Review
Cell Biology
Claire Osgood, Zubair Ahmed, Valentina Di Pietro
Summary: TBI is a major cause of mortality and morbidity worldwide, with a lack of therapeutic agents necessitating the discovery of new treatment targets. This study investigated miRNA and protein expression in rat models of TBI, uncovering potential roles of miRNAs in the pathogenesis of TBI and identifying potential therapeutic targets in the endocytosis and TNF signaling pathways.
Article
Genetics & Heredity
Yawen Ma, Yunhui Liu, Xuelei Ruan, Xiaobai Liu, Jian Zheng, Hao Teng, Lianqi Shao, Chunqing Yang, Di Wang, Yixue Xue
Summary: By analyzing gene expression and coexpression networks, we identified important modules and hub genes associated with neurodevelopment and immune inflammation in TBI. These findings may offer new insights for the early diagnosis and treatment of TBI.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Xing Zhou, Lidong Wu
Summary: This study aimed to find potential diagnostic markers and molecular therapeutic targets for rheumatoid arthritis (RA) at the mRNA molecular level. Through analyzing gene expression dataset, screening differentially expressed genes, performing functional enrichment analysis and constructing protein-protein interaction network, the study identified crucial genes and potential compound drugs for RA.
FRONTIERS IN GENETICS
(2023)
Article
Clinical Neurology
Michael R. Fiorini, Allison A. Dilliott, Sali M. K. Farhan
Summary: In this study, a sex-stratified RNA sequencing analysis was conducted to investigate the transcriptome changes associated with traumatic brain injury (TBI) that may contribute to dementia. The results revealed a correlation between gene expression in the hippocampus of female TBI donors and dementia. This study contributes to our understanding of the pathophysiological link between TBI and dementia, emphasizing the importance of sex as a biological variable affecting TBI outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Ophthalmology
Matthew M. Harper, Nickolas Boehme, Laura M. Dutca, Michael G. Anderson
Summary: This study examined the influence of genetic background on the retinal ganglion cell (RGC) response to blast-mediated traumatic brain injury (TBI) in mice. It found significant differences in RGC response between different genetic backgrounds, indicating a strong dependency of RGC response on genetic factors.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Clement Delage, Toufik Taib, Celia Mamma, Dominique Lerouet, Valerie C. Besson
Summary: Traumatic brain injury (TBI) is a major cause of death and disability worldwide, leading to inflammatory responses, white matter injuries, and neurodegenerative pathologies. The consequences of TBI and pharmacological responses vary with age, emphasizing the need for age-specific approaches in therapy development.
Article
Clinical Neurology
Gengshui Zhao, Yongqi Fu, Chao Yang, Xuehui Yang, Xiaoxiao Hu
Summary: This article aims to provide a promising target for future therapeutic interventions by analyzing gene expression and immune infiltration data. The study found that CASP8 may have a potential role in the pathogenesis of TBI and could be a new target for individualized therapy and drug development.
WORLD NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Gang Li, Shaoping Li, Ruining Liu, Jiangtao Yu, Haoli Ma, Yan Zhao
Summary: This study analyzed the circular RNA expression profiles in rat cerebral cortex after moderate traumatic brain injury, and identified differentially expressed circular RNAs. A circRNA-miRNA interaction network was constructed based on the differentially expressed circular RNAs. The findings provide valuable information for circular RNA research in the field of traumatic brain injury.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jianwei Zhao, Weihua Wang, Ke Yan, Haifeng Zhao, Zhen Zhang, Yu Wang, Wenyu Zhu, Shiwen Chen
Summary: In this study, Illumina RNA-seq technology was used to analyze the gene expression profile in the hippocampus of mice after TBI. Bioinformatics analysis identified differentially expressed genes (DEGs) associated with TBI-induced pathology in the hippocampus. The study suggests functional changes in the nervous system and highlights the potential therapeutic target of nucleoporin 62 (Nup62) for the treatment of impaired hippocampus after TBI.
