Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota

Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea

(2018) Eric J. Battaglioli et al.   Science Translational Medicine

Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease

(2017) Maaike Vancamelbeke et al.   INFLAMMATORY BOWEL DISEASES

Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial

(2017) Sudarshan Paramsothy et al.   LANCET

Phascolarctobacterium faecium abundant colonization in human gastrointestinal tract

(2017) Feifan Wu et al.   Experimental and Therapeutic Medicine

Effect of vedolizumab (anti-α4β7-integrin) therapy on histological healing and mucosal gene expression in patients with UC

(2016) Ingrid Arijs et al.   GUT

What Have We Learned from Glycosyltransferase Knockouts in Mice?

(2016) Pamela Stanley   JOURNAL OF MOLECULAR BIOLOGY

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

A pathogenic role for T cell–derived IL-22BP in inflammatory bowel disease

(2016) Penelope Pelczar et al.   SCIENCE

Microbiome changes associated with sustained eradication ofClostridium difficileafter single faecal microbiota transplantation in children with and without inflammatory bowel disease

(2015) S. K. Hourigan et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Insight into alteration of gut microbiota in Clostridium difficile infection and asymptomatic C. difficile colonization

(2015) Lihua Zhang et al.   ANAEROBE

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection

(2015) Michael C. Abt et al.   Cell Host & Microbe

Interleukin-22 and CD160 play additive roles in the host mucosal response toClostridium difficileinfection in mice

(2015) Amir A. Sadighi Akha et al.   IMMUNOLOGY

High Suppressor of Cytokine Signaling-3 Expression Impairs STAT3-dependent Protective Effects of Interleukin-22 in Ulcerative Colitis in Remission

(2015) An Tao Xu et al.   INFLAMMATORY BOWEL DISEASES

IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis

(2015) J C Martin et al.   Mucosal Immunology

Humanized microbiota mice as a model of recurrent Clostridium difficile disease

(2015) James Collins et al.   Microbiome

Gut Microbiota-Produced Succinate Promotes C. difficile Infection after Antibiotic Treatment or Motility Disturbance

(2014) Jessica A. Ferreyra et al.   Cell Host & Microbe

Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

(2014) Tu Anh N. Pham et al.   Cell Host & Microbe

Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile

(2014) Robert A. Britton et al.   GASTROENTEROLOGY

Interleukin-22 Regulates the Complement System to Promote Resistance against Pathobionts after Pathogen-Induced Intestinal Damage

(2014) Mizuho Hasegawa et al.   IMMUNITY

Human Gut Dendritic Cells Drive Aberrant Gut-specific T-cell Responses in Ulcerative Colitis, Characterized by Increased IL-4 Production and Loss of IL-22 and IFNγ

(2014) Elizabeth R. Mann et al.   INFLAMMATORY BOWEL DISEASES

A simple cage-autonomous method for the maintenance of the barrier status of germ-free mice during experimentation

(2014) G Hecht et al.   LABORATORY ANIMALS

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

(2014) Charlie G. Buffie et al.   NATURE

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

(2014) Joseph M. Pickard et al.   NATURE

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

(2014) Y. Goto et al.   SCIENCE

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection

(2014) Casey M. Theriot et al.   Nature Communications

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

(2013) James J. Kozich et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Dysregulation of T cell receptor N-glycosylation: a molecular mechanism involved in ulcerative colitis

(2013) Ana M. Dias et al.   HUMAN MOLECULAR GENETICS

Clostridium difficile Infection and Inflammatory Bowel Disease

(2013) Sheela S. Reddy et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Role of the Gut Microbiota in the Development and Function of Lymphoid Cells

(2013) N. Kamada et al.   JOURNAL OF IMMUNOLOGY

IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue

(2013) J M Leung et al.   Mucosal Immunology

The regulatory power of glycans and their binding partners in immunity

(2013) Jenny L. Johnson et al.   TRENDS IN IMMUNOLOGY

Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy

(2012) Akiyoshi Hirayama et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Innate Lymphoid Cell Interactions with Microbiota: Implications for Intestinal Health and Disease

(2012) Gregory F. Sonnenberg et al.   IMMUNITY

Increased Suppressor of Cytokine Signaling-3 Expression Predicts Mucosal Relapse in Ulcerative Colitis

(2012) Yi Li et al.   INFLAMMATORY BOWEL DISEASES

Clostridium difficile Infection in the Inflammatory Bowel Disease Patient

(2012) Adam M. Berg et al.   INFLAMMATORY BOWEL DISEASES

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

(2012) G. F. Sonnenberg et al.   SCIENCE

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

Reducing Time and Increasing Sensitivity in Sample Preparation for Adherent Mammalian Cell Metabolomics

(2011) Matthew A. Lorenz et al.   ANALYTICAL CHEMISTRY

Characterization of Phascolarctobacterium succinatutens sp. nov., an Asaccharolytic, Succinate-Utilizing Bacterium Isolated from Human Feces

(2011) Yohei Watanabe et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities

(2009) P. D. Schloss et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Mucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment

(2009) Ingrid Arijs et al.   PLoS One

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES