Article
Biochemistry & Molecular Biology
Tsukasa Hamaoka, Xiajie Fu, Shozo Tomonaga, Osamu Hashimoto, Masaru Murakami, Masayuki Funaba
Summary: The study found that beta-alanine can directly act on HB2 brown adipocytes to promote energy expenditure, possibly by accelerating phosphorylation and activation of CREB, thereby enhancing forskolin-induced Ucp1 expression during brown adipogenesis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Md. Reyad-ul-Ferdous, Yongfeng Song
Summary: Further studies are required in both murine and human models to understand the full mechanism of action by mitochondrial modulation. Drug development investigation also requires the development of a precise formulation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
IkRak Jung, Becky Tu-Sekine, Sunghee Jin, Frederick Anokye-Danso, Rexford S. Ahima, Todd T. Brown, Sangwon F. Kim
Summary: The study found that DTG targets UCP1 and mitochondrial functions in brown and beige adipocytes, disrupting thermogenic functions in preclinical models.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Thomas F. Martinez, Sally Lyons-Abbott, Angie L. Bookout, Eduardo V. De Souza, Cynthia Donaldson, Joan M. Vaughan, Calvin Lau, Ariel Abramov, Arian F. Baquero, Karalee Baquero, Dave Friedrich, Justin Huard, Ray Davis, Bong Kim, Ty Koch, Aaron J. Mercer, Ayesha Misquith, Sara A. Murray, Sakara Perry, Lindsay K. Pino, Christina Sanford, Alex Simon, Yu Zhang, Garrett Zipp, Cristiano V. Bizarro, Maxim N. Shokhirev, Andrew J. Whittle, Brian C. Searle, Michael J. MacCoss, Alan Saghatelian, Christopher A. Barnes
Summary: Microproteins (MPs) in adipocytes were identified using ribosome profiling. 3,877 unannotated MP-encoding small ORFs were curated, and 85 MPs were validated, including 33 circulating MPs in mouse plasma. The analysis revealed the regulation of MPs in adipose tissue and their co-expression with metabolic genes. One secreted MP Gm8773 was found to be highly expressed in the hypothalamus and showed orexigenic activity in obese mice.
Article
Medicine, Research & Experimental
Dae Young Jung, Nanjoo Suh, Myeong Ho Jung
Summary: The study demonstrates that Tanshinone 1 plays a crucial role in activating brown adipocytes and inducing browning of white adipocytes, which can protect against high fat diet-induced obesity.
Article
Multidisciplinary Sciences
Lasse K. Markussen, Elizabeth A. Rondini, Olivia Sveidahl Johansen, Jesper G. S. Madsen, Elahu G. Sustarsic, Ann-Britt Marcher, Jacob B. Hansen, Zachary Gerhart-Hines, James G. Granneman, Susanne Mandrup
Summary: This study uncovers the transcriptional network controlled by lipolysis in brown adipocytes and shows that lipolysis is required for the activation of the thermogenic gene program by beta-adrenergic signals. PPARs are identified as key mediators of lipolysis-induced activation of lipid metabolism and thermogenic genes. Additionally, lipolysis also activates the unfolded protein response and regulates the core circadian transcriptional machinery independently of PPARs.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ching-Fang Chang, Amanda L. Gunawan, Irene Liparulo, Peter-James H. Zushin, Ambre M. Bertholet, Yuriy Kirichok, Andreas Stahl
Summary: Coenzyme Q deficiency affects respiration in brown adipose tissue by regulating UCP1 expression, leading to increased mitochondrial membrane potential and decreased ADP/ATP ratios. This deficiency also enhances cold sensitivity.
Article
Multidisciplinary Sciences
Qingwen Zhao, Chao Yu, Xiaoxuan Xu, Wenfang Jin, Zhe Zhang, Haiyan Huang, Yue Gao, Dongning Pan
Summary: YBX2 protein level in brown adipose tissue is induced by thermogenic stimuli through phosphorylation modification, and plays a crucial role in regulating glycolysis and thermogenesis by stabilizing YBX2.
Editorial Material
Immunology
Cecilia Garlanda, Domenico Supino
Summary: The researchers in this study designed a new drug to selectively inhibit IL-1 by analyzing an IL-1 receptor missense mutation associated with un-leashed IL-1-mediated inflammation.
