Article
Neurosciences
Ranjithkumar Chellian, Isaac Wilks, Brandon Levin, Song Xue, Azin Behnood-Rod, Ryann Wilson, Megan McCarthy, Abhigyan Ravula, Hardik Chandasana, Hartmut Derendorf, Adriaan W. Bruijnzeel
Summary: The experiment found that exposure to tobacco smoke enhances brain reward function, but does not potentiate the rewarding effects of nicotine in male and female rats.
PSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Lindsay Ferguson, Christopher C. Giza, Rebecka O. Serpa, Tiffany Greco, Hannah Robert, Michael Folkerts, Mayumi L. Prins
Summary: Adolescence is a period marked by puberty onset, cognitive and social developments, and physical changes, with sex differences impacting athletic performance. Results from a study on adolescent rats engaging in 10 days of exercise show changes in physiological functions, with females exhibiting greater running distances and durations.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Deepak Patel, Prabhat Kumar Vishwakarma, Richa Patel, Nishant Sudhir Jain
Summary: The study investigated the role of central histaminergic transmission in modulating nicotine withdrawal-induced anxiety and somatic behaviors in mice. It was found that pre-treatment with histaminergic agents exacerbated anxiety and somatic behaviors in nicotine withdrawn mice, while blockade of histamine H1 or H2 receptors alleviated these symptoms.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Anne K. Baker, Lauren C. Ericksen, Vincent Koppelmans, Brian J. Mickey, Katherine T. Martucci, Jon-Kar Zubieta, Tiffany M. Love
Summary: There is a reciprocal relationship between chronic pain and reward processing. This study found that males with chronic pain exhibited reduced anticipatory responses to reward in the striatum compared to control males, while no significant sex differences were observed among female patients. These findings highlight the importance of considering sex as a factor of interest in future studies on reward processing in the context of chronic pain.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Nicole Arguelles, Sharon Miksys, Rachel F. Tyndale
Summary: Studies have shown that female rats in diestrus have higher oxycodone analgesia and brain oxycodone levels. Sex and estrous cycle impact oxycodone analgesia and brain oxycodone levels, likely through regulation of brain CYP2D oxycodone metabolism.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Yasmin Alkhlaif, Medhat El-Halawany, Wisam Toma, Abigail Park, Ayman K. Hamouda, M. Imad Damaj
Summary: This study found that L-theanine can alleviate physical and emotional symptoms of nicotine withdrawal and reduce the rewarding effects of nicotine, but it does not affect acute responses to nicotine. This suggests that L-theanine may be a promising candidate for treating nicotine dependence.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Yocasta Alvarez-Bagnarol, Renata C. N. Marchette, Chase Francis, Marisela Morales, Leandro F. Vendruscolo
Summary: This study found that hyperalgesia and somatic withdrawal symptoms in opioid withdrawal are associated with c-Fos expression in different brain regions. The lateral hypothalamus, central nucleus of the amygdala, ventral tegmental area, parabrachial nucleus, dorsal raphe, and locus coeruleus were associated with hyperalgesia, while the paraventricular nucleus of the thalamus, lateral habenula, dorsal raphe, and locus coeruleus were associated with somatic withdrawal. The expression of c-Fos in the dorsal raphe and locus coeruleus was associated with both hyperalgesia and somatic withdrawal.
Article
Multidisciplinary Sciences
Daniel J. Kalamarides, Aditi Singh, Shannon L. Wolfman, John A. Dani
Summary: The effectiveness of current treatments for opioid use disorder varies by sex, and there is a lack of understanding about the neurobiological mechanisms mediating negative states during withdrawal, particularly in terms of sex differences. Preclinical research in male subjects suggests that opioid withdrawal is accompanied by increased GABA release probability in the VTA. However, it is uncertain if these findings extend to females. In this study, it was found that inhibitory synaptic long-term potentiation is occluded in the VTA in male mice after repeated morphine injections and withdrawal, while female mice maintain the ability to evoke synaptic potentiation.
SCIENTIFIC REPORTS
(2023)
Review
Behavioral Sciences
Henry L. Blanton, Robert C. Barnes, Melissa C. McHann, Joshua A. Bilbrey, Jenny L. Wilkerson, Josee Guindon
Summary: Cannabis use, particularly for pain relief, is increasing among women. Sex differences in response to cannabinoids have been observed in preclinical studies, with female rodents generally being more sensitive to Delta(9)-THC. Factors such as metabolism, cannabinoid receptor expression, and ovarian hormones may contribute to these differences. Further research into the role of sex in endocannabinoid system function is needed as we continue to study the impact of cannabinoids in various disease states, including chronic pain.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
A. Florido, E. R. Velasco, C. M. Soto-Faguas, A. Gomez-Gomez, L. Perez-Caballero, P. Molina, R. Nadal, O. J. Pozo, C. A. Saura, R. Andero
Summary: Memory formation is crucial for brain function, and understanding the mechanisms behind it helps in understanding neural processes. The Tac2 pathway in the central amygdala plays a key role in fear memory consolidation, with opposite effects observed in male and female mice.
