Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained RNA Release and Potent Immune Activation

Development of a Nanostructured RNA/DNA Assembly as an Adjuvant Targeting Toll-Like Receptor 7/8

(2019) Fusae Komura et al.   Nucleic Acid Therapeutics

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

RNA-Based Immunostimulatory Liposomal Spherical Nucleic Acids as Potent TLR7/8 Modulators

(2018) Chenxia Guan et al.   Small

Retardation of Antigen Release from DNA Hydrogel Using Cholesterol-Modified DNA for Increased Antigen-Specific Immune Response

(2017) Yuka Umeki et al.   Advanced Healthcare Materials

Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene

(2017) Shozo Ohtsuki et al.   Scientific Reports

Engineered Hydrogels for Local and Sustained Delivery of RNA-Interference Therapies

(2016) Leo L. Wang et al.   Advanced Healthcare Materials

Systemic activation of antigen-presenting cells via RNA-loaded nanoparticles

(2016) Elias J. Sayour et al.   OncoImmunology

Induction of Potent Antitumor Immunity by Sustained Release of Cationic Antigen from a DNA-Based Hydrogel with Adjuvant Activity

(2015) Yuka Umeki et al.   ADVANCED FUNCTIONAL MATERIALS

TLR7/8 agonists promote NK–DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma

(2015) Zhixia Zhou et al.   CANCER LETTERS

Lipid-Based Nanocarriers for RNA Delivery

(2015) Hui Xue et al.   CURRENT PHARMACEUTICAL DESIGN

Injectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen delivery

(2014) Makiya Nishikawa et al.   JOURNAL OF CONTROLLED RELEASE

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

Hydrogel Doped with Nanoparticles for Local Sustained Release of siRNA in Breast Cancer

(2014) Nathaly Segovia et al.   Advanced Healthcare Materials

The TLR7/8 ligand resiquimod targets monocyte-derived dendritic cell differentiation via TLR8 and augments functional dendritic cell generation

(2011) Holger Hackstein et al.   CELLULAR IMMUNOLOGY

Sustained Small Interfering RNA Delivery by Mesoporous Silicon Particles

(2010) Takemi Tanaka et al.   CANCER RESEARCH

Cancer immunotherapeutic potential of novel small molecule TLR7 and TLR8 agonists

(2009) Svetlana Hamm et al.   Journal of Immunotoxicology

Lipid nanoparticles for parenteral delivery of actives

(2008) Medha D. Joshi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS