Article
Behavioral Sciences
Xusan Xu, Bin He, Jieqing Zeng, Jingwen Yin, Xiaoxia Wang, Xudong Luo, Chunmei Liang, Shucun Luo, Haifeng Yan, Susu Xiong, Zhi Tan, Dong Lv, Zhun Dai, Zhixiong Lin, Juda Lin, Xiaoqing Ye, Riling Chen, You Li, Yajun Wang, Wubiao Chen, Zebin Luo, Keshen Li, Guoda Ma
Summary: This study found an association between the DOCK4 gene and susceptibility to schizophrenia, as well as its relationship with clinical symptoms and brain function in Chinese patients. The selected SNPs were significantly associated with schizophrenia, and T allele carriers had higher scores in letter fluency and motor speed. Brain activity, connectivity, and centrality in certain brain regions were also positively correlated with verbal fluency and motor speed.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemical Research Methods
Yu-Jian Kang, Jing-Yi Li, Lan Ke, Shuai Jiang, De-Chang Yang, Mei Hou, Ge Gao
Summary: This study introduces the ribosome calculator, which quantitatively models the coding ability of RNAs in the human genome, and successfully predicts transcripts with different coding abilities in various cell types. This suggests that the coding ability of transcripts should be modeled as a continuous spectrum with context-dependent nature.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Gaelle Odelin, Adele Faucherre, Damien Marchese, Amelie Pinard, Hager Jaouadi, Solena Le Scouarnec, Emmanuelle FranceGenRef Consortium, Jean-Francois Deleuze, Emmanuelle Genin, Pierre Lindenbaum, Richard Redon, Jean-Jacques Schott, Raphael Chiarelli, Younes Achouri, Emilie Faure, Marine Herbane, Alexis Theron, Jean-Francois Avierinos, Chris Jopling, Gwenaelle Collod-Beroud, Rene Rezsohazy, Stephane Zaffran
Summary: The study identifies variants in the poly-histidine repeat motif of the HOXA1 gene that are associated with Bicuspid Aortic Valve (BAV), and validates the disruption of these variants in a mouse model. This research is significant in exploring the genetic mechanisms underlying BAV.
NATURE COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Alice W. Yu, J. David Peery, Hyejung Won
Summary: Genetic variants associated with schizophrenia contribute to transcriptomic dysregulation, with differentially expressed genes and co-expression networks showing nominal heritability enrichment. This association may be partly explained by cellular heterogeneity, indicating that the transcriptomic features of schizophrenia are influenced by transcriptional regulatory cascades elicited by genetic risk factors.
Article
Agriculture, Dairy & Animal Science
Zehu Yuan, Bolormaa Sunduimijid, Ruidong Xiang, Ralph Behrendt, Matthew I. Knight, Brett A. Mason, Coralie M. Reich, Claire Prowse-Wilkins, Christy J. Vander Jagt, Amanda J. Chamberlain, Iona M. MacLeod, Fadi Li, Xiangpeng Yue, Hans D. Daetwyler
Summary: By analyzing RNA sequence data and genotypes from 149 sheep, a large number of significant eQTL were discovered, with prevalence of overlap between different types of eQTL and tissues. Many eQTL were also found to be quantitative trait loci for meat traits. This study contributes to understanding the regulatory variants in complex traits in sheep.
GENETICS SELECTION EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Shinobu Hirai, Hideki Miwa, Tomoko Tanaka, Kazuya Toriumi, Yasuto Kunii, Hiroko Shimbo, Takuya Sakamoto, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hirooki Yabe, Tomoya Nakamachi, Seiji Shioda, Takashi Dan, Toshio Miyata, Yasumasa Nishito, Kazuhiro Suzuki, Mitsuhiro Miyashita, Toshifumi Tomoda, Takatoshi Hikida, Junjiro Horiuchi, Masanari Itokawa, Makoto Arai, Haruo Okado
Summary: Metabolic dysfunction is believed to exacerbate psychiatric disorders, and a high-sucrose diet during adolescence has been shown to induce psychosis-related behaviors in mice deficient for glyoxalase-1. This diet also caused microcapillary impairments and reduced brain glucose uptake, with aspirin offering protection against these vascular changes and abnormal behavioral phenotypes. The findings suggest that psychiatric disorders may be associated with brain angiopathy caused by metabolic stress.
