4.7 Review

Using empirically-derived dimensional phenotypes to accelerate clinical neuroscience: the Hierarchical Taxonomy of Psychopathology (HiTOP) framework

Journal

NEUROPSYCHOPHARMACOLOGY
Volume 45, Issue 7, Pages 1083-1085

Publisher

SPRINGERNATURE
DOI: 10.1038/s41386-020-0639-6

Keywords

-

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Psychology, Clinical

General v. specific vulnerabilities: polygenic risk scores and higher-order psychopathology dimensions in the Adolescent Brain Cognitive Development (ABCD) Study

Monika A. Waszczuk, Jiaju Miao, Anna R. Docherty, Andrey A. Shabalin, Katherine G. Jonas, Giorgia Michelini, Roman Kotov

Summary: This study systematically tested which polygenic risk scores (PRSs) are associated with various forms of childhood psychopathology. The results indicate that PRSs developed to predict vulnerability to emotional difficulties and chronic pain generally capture genetic risk for all forms of childhood psychopathology, while PRSs developed to predict vulnerability to externalizing difficulties tend to be more specific in predicting behavioral problems.

PSYCHOLOGICAL MEDICINE (2023)

Article Psychology, Clinical

Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene x environment moderation and mediation

Laurent Elkrief, Bochao Lin, Mattia Marchi, Mohammad H. Afzali, Tobias Banaschewski, Arun L. W. Bokde, Erin Burke Quinlan, Sylvane Desrivieres, Herta Flor, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jurjen Luykx, Marco P. Boks, Patricia J. Conrod

Summary: This study examines the relationship between cannabis use, genetic risk for schizophrenia, and psychotic-like experiences. The results suggest that cannabis use remains a risk factor for psychotic-like experiences, above and beyond genetic vulnerability for schizophrenia.

PSYCHOLOGICAL MEDICINE (2023)

Article Psychology, Clinical

Dynamic risk for first onset of depressive disorders in adolescence: does change matter?

Wenting Mu, Kaiqiao Li, Yuan Tian, Greg Perlman, Giorgia Michelini, David Watson, Hans Ormel, Daniel N. Klein, Roman Kotov

Summary: The study found that girls who experienced first-onset depressive disorders generally did not have a sharp increase in risk levels shortly before the onset of the disorder. Instead, they exhibited elevated levels of risk for several years before the onset. This suggests that the chronicity of risk factors should be a focal point in screening high-risk populations to prevent the onset of depressive disorders. Regular monitoring of risk factors in school settings is particularly informative.

PSYCHOLOGICAL MEDICINE (2023)

Article Psychology, Clinical

Loneliness in Gender-Diverse and Sexual Orientation-Diverse Adolescents: Measurement Invariance Analyses and Between-Group Comparisons

Riley McDanal, Jessica L. Schleider, Kathryn R. Fox, Nicholas R. Eaton

Summary: Youth loneliness is a risk factor for adverse psychosocial outcomes, and LGBTQ+ youths may be at higher risk due to minority stressors. Our study confirms the structure of the UCLA Loneliness Scale and shows that loneliness scores can be meaningfully compared across gender and sexual identities.

ASSESSMENT (2023)

Article Neurosciences

Brainmarker-I Differentially Predicts Remission to Various Attention-Deficit/Hyperactivity Disorder Treatments: A Discovery, Transfer, and Blinded Validation Study

Helena Voetterl, Guido van Wingen, Giorgia Michelini, Kristi R. Griffiths, Evian Gordon, Roger DeBeus, Mayuresh S. Korgaonkar, Sandra K. Loo, Donna Palmer, Rien Breteler, Damiaan Denys, L. Eugene Arnold, Paul du Jour, Rosalinde van Ruth, Jeanine Jansen, Hanneke van Dijk, Martijn Arns

Summary: This study develops a clinically interpretable and actionable biomarker based on resting-state electroencephalography, which can stratify patients with attention-deficit/hyperactivity disorder to their individual best treatment, thereby increasing remission rates.

BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING (2023)

Article Psychology, Developmental

Electrophysiological and Clinical Predictors of Methylphenidate, Guanfacine, and Combined Treatment Outcomes in Children With Attention-Deficit/Hyperactivity Disorder

Giorgia Michelini, Agatha Lenartowicz, Juan Diego Vera, Robert M. Bilder, James J. McGough, James T. McCracken, Sandra K. Loo

Summary: This study is the first to investigate pretreatment clinical and EEG profiles as predictors of treatment outcome in children with ADHD. The study found that clinical and EEG measures can predict treatment response in children with ADHD.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2023)

Article Psychology, Developmental

Methylphenidate, Guanfacine, and Combined Treatment Effects on Electroencephalography Correlates of Spatial Working Memory in Attention-Deficit/Hyperactivity Disorder

Giorgia Michelini, Agatha Lenartowicz, Joel P. Diaz-Fong, Robert M. Bilder, James J. McGough, James T. McCracken, Sandra K. Loo

