Journal
NANO LETTERS
Volume 20, Issue 3, Pages 1590-1597Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b04290
Keywords
Biomaterials; Self-assembly; Microhydrogels; Organic/inorganic interfaces; Antibacterial materials; Regenerated silk fibroin
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Funding
- European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013) through the ERC grant PhysProt [337969]
- Israeli Ministry of Science, Technology and Space
- FEBS Long-Term Fellowship
- Oppenheimer Early Career Fellowship
- BBSRC
- Newman Foundation
- Wellcome Trust
- Cambridge Centre for Misfolding Diseases
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Self-assembling peptides and proteins have the potential to serve as multifunctional building blocks for the generation of versatile materials for a wide range of biomedical applications. In particular, supramolecular hydrogels comprised of self-assembled protein nanofibrils, have been used in contexts ranging from tissue engineering to drug delivery. Due to the rapid emergence of multidrug resistant bacteria, development of biomaterials with intrinsic antimicrobial properties has been continuously increasing. Here, we describe hybrid organic/inorganic nanofibrillar silk microgels decorated with silver nanoparticles that display potent antimicrobial activity in vitro and in vivo and are able to adhere bacterial cells to their surfaces while subsequently eradicating them, through a two-step mechanism of action. Importantly, in contrast to treatments involving conventional silver, these silk-silver microgels are nonhemolytic and noncytotoxic toward mammalian cell lines. Finally, we show that these hybrid microgels display substantial efficacy as topical antimicrobial agents in a murine model of surgical site infections.
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