Article
Medicine, General & Internal
Amaury Broussier, Jean Philippe David, Mounira Kharoubi, Silvia Oghina, Lauriane Segaux, Emmanuel Teiger, Marie Laurent, Isabelle Fromentin, Sylvie Bastuji-Garin, Thibaud Damy
Summary: Frailty is common in patients with ATTRwt-CA, with certain parameters significantly associated with disease severity and course. Taking frailty into account in the assessment and management of ATTRwt should enhance patients' quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Carlo Fumagalli, Mattia Zampieri, Federico Perfetto, Chiara Zocchi, Niccolo Maurizi, Luigi Tassetti, Andrea Ungar, Martina Gabriele, Giulia Nardi, Guido Del Monaco, Katia Baldini, Alessia Tomberli, Benedetta Tomberli, Niccolo Marchionni, Carlo Di Mario, Iacopo Olivotto, Francesco Cappelli
Summary: This study investigated the long-term association between diagnostic timing and mortality in patients with ATTRwt-CA. The results showed that delayed diagnostic timing was associated with higher mortality, highlighting the importance of timely diagnosis when red flags are present.
MAYO CLINIC PROCEEDINGS
(2021)
Review
Cardiac & Cardiovascular Systems
Angelica Cersosimo, Andrea Bonelli, Carlo M. M. Lombardi, Antonella Moreo, Matteo Pagnesi, Daniela Tomasoni, Gianmarco Arabia, Enrico Vizzardi, Marianna Adamo, Davide Farina, Marco Metra, Riccardo M. M. Inciardi
Summary: Severe aortic stenosis (AS) and cardiac amyloidosis (CA), particularly wild-type transthyretin (wTTR), have high prevalence rates in elderly populations. Detecting the coexistence of CA and AS is challenging due to their similar effects on the left ventricle. This review aims to identify imaging methods that can help recognize occult wtATTR-CA in AS patients, providing insights into the crucial diagnostic process.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Aldostefano Porcari, Marianna Fontana, Julian D. Gillmore
Summary: Transthyretin cardiac amyloidosis (ATTR-CA) is a common cause of heart failure and mortality, with advances in diagnosis and treatment making it a condition that clinicians should consider daily. Amyloid fibril formation is caused by age-related failure of homoeostatic mechanisms or mutations. Large-scale studies show an increasing incidence of cardiac amyloidosis, with cardiac involvement being the leading cause of mortality. Early recognition is important for optimal treatment.
CARDIOVASCULAR RESEARCH
(2023)
Article
Medicine, General & Internal
Su Shen Lim, Ling Kuo, Fu-Pang Chang, Chun-Chin Chang, Wen-Chung Yu
Summary: Amyloidosis cardiomyopathy is a rare and underdiagnosed disease characterized by amyloid fibril deposition in the myocardium. The diagnosis of cardiac amyloidosis is often delayed due to a lack of awareness and the necessity of biopsy to confirm the diagnosis. However, recent advances in cardiovascular imaging modalities have enhanced earlier recognition of this disease.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Shreya Ghosh, Dibbendhu Khanra, Vinay Krishna, Ashwani Kumar Thakur
Summary: Senile systemic amyloidosis primarily affects the elderly, but can also occur in younger patients and should be taken seriously. Jugular vein distention and improvement in global cardiac function can serve as early diagnostic markers for this condition.
Article
Cardiac & Cardiovascular Systems
Takuma Iwaya, Atsushi Okada, Emi Tateishi, Yasutoshi Ohta, Yoshiaki Morita, Keiko Ohta-Ogo, Chisato Izumi
Summary: This article reports a case of a 81-year-old Japanese woman with wild-type ATTR-CA, who presented with no ventricular hypertrophy and negative bone scintigraphy. The case highlights the importance of multimodality assessments for early diagnosis in patients with atypical cardiac morphologies and emphasizes the consideration of ATTR-CA in patients with non-cardiac manifestations of ATTR amyloidosis.
Review
Biochemistry & Molecular Biology
Dominik Waldmeier, Jan Herzberg, Frank-Peter Stephan, Marcus Seemann, Nisha Arenja
Summary: This review provides an overview of the use of multimodality imaging in cardiac amyloidosis, highlighting its diagnostic possibilities and prognostic values. Echocardiography is the preferred diagnostic tool, while cardiac magnetic resonance and scintigraphy play crucial roles in diagnosis and subtype differentiation.