Article
Biochemistry & Molecular Biology
Emily K. Miller, Mandana Pahlavani, Latha Ramalingam, Shane Scoggin, Naima Moustaid-Moussa
Summary: The study showed that in female mice, UCP1 deficiency in thermoneutral conditions has a negative impact on energy metabolism. Surprisingly, the protective effects of EPA against diet-induced obesity and glucose intolerance were found to be independent of UCP1.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Minh-Hanh Thi Nguyen, Dat Da Ly, Nhung Thi Nguyen, Xu-Feng Qi, Hyon-Seung Yi, Minho Shong, Seung-Kuy Cha, Sangkyu Park, Kyu-Sang Park
Summary: Short-term exposure to T-3 induces UCP1 upregulation and mitochondrial activation in brown adipocytes through PLC-mediated elevation of [Ca2+].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jungin Kwon, Yu-Sheng Yeh, Satoko Kawarasaki, Hiroto Minamino, Yoshihito Fujita, Yuko Okamatsu-Ogura, Haruya Takahashi, Wataru Nomura, Shigenobu Matsumura, Rina Yu, Kazuhiro Kimura, Masayuki Saito, Nobuya Inagaki, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto
Summary: This study demonstrates the role of the mevalonate (MVA) biosynthesis pathway in regulating brown adipocyte development and survival. Inhibiting the rate-limiting enzyme in the MVA pathway, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), suppresses brown adipocyte differentiation and leads to apoptosis of mature brown adipocytes. The study reveals that geranylgeranyl pyrophosphate (GGPP) generated from the MVA pathway is essential for brown adipocyte development and survival.
Article
Nutrition & Dietetics
Katarzyna Maliszewska, Edyta Adamska-Patruno, Katarzyna Miniewska, Witold Bauer, Angelika Buczynska, Malgorzata Mojsak, Adam Kretowski
Summary: The study suggests that different macronutrient consumption may be a new way to modulate brown adipose tissue (BAT) activity, leading to weight reduction.
Article
Integrative & Complementary Medicine
Yo-Han Han, Ji-Ye Kee, Seung-Heon Hong
Summary: The study found that gomisin A (GA) can inhibit obesity by regulating phenotypic changes in adipose tissues through induction of browning and inhibition of whitening, resulting in decreased weight gain, epididymal white adipose tissue (eWAT) and liver weight, and increased levels of high-density lipoprotein (HDL) cholesterol in mice. GA suppresses adipogenesis by activating AMP-activated protein kinase (AMPK) and inducing browning by increasing the expression levels of uncoupling protein 1 (UCP1). These findings suggest that GA may be a potential therapeutic agent for obesity treatment.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Cell Biology
XiaoLuan Xu, AnQi Ma, TieSong Li, WenXue Cui, XueFeng Wang, Jun Li, Qingwei Li, Yue Pang
Summary: Research on lampreys has identified brown-like adipocytes in the brain periphery, similar to human BAT, that play a role in generating heat, adapting to low temperatures, and enhancing inflammation response. This provides new insights for understanding the function and characteristics of BAT in humans, as well as the adaptation mechanisms of lampreys in cold environments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hicham Benabdelkamel, Afshan Masood, Meshail Okla, Mohammed Y. Al-Naami, Assim A. Alfadda
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Endocrinology & Metabolism
Michaela Tencerova, Meshail Okla, Moustapha Kassem
CURRENT OSTEOPOROSIS REPORTS
(2019)
Article
Food Science & Technology
Rong Fan, Mikyoung You, Ashley M. Toney, Judy Kim, David Giraud, Yibo Xian, Feng Ye, Liwei Gu, Amanda E. Ramer-Tait, Soonkyu Chung
MOLECULAR NUTRITION & FOOD RESEARCH
(2020)
Article
Nutrition & Dietetics
Mikyoung You, Rong Fan, Judy Kim, Seung-Ho Shin, Soonkyu Chung
Review
Endocrinology & Metabolism
Meshail Okla, Moustapha Kassem
Summary: Bone marrow adipose tissue (MAT) is a unique fat depot near bone surfaces that regulates skeletal function. Recent studies show that MAT responds to changes in energy metabolism, leading to potential detrimental effects on bone health. Understanding the thermogenic potential of MAT could improve bone health and overall energy metabolism.
