Article
Orthopedics
Keiko Yamada, Heather Adams, Tamra Ellis, Robyn Clark, Craig Sully, Christian Lariviere, Michael J. L. Sullivan
Summary: This study investigated the temporal relation between changes in pain and changes in fatigue in individuals with musculoskeletal pain. The results showed that pain severity predicted later fatigue, but fatigue did not predict later pain severity.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Medicine, General & Internal
Jing Tian, Graeme Jones, Xin Lin, Yuan Zhou, Anna King, James Vickers, Feng Pan
Summary: This study investigates the association between the number of chronic pain sites and the risk of dementia and its subtypes. The findings suggest that a greater number of chronic pain sites is associated with an increased risk of all-cause dementia and Alzheimer's disease, but not vascular and frontotemporal dementia.
Article
Biochemistry & Molecular Biology
Carmela L. Marciano, Taylor A. Hiland, Krista L. Jackson, Sierra Street, Carson Maris, Andrew Ehrsam, Julia M. Hum, Mary Terry Loghmani, Tien-Min G. Chu, Kyung S. Kang, Jonathan W. Lowery
Summary: This study investigated the effects of instrument-assisted soft tissue manipulation (IASTM) on pro- and anti-inflammatory cytokines in rats with chronic low back pain. The results showed that IASTM was associated with reduced levels of pro-inflammatory cytokine RANTES/CCL5 and increased levels of anti-inflammatory cytokine IL-4 in the soft tissues. However, no changes were observed in other pro- or anti-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Lorenzo Di Cesare Mannelli, Laura Micheli, Chiara Cervetto, Alessandra Toti, Elena Lucarini, Carmen Parisio, Manuela Marcoli, Carla Ghelardini
Summary: The role of interleukin 1 alpha (IL-1 alpha) in the interaction between neurons and astrocytes has been studied, and it has been found to have a protective effect. Treatment with IL-1 alpha can reduce the mortality of neurons when co-cultured with astrocytes. In rat experiments, IL-1 alpha treatment can alleviate hypersensitivity and pain caused by neuropathy. IL-1 alpha can also decrease the release of endogenous glutamate induced by neurotoxicity by reducing extracellular ATP and increasing the release of transforming growth factor beta 1.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Chemistry, Medicinal
Marion Voute, Veronique Morel, Gisele Pickering
Summary: Topical lidocaine is a safe and effective option for pain management, with proven efficacy in various pain conditions. It can be used alone or in conjunction with systemic drugs and non-pharmacological approaches for optimized pain management and multimodal analgesia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Medicine, General & Internal
Roberto Bonanni, Ida Cariati, Virginia Tancredi, Riccardo Iundusi, Elena Gasbarra, Umberto Tarantino
Summary: Musculoskeletal pain is a growing problem that causes significant socio-economic burden. Understanding the underlying pathological mechanisms and the relationship between immune cells and neurons is crucial for effective evaluation and treatment of this pain.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Ferran Cuenca-Martinez, Luis Suso-Marti, Joaquin Calatayud, Francisco Jose Ferrer-Sargues, Vicente Munoz-Alarcos, Patricio Alba-Quesada, Gemma Bivia-Roig
Summary: Pain neuroscience education (PNE) has been extensively studied in the field of physical therapy, but its effectiveness remains controversial. This umbrella review found that adding PNE-based intervention to other treatments can lead to greater clinical improvements in patients with chronic musculoskeletal pain, particularly in reducing the influence of psychosocial variables. However, studies testing the effectiveness of PNE alone did not show statistically significant improvements in pain intensity, disability levels, or psychosocial variables.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Daniela Poenaru, Miruna Ioana Sandulescu, Delia Cinteza
Summary: Botulinum neurotoxin (BoNT), produced by Clostridium botulinum, inhibits the release of acetylcholine at the neuromuscular junction reversibly. It also blocks the transmission of pain-related substances and has anti-inflammatory effects, potentially contributing to analgesia. When initial treatments fail, BoNT may be considered as a second-line option. Studies on chronic and recurrent pain using various mechanisms have yielded diverse results, emphasizing the need for validation and standardization.
