Article
Medicine, General & Internal
Hui-Juan Jin, Jun-Li Wang, Xin-Yan Geng, Chun-Yan Wang, Bin-Bin Wang, Su-Ren Chen
Summary: This study highlights the importance of CFAP70 gene in male infertility, demonstrating that CFAP70 deficiency leads to oligo-astheno-teratozoospermia. A homozygous nonsense variant of CFAP70 was identified in an infertile Chinese man. CFAP70 could serve as a diagnostic target for male infertility with oligo-astheno-teratozoospermia in the clinic.
Article
Biochemistry & Molecular Biology
Ling-Yu Yeh, Robert Kuo-Kuang Lee, Ming-Huei Lin, Chih-Hung Huang, Sheng-Hsiang Li
Summary: This study aimed to assess the correlation between sperm miRNA levels and ICSI outcomes. The results showed that miR-34b and miR-34c were significantly associated with ICSI clinical outcomes in male factor infertility, especially teratozoospermia. However, these miRNAs were not associated with fertilization rate and early embryo development, but with implantation, pregnancy, and live birth rates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Andrology
Ashok Agarwal, Rakesh Sharma, Sajal Gupta, Renata Finelli, Neel Parekh, Manesh Kumar Panner Selvam, Ralf Henkel, Damayanthi Durairajanayagam, Camila Pompeu, Sarah Madani, Andrea Belo, Neha Singh, Simryn Covarrubias, Sara Darbandi, Raha Sadeghi, Mahsa Darbandi, Paraskevi Vogiatzi, Florence Boitrelle, Mara Simopoulou, Ramadan Saleh, Mohamed Arafa, Ahmad Majzoub, Hussein Kandil, Armand Zini, Edmund Ko, Juan G. Alvarez, Marlon Martinez, Jonathan Ramsay, Sunil Jindal, Gian Maria Busetto, Hassan Sallam, Israel Maldonado, Christina Anagnostopoulou, Marco G. Alves, Pallav Sengupta, Kambiz Gilany, Donald P. Evenson, Sheena E. M. Lewis, Jaime Gosalvez, Rafael F. Ambar, Rupin Shah
Summary: Semen analysis is the first step in evaluating male fertility, but sperm morphology assessment is difficult to standardize and obtain reproducible results. Standardization of laboratory protocols is crucial in ensuring reliable laboratory results.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Biology
Maja Tomic, Luka Bolha, Joze Pizem, Helena Ban-Frangez, Eda Vrtacnik-Bokal, Martin Stimpfel
Summary: This study identified 9 miRNAs that could serve as biomarkers for sperm quality in relation to teratozoospermia, highlighting the need for objective markers to personalize the treatment of male infertility.
Article
Pharmacology & Pharmacy
L. Ma, Y. Sun
Summary: This study compared the effects of L-carnitine vs. CoQ10 and Vitamin E therapy on sperm parameters and hormonal levels in patients with asthenozoospermia and teratozoospermia. The results showed that L-carnitine significantly improved sperm motility, morphology, and concentration, as well as testosterone and luteinizing hormone levels. On the other hand, CoQ10 and Vitamin E only improved sperm motility, morphology, and testosterone levels. Therefore, L-carnitine was found to be superior to the combination of CoQ10 and Vitamin E in improving sperm parameters.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Genetics & Heredity
Jiaxiong Wang, Xiaoran Liu, Ce Zhang, Yongle Xu, Weizhuo Wang, Hong Li, Shenmin Yang, Jing Zhao
Summary: By observing the morphology of the patient's sperm and conducting genetic testing, we identified a novel ARMC2 mutation that contributes to male infertility and multiple morphological abnormalities of sperm flagella (MMAF). We also discovered several proteins interacting with ARMC2. After undergoing ICSI treatment, the patient successfully achieved pregnancy and gave birth to boy-girl twins. This study provides important insights into the genetic basis of male infertility.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Developmental Biology
Huanping Guo, Xipeng Shen, Hua Hu, Peng Zhou, Tong He, Lin Xia, Dongmei Tan, Xi Zhang, Yunfang Zhang
Summary: This study characterized the RNA modification signature of human sperm for the first time using a high-throughput detection platform, revealing RNA modifications with high linear correlations with clinical sperm motility. These findings provide promising candidates for clinical sperm quality assessment and offer new research insights into the underlying pathological mechanisms of human male infertility syndromes.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Genetics & Heredity
