Journal
MOLECULES
Volume 25, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/molecules25020332
Keywords
Oridonin; structural modification; formulations; solubility; bioavailability; biological activity
Funding
- Shandong Provincial Natural Science Foundation, China [BS2014YY047]
- Medical and Health Science and Technology Development Plan of Shandong Province, China [2018WS202]
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Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.
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