Review
Medicine, General & Internal
Olli Tenovuo, Ramon Diaz-Arrastia, Lee E. Goldstein, David J. Sharp, Joukje van der Naalt, Nathan D. Zasler
Summary: Assessment of TBI severity is currently based on non-specific and unreliable clinical evaluations, leading to difficulties in predicting long-term disability. Current approaches to classifying and assessing TBI severity face numerous challenges, and a new method based on risk classification and multimodal data may offer benefits for both patients and clinical research in the field.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Heather C. Bouchard, Delin Sun, Emily L. Dennis, Mary R. Newsome, Seth G. Disner, Jeremy Elman, Annelise Silva, Carmen Velez, Andrei Irimia, Nicholas D. Davenport, Scott R. Sponheim, Carol E. Franz, William S. Kremen, Michael J. Coleman, M. Wright Williams, Elbert Geuze, Inga K. Koerte, Martha E. Shenton, Maheen M. Adamson, Raul Coimbra, Gerald Grant, Lori Shutter, Mark S. George, Ross D. Zafonte, Thomas W. McAllister, Murray B. Stein, Paul M. Thompson, Elisabeth A. Wilde, David F. Tate, Aristeidis Sotiras, Rajendra A. Morey
Summary: Mild traumatic brain injury (mTBI) is common in military personnel and is associated with age-related neurodegenerative disorders affecting white matter in the brain. Non-negative matrix factorization (NMF) was used to detect covarying patterns of fractional anisotropy (FA) associated with mTBI in a large dataset of military Veterans. The study showed significant age-dependent differences in WM alterations between Veterans with and without TBI, highlighting the importance of considering age in assessing the effects of mTBI.
HUMAN BRAIN MAPPING
(2022)
Article
Horticulture
Xintong Xu, Yuying Wang, Xueqing Zhao, Zhaohe Yuan
Summary: In this study, 33 PgEXPs were identified from the whole genome data of pomegranate. These PgEXPs belong to the EXPA, EXPB, EXLA, and EXLB subfamilies. Analysis revealed that members within the same subfamily shared similar gene structures and motif compositions, indicating similar biological functions. Gene expression analysis and protein interaction network suggested potential roles of PgEXPs in pectin lyase protein synthesis and cell wall formation enzymes. Additionally, the expression levels of PgEXP varied significantly across different fruit developmental phases.
Article
Geriatrics & Gerontology
Gengshui Zhao, Yongqi Fu, Chao Yang, Xuehui Yang, Xiaoxiao Hu
Summary: This study aims to explore the common molecular mechanism between traumatic brain injury (TBI) and epilepsy, providing theoretical basis for the prevention and treatment of post-traumatic epilepsy (PTE). Through gene expression analysis, functional enrichment analysis, and network construction, key genes and miRNAs related to TBI and epilepsy were identified. The results suggest the potential role of interferon gamma signaling pathway in the pathogenesis of PTE.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Immunology
Hongtu Cui, Ruilin Ma, Tao Hu, Gary Guishan Xiao, Chengjun Wu
Summary: In this study, a set of aberrantly expressed key genes was identified from the TCGA database, which accurately predicted the survival rate of patients with cervical squamous cell carcinoma (CESC). These genes were related to biological activities previously associated with cervical cancer and HPV infection. Furthermore, 5 key genes were highlighted as robust prognostic markers for patient's survival rate, providing novel options for cervical cancer prognosis and drug targets.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Clinical Neurology
Grace M. Turner, Christel McMullan, Olalekan Lee Aiyegbusi, Danai Bem, Tom Marshall, Melanie Calvert, Jonathan Mant, Antonio Belli
Summary: This study found that traumatic brain injury is an independent risk factor for stroke, with patients experiencing significantly increased risk of stroke post-traumatic brain injury which may persist up to five years. Meta-analysis results also indicate that traumatic brain injury may increase the risk of stroke, and certain medications may be associated with either reduced or increased risk of stroke.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Nutrition & Dietetics
Shuqiang Cao, Manrui Li, Yuwen Sun, Peiyan Wu, Wenjie Yang, Hao Dai, Yadong Guo, Yi Ye, Zheng Wang, Xiaoqi Xie, Xiameng Chen, Weibo Liang
Summary: This study suggests that intermittent fasting (IF) promotes hippocampal neurogenesis after traumatic brain injury (TBI) by enhancing the expression of neuropeptide Y (NPY), leading to an improvement in cognitive dysfunction caused by injury.
Article
Computer Science, Artificial Intelligence
Yuan Li, Jian Wang, Weibo Liang, Hui Xue, Zhenan He, Jiancheng Lv, Lin Zhang
Summary: This study proposes a novel craniofacial reconstruction method to identify human remains by synthesizing corresponding craniofacial images from 2D skull images. The method utilizes deep generative adversarial nets to automatically transform skull data to facial images. Experimental results demonstrate that the method can be used as an effective forensic tool.