Mohan Liu, Jinhui Li, Chuan Jiang, Yanning Zhou, Yongkang Sun, Yihong Yang, Ying Shen
Summary: A novel homozygous frameshift mutation in DNAJB13 was found to be associated with the teratozoospermia phenotype. This study expands the spectrum of DNAJB13 mutations and provides a better understanding for genetic counseling and treatment of male infertility.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Maria-Anna Kyrgiafini, Themistoklis Giannoulis, Alexia Chatziparasidou, Nikolaos Christoforidis, Zissis Mamuris
Summary: Male infertility is a global health issue with significant genetic factors. This study identified unique mutations in long-noncoding RNAs (lncRNAs) associated with teratozoospermia using whole-genome sequencing and RNA expression analysis. Variants were found to potentially impact lncRNA structure, function, and lncRNA-miRNA interactions. Furthermore, dysregulated pathways in teratozoospermia and a link between male infertility and cancer were discovered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yieh-Loong Tsai, Tsung-Hsuan Lai, Hsuan-Che Liu, Ya-Yun Wang, Yu-Hua Lin, Chih-Chun Ke, Ming-Ting Chung, Chying-Chyuan Chan, Ying-Hung Lin
Summary: This study found that RAB3C is more abundant than RAB3A, 3B, and 3D in human testicular tissues. During human spermatogenesis, RAB3C protein is mainly enriched in elongated spermatids, and in mature human spermatozoa, it is concentrated in the postacrosomal region, neck, and midpiece. The delocalization of RAB3C signals was observed in human spermatozoa with SEPT14 mutation, along with defective head and tail.
MEDICINA-LITHUANIA
(2022)
Review
Andrology
Shan Huang, Yingting Huang, Shan Li, Yu He
Summary: This study presents two cases of infertile males with teratozoospermia resulting from chromosome 17 translocation. The patients have unique karyotypes that have not been reported previously. Analysis of genes located on breakpoints suggests that interactions involving ALKBH5, TOP3A, and LLGL1 may contribute to abnormal sperm head morphology. Chromosome 17 translocation occurs in conjunction with chromosome 9 and chromosome 11 translocations, leading to oligozoospermia and asthenozoospermia, respectively. The abnormal phenotypes observed in these cases may be related to genes involved in meiosis and sperm motility. The study highlights the importance of investigating genes associated with sperm morphology, as well as the reproductive risks associated with chromosome 17 translocation. For individuals interested in pre-pregnancy screening, preimplantation genetic diagnosis is recommended to minimize the risk of karyotypically unbalanced fetuses and birth defects.
Article
Andrology
Seyedeh-Hanieh Hosseini, Marjan Sabbaghian, Anahita Mohseni Meybodi, Saman Maroufizadeh, Mohammad Ali Sadighi Gilani
Summary: The study showed that short tail sperm defect does not affect the clinical pregnancy rate in ICSI. ICSI may be an effective treatment for infertile men with short tail sperm defect.
Article
Cell Biology
Ziqi Wang, Kailun Fang, Yanling Wan, Yingying Yin, Mengjing Li, Ke Xu, Tongtong Li, Yongzhi Cao, Yue Lv, Gang Lu, Hongbin Liu, Tao Huang
Summary: In this study, the researchers found that the Ttc6 gene, expressed mainly in the testes, plays a crucial role in maintaining male fertility in mice. Knockout of Ttc6 resulted in decreased sperm motility and abnormal circular swimming pattern, leading to male subfertility. Morphological and ultrastructural analysis showed atypical appearance and unsheathed flagella in the spermatozoa. These findings suggest that TTC6 is essential for maintaining the stability of the annulus region of the sperm flagellum, ensuring swift and directed sperm motion.
Article
Obstetrics & Gynecology
Yaqian Li, Yan Wang, Yuting Wen, Tao Zhang, Xiaodong Wang, Chuan Jiang, Rui Zheng, Fan Zhou, Daijuan Chen, Yihong Yang, Ying Shen
Summary: Whole-exome sequencing and in vitro validation studies have identified new causative genes associated with teratozoospermia, specifically for sperm head defects. The study revealed rare and novel deleterious gene variants correlated with sperm head or tail abnormalities, and suggested potential treatment strategies for personalized medicine.
