroli
Summary: This study aims to compare the effects of computer-based interventions on participants with neurocognitive disorders in two different modalities: at the hospital and at home. Conducting a non-inferiority trial to verify the comparability of HomeCoRe with CoRe, and to provide further support for the use of HomeCoRe in distance treatment.
FRONTIERS IN NEUROLOGY
(2021)
Review
Behavioral Sciences
Leonie C. P. Banning, H. G. B. Inez, Ramakers Kay Deckers, Frans R. J. Verhey, Pauline Aalten
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Article
Geriatrics & Gerontology
Leonie C. P. Banning, Eveline P. C. J. Janssen, Renske E. G. Hamel, Marjolein de Vugt, Sebastian Kohler, Claire A. G. Wolfs, Saskia M. Oosterveld, Rene J. F. Melis, Marcel G. M. Olde Rikkert, Roy P. C. Kessels, Yolande A. L. Pijnenburg, Ted Koene, Wiesje M. van der Flier, Philip Scheltens, Pieter Jelle Visser, Frans R. J. Verhey, Pauline Aalten, Inez H. G. B. Ramakers
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2020)
Article
Geriatrics & Gerontology
Leonie C. P. Banning, Inez H. G. B. Ramakers, Sebastian Koehler, Esther E. Bron, Frans R. J. Verhey, Peter Paul de Deyn, Jurgen A. H. R. Claassen, Huiberdina L. Koek, Huub A. M. Middelkoop, Wiesje M. van der Flier, Aad van der Lugt, Pauline Aalten
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2020)
Article
Geriatrics & Gerontology
Leonie C. P. Banning, Inez H. G. B. Ramakers, Paul B. Rosenberg, Constantine G. Lyketsos, Jeannie-Marie S. Leoutsakos
Summary: This study examined the trajectories of depression and apathy in (prodromal) Alzheimer's disease patients and found that they were associated with AD biomarkers. Lower A beta(42) and higher tau levels were related to increased probability of depression and apathy over time.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Neurosciences
Domante Kucikiene, Ana Sofia Costa, Leonie C. P. Banning, Veerle van Gils, Jorg B. Schulz, Inez H. G. B. Ramakers, Frans R. J. Verhey, Stephanie J. B. Vos, Kathrin Reetz
Summary: This study aimed to evaluate the prevalence of VRFs in AD patients based on biomarkers and their associations with AD CSF biomarkers, brain MRI, and cognition. The findings showed that VRFs were common in memory clinic patients, with differences across AT(N) biomarker groups.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Sport Sciences
Dymphie In de Braek, Kay Deckers, Timo Kleinhesselink, Leonie Banning, Rudolf Ponds
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)
