Article
Biochemistry & Molecular Biology
Gagandeep Kaur, Krishna Prahlad Maremanda, Michael Campos, Hitendra S. Chand, Feng Li, Nikhil Hirani, M. A. Haseeb, Dongmei Li, Irfan Rahman
Summary: The study investigated the miRNA profiles of lung-tissue-derived exosomes in COPD and IPF patients, revealing miRNA downregulation in exosomes derived from the lung tissue of COPD patients, while a large number of differentially expressed miRNAs were found in exosomes derived from the lung tissue of IPF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Henryka Hometowska, Jakub Klekowski, Natalia Swiatoniowska-Lonc, Beata Jankowska-Polanska, Mariusz Chabowski
Summary: This study aimed to assess the prevalence of fatigue, anxiety, and depression in patients with asthma, COPD, and ACO and to consider their mutual correlations. The results showed that patients with COPD, asthma, and ACO generally suffered from an increased level of fatigue and depression. Anxiety was high in all groups, but it was at a similar level for patients suffering from each of the three diseases under consideration. It is important to treat the physical symptoms as well as the psychological disorders since they greatly impact patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Howraman Meteran, Pradeesh Sivapalan, Jens-Ulrik Staehr Jensen
Summary: Asthma and COPD, two common chronic diseases worldwide, have heterogeneous and complex characteristics with different responses to treatment, despite their similarities in pathophysiology and immunology. Systematic assessment of diagnosis and identification of biomarkers are essential for clinical management. Advances in understanding asthma and COPD, particularly related to eosinophilia as a treatable trait, have led to targeted treatments and improved outcomes.
Review
Medicine, General & Internal
Ileana Andreea Ratiu, Tomasz Ligor, Victor Bocos-Bintintan, Chris A. Mayhew, Boguslaw Buszewski
Summary: Lung cancer, COPD, and asthma are inflammatory diseases with increasing global prevalence, causing physical and psychological distress to patients while incurring high societal costs. Analyzing trace VOCs in exhaled breath has the potential to provide cheaper, rapid, and non-invasive screening procedures for diagnosing and monitoring lung diseases, but challenges remain in terms of research consensus and clinical implementation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Haiman Ma, Liu Yang, Lingli Liu, Ying Zhou, Xiaoya Guo, Shuo Wu, Xiaoxiao Zhang, Xi Xu, Xinyu Ti, Shuoyao Qu
Summary: This study investigated the role of inflammatory biomarkers in distinguishing asthma, asthma-COPD overlap (ACO), and chronic obstructive pulmonary disease (COPD). The results showed that higher platelet, neutrophil-lymphocyte ratio (NLR), and eosinophil-basophil ratio (EBR) indexes were associated with a higher likelihood of asthma and COPD, while higher eosinophil levels were associated with a lower likelihood. Hemoglobin and lymphocyte-monocyte ratio (LMR) were negatively correlated with symptom severity, platelet-lymphocyte ratio (PLR) was negatively correlated with lung function parameters (FEV1/FVC and FEV1% pred), and EBR was positively correlated with FEV1% pred.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Tinne Goos, Laurens J. De Sadeleer, Jonas Yserbyt, Ellen De Langhe, Adriana Dubbeldam, Erik K. Verbeken, Geert M. Verleden, Marie Vermant, Johny Verschakelen, Robin Vos, Birgit Weynand, Stijn E. Verleden, Wim A. Wuyts
Summary: Randomized placebo-controlled trials have shown the effectiveness of antifibrotic treatment in non-IPF progressive fibrosing ILD. However, there is no consensus on how progression should be defined and clinical data of non-IPF fILD patients in real-world settings are scarce. The study identified predictors of mortality and progression in fILD patients, with a high prevalence of progressive fibrosis but a discrepancy between predictors of mortality and progression.
RESPIRATORY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ayazoddin Aunoddin Kazi, B. V. Subba Reddy, L. Ravithej Singh
Summary: Respiratory infections caused by pulmonary inflammation are a leading cause of death worldwide, yet only twenty-seven new drugs have been approved in the past fifty years. This review outlines synthetic approaches and mode of action for these FDA-approved medications used to treat asthma and COPD.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Immunology
Sha-Sha Tao, Fan Cao, Napoleon Bellua Sam, Hong-Miao Li, Ya-Ting Feng, Jing Ni, Peng Wang, Xiao-Mei Li, Hai-Feng Pan
Summary: DKK-1 is known for inhibiting classic Wnt signaling pathways in bone formation and metastasis, but recent studies have shown its roles in bone resorption, immune homeostasis, inflammation, and autoimmune diseases. Research suggests DKK-1 could be a biomarker for autoimmune diseases and a potential treatment target.
CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Madhur D. Shastri, Venkata Sita Rama Raju Allam, Shakti D. Shukla, Niraj Kumar Jha, Keshav Raj Paudel, Gregory M. Peterson, Rahul P. Patel, Philip M. Hansbro, Dinesh K. Chellappan, Kamal Dua
Summary: Non-communicable, chronic respiratory diseases affect millions worldwide, with microbial infections exacerbating the course and increasing risk of morbidity and mortality. Interleukin-13 is believed to play a key role in exacerbating inflammation during viral infections, particularly in those with pre-existing CRDs.