HUMAN REPRODUCTION
(2022)
Article
Multidisciplinary Sciences
Marion Delessard, Laura Stalin, Aurelie Rives-Feraille, Laura Moutard, Justine Saulnier, Ludovic Dumont, Nathalie Rives, Christine Rondanino
Summary: This study investigated the effects of chemotherapy on in vitro spermatogenesis in mice and found that combination chemotherapy led to significant changes and apoptosis in testicular tissue, but did not affect the ability of in vitro sperm production.
SCIENTIFIC REPORTS
(2022)
Article
Reproductive Biology
Saeed Zandiyeh, Abdolhossein Shahverdi, Bita Ebrahimi, Marjan Sabbaghian
REPRODUCTIVE BIOLOGY
(2020)
Article
Reproductive Biology
Nastaran Vahabi Barzi, Kianoosh Kakavand, Niloofar Sodeifi, Zeinab Ghezelayagh, Marjan Sabbaghian
REPRODUCTIVE BIOLOGY
(2020)
Article
Obstetrics & Gynecology
Kimiya Padidar, Elham Vahidi, Marjan Sabbaghian, Ali Behmanesh, Roshanak Shams
Summary: Smoking has a significant impact on male fertility, reducing sperm production, motility, and fertilizing capacity. This study used bioinformatics analysis to identify miRNAs and their target genes associated with male infertility in smokers. Several differentially expressed miRNAs were found in smoking men compared to non-smokers, and a module of eight hub genes highly correlated with male infertility and impairment of spermatogenesis was identified. These findings provide potential markers for the early detection of infertility in smokers.
Article
Andrology
Seyedeh-Hanieh Hosseini, Marjan Sabbaghian, Anahita Mohseni Meybodi, Saman Maroufizadeh, Mohammad Ali Sadighi Gilani
Summary: The study showed that short tail sperm defect does not affect the clinical pregnancy rate in ICSI. ICSI may be an effective treatment for infertile men with short tail sperm defect.
Article
Immunology
Seyed Omidreza Mousavi, Roudabeh Mohammadi, Fatemehsadat Amjadi, Zahra Zandieh, Samaneh Aghajanpour, Khashayar Aflatoonian, Marjan Sabbaghian, Maryam Eslami, Tahereh Madani, Reza Aflatoonian
Summary: This study demonstrates that sperm interaction with fallopian tube epithelial cells leads to significant changes in the expression of certain cytokines and growth factors, with some genes showing increased expression and others decreased expression. Panther pathway analysis revealed different signaling pathways involved, with the inflammation signaling pathway containing the most genes.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Hamideh Karimi, Parnaz Borjian Boroujeni, Marjan Sabbaghian, Anahita Mohseni Meybodi
Summary: Genetic variations in the NANOS3 gene play a crucial role in non-obstructive azoospermia, while the mRNA expression levels of NANOS3 show significant differences among patients with obstructive azoospermia, Sertoli cell-only syndromes (SCOS), and maturation arrest (MA).
REPRODUCTIVE SCIENCES
(2022)
Article
Andrology
Roudabeh Mohammadi, Seyed Omidreza Mousavi, Nadia Sheibak, Fatemehsadat Amjadi, Zahra Zandieh, Samaneh Aghajanpour, Khashayar Aflatoonian, Marjan Sabbaghian, Maryam Eslami, Reza Aflatoonian
Summary: This study investigated the effects of DNA fragmentation of spermatozoa on the expression of growth factors by a human oviduct epithelial cell line. The results showed that most of the growth factors were upregulated under the influence of spermatozoa with abnormal DNA fragmentation index, while only one gene was down-regulated. The study suggests that DNA fragmentation in spermatozoa may alter sperm behavior in the oviduct.
Article
Multidisciplinary Sciences
Alemeh Rafaee, Elaheh Kashani-Amin, Anahita Mohseni Meybodi, Azadeh Ebrahim-Habibi, Marjan Sabbaghian
Summary: AKAP3, a member of the A-kinase anchoring proteins, plays a vital role in sperm flagellum structure, sperm motility, and male fertility. This study analyzed the impact of mutations on AKAP3 stability, finding that while substitutions decreased stability, they did not induce structural disturbances. Providing structural insights on AKAP3 and the impact of mutations could help elucidate the etiology of male infertility.
