Article
Urology & Nephrology
Osama El Shamy, Graham Abra, Christopher Chan
Summary: The article discusses the complexity and multifactorial nature of writing a home hemodialysis prescription, emphasizing the importance of considering patient values, preferences, and lifestyle. It also introduces different home HD modalities and machines, along with their attributes and limitations, to guide providers in delivering a patient-centered home HD approach.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Ryan Aylward, Brian Bieber, Murilo Guedes, Ronald Pisoni, Elliot Koranteng Tannor, Gavin Dreyer, Adrian Liew, Valerie Luyckx, Dibya Singh Shah, Chimota Phiri, Rhys Evans, Rehab Albakr, Jeffrey Perl, Vivekanand Jha, Roberto Pecoits-Filho, Bruce Robinson, Fergus J. Caskey
Summary: There is wide global variation in the rates of SARS-CoV-2 infection and mortality among HD patients and staff in dialysis centers. Availability of personal protective equipment (PPE) and diagnostic testing also varies across regions. Different responses and service redesigns have been implemented in different regions in response to the pandemic.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Htay Htay, Aminu K. Bello, Adeera Levin, Meaghan Lunney, Mohamed A. Osman, Feng Ye, Gloria E. Ashuntantang, Ezequiel Bellorin-Font, Mohammed Benghanem Gharbi, Sara N. Davison, Mohammad Ghnaimat, Paul Harden, Vivekanand Jha, Kamyar Kalantar-Zadeh, Peter G. Kerr, Scott Klarenbach, Csaba P. Kovesdy, Valerie A. Luyckx, Brendon Neuen, Donal O'Donoghue, Shahrzad Ossareh, Jeffrey Perl, Harun Ur Rashid, Eric Rondeau, Emily J. See, Syed Saad, Laura Sola, Irma Tchokhonelidze, Vladimir Tesar, Kriang Tungsanga, Rumeyza Turan Kazancioglu, Angela Yee-Moon Wang, Chih-Wei Yang, Alexander Zemchenkov, Ming-hui Zhao, Kitty J. Jager, Fergus J. Caskey, Vlado Perkovic, Kailash K. Jindal, Ikechi G. Okpechi, Marcello Tonelli, David C. Harris, David W. Johnson
Summary: This study examined the use, availability, accessibility, affordability, and quality of hemodialysis care worldwide, revealing significant variations between countries, with the lowest utilization seen in low- and lower-middle-income countries.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Urology & Nephrology
Mark Lambie, Junhui Zhao, Keith McCullough, Simon J. Davies, Hideki Kawanishi, David W. Johnson, James A. Sloand, Mauricio Sanabria, Talerngsak Kanjanabuch, Yong-Lim Kim, Jenny I. Shen, Ronald L. Pisoni, Bruce M. Robinson, Jeffrey Perl, PDOPPS Steering Comm
Summary: This study analyzes data from a multinational observational study to demonstrate the relationship between time on peritoneal dialysis and outcomes such as transfer to hemodialysis, death, and kidney transplantation. The study finds that countries with higher rates of kidney transplantation tend to have shorter median times on peritoneal dialysis, and infection is the leading cause of hemodialysis transfer.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Bruno Legendre, Thierry Lobbedez, Cecile Couchoud, Mathilde Lassalle, Isabelle Kazes, Antoine Lanot, Annabel Boyer, Clemence Bechade
Summary: The duration of hemodialysis before transfer to peritoneal dialysis affects the outcomes and survival of patients on peritoneal dialysis.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Jennifer M. Kaplan, Jingbo Niu, Vivian Ho, Wolfgang C. Winkelmayer, Kevin F. Erickson
Summary: The study shows that for patients over 67 years old, peritoneal dialysis (PD) has a significant advantage over in-center hemodialysis in terms of Medicare expenditures, although there is no significant difference in the dialysis modality. Over time, the gap in dialysis expenditures gradually narrowed, while the gap in nondialysis expenditures widened.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Joaquim Barreto, Cynthia Borges, Tais Betoni Rodrigues, Daniel C. Jesus, Alessandra M. Campos-Staffico, Wilson Nadruz, Jose Luiz da Costa, Rodrigo Bueno de Oliveira, Andrei C. Sposito
Summary: The study aimed to evaluate the effects of SGLT2 inhibitors on cardiovascular outcomes in patients with conservatively managed CKD. It was found that dapagliflozin was well tolerated and had nonaccumulating pharmacokinetic properties in patients with kidney failure on dialysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Eiichiro Kanda, Daniel Muenz, Brian Bieber, Aleix Cases, Francesco Locatelli, Friedrich K. Port, Roberto Pecoits-Filho, Bruce M. Robinson, Jeffrey Perl