Article
Immunology
Teruyuki Ishikura, Makoto Kinoshita, Mikito Shimizu, Yoshiaki Yasumizu, Daisuke Motooka, Daisuke Okuzaki, Kazuya Yamashita, Hisashi Murata, Shohei Beppu, Toru Koda, Satoru Tada, Naoyuki Shiraishi, Yasuko Sugiyama, Katsuichi Miyamoto, Susumu Kusunoki, Tomoyuki Sugimoto, Atsushi Kumanogoh, Tatsusada Okuno, Hideki Mochizuki
Summary: The study demonstrates the release of extracellular ATP from astrocytes induced by anti-AQP4 antibody. The ATP-mediated development of mechanical allodynia was also suggested in rats treated with anti-AQP4 antibody. The pivotal role of ATP in the pain mechanism of NMOSD is indicated by the study.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell & Tissue Engineering
Hanchao Liu, Xinning Zhu, Xiaohui Cao, Ani Chi, Jian Dai, Zhenqing Wang, Chunhua Deng, Min Zhang
Summary: IL-1 beta-primed MSCs exhibited significant immunomodulatory and targeted migration ability in a mouse model of chronic prostatitis, potentially alleviating CP/CPPS by modulating systemic immunity.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, General & Internal
Carina F. Pinheiro, Anamaria S. Oliveira, Tenysson Will-Lemos, Lidiane L. Florencio, Cesar Fernandez-de-las-Penas, Fabiola Dach, Debora Bevilaqua-Grossi
Summary: Episodic and chronic migraines were associated with reduced total range of motion and mean angular velocity of neck movements, while muscle activity during active neck movements did not show significant differences. Neck disability and kinesiophobia were weakly correlated with cervical movement parameters.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Hao Li, Xiaoyu Yu, Baojie Shi, Kun Zhang, Liyun Yuan, Xueni Liu, Pusen Wang, Junwei Lv, Guangxun Meng, Qiankun Xuan, Wenjuan Wu, Bin Li, Xiao Peng, Xuebin Qin, Wanqing Liu, Lin Zhong, Zhihai Peng
Summary: The study revealed that genetic predisposition to reduced PANX1 function increases the risk of MRSA infection in liver transplantation patients. Panx1 deficiency results in increased MRSA-induced liver injury and animal death. Decreased PANX1 expression leads to reduced ATP release from hepatocytes and impairs hepatic host innate immune response mediated by IL-33.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Barbara Fulop, Agnes Hunyady, Noemi Bencze, Viktoria Kormos, Nikolett Szentes, Adam Denes, Nikolett Lenart, Eva Borbely, Zsuzsanna Helyes
Summary: Chronic stress can lead to various pain conditions, including fibromyalgia. The study found that interleukin-1 (IL-1) plays a role in stress-induced pain. In a mouse model of chronic restraint stress, IL-1 was found to mediate hyperalgesia in female mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Multidisciplinary
Hee Jun Kim, Timothy J. Meeker, Ju-Yang Jung, Ji-Won Kim, Hyoun-Ah Kim
Summary: This study explored factors associated with chronic secondary musculoskeletal pain in rheumatic diseases. It found that psychological and social factors play a role in pain intensity and interference. Females are more directly affected by depressive symptoms, while pain catastrophizing affects both males and females.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Anesthesiology
Katarina Aili, Paul Campbell, Zoe A. Michaleff, Vicky Y. Strauss, Kelvin P. Jordan, Ann Bremander, Peter Croft, Stefan Bergman
Summary: The study found that while the majority of people reported no chronic pain over a 21-year period, there was also a subset of individuals whose pain status changed over time. Few transitioned from no chronic pain to chronic regional pain or chronic widespread pain, while more transitioned from chronic regional pain to chronic widespread pain.
Review
Medicine, Research & Experimental
Josefa Belen Alarcon, Priscila Belen Chuhuaicura, Kathleen Anne Sluka, Carol G. T. Vance, Valeria Paula Sasoli Fazan, Karina Alejandra Godoy, Ramon Eduardo Fuentes, Fernando Jose Dias
Summary: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive electrical stimulation therapy that can accelerate nerve regeneration and increase axon quantity and diameter. Low-frequency TENS application can promote normal myelination, while high-frequency TENS application can stimulate motor regeneration but may increase the risk of neuropathic pain. Although further research is needed, TENS seems to be a promising treatment for nerve injury.
Article
Anesthesiology
Muath A. Shraim, Kathleen A. Sluka, Michele Sterling, Lars Arendt-Nielsen, Charles Argoff, Karl S. Bagraith, Ralf Baron, Helena Brisby, Daniel B. Carr, Ruth L. Chimenti, Carol A. Courtney, Michele Curatolo, Beth D. Darnall, Jon J. Ford, Thomas Graven-Nielsen, Melissa C. Kolski, Eva Kosek, Richard E. Liebano, Shannon L. Merkle, Romy Parker, Felipe J. J. Reis, Keith Smart, Rob J. E. M. Smeets, Peter Svensson, Bronwyn L. Thompson, Rolf-Detlef Treede, Takahiro Ushida, Owen D. Williamson, Paul W. Hodges
Summary: This study used the Delphi expert consensus method to identify classification features and generated a list of candidate features that could aid in discrimination between types of musculoskeletal pain.