SCIENTIFIC REPORTS
(2022)
Article
Andrology
Hamid Kalantari, Marjan Sabbaghian, Paraskevi Vogiatzi, Amarnath Rambhatla, Ashok Agarwal, Giovanni M. Colpi, Mohammad Ali Sadighi Gilani
Summary: This study investigated the indications for performing AZF screening in infertile males and the correlation between sperm count and AZF deletions. The findings suggest that certain chromosomal abnormalities and low sperm count should be considered as indicators for Y chromosome microdeletion (YCM) screening during infertility evaluation. These results highlight the need to update male infertility guidelines to improve the quality of diagnosis.
WORLD JOURNAL OF MENS HEALTH
(2023)
Review
Andrology
Sajal Gupta, Rakesh Sharma, Ashok Agarwal, Neel Parekh, Renata Finelli, Rupin Shah, Hussein Kandil, Ramadan Saleh, Mohamed Arafa, Edmund Ko, Mara Simopoulou, Armand Zini, Osvaldo Rajmil, Parviz Kavoussi, Keerti Singh, Rafael F. Ambar, Haitham Elbardisi, Pallav Sengupta, Marlon Martinez, Florence Boitrelle, Marco G. Alves, Kareim Khalafalla, Shubhadeep Roychoudhury, Gian Maria Busetto, Jaime Gosalvez, Nicholas Tadros, Ayad Palani, Marcelo Gabriel Rodriguez, Christina Anagnostopoulou, Sava Micic, Lucia Rocco, Taymour Mostafa, Juan G. Alvarez, Sunil Jindal, Hassan Sallam, Israel Maldonado Rosas, Sheena E. M. Lewis, Sami AlSaid, Mesut Altan, Hyun Jun Park, Jonathan Ramsay, Sijo Parekattil, Marjan Sabbaghian, Kelton Tremellen, Paraskevi Vogiatzi, Mohammad Ali Sadighi Gilani, Donald P. Evenson, Giovanni M. Colpi
Summary: Retrograde ejaculation is a condition where semen flows backward during ejaculation, potentially causing infertility. This may be due to anatomical, neurological, or pharmacological reasons, and treatment approaches depend on the specific cause. Alkalinizing urinary pH or adding sperm wash media before ejaculation may help preserve sperm viability in cases of RE.
WORLD JOURNAL OF MENS HEALTH
(2022)
Review
Andrology
Ashok Agarwal, Rakesh K. Sharma, Sajal Gupta, Florence Boitrelle, Renata Finelli, Neel Parekh, Damayanthi Durairajanayagam, Ramadan Saleh, Mohamed Arafa, Chak Lam Cho, Ala'a Farkouh, Amarnath Rambhatla, Ralf Henkel, Paraskevi Vogiatzi, Nicholas Tadros, Parviz Kavoussi, Edmund Ko, Kristian Leisegang, Hussein Kandil, Ayad Palani, Gianmaria Salvio, Taymour Mostafa, Osvaldo Rajmil, Saleem Ali Banihani, Samantha Schon, Tan V. Le, Ponco Birowo, Gokhan Ceker, Juan Alvarez, Juan Manuel Corral Molina, Christopher C. K. Ho, Aldo E. Calogero, Kareim Khalafalla, Mesut Berkan Duran, Shinnosuke Kuroda, Giovanni M. Colpi, Armand Zini, Christina Anagnostopoulou, Edoardo Pescatori, Eric Chung, Ettore Caroppo, Fotios Dimitriadis, Germar-Michael Pinggera, Gian Maria Busetto, Giancarlo Balercia, Haitham Elbardisi, Hisanori Taniguchi, Hyun Jun Park, Israel Maldonado Rosas, Jean de la Rosette, Jonathan Ramsay, Kasonde Bowa, Mara Simopoulou, Marcelo Gabriel Rodriguez, Marjan Sabbaghian, Marlon Martinez, Mohamed Ali Sadighi Gilani, Mohamed S. Al-Marhoon, Raghavender Kosgi, Rossella Cannarella, Sava Micic, Shinichiro Fukuhara, Sijo Parekattil, Sunil Jindal, Taha Abo-Almagd Abdel-Meguid, Yoshiharu Morimoto, Rupin Shah
Summary: Sperm vitality testing is essential in infertility management to differentiate between asthenozoospermia and necrozoospermia. The management of necrozoospermia depends on its etiology, with no standardized treatment available currently.