PATTERN RECOGNITION
(2022)
Article
Multidisciplinary Sciences
Lei Luo, Zifeng Yang, Jingyi Liang, Yu Ma, Hui Wang, Chitin Hon, Mei Jiang, Zhengshi Lin, Wenda Guan, Zhitong Mai, Yongming Li, Kailin Mai, Zhiqi Zeng, Chuanmeizi Tu, Jian Song, Bin Liu, Yong Liu, Jianfeng He, Huiyuan Li, Bosheng Li, Hang Dong, Yutian Miao, Shujun Fan, Lirui Fan, Xingyi Liang, Ke Li, Chun Chen, Huihong Deng, Zhicong Yang, Nanshan Zhong
Summary: This study analyzed the transmission characteristics of the Delta variant in Guangzhou and found that it spread rapidly within a short period of time. By redefining close contact and implementing measures such as health-code usage, the proportion of confirmed cases discovered from close contacts significantly increased. The establishment of makeshift inflatable laboratories and mass testing effectively controlled the Delta epidemic in Guangzhou.
NATIONAL SCIENCE REVIEW
(2022)
Article
Genetics & Heredity
Rangran Zhang, Yu Tan, Li Wang, Hui Jian, Jing Zhu, Yuanyuan Xiao, Mengyu Tan, Jiaming Xue, Fan Yang, Weibo Liang
Summary: A new set of SNP-SNP microhaplotypes with short amplicons was developed for detecting minor DNA in complex mixtures, showing potential for mixture studies and noninvasive prenatal paternity testing. The SNP-SNP strategy based on the CE platform proved to be useful for UDM detection and NIPPT.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Wei Li, Shuai Yang, Peng Xu, Dapeng Zhang, Ying Tong, Lu Chen, Ben Jia, Ang Li, Cheng Lian, Daoping Ru, Baolong Zhang, Mengxing Liu, Cancan Chen, Weihui Fu, Songhua Yuan, Chenjian Gu, Lu Wang, Wenxuan Li, Ying Liang, Zhicong Yang, Xiaoguang Ren, Shaoxuan Wang, Xiaoyan Zhang, Yuanlin Song, Youhua Xie, Hongzhou Lu, Jianqing Xu, Hailin Wang, Wenqiang Yu
Summary: This study reveals the mechanism of interaction between SARS-CoV-2 virus and host and the development of various symptoms in COVID-19. The study found that the virus shares similar RNA sequences with the human genome, and these sequences can upregulate the expression of host genes, including hyaluronan and cytokine genes, through direct genomic interaction. The study also found that severe COVID-19 patients have elevated levels of hyaluronan, and hymecromone can inhibit hyaluronan production, showing potential as a therapeutic option.
Article
Environmental Sciences
Shujun Fan, Wenru Feng, Ziyan Zhou, Yuming Guo, Zhenxiang Xue, Jun Yuan, Yuzhong Wang, Congcong Li, Yi Zhong, Weiyun He, Guanghui Dong, Boyi Yang, Zhicong Yang, Zhoubin Zhang
Summary: The study found that living in greener areas was associated with lower waist circumference and body mass index levels among rural Uyghur adults in China. Higher residential greenness levels were also linked to a lower odds of peripheral overweight/obesity prevalence, especially in older adults.
ENVIRONMENTAL RESEARCH
(2022)
Article
Medicine, Legal
Jiaming Xue, Shengqiu Qu, Mengyu Tan, Yuanyuan Xiao, Ranran Zhang, Dezhi Chen, Meili Lv, Yiming Zhang, Lin Zhang, Weibo Liang
Summary: Microhaplotypes (MHs) are a promising new type of forensic markers that have advantages such as low mutation rates, lack of stutter artifacts, and short amplicons. They have improved human identification, kinship analysis, ancestry prediction, and mixture deconvolution capabilities. While there are some public databases available for MHs, there is a need for a more comprehensive database that integrates information from other databases. This study successfully established a dual-SNP MH database (D-SNPsDB) for 26 populations, providing basic data such as physical positions, allele frequencies, and variant information.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yuwen Sun, Manrui Li, Shuqiang Cao, Yang Xu, Peiyan Wu, Shuting Xu, Qian Pan, Yadong Guo, Yi Ye, Zheng Wang, Hao Dai, Xiaoqi Xie, Xiameng Chen, Weibo Liang
Summary: Optogenetics is a promising method for controlling cellular activity, particularly in the field of brain injury. This review discusses the latest research on optogenetics, focusing on its improvement, existing challenges, and potential clinical applications. It highlights the importance of advancing optogenetics in the study of brain injury and explores the future prospects of this technology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Shuangshuang Wang, Feng Song, Haoyu Gu, Zhilong Shu, Xiaowen Wei, Ke Zhang, Yuxiang Zhou, Lanrui Jiang, Zefei Wang, Jienan Li, Haibo Luo, Weibo Liang
Summary: This study investigated the gut microbiota of healthy adults with different traits. The results showed differences in gut microbiota composition between male and female subjects. Additionally, the gut microbiota composition was able to distinguish between different BMI groups. At the phylum level, specific phyla were found to be increased in different BMI groups for both males and females. At the genus level, several distinct genera were identified across BMI groups. The accuracy of predicting body type using a linear regression model was 74%.