NATURE COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Paloma Molina Hernandes, Matheus Fitipaldi Batistela, Jefferson Manoel Nascimento-Silva, Alana Tercino Frias, Melina Matthiesen, Alline Cristina Campos, Thelma Anderson Lovick, Helio Zangrossi Jr
Summary: Clinical and preclinical studies have shown that cannabidiol (CBD) has anxiolytic effects, but its effects on panic disorder and in females have been less explored. This study compared the effects of CBD on male and female rats and mice in response to panicogenic challenges. The results showed that CBD had panicolytic effects in female rats and mice, but not in males. In rats, the effects were influenced by the estrous cycle, with the most significant response in the late diestrus phase. Higher doses were required to elicit effects in mice, and the estrous cycle had no effect.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
Maylen Perez Diaz, Jean-Baptiste Pochon, Dara G. Ghahremani, Andy C. Dean, Paul Faulkner, Nicole Petersen, Rachel F. Tyndale, Andrea Donis, Diana Paez, Citlaly Cahuantzi, Gerhard S. Hellemann, Edythe D. London
Summary: The study found that women reported stronger craving for cigarettes than men, regardless of smoking condition. Nicotine dependence was positively associated with craving, with no sex differences in this association. There was a negative association of right anterior insula thickness with craving in women only.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Neurosciences
Anita Sikic, Jude A. Frie, Jibran Y. Khokhar, Jennifer E. Murray
Summary: Smoking is the leading cause of preventable death worldwide, and women are more susceptible to nicotine addiction and face greater difficulty quitting. Smoking during pregnancy has significant health implications, including an increased risk of behavioral disorders. There are gender-specific behavioral outcomes related to smoking in adolescence and adulthood, and it is likely that the same applies to gestational nicotine or tobacco exposure. With the rise of vaping as a perceived safer alternative to cigarettes, especially among pregnant women, further research is required to understand the sex-dependent behavioral outcomes of prenatal nicotine exposure.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Robert Hitzemann, Susan E. Bergeson, Ari E. Berman, Jason A. Bubier, Elissa J. Chesler, Deborah A. Finn, Matthew Hein, Paula Hoffman, Andrew Holmes, Brent R. Kisby, Denesa Lockwood, Kerrie H. Lodowski, Michelle McManus, Julie A. Owen, Angela R. Ozburn, Praneetha Panthagani, Igor Ponomarev, Laura Saba, Boris Tabakoff, Aashlesha Walchale, Robert W. Williams, Tamara J. Phillips
Summary: There is compelling evidence that sex and gender differences play a crucial role in excessive alcohol consumption, particularly in neuroimmune processes. Studies have shown significant transcriptional differences between males and females, especially in the extended amygdala and nucleus accumbens. Even phenotypically similar males and females in animal models show significant differences at the transcriptome level.
BIOLOGICAL PSYCHIATRY
(2022)
Review
Neurosciences
Janna K. Moen, Anna M. Lee
Summary: Alcohol and nicotine, the two most widely used and misused drugs globally, show significant sex differences in their rewarding properties, yet most preclinical studies on their mechanisms utilize only male rodents. Understanding the influence of sex and sex hormones on alcohol and nicotine reward is crucial for developing therapies to reduce drug consumption.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Junhui Bai, Yukun Li, Meixiang Li, Sijie Tan, Daichao Wu
CURRENT DRUG TARGETS
(2020)
Article
Neurosciences
Zeyi Huang, Daichao Wu, Xilin Qu, Meixiang Li, Ju Zou, Sijie Tan
Summary: Smoking, a major preventable cause of death worldwide, is associated with nicotine addiction, which is considered a serious public health issue. The brain-derived neurotrophic factor (BDNF) plays a crucial role in nicotine dependence, as its expression in the brain is affected by nicotine.
REVIEWS IN THE NEUROSCIENCES
(2021)
Review
Pharmacology & Pharmacy
Zeyi Huang, Sijie Tan
Summary: Major depressive disorder (MDD) is a common mental disorder, and its development is primarily related to pathological changes in the brain. Investigations suggest that the P2X7 receptor may be a potential mechanism underlying MDD induced by chronic stress.
CURRENT DRUG TARGETS
(2021)
Article
Clinical Neurology
Caesar M. Hernandez, Caitlin A. Orsini, Shelby L. Blaes, Jennifer L. Bizon, Marcelo Febo, Adriaan W. Bruijnzeel, Barry Setlow
Summary: A study using a rat model found that adolescent exposure to cannabis smoke did not have significant adverse effects on adult behavioral and cognitive outcomes, and in some tests even showed improved performance.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Ranjithkumar Chellian, Isaac Wilks, Brandon Levin, Song Xue, Azin Behnood-Rod, Ryann Wilson, Megan McCarthy, Abhigyan Ravula, Hardik Chandasana, Hartmut Derendorf, Adriaan W. Bruijnzeel
Summary: The experiment found that exposure to tobacco smoke enhances brain reward function, but does not potentiate the rewarding effects of nicotine in male and female rats.