WORLD JOURNAL OF MENS HEALTH
(2022)
Review
Andrology
Rakesh Sharma, Sajal Gupta, Ashok Agarwal, Ralf Henkel, Renata Finelli, Neel Parekh, Ramadan Saleh, Mohamed Arafa, Edmund Ko, Armand Zini, Nicholas Tadros, Rupin Shah, Rafael F. Ambar, Haitham Elbardisi, Pallav Sengupta, Marlon Martinez, Florence Boitrelle, Mara Simopoulou, Paraskevi Vogiatzi, Jaime Gosalvez, Parviz Kavoussi, Hussein Kandil, Ayad Palani, Marcelo Rodriguez Pena, Osvaldo Rajmil, Gian Maria Busetto, Christina Anagnostopoulou, Sava Micic, Marco G. Alves, Lucia Rocco, Taymour Mostafa, Juan G. Alvarez, Sunil Jindal, Hassan N. Sallam, Israel Maldonado Rosas, Sheena E. M. Lewis, Sami AlSaid, Mesut Altan, Hyun Jun Park, Jonathan Ramsay, Sijo Parekattil, Marjan Sabbaghian, Kelton Tremellen, Kareim Khalafalla, Damayanthi Durairajanayagam, Giovanni M. Colpi
Summary: Leukocytospermia, defined as the presence of peroxidase-positive leukocytes in semen, may lead to oxidative stress and is associated with issues such as reduced sperm quality and DNA fragmentation. It could be a sign of infection in the male genital tract, caused by common uro-pathogens.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Andrology
Ashok Agarwal, Renata Finelli, Manesh Kumar Panner Selvam, Kristian Leisegang, Ahmad Majzoub, Nicholas Tadros, Edmund Ko, Neel Parekh, Ralf Henkel, Damayanthi Durairajanayagam, Giovanni M. Colpi, Chak Lam Cho, Hassan N. Sallam, Hyun Jun Park, Ramadan Saleh, Sava Micic, Rafael F. Ambar, Armand Zini, Kelton Tremellen, Juan G. Alvarez, Ayad Palani, Mohamed Arafa, Marcello M. Gava, Sunil Jindal, Edouard Amar, Zsolt Kopa, Mohammad Reza Moein, Gian Maria Busetto, Pallav Sengupta, Parviz Kavoussi, Israel Maldonado, Jamal Fikri, Edson Borges, Marlon Martinez, Djordje Bojovic, Osvaldo Rajmil, Kaan Aydos, Sijo Parekattil, Joel L. Marmar, Omar Sefrioui, Andreas Jungwirth, Marcelo Gabriel Rodriguez Pena, Emerson B. Cordts, Haitham Elbardisi, Taymour Mostafa, Marjan Sabbaghian, Mohammad Ali Sadighi Gilani, Yoshiharu Morimoto, Marco G. Alves, Aleksandra Spasic, Uros Kenic, Jonathan Ramsay, Ebenezer Oluwole Akande, Amina Oumeziane, Dmitri Dozortsev, Eric Chung, Ernestine Gwet Bell, Adolfo Allegra, Vasilios Tanos, Moise Fiadjoe, Timur Gurgan, Michel Abou-Abdallah, Hazem Al-Rumaih, Ivana Oborna, Hesham Arab, Sandro Esteves, Medhat Amer, Ates Kadioglu, Oleksandr Yuzko, Vladislav Korsak, Rupin Shah
Summary: This study conducted an online survey to evaluate the practice pattern of reproductive specialists in the use of oxidative stress testing and antioxidant prescriptions for the treatment of male infertility. The results showed a global understanding of the importance of this therapeutic option and a widespread use of antioxidants for male infertility treatment. It emphasizes the necessity of evidence-based clinical practice guidelines from professional societies.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Obstetrics & Gynecology
Neda Sharifi, Marjan Sabbaghian, Faramarz Farrahi, Navid Almadani, Parnaz Borjian Boroujeni, Anahita Mohseni Meybodi
JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA
(2020)