4.6 Editorial Material

Macrophages produce collagen for myocardial scar formation

Journal

NATURE REVIEWS CARDIOLOGY
Volume 17, Issue 5, Pages 267-267

Publisher

NATURE RESEARCH
DOI: 10.1038/s41569-020-0353-4

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Macrophages directly contribute collagen to scar formation as part of heart regeneration in zebrafish and heart repair in mice; this finding develops the current paradigm of collagen deposition for scar formation being generated exclusively via macrophage-mediated activation of cardiac fibroblasts to myofibroblasts.

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