PSYCHOPHARMACOLOGY
(2021)
Review
Clinical Neurology
Ranjithkumar Chellian, Azin Behnood-Rod, Dawn M. Bruijnzeel, Ryann Wilson, Vijayapandi Pandy, Adriaan W. Bruijnzeel
Summary: This review discusses nicotine withdrawal symptoms in rats and mice following cessation of nicotine, tobacco smoke, nicotine vapor, and e-cigarette aerosol exposure. Withdrawal symptoms are most pronounced within the first week after cessation, with anxiety and depressive-like behavior and memory deficits potentially lasting for months. Age and sex differences impact the expression of nicotine withdrawal symptoms.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Cell Biology
Min Tang, Yukun Li, Xianyu Luo, Jiao Xiao, Juan Wang, Xin Zeng, Qihao Hu, Xiaoyan Chen, Si-jie Tan, Jun Hu
Summary: The study analyzed LSCC expression data and identified a close relationship between LSCC and CD8(+) T cells, verifying six hub genes associated with cancer development. METTL8 was selected as a prognostic biomarker and its inhibition can induce G1 cell cycle arrest and suppress proliferation, making it a potential biomarker and gene therapy target in LSCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Rui Chang, Zeyi Huang, Size Zhao, Ju Zou, Yukun Li, Sijie Tan
Summary: FTO is a gene associated with obesity, expressed mainly in tissues like the brain. Recent studies have shown that FTO affects neurological function through the m6A modification of mRNA, and is associated with various neuropsychiatric disorders.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Psychiatry
Rui Chang, Jionghong Peng, Yunfan Chen, Hailin Liao, Size Zhao, Ju Zou, Sijie Tan
Summary: This article reviews the research progress on deep brain stimulation (DBS) for drug addiction, with a focus on the treatment effects of NAc DBS and other brain regions.
FRONTIERS IN PSYCHIATRY
(2022)
Letter
Psychiatry
Zeyi Huang, Rui Chang, Jionghong Peng, Yunfan Chen, Hailin Liao, Size Zhao, Zhenyi Lang, Ju Zou, Sijie Tan
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Ranjithkumar Chellian, Azin Behnood-Rod, Ryann Wilson, Karen Lin, Grace Wing-Yan King, Adriaan W. Bruijnzeel
Summary: The D1/D2-like receptor antagonist flupentixol and the D2-like receptor antagonist L-741626 decrease nicotine intake and locomotor activity in both male and female rats. These compounds also decrease operant responding for food, and there may be a sex difference in the effects on food intake.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ranjithkumar Chellian, Azin Behnood-Rod, Ryann Wilson, Karen Lin, Grace Wing-Yan King, Adriaan W. Bruijnzeel
Summary: Nicotine and tobacco products are highly addictive, and the dopaminergic system plays a crucial role in nicotine intake. Nicotine intake in rats with short access to nicotine can be reduced by blocking dopamine D1-like receptors, but little is known about the effects in rats with long access. This study found that dopamine D1-like receptor antagonist and agonist both decrease nicotine intake in rats with long access to nicotine, suggesting that this intermittent long access model closely mimics human smoking and vaping.
Article
Substance Abuse
Ruixuan Wang, Jaclyn M. Hall, Ramzi G. Salloum, Frederick Kates, Christopher R. Cogle, Adriaan W. Bruijnzeel, Young-Rock Hong, Jennifer H. Lelaurin
Summary: This study assessed the prevalence of underreported nicotine exposure in a nationally representative sample of US nonsmoking adults. The results showed that between 2013 and 2020, the self-reported SHS exposure rate was 22.0%, the serum cotinine-assessed nicotine exposure rate was 51.2%, and the underreported nicotine exposure rate was 34.6% among US nonsmokers. Findings also revealed that a significant portion of individuals with detectable serum cotinine reported no SHS exposure, and certain sociodemographic factors were associated with underreporting nicotine exposure.
NICOTINE & TOBACCO RESEARCH
(2023)
Review
Substance Abuse
Ranjithkumar Chellian, Azin Behnood-Rod, Adriaan W. Bruijnzeel
Summary: Summary: Adolescents and young adults who smoke or vape can develop nicotine dependence, leading to withdrawal symptoms such as cravings, depression, anxiety, sleep problems, and cognitive deficits. Clinical studies show that daily smokers have a higher risk of developing dependence compared to occasional smokers, and this dependence develops in adulthood. Preclinical studies with animals indicate that rats self-administering nicotine also show signs of dependence, including anxiety, depressive behavior, cognitive deficits, and changes in sensitivity to pain. It is important to include both sexes and start nicotine intake during adolescence in animal studies to better model smoking and vaping.
NICOTINE & TOBACCO RESEARCH
(2023)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.