MICROBIAL CELL FACTORIES
(2022)
Article
Veterinary Sciences
Yuehong Wei, Dapeng Li, Zhicong Yang, Kuncai Chen, Xinhong Pan, Jianmin Xu, Shouyi Chen
Summary: A multidisciplinary One Health intervention was effective in controlling the rabies outbreak and addressing the issue of attacks by stray dogs.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Environmental Sciences
Li-Xin Hu, Shujun Fan, Yinghua Ma, Xiao-Xuan Liu, Wen-Wen Bao, Yuming Guo, Li-Wen Hu, Gongbo Chen, Xiao-Wen Zeng, Zhiyong Zou, Bo-Yi Yang, Jun Ma, Zhicong Yang, Ya-Jun Chen, Guang-Hui Dong
Summary: There is a positive association between greenspace surrounding schools and lipid levels and dyslipidemia prevalence among Chinese children and teenagers. The association is stronger in students with lower education levels and those aged <= 12 years. Part of the association can be explained by lower levels of PM2.5 in the air.
ENVIRONMENTAL POLLUTION
(2023)
Article
Multidisciplinary Sciences
Manrui Li, Xiameng Chen, Qiuyun Yang, Shuqiang Cao, Steven Wyler, Ruixuan Yuan, Lingxuan Zhang, Miao Liao, Meili Lv, Feng Wang, Yadong Guo, Jihong Zhou, Lin Zhang, Xiaoqi Xie, Weibo Liang
Summary: Explosive blast-related traumatic brain injuries (bTBIs) are common in war zones and terrorist attacks, but there is a lack of specific strategies for diagnosing and treating them. This study uses single-nucleus RNA-sequencing of the sub-ventricular zone (SVZ) to explore the mechanisms underlying the pathogenesis of bTBIs and provide a reference for future studies on diagnosis and treatment.
Article
Genetics & Heredity
Ranran Zhang, Jiaming Xue, Mengyu Tan, Dezhi Chen, Yuanyuan Xiao, Guihong Liu, Yazi Zheng, Qiushuo Wu, Miao Liao, Meili Lv, Shengqiu Qu, Weibo Liang
Summary: In this study, a panel of 50 Microhaplotypes (MHs) was constructed and analyzed using the Multiseq multiple polymerase chain reaction (multi-PCR) targeted capture sequencing protocol. It was found that this panel has the advantages of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs), with high sensitivity and specificity. It also showed measurable polymorphism among a group of Han individuals and had high detection rates for highly degraded samples and mixtures.
Article
Microbiology
Shujuan Wang, Yanjie Shang, Zhiyun Pi, Ziqi Zhou, Xiangyan Zhang, Lipin Ren, Weibo Liang, Yadong Guo, Jifeng Cai, Changquan Zhang
Summary: A mild traumatic brain injury (mTBI) can increase the risk of neurodegenerative-related disease, and serious long-term outcomes are often overlooked. Recent research has revealed that the oral cavity and fecal microbiota play a fundamental role in deeply interconnecting the gut and brain injury. We investigated the relationship between the temporal changes of the oral cavity and fecal bacterial communities with damage identification and post-injury time estimation after mTBI.
Article
Multidisciplinary Sciences
Lingxuan Zhang, Qiuyun Yang, Ruixuan Yuan, Manrui Li, Meili Lv, Lin Zhang, Xiaoqi Xie, Weibo Liang, Xiameng Chen
Summary: This study employed single-nucleus RNA sequencing to sequence the hippocampal nuclei of mice from bTBI and sham groups, obtaining reliable gene expression data. The dataset holds important reference value for exploring secondary hippocampal injury and neurogenesis mechanisms following bTBI.