Article
Respiratory System
Sara Melo-Dias, Carla Valente, Lilia Andrade, Alda Marques, Ana Sousa
Summary: Individuals with COPD have been found to have a distinct oral microbiota composition, with differences in bacterial profiles compared to healthy individuals. Salivary bacteria show associations with COPD, particularly in relation to severe exacerbations, suggesting the potential use of saliva as a non-invasive specimen for future studies on respiratory diseases like COPD.
RESPIRATORY RESEARCH
(2022)
Article
Physiology
Kaveh Moghbeli, Eleanor Valenzi, Rachel Naramore, John Charles Sembrat, Kong Chen, Mauricio M. Rojas, Sally E. Wenzel, Robert Lafyatis, Brian Modena, Nathaniel M. Weathington
Summary: The study analyzed BAL samples from Severe Asthma patients and found suppression of the BALcAMP gene module, influenced by various factors. The results showed that the BALcAMP gene network expression was suppressed in multiple cell populations, particularly significantly in macrophages.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Immunology
Lucia Cremades-Jimeno, Maria Angeles de Pedro, Maria Lopez-Ramos, Joaquin Sastre, Pablo Minguez, Ignacio Mahillo Fernandez, Selene Baos, Blanca Cardaba
Summary: This study prioritized biomarkers based on their functionality associated with each respiratory disease and specific molecular motifs, improving the definition and usefulness of new molecular biomarkers. The research analyzed biomarker candidates for asthma and allergies to establish comprehensive disease models, emphasizing the importance of specificity and mechanistic implications for personalized diagnostics.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Medicinal
Katarzyna Kaczynska, Monika Jampolska, Piotr Wojciechowski, Dorota Sulejczak, Kryspin Andrzejewski, Dominika Zajac
Summary: Lactoferrin (LF) is a versatile glycoprotein with various properties that can be used to treat lung diseases. Although in vitro and in vivo studies show significant potency of LF in treating lung diseases, its effectiveness in human studies is only confirmed for respiratory tract infections. For other diseases such as lung cancer, COVID-19, and sepsis, the reports are conflicting, and there is a lack of conclusive human studies on the beneficial effects of LF.
Article
Endocrinology & Metabolism
Si-jin Zhang, Xian-zheng Qin, Jie Zhou, Bin-feng He, Surendra Shrestha, Jing Zhang, Wei-ping Hu
Summary: The relationship between obesity and COPD is paradoxical and complex. This study aims to explore their inherent associations from clinical, genetic, and animal levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Respiratory System
Franck F. Rahaghi, Vivien M. Hsu, Robert J. Kaner, Maureen D. Mayes, Ivan O. Rosas, Rajan Saggar, Virginia D. Steen, Mary E. Strek, Elana J. Bernstein, Nitin Bhatt, Flavia V. Castelino, Lorinda Chung, Robyn T. Domsic, Kevin R. Flaherty, Nishant Gupta, Bashar Kahaleh, Fernando J. Martinez, Lee E. Morrow, Teng Moua, Nina Patel, Oksana A. Shlobin, Brian D. Southern, Elizabeth R. Volkmann, Dinesh Khanna
Summary: This study aimed to develop consensus recommendations on the management of patients with SSc-ILD based on expert physician insights. A modified Delphi process was completed by pulmonologists and rheumatologists, resulting in the generation of a management algorithm that addresses the current gaps in management approaches.
RESPIRATORY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mahsa Torkamanian-Afshar, Sajjad Nematzadeh, Maryam Tabarzad, Ali Najafi, Hossein Lanjanian, Ali Masoudi-Nejad
Summary: Using a genetic algorithm and binding predictor fitness function, we successfully designed an aptamer pool against aminopeptidase N (CD13) biomarker in silico. The designed aptamers based on known RNA-protein complexes showed 3 to 6 times higher fitness scores than parent oligonucleotides. The reliability of the obtained sequences was confirmed through docking and molecular dynamic simulation.
MOLECULAR DIVERSITY
(2021)
Article
Biology
Vahid Ghafarpour, Mohammad Khansari, Ali M. Banaei-Moghaddam, Ali Najafi, Ali Masoudi-Nejad
Summary: Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer worldwide, accounting for approximately 6% of all cases and around 2% of all cancer deaths. Despite advancements in treatment, survival rates remain low. Epigenetic modifications have associations with biological processes and cancer, suggesting a need for a more systematic approach to identify potential targets and effective therapies.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Solmaz Khalighfard, Mohammad Reza Kalhori, Taghi Amiriani, Amirhoushang Poorkhani, Vahid Khori, Ebrahim Esmati, Marzieh Lashkari, Ali Najafi, Ali Mohammad Alizadeh
Summary: "The study revealed that the interactions of miRNA/mRNA in plasma of rectal cancer patients during radiotherapy could serve as a potential diagnostic tool to track the recovery process and evaluate the efficacy of standard treatments."