Summary: This study found that the combination of d-methylphenidate and guanfacine can reduce midoccipital neural activity and improve symptoms in children with ADHD, while the monotherapy with these two drugs has limited effects and may have detrimental effects on performance. These findings are important for monitoring the treatment of children with ADHD in the future.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2023)

Article Psychology, Developmental

Predictors of expert providers' familiarity with intervention practices for school- and transition-age youth with autism spectrum disorder

Chelsea M. Cooper, Tamara Rosen, Hyunsik Kim, Nicholas R. Eaton, Elizabeth Cohn, Amy Drahota, Lauren J. Moskowitz, Matthew D. Lerner, Connor M. Kerns

Summary: Understanding providers' familiarity with intervention practices is crucial for optimizing care for autistic youth. Factors such as discipline, experience, and client characteristics can predict differences in knowledge. It is important to reduce disparities in care.

AUTISM (2023)

Article Psychology, Clinical

Do general and specific factors of preschool psychopathology predict preadolescent outcomes? A transdiagnostic hierarchical approach

Giorgia Michelini, Kelly Gair, Yuan Tian, Jiaju Miao, Lea R. Dougherty, Brandon L. Goldstein, Leigha A. MacNeill, Deanna M. Barch, Joan L. Luby, Lauren S. Wakschlag, Daniel N. Klein, Roman Kotov

Summary: The study found that both general and specific dimensions of preschool psychopathology are valuable for predicting clinical and functional outcomes nearly a decade later. These findings highlight the importance of transdiagnostic dimensions for early intervention and prevention.

PSYCHOLOGICAL MEDICINE (2023)

Article Psychiatry

Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans

Nathan A. Kimbrel, Allison E. Ashley-Koch, Xue J. Qin, Jennifer H. Lindquist, Melanie E. Garrett, Michelle F. Dennis, Lauren P. Hair, Jennifer E. Huffman, Daniel A. Jacobson, Ravi K. Madduri, Jodie A. Trafton, Hilary Coon, Anna R. Docherty, Niamh Mullins, Douglas M. Ruderfer, Philip D. Harvey, Benjamin H. McMahon, David W. Oslin, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser

Summary: This study aimed to identify the genetic basis of suicidal thoughts and behaviors. Through genome-wide association analysis, several risk loci for suicide were identified, and some of these loci were replicated in independent samples, providing evidence for their involvement in suicide.

JAMA PSYCHIATRY (2023)

Editorial Material Psychology, Developmental

Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies - a commentary on Lannoy et al. (2022)

Salahudeen Mirza, Anna R. Docherty, Eric T. Monson, Hilary Coon, Brooks Keeshin, Gabriel R. Fries

Summary: Preventing suicidal thoughts and behaviors among youth is a global public health priority. Genetic and environmental factors play a key role in the development of risk for STB. A recent study by Lannoy et al. found that polygenic risk for suicide attempt and recent negative life events were associated with suicidal ideation in adolescents. This highlights the importance of further research in suicide genetics to better understand and address the underlying pathways to STB.

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY (2023)

Article Multidisciplinary Sciences

Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders

Monika A. Waszczuk, Olga Morozova, Elizabeth Lhuillier, Anna R. Docherty, Andrey A. Shabalin, Xiaohua Yang, Melissa A. Carr, Sean A. P. Clouston, Roman Kotov, Benjamin J. Luft

Summary: Genetic risk scores for asthma and allergic disease are associated with the severity and symptoms of COVID-19, while risk scores for coronary artery disease and type II diabetes are not.

PLOS ONE (2023)

Editorial Material Psychiatry

Rare Copy Number Variation in Schizophrenia and Implications for Treatment

Anna R. Docherty

SCHIZOPHRENIA BULLETIN (2023)

Review Biochemistry & Molecular Biology

Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies

Monika A. Waszczuk, Katherine G. Jonas, Marina Bornovalova, Gerome Breen, Cynthia M. Bulik, Anna R. Docherty, Thalia C. Eley, John M. Hettema, Roman Kotov, Robert F. Krueger, Todd Lencz, James J. Li, Evangelos Vassos, Irwin D. Waldman

Summary: Genome-wide association studies (GWAS) have the potential to provide biological insights into disease mechanisms and offer clinically useful biomarkers. This review examines the use of quantitative and transdiagnostic phenotypes in GWAS for major psychiatric disorders. The authors discuss themes and recommendations, including issues of sample size, phenotypic reliability, sources of phenotypic information, and the use of biological and behavioral markers. The review also highlights the importance of multi-trait methods and the potential of dimensional and transdiagnostic phenotypes for gene discovery in psychiatric conditions.

MOLECULAR PSYCHIATRY (2023)

Editorial Material Psychiatry

Pleiotropic CACNA1C Variants and Neuronal Function in Psychosis

Anna R. Docherty

SCHIZOPHRENIA BULLETIN (2023)

No Data Available