Summary: The study found a tenfold decrease in DRA-related hospitalization rates from 1998 to 2018. Even in the current era of high-flux HD, serum beta 2M remains positively associated with mortality, with mortality risk increasing monotonically with increasing beta 2M levels.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Urology & Nephrology
Annie-Claire Nadeau-Fredette, Nidhi Sukul, Mark Lambie, Jeffrey Perl, Simon Davies, David W. Johnson, Bruce Robinson, Wim Van Biesen, Anneke Kramer, Kitty J. Jager, Rajiv Saran, Ronald Pisoni, Christopher T. Chan
Summary: This multinational study found that mortality rates were highest in the first month after transitioning from peritoneal dialysis to hemodialysis, and gradually declined afterwards. Older age, earlier initiation of peritoneal dialysis, and longer peritoneal dialysis duration were associated with increased risk of death.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Qianying Zhang, Pei Wu, Jingyuan Xie, Xiao Li, Tian Xu, Xiaomin Huang, Chunyan Zhang, Nan Chen, Hong Ren
Summary: The use of automated peritoneal dialysis (APD) may be more favorable than hemodialysis (HD) for protecting residual renal function when initiating peritoneal dialysis. Both methods have similar rates of mechanical and infectious complications.
Article
Economics
Eugene Lin, Khristina Lung, Glenn M. Chertow, Jay Bhattacharya, Darius Lakdawalla
Summary: In a study comparing PD and HD among uninsured patients, starting PD later in the month was associated with increased PD uptake. However, no significant differences were observed in mortality, hospitalization rates, or Medicare spending between PD and HD within the first 12 months of treatment.
Article
Medicine, General & Internal
Hafedh Fessi, Philippe Nicoud, Tomas Serrato, Olivia Gilbert, Cecile Courivaud, Salima Daoud, Marion Morena, Michel Thomas, Bernard Canaud, Jean-Paul Cristol
Summary: The RECAP study reported the results and outcomes of using the S-3 system as an intensive home hemodialysis (HHD) platform over a three-year French multicenter study. The study included 94 dialysis patients from ten dialysis centers who were treated with S-3 for more than 6 months. The S-3 system showed satisfactory results in terms of clinical performances, patient acceptance, cardiac outcomes, and technical survival. It provides an appealing option for home treatment with improved patient perception and reduced treatment burden.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ming-Hsien Tsai, Yun-Yi Chen, Tsrang-Neng Jang, Jing-Tong Wang, Yu-Wei Fang
Summary: This study evaluated the clinical outcomes of patients transitioning from peritoneal dialysis (PD) to hemodialysis (HD) compared to HD-only patients. The findings showed that patients transitioning from PD had a higher risk of all-cause death, especially in the first 5 months after transition.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Nisha Bansal, David Glidden, Rajnish Mehrotra, Raymond R. Townsend, Jordana Cohen, Lori Linke, Farshad Palad, Hannah Larson, Chi-yuan Hsu
Summary: This pilot trial aimed to test the feasibility of treating home versus predialysis blood pressure in hemodialysis patients. The study demonstrated high adherence to home blood pressure measurement and treatment, but also showed some adverse reactions such as increased frequency of fatigue in the home blood pressure arm. Further larger trials should be conducted to assess the long-term feasibility, efficacy, and safety of home blood pressure treatment in hemodialysis patients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Review
Pharmacology & Pharmacy
Emily Blaine, Robin Tumlinson, Marion Colvin, Tyler Haynes, Heather P. Whitley
Summary: Chronically uncontrolled hyperglycemia is a common factor in end stage kidney disease (ESKD) that requires dialysis. However, there is a lack of clear clinical recommendations for adjusting insulin dosing during the transition to hemodialysis (HD) or peritoneal dialysis (PD).