Article
Biochemistry & Molecular Biology
Hicham Benabdelkamel, Hanadi Alamri, Meshail Okla, Afshan Masood, Mai Abdel Jabar, Ibrahim O. Alanazi, Assim A. Alfadda, Imran Nizami, Majed Dasouki, Anas M. Abdel Rahman
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Food Science & Technology
Yibo Xian, Rong Fan, Jing Shao, Ashley Mulcahy Toney, Soonkyu Chung, Amanda E. Ramer-Tait
Summary: Polyphenol extracts from red raspberry whole fruit or pulp, but not seed, can attenuate high-fat diet induced obesity in mice. These polyphenols have significant effects on the microbiota, decreasing specific taxa abundance and increasing beneficial Roseburia. Changes in the microbiome are closely correlated with improvements in host metabolic markers.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Multidisciplinary Sciences
Jin-Seon Yook, Mikyoung You, Jiyoung Kim, Ashley M. Toney, Rong Fan, Bhanwar Lal Puniya, Tomas Helikar, Sophie Vaulont, Jean-Christophe Deschemin, Meshail Okla, Liwei Xie, Manik C. Ghosh, Tracey A. Rouault, Jaekwon Lee, Soonkyu Chung
Summary: This study investigates the iron-regulatory network underlying beige adipogenesis, showing that thermogenic stimulus leads to redistribution of iron into beige fat through interplay between adipocyte iron demands and systemic iron liberation. Disruption of systemic iron homeostasis impairs beige fat development, suggesting coordinated interplay between renal hypoxia and hepcidin down-regulation as a key mechanism for activating adaptive thermogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Rigmor Solberg, Ngoc Nguyen Lunde, Karl Martin Forbord, Meshail Okla, Moustapha Kassem, Abbas Jafari
Summary: Legumain, a cysteine protease, plays a crucial role in various physiological processes and diseases through its proteolytic and nonproteolytic ligase functions. This review provides an overview of legumain's functions in kidney homeostasis, hematopoietic homeostasis, bone remodeling, cardiovascular and cerebrovascular diseases, neurodegenerative diseases, and cancer, as well as its interaction with marketed drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Thi My Tien Truong, Seok Hee Seo, Soonkyu Chung, Inhae Kang
Summary: A prolonged HFHS diet induces hepatic inflammation and mediates HSC activation, resulting in hepatic fibrosis. PCA-enriched peanut sprout extracts can reduce hepatic fibrosis by modulating innate immunity and HSC activation, and have anti-inflammatory effects.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Saeed Al Mahri, Meshail Okla, Mamoon Rashid, Shuja Shafi Malik, Jahangir Iqbal, Maria Al Ibrahim, Ghida Dairi, Amer Mahmood, Manikandan Muthurangan, Ahmed Yaqinuddin, Sameer Mohammad
Summary: G protein-coupled receptors (GPCRs) play important roles in adipose tissue, with their expression being influenced by adipocyte differentiation and obesity. In mouse adipose tissue, 292 and 271 GPCRs were detected in white and brown adipose tissue, respectively, with some GPCRs being specific to each tissue type. The expression of numerous GPCRs was also identified in subcutaneous adipose tissue from human subjects and was altered in obesity and high-fat diet conditions. These GPCRs could have significant implications for adipose metabolism and serve as valuable resources for obesity and metabolic research.
Article
Engineering, Biomedical
Ou Wang, Li Han, Haishuang Lin, Mingmei Tian, Shuyang Zhang, Bin Duan, Soonkyu Chung, Chi Zhang, Xiaojun Lian, Yong Wang, Yuguo Lei
Summary: Transplanting injectable microtissues of brown adipocytes can improve cell survival and effectively treat obesity and type 2 diabetes.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Rukhsana Gul, Meshail Okla, Amer Mahmood, Shahid Nawaz, Amina Fallata, Arwa Bazighifan, Musaad Alfayez, Assim A. Alfadda
Summary: In this study, we compared the cardioprotective effects of the third-generation vasodilating beta-blocker nebivolol and the conventional beta-blocker metoprolol on LPS-induced injury in H9c2 cardiomyoblasts for the first time. Our findings demonstrate that both nebivolol and metoprolol pretreatment can alleviate LPS-induced cytotoxicity and oxidative stress. However, only nebivolol significantly suppresses LPS-triggered inflammatory cytokines activation. Nebivolol and metoprolol pretreatment can both alleviate LPS-induced mitochondrial impairment, but nebivolol specifically upregulates mitochondrial fusion-related genes. These findings suggest that both nebivolol and metoprolol can ameliorate LPS-induced cytotoxicity and oxidative stress, while nebivolol may further down-regulate LPS-induced proinflammatory factors through enhancing mitochondrial biogenesis and fusion.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