Article
Clinical Neurology
Dana L. Dailey, Carol G. T. Vance, Ruth Chimenti, Barbara A. Rakel, Miriam Bridget Zimmerman, Jon M. Williams, Kathleen A. Sluka, Leslie J. Crofford
Summary: This study found that regular use of opioid medications does not diminish the effectiveness of transcutaneous electrical nerve stimulation (TENS) for movement-evoked pain. However, women with fibromyalgia regularly taking opioids did experience greater bodily pain and fatigue compared to those not regularly taking opioids. These differences, while statistically significant, may not have clear clinical significance.
Article
Anesthesiology
Joseph B. Lesnak, Alexis Fahrion, Amber Helton, Lynn Rasmussen, Megan Andrew, Stefanie Cunard, Michaela Huey, Austin Kreber, Joseph Landon, Travis Siwiec, Kenan Todd, Laura A. Frey-Law, Kathleen A. Sluka
Summary: Resistance training can prevent the development of muscle pain through the activation of androgen receptors. It acutely increases lactate and testosterone, and increases strength over time.
Article
Anesthesiology
Saman Haider, Adam J. Janowski, Joseph B. Lesnak, Kazuhiro Hayashi, Dana L. Dailey, Ruth Chimenti, Laura A. Frey-Law, Kathleen A. Sluka, Giovanni Berardi
Summary: An increasing number of individuals experience prolonged symptoms after having COVID-19, known as post-COVID-19 condition. This study aimed to compare the symptom profiles of individuals with post-COVID-19, fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS). The study found that all three conditions had elevated levels of pain, fatigue, anxiety, depression, catastrophizing, and kinesiophobia. Physical and cognitive function were similarly affected in post-COVID-19, FMS, and CFS, but post-COVID-19 individuals reported lower levels of pain and fatigue compared to FMS and CFS. The comorbidity of post-COVID-19 with FMS and/or CFS worsened pain, fatigue, and psychological aspects. These findings suggest the importance of a biopsychosocial approach in managing post-COVID-19 symptoms.
Article
Anesthesiology
Ruth L. Chimenti, Andrew A. Post, Ebonie K. Rio, G. Lorimer Moseley, Megan Dao, Hadley Mosby, Mederic Hall, Cesar de Cesar Netto, Jason M. Wilken, Jessica Danielson, Emine O. Bayman, Kathleen A. Sluka
Summary: Exercise is the standard treatment for Achilles tendinopathy (AT), but a significant number of patients still experience pain after rehabilitation. Adding pain science education (PSE) to an exercise program may improve clinical outcomes, but this has not been studied in AT patients. Moreover, we have limited knowledge about how AT rehabilitation affects fear of movement and central nervous system nociceptive processing.
Article
Anesthesiology
Joseph B. Lesnak, David S. Nakhla, Ashley N. Plumb, Alexandra McMillan, Sanjib Saha, Nikesh Gupta, Yan Xu, Pornpoj Phruttiwanichakun, Lynn Rasmussen, David K. Meyerholz, Aliasger K. Salem, Kathleen A. Sluka
Summary: Chronic pain is a major health problem that affects disability and quality of life. Current treatments for chronic pain are ineffective, so there is a need for new analgesics. In this study, the researchers tested the efficacy of selective androgen receptor modulators (SARMs) in a mouse model of muscle pain. They found that SARMs alleviated muscle hyperalgesia in both male and female mice, and this effect was mediated through androgen receptors. The SARM-loaded microparticles released the drug for a sustained period and did not produce toxic or rewarding effects. These findings suggest that SARM-loaded microparticles could be a potential therapy for chronic muscle pain.
Article
Orthopedics
Andrew A. Post, Ebonie K. Rio, Kathleen A. Sluka, G. Lorimer Moseley, Emine O. Bayman, Mederic M. Hall, Cesar de Cesar Netto, Jason M. Wilken, Jessica Danielson, Ruth L. Chimenti
Summary: The study compared the efficacy of physical therapy delivered via telehealth or hybrid format with in-person format for individuals with chronic Achilles tendinopathy (AT). The results showed that there was no significant difference in pain outcomes between the telehealth/hybrid groups and the in-person group. This suggests that telehealth-based physical therapy can improve accessibility to AT rehabilitation and prioritize patient preferences for treatment format.
Review
Orthopedics
Kazuhiro Hayashi, Adam Janowski, Joseph B. Lesnak, Kathleen A. Sluka
Summary: Preoperative exercise can reduce postoperative pain and improve function, as well as decrease the risk of complications. This systematic review found that preoperative exercise in joint replacement surgery can significantly reduce pain within 2-5 months after surgery and improve quality of life and function within the first 2 months. However, the effect on pain and function after 6 months is not significant, and the impact on other surgery types is inconclusive.