Article
Transplantation
Mark K. Tiong, Edward R. Smith, Elaine M. Pascoe, Grahame J. Elder, Nicole M. Lioufas, Eugenia Pedagogos, Carmel M. Hawley, Andrea Valks, Stephen G. Holt, Tim D. Hewitson, Nigel D. Toussaint
Summary: This study investigated the impact of lanthanum carbonate on serum calciprotein particles (CPP) in patients with early-stage chronic kidney disease (CKD). The results suggest that lanthanum carbonate is not effective in reducing CPP levels at 96 weeks compared with placebo.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Ashik Hayat, David W. Johnson, Carmel M. Hawley, Lauren R. Jaffrey, Usman Mahmood, Sarah Saw Yu Mon, Yeoungjee Cho
Summary: This study aimed to compare the associations, microbiologic profiles, and outcomes between pre-training peritonitis (PTP) and post-training peritonitis in patients with kidney failure. The results showed that PTP was closely associated with prior exit-site infection, often had culture-negative peritonitis, and was associated with worse outcomes of hemodialysis transfer or death.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Health Policy & Services
Dharmenaan Palamuthusingam, Elaine M. Pascoe, Carmel M. Hawley, David W. Johnson, Gishan Ratnayake, Stephen McDonald, Neil Boudville, Matthew Jose, Magid Fahim
Summary: This study assessed the concordance between comorbidities recorded in the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry and those in state-based hospital admission datasets. The results showed that the accuracy of diabetes mellitus recording was the highest, while the accuracy of cerebrovascular disease recording was the lowest.
HEALTH INFORMATION MANAGEMENT JOURNAL
(2023)
Article
Urology & Nephrology
Wai H. Lim, Jenny H. C. Chen, Kimberley Minas, David W. Johnson, Maleeka Ladhani, Esther Ooi, Neil Boudville, Carmel Hawley, Andrea K. Viecelli, Matthew Roberts, Kate Wyburn, Rachael Walker, Monique Borlace, Helen Pilmore, Christopher E. Davies, Charmaine E. Lok, Armando Teixeira-Pinto, Germaine Wong
Summary: This study investigates the cause-specific mortality rates between male and female dialysis patients in Australia and New Zealand from 1998 to 2018. It found that female patients had a higher risk of all-cause mortality in the first 5 years after dialysis initiation, primarily due to mortality from infections and dialysis withdrawals.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Urology & Nephrology
Sibel G. Bek, Simone Marschner, Kamal Sud, David W. Johnson, Clara K. Chow, Carmel Hawley, Helen Pilmore, Germaine Wong, Wai Lim, Vincent W. Lee
Summary: This study found that smoking is associated with increased rates of all-cause mortality, cardiovascular mortality, respiratory failure, chronic lung disease, and malignancy in dialysis patients. It also increases the risk of non-skin cancers, de novo vascular disease, and chronic lung disease.
Article
Pediatrics
Chandana Guha, Rabia Khalid, Anita van Zwieten, Anna Francis, Carmel M. Hawley, Allison Jaure, Armando Teixeira-Pinto, Alistair R. Mallard, Amelie Bernier-Jean, David W. Johnson, Deirdre Hahn, Donna Reidlinger, Elaine M. Pascoe, Elizabeth G. Ryan, Fiona Mackie, Hugh J. McCarthy, Jonathan C. Craig, Julie Varghese, Charani Kiriwandeniya, Kirsten Howard, Nicholas G. Larkins, Luke Macauley, Amanda Walker, Martin Howell, Michelle Irving, Patrina H. Y. Caldwell, Reginald Woodleigh, Shilpanjali Jesudason, Simon A. Carter, Sean E. Kennedy, Stephen Alexander, Steven McTaggart, Germaine Wong
Summary: This study aims to evaluate the effectiveness of a patient navigator program in children with chronic kidney disease. A total of 162 patients were enrolled and randomized into immediate intervention and waitlisted groups. The results of the study will be completed by October 2022.