Article
Cardiac & Cardiovascular Systems
Carlo Fumagalli, Mattia Zampieri, Alessia Argiro, Luigi Tassetti, Gabriele Rossi, Beatrice Musumeci, Giacomo Tini, Domitilla Russo, Matteo Sclafani, Alberto Cipriani, Giulio Sinigiani, Gianluca Di Bella, Roberto Licordari, Marco Canepa, Pier Filippo Vianello, Marco Merlo, Aldostefano Porcari, Maddalena Rossi, Gianfranco Sinagra, Claudio Rapezzi, Carlo Di Mario, Andrea Ungar, Iacopo Olivotto, Federico Perfetto, Francesco Cappelli
Summary: This study found that almost 70% of patients with ATTRwt-CA had atrial fibrillation (AF), and longer PR and QRS duration as well as left atrial dilation were associated with the onset of arrhythmia.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Clinical Neurology
Marta Campagnolo, Mario Cacciavillani, Alberto Cipriani, Alessandro Salvalaggio, Francesca Castellani, Kalliopi Pilichou, Chiara Briani
Summary: The aim of this study was to investigate peripheral nerve involvement in ATTRwt. The study found that despite being uncommon, there is peripheral nervous system involvement in ATTRwt patients, with age-related conditions possibly acting as confounding factors for the diagnosis of neuropathy.
NEUROLOGICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yuri Ochi, Toru Kubo, Yuichi Baba, Kenta Sugiura, Kazuya Miyagawa, Tatsuya Noguchi, Takayoshi Hirota, Tomoyuki Hamada, Naohito Yamasaki, Hiroaki Kitaoka
Summary: The study presented the early experience of using Tafamidis treatment for Japanese patients with ATTRwt CA, indicating that Tafamidis may maintain disease status in the short term without significant adverse events.
CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Kimon Stamatelopoulos, Dimitrios Delialis, Georgios Georgiopoulos, Maria-Irini Tselegkidi, Foteini Theodorakakou, Ioanna Dialoupi, Dimitrios Bambatsias, Ioannis Petropoulos, Giuseppe Vergaro, Ignatios Ikonomidis, Stavros Tzortzis, Alexandros Briasoulis, John Kanakakis, Ioannis Trougakos, Meletios A. Dimopoulos, Efstathios Kastritis
Summary: This study found that patients with ATTRwt have distinct peripheral vascular characteristics compared to those with AL-HF or HFpEF, including lower peripheral and aortic blood pressure, prolonged Tr/HR, and FMD within the reference population range.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Oncology
Jose Nativi-Nicolau, Alfonso Siu, Angela Dispenzieri, Mathew S. Maurer, Claudio Rapezzi, Arnt Kristen, Pablo Garcia-Pavia, Samantha LoRusso, Marcia Waddington-Cruz, Olivier Lairez, Ronald Witteles, Doug Chapman, Leslie Amass, Martha Grogan
Summary: In the past decade, the diagnosis of ATTRwt amyloidosis has increased globally, especially in the United States. Despite the increasing use of bone scintigraphy, patients are still diagnosed several years after symptom onset.
JACC: CARDIOONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Bertil Ladefoged, Tor Clemmensen, Anne Dybro, Charlotte Hartig-Andreasen, Lone Kirkeby, Lars Christian Gormsen, Peter Bomholt, Julian Gillmore, Steen Hvitfeldt Poulsen
Summary: The prevalence of ATTRwt was found to be 8.3% in a population of age and gender-selected patients with a recent history of CTS. Patients diagnosed with ATTRwt through screening had less cardiac involvement in terms of structure and function compared to clinical ATTRwt patients.
Article
Cardiac & Cardiovascular Systems
Bertil Thyrsted Ladefoged, Anne Dybro, Anders Lehmann Dahl Pedersen, Torsten Bloch Rasmussen, Henrik olholm Vase, Tor Skibsted Clemmensen, Julian Gillmore, Steen Hvitfeldt Poulsen
Summary: This study found a high incidence and recurrence of hospitalizations with worsening heart failure (WHF) in patients with wild-type transthyretin amyloidosis (ATTRwt), which was associated with reduced survival. Patients with pacemaker devices prior to ATTRwt diagnosis were more likely to be hospitalized with WHF. Pacemaker implantation prior to diagnosis and right atrial enlargement were identified as independent predictors of WHF during follow-up.