Article
Biochemistry & Molecular Biology
Mohammad Moradi, Reza Golmohammadi, Ali Najafi, Mehrdad Moosazadeh Moghaddam, Mahdi Fasihi-Ramandi, Reza Mirnejad
Summary: The study aimed to suppress the activity of a critical enzyme in SARS-CoV-2 using plant-derived protease inhibitor peptides, with VcTI identified as a potentially effective inhibitory ligand. Molecular dynamic assay confirmed the stability of the selected receptor and ligand complex, further in vitro and in vivo investigations are needed to verify the therapeutic efficiency of this compound against SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2022)
Article
Genetics & Heredity
Taleb Badri, Masoud Arabfard, Ali Najafi, Gholamreza Farnoosh, Reza Heidari, Zahra Salehi, Said Yaghoob Sehri, Kazem Hassanpour
Summary: Neurodegenerative diseases (NDs) are common disorders affecting over 40 million people worldwide. Multiple Sclerosis (MS) and Parkinson's Disease (PD) are two leading causes of disability and immune system dysregulation. This study aimed to investigate the potential role of common genes between MS and PD as biomarkers for these diseases. By analyzing gene expression data, several common genes between MS and PD were identified. These findings have practical implications for the development of diagnostic strategies and the search for new drugs and drug targets.
Article
Chemistry, Multidisciplinary
Seyed-Hashem Daryabari, Hossein Aghamollaei, Khosrow Jadidi, Ali Najafi, Esmaeil Behmard
Summary: In this study, molecular docking and molecular dynamic simulations were used to investigate the binding of three putative amyloid-binding octapeptides (RVTWEGKF, RGTFEGRF, and RITFEIKF) to mutant gamma-crystallin protein. The results showed that RVTWEGKF had a more favorable binding energy and could reduce the formation of protein dimers. It is proposed that RGTFEGRF should be experimentally tested as a potential treatment for cataract disease.
STRUCTURAL CHEMISTRY
(2023)
Article
Respiratory System
Shahram Parvin, Masoud Arabfard, Ali Ghazvini, Mostafa Ghanei, Ali Najafi
Summary: This study compared the serum proteome of chronic gas-exposed patients and healthy controls, revealing significant differences in protein expression associated with inflammatory and cell adhesion signaling pathways. The findings suggest impaired repair cycles of cell degeneration and regeneration in the injured organs of exposed individuals. The study highlights the role of systems biology in enhancing our understanding of pathophysiological mechanisms and identifying potential disease biomarkers.
BMC PULMONARY MEDICINE
(2022)
Article
Agronomy
Masoud Ghayoumi, Abbasali Emamjomeh, Kaveh Kavousi, Ali Najafi
Summary: This study utilized a metagenomic approach to investigate the differences in rhizosphere microbial community and quality indices of saffron in the Ghayen region of Iran. The results showed that rhizobacteria have a significant impact on enhancing the quality of saffron by improving the plant secondary metabolites.
Article
Chemistry, Multidisciplinary
Reza Mirnejad, Mahdi Fasihi-Ramandi, Esmaeil Behmard, Ali Najafi, Mehrdad Moosazadeh Moghaddam
Summary: All-atom molecular dynamics simulations were used to investigate the molecular mechanism of CM11 activity against Gram-positive and Gram-negative bacterial membranes. The peptide showed stronger and faster binding to the Gram-positive membrane and electrostatic interactions were the main driving force in peptide adsorption and surface localization. Residues W1, K2, K5, K6 and K9 played an important role in the activity of the peptide. These findings provide insights for the design of effective peptides against multidrug-resistant bacteria.
Article
Biochemical Research Methods
Roohallah Mahdi-Esferizi, Behnaz Haji Molla Hoseyni, Amir Mehrpanah, Yazdan Golzade, Ali Najafi, Fatemeh Elahian, Amin Zadeh Shirazi, Guillermo A. Gomez, Shahram Tahmasebian
Summary: P4 medicine is a new approach to diagnosing and predicting diseases on a patient-by-patient basis. Researchers have developed a deep learning model called DeeP4med that can predict the state of the disease based on gene expression data. The model outperforms classic machine learning models in tissue and disease classification.
BMC BIOINFORMATICS
(2023)
Article
Microbiology
Sadaf Najafi, Sadegh Azimzadeh Jamalkandi, Ali Najafi, Jafar Salimian, Ali Ahmadi
Summary: Using integrative and network-based approaches, this study explored the relationships among members of the lung microbial community in lung cancer patients. Differential abundance analyses revealed differences in bacterial taxa between tumor and tumor-adjacent normal tissues. Clustering methods detected distinct modules of bacterial families. The network analysis approach identified key microbial taxa in lung cancer pathogenesis.
Article
Medicine, General & Internal
Masoud E. Razliqi, Ali Najafi, Gholamreaza Olad, Hadi E. G. Ghaleh
Summary: Chicken anemia virus (CAV) is a common immunosuppressive virus in poultry, with its encoded protein Apoptin showing selective activity against tumor cells. In-silico analysis revealed Apoptin's stable structure, making it a promising candidate for therapeutic use as an anti-cancer agent.
ROMANIAN JOURNAL OF MILITARY MEDICINE
(2021)
