Journal
NANOMEDICINE
Volume 15, Issue 1, Pages 55-75Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2019-0290
Keywords
apoptosis; cellular uptake; Cornus mas fruit; dysplastic oral keratinocytes; gold nanoparticles; green synthesis; oral cancer; p53; BAX; BCL2; silver nanoparticles
Funding
- Ministry of National Education, Romania [PN-III-P4-ID-PCE-2016-0396, 161/2017]
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Background: Oral cancer is highly aggressive due to difficult diagnosis, therapy resistance and increasing frequency; thus finding prevention therapies is very important. Aim: This study evaluates the use of gold and silver nanoparticles (NPs), phyto-synthesized with Cornus mas extract against oral dysplastic lesions. Methods: NPs were characterized by UV-Vis, Fourier-transform infrared spectroscopy, transmission electron microscopy, x-ray diffraction and laser Doppler microelectrophoresis. Biological testing employed two human oral cell lines: gingival fibroblasts and dysplastic keratinocytes and evaluated viability, cell death mechanisms and cellular uptake. Results: NPs induced selective toxic effects against dysplastic cells. p53/BAX/BCL2 activation and PI3K/AKT inhibition led to cell death through necrosis and apoptosis. NPs also induced antioxidant and anti-inflammatory effects. Conclusion: NPs of gold and silver showed promising beneficial effects in the therapy of oral dysplasia.
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