Article
Anesthesiology
Kazuhiro Hayashi, Joseph B. B. Lesnak, Ashley N. N. Plumb, Lynn A. A. Rasmussen, Kathleen A. A. Sluka
Summary: We developed an animal model of activity-induced muscle pain that relies on the activation of macrophages and the release of interleukin-1 β. The P2X7/NLRP3/Caspase-1 pathway plays a crucial role in the initiation and early maintenance phases of muscle pain in male mice. However, this pathway does not contribute to late maintenance phases in male mice or to muscle pain in female mice.
Review
Anesthesiology
Kathleen A. Sluka, Tor D. Wager, Stephani P. Sutherland, Patricia A. Labosky, Tessa Balach, Emine O. Bayman, Giovanni Berardi, Chad M. Brummett, John Burns, Asokumar Buvanendran, Brian Caffo, Vince D. Calhoun, Daniel Clauw, Andrew Chang, Christopher S. Coffey, Dana L. Dailey, Dixie Ecklund, Oliver Fiehn, Kathleen M. Fisch, Laura A. Frey Law, Richard E. Harris, Steven E. Harte, Timothy D. Howard, Joshua Jacobs, Jon M. Jacobs, Kristen Jepsen, Nicolas Johnston, Carl D. Langefeld, Louise C. Laurent, Rebecca Lenzi, Martin A. Lindquist, Anna Lokshin, Ari Kahn, Robert J. McCarthy, Michael Olivier, Linda Porter, Wei-Jun Qian, Cheryse A. Sankar, John Satterlee, Adam C. Swensen, Carol G. T. Vance, Jennifer Waljee, Laura D. Wandner, David A. Williams, Richard L. Wixson, Xiaohong Joe Zhou
Summary: Chronic pain affects a large number of Americans and there is a lack of understanding of the underlying mechanisms. Biomarkers have the potential to identify and measure changes caused by pain, provide treatment targets, and identify at-risk patients. The A2CPS program aims to evaluate and develop biomarkers for chronic pain after surgery, including genomic, proteomic, metabolomic, and neuroimaging measures.
Article
Engineering, Biomedical
Adam J. Janowski, Andrew A. Post, Alberto M. Heredia-Rizo, Hadley Mosby, Megan Dao, Laura Frey Law, Emine O. Bayman, Jason M. Wilken, Kathleen A. Sluka, Ruth L. Chimenti
Summary: This study characterized movement-evoked pain in individuals with Achilles tendinopathy during tendon loading and stretching tasks, and found associations between movement-evoked pain and biomechanical and psychological variables.
CLINICAL BIOMECHANICS
(2023)
Article
Pharmacology & Pharmacy
Carolina Ocanha Jorge, Bruna de Melo-Aquino, Diogo Francisco da Silva dos Santos, Maria Claudia Goncalves de Oliveira
Summary: This study suggests that TRPV1 and TRPA1 receptors may be involved in muscle pain induced by static contraction. These receptors may work together in the peripheral and central terminals to sensitize nociceptive fibers and could be potential targets for controlling inflammatory muscle pain.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Carol G. T. Vance, Dana L. Dailey, Ruth L. Chimenti, Barbara J. Van Gorp, Leslie J. Crofford, Kathleen A. Sluka
Summary: TENS is a non-pharmacological intervention used for acute and chronic pain conditions. Research has improved understanding of TENS efficacy mechanisms, but uncertainty remains regarding clinical effectiveness, requiring further high-quality studies to evaluate the therapeutic potential.
MEDICINA-LITHUANIA
(2022)
Article
Clinical Neurology
Nathan Augeard, Geoff Bostick, Jordan Miller, David Walton, Yannick Tousignant-Laflamme, Anne Hudon, Andre Bussieres, Lynn Cooper, Nicol McNiven, Aliki Thomas, Lesley Singer, Scott M. Fishman, Marie H. Bement, Julia M. Hush, Kathleen A. Sluka, Judy Watt-Watson, Lisa C. Carlesso, Sinead Dufour, Roland Fletcher, Katherine Harman, Judith Hunter, Suzy Ngomo, Neil Pearson, Kadija Perreault, Barbara Shay, Peter Stilwell, Susan Tupper, Timothy H. Wideman
Summary: This study aimed to create a consensus-based competency profile for pain management specific to the Canadian context of physiotherapy. Through a modified Delphi design, a total of 15 competencies reached consensus, and the majority of participants reported being very satisfied with the process. This study contributes to the field of integrated research in pain management.
CANADIAN JOURNAL OF PAIN-REVUE CANADIENNE DE LA DOULEUR
(2022)