Review
Biochemistry & Molecular Biology
Paul J. Farrell, Robert E. White
Summary: The incidence of diseases associated with EBV infection varies greatly in different parts of the world, which may be influenced by the variation in the virus genome. This article describes the main forms of EBV genome sequence variation and the potential contribution of these variations to disease development. Polymorphisms or deletions in the EBV genome can also serve as useful markers for disease monitoring. If certain strains of EBV are proven to be more pathogenic than others, immunization against these pathogenic strains may be valuable.
Article
Multidisciplinary Sciences
Enrica Flori, Arianna Mastrofrancesco, Sarah Mosca, Monica Ottaviani, Stefania Briganti, Giorgia Cardinali, Angela Filoni, Norma Cameli, Marco Zaccarini, Christos C. Zouboulis, Mauro Picardo
Summary: This study explores the role of sebaceous glands in the development of melasma. It found that sebocytes exposed to UVA radiation produce a range of substances related to melanogenesis and inflammation. The experiments also demonstrated the promoting effect of sebocytes on melanogenesis and confirmed the existence of these effects in vivo through analysis of sebum from melasma patients.
Editorial Material
Pharmacology & Pharmacy
Laura B. Ramsey, Andrea Gaedigk
Summary: A study using a large dataset suggested the need for reevaluation of values assigned to CYP2D6*9 and *41 alleles to improve phenotype prediction accuracy. Metabolic ratios across different drugs were found to be similar, indicating consistent CYP2D6 activity.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Agronomy
Pan Li, Tongbing Su, Hui Li, Yudi Wu, Limin Wang, Fenglan Zhang, Zheng Wang, Shuancang Yu
Summary: BrLMI1 is a positive regulator of leaf lobe formation in non-heading Chinese cabbage, and variations in the promoter region lead to the phenotype of lobed or entire leaf margins.
THEORETICAL AND APPLIED GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Rohan Alibutud, Sammy Hansali, Xiaolong Cao, Anbo Zhou, Vaidhyanathan Mahaganapathy, Marco Azaro, Christine Gwin, Sherri Wilson, Steven Buyske, Christopher W. Bartlett, Judy F. Flax, Linda M. Brzustowicz, Jinchuan Xing
Summary: This study aimed to assess the contribution of structural variations to autism spectrum disorder and related language impairments, and identified several genes involved in brain development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Samaneh Jafari Roshan, Yaser Mansoori, Seyed Reza Hosseini, Davood Sabour, Abdolreza Daraei
Summary: This study found that functional polymorphisms in ATM-rs228589 and H2AX-rs7759 gene loci are associated with the risk of abnormal hematological indices in workers exposed to BTEX. These findings contribute to the understanding of BTEX hematotoxicity mechanisms and provide useful biomarkers for risk assessment in workers exposed to BTEX.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Urban Studies
Seung Kyum Kim, Soonae Park
Summary: The increasing occurrence and severity of extreme weather events are influencing people's decisions on future city living. The social impacts of heightened exposure to climate risks call for transformative measures in coastal cities. However, few studies have examined the overall effects of risk-induced household migration behavior. Using a difference-in-differences framework, this study examines hurricane-prone coastal cities in the US to understand the cumulative consequences of climate risk-related residential migration. The findings reveal that migration triggered by climate risks may contribute to climate gentrification in low-risk areas, leading to a 13.8% increase in median income in low storm intensity areas and an 18.9% decrease in non-Hispanic African American residents in low flood-risk areas. These results highlight the importance for state and local governments to promote effective climate adaptations at the local level, not only for urban sustainability in hazard-prone areas but also to address potential social inequality in low-risk areas.