PEDIATRIC NEPHROLOGY
(2023)
Review
Urology & Nephrology
Ashik Hayat, Rachael C. Walker, Andrea K. Viecelli, Karine E. Manera, Allison Jaure, Rathika Krishnasamy, Elaine M. Pascoe, Yeoungjee Cho, David W. Johnson
Summary: This study assessed the range and consistency of gastrointestinal (GI) outcomes reported in contemporary peritoneal dialysis (PD) trials. It found that only 19% of PD trials reported GI outcomes, with nausea, diarrhea, vomiting, constipation, and abdominal pain being the most frequently reported outcomes. The majority of GI outcomes were patient-reported adverse events with no defined metrics.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Urology & Nephrology
Ryan Gately, Elasma Milanzi, Wai Lim, Armando Teixeira-Pinto, Phil Clayton, Nicole Isbel, David W. Johnson, Carmel Hawley, Scott Campbell, Germaine Wong
Summary: BK polyomavirus-associated nephropathy (BKPyVAN) is associated with an increased risk of graft dysfunction and loss in kidney transplant recipients. This cohort study in Australia and New Zealand found that BKPyVAN occurred in 3% of recipients and was linked to higher rates of graft loss, rejection, and death. Changes in immunosuppression, such as reducing tacrolimus and mycophenolate doses, were commonly made after BKPyVAN. Several factors, including gender, age, blood group, donor characteristics, transplantation era, immunosuppression use, and transplant center volume, were associated with the development of BKPyVAN. The study also found that BKPyVAN increased the risk of graft loss but not mortality. It highlights the need for interventional trials to evaluate strategies for reducing immunosuppression and minimizing adverse outcomes associated with BKPyVAN.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Katharine Hegerty, Allison Jaure, Nicole Scholes-Robertson, Kirsten Howard, Angela Ju, Nicole Evangelidis, Martin Wolley, Amanda Baumgart, David W. Johnson, Carmel M. Hawley, Donna Reidlinger, Laura Hickey, Alyssa Welch, Yeoungjee Cho, Peter G. Kerr, Matthew A. Roberts, Jenny I. Shen, Jonathan Craig, Rathika Krishnasamy, Andrea K. Viecelli
Summary: This study aimed to explore patients' perspectives on incremental hemodialysis (HD) and their priorities and concerns regarding HD. The study found that patients with kidney failure preferred incremental initiation of HD to minimize disruption to daily living and improve quality of life. The top prioritized outcomes were quality of life, residual kidney function, and mortality.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Transplantation
Gregory J. Wilson, Kim Van, Emma O'Lone, Allison Tong, Jonathan C. Craig, Benedicte Sautenet, Klemens Budde, Derek Forfang, John Gill, William G. Herrington, Tazeen H. Jafar, David W. Johnson, Vera Krane, Adeera Levin, Jolanta Malyszko, Patrick Rossignol, Deirdre Sawinski, Nicole Scholes-Robertons, Giovanni Strippoli, Angela Wang, Wolfgang C. Winkelmayer, Carmel M. Hawley, Andrea K. Viecelli
Summary: This study aimed to assess the range and consistency of cardiovascular outcomes reported by contemporary trials in kidney transplant recipients, revealing substantial heterogeneity in cardiovascular outcome reporting.
TRANSPLANTATION DIRECT
(2023)
Article
Urology & Nephrology
Ashik Hayat, Yeoungjee Cho, Carmel M. Hawley, Htay Htay, Rathika Krishnasamy, Elaine Pascoe, Isaac Teitelbaum, Marliene Varnfield, David W. Johnson
Summary: Comparing with full-dose PD start, incremental PD start shows similar declines in RKF and UV.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Urology & Nephrology
Yeoungjee Cho, Kai-Ming Chow, Philip Kam-Tao Li, Naomi Runnegar, David W. Johnson
Summary: Peritoneal dialysis is an important treatment option for patients with kidney failure, providing various benefits such as enhanced participation in daily activities, flexibility in schedules, cost savings, and improved quality of life. However, the utilization of peritoneal dialysis has remained static or declining in certain regions due to concerns about PD-related infections. This review aims to provide an overview of the definition, epidemiology, risk factors, prevention, and treatment of PD-related infections based on current evidence.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Yu-Hui Zhang, Xiao Xu, Hai-Chen Pi, Zhi-Kai Yang, David W. Johnson, Jie Dong
Summary: This study aimed to examine the effects of vitamin D supplementation on the risk of PD-related peritonitis. The results showed that oral natural vitamin D supplementation can increase serum 25(OH)D levels in PD patients, without affecting the occurrence or outcome of peritonitis. The study suggests that conducting this type of randomized controlled trial is feasible and safe.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)