Article
Cardiac & Cardiovascular Systems
Yuping Yan, Xiangli Yin, Jingjie Li, Haiyue Li, Jianfeng Liu, Yuanwei Liu, Gang Tian
Summary: This study investigated the relationship between NPAS4 gene polymorphisms and the risk of coronary heart disease in the Chinese Han population. The results showed that certain SNPs in the NPAS4 gene were associated with an increased risk of coronary heart disease, and the expression levels of the NPAS4 gene were significantly lower in coronary heart disease patients.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Juan Antonio Suarez-Cuenca, Gustavo De la Pena-Sosa, Karen De la Vega-Moreno, Diana Zaineff Banderas-Lares, Moises Salamanca-Garcia, Jose Enrique Martinez-Hernandez, Eduardo Vera-Gomez, Alejandro Hernandez-Patricio, Carlos Ramiro Zamora-Aleman, Gabriela Alexandra Dominguez-Perez, Atzin Sua Ruiz-Hernandez, Juan Ariel Gutierrez-Buendia, Alberto Melchor-Lopez, Moises Ortiz-Fernandez, Jesus Montoya-Ramirez, Omar Felipe Gaytan-Fuentes, Angelica Toriz-Ortiz, Mario Osorio-Valero, Julita Orozco-Vazquez, Sofia Lizeth Alcaraz-Estrada, Martha Eunice Rodriguez-Arellano, Brenda Maldonado-Arriaga, Rebeca Perez-Cabeza de Vaca, Monica Escamilla-Tilch, Juan Antonio Pineda-Juarez, Mario Antonio Tellez-Gonzalez, Silvia Garcia, Paul Mondragon-Teran
Summary: This study investigated the impact of adipose tissue characteristics on metabolic and atherogenic risks, finding that adipocyte size and source are associated with cardiovascular risks in obese populations, with gender and Diabetes Mellitus playing significant roles in this relationship.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Ling-Yan Su, Hao Li, Li Lv, Yue-Mei Feng, Guo-Dong Li, Rongcan Luo, He-Jiang Zhou, Xiao-Guang Lei, Liang Ma, Jia-Li Li, Lin Xu, Xin-Tian Hu, Yong-Gang Yao
Article
Multidisciplinary Sciences
Liang Ma, Peilin Jia, Zhongming Zhao
SCIENTIFIC REPORTS
(2018)
Article
Psychiatry
Liang Ma, Dong-Dong Wu, Suk Ling Ma, Liwen Tan, Xiaogang Chen, Nelson L. S. Tang, Yong-Gang Yao
JOURNAL OF PSYCHIATRIC RESEARCH
(2014)
Article
Agriculture, Dairy & Animal Science
L. Ma, Y. J. Qu, Y. T. Huai, Z. J. Li, J. Wang, X. Y. Lan, C. L. Zhang, J. Q. Wang, H. Chen
Article
Biochemistry & Molecular Biology
J. Wang, Z. J. Li, X. Y. Lan, L. S. Hua, Y. T. Huai, Y. Z. Huang, L. Ma, M. Zhao, Y. J. Jing, H. Chen, J. Q. Wang
MOLECULAR BIOLOGY REPORTS
(2010)
Article
Biochemistry & Molecular Biology
Zhuanjian Li, Zhongqi Chen, Xianyong Lan, Liang Ma, Yujiao Qu, Yanli Liu, Mijie Li, Ping Wang, Fei Li, Hong Chen
MOLECULAR BIOLOGY REPORTS
(2010)
Article
Biochemistry & Molecular Biology
Yujiao Qu, Yanli Liu, Liang Ma, Sandra Sweeney, Xianyong Lan, Zhongqi Chen, Zhuanjian Li, Chuzhao Lei, Hong Chen
MOLECULAR BIOLOGY REPORTS
(2011)
Article
Biochemistry & Molecular Biology
Yong-Zhen Huang, En-Ping Zhang, Jing Wang, Yong-Tao Huai, Liang Ma, Fu-Ying Chen, Xian-Yong Lan, Chu-Zhao Lei, Xing-Tang Fang, Ju-Qiang Wang, Hong Chen
MOLECULAR BIOLOGY REPORTS
(2011)
Letter
Biochemistry & Molecular Biology
L. Ma, J. Tang, D. Wang, W. Zhang, W. Liu, D. Wang, X-H Liu, W. Gong, Y-G Yao, X. Chen
MOLECULAR PSYCHIATRY
(2013)
Article
Genetics & Heredity
Liang Ma, Wen Zhang, Jinsong Tang, Liwen Tan, Yong-Gang Yao, Xiaogang Chen
PSYCHIATRIC GENETICS
(2013)
Article
Biochemistry & Molecular Biology
Liang Ma, Stephen A. Semick, Qiang Chen, Chao Li, Ran Tao, Amanda J. Price, Joo Heon Shin, Yankai Jia, Nicholas J. Brandon, Alan J. Cross, Thomas M. Hyde, Joel E. Kleinman, Andrew E. Jaffe, Daniel R. Weinberger, Richard E. Straub
MOLECULAR PSYCHIATRY
(2020)
Article
Biochemical Research Methods
Jessica D. Tenenbaum, Krithika Bhuvaneshwar, Jane P. Gagliardi, Kate Fultz Hollis, Peilin Jia, Liang Ma, Radhakrishnan Nagarajan, Gopalkumar Rakesh, Vignesh Subbian, Shyam Visweswaran, Zhongming Zhao, Leon Rozenblit
BRIEFINGS IN BIOINFORMATICS
(2019)