Review
Biochemistry & Molecular Biology
Laura Passeri, Fortunato Marta, Virginia Bassi, Silvia Gregori
Summary: Dendritic cells play a crucial role in autoimmune diseases by instructing T cells to respond to antigens, leading to organ damage or promoting immune tolerance. Research on different subsets of human DCs and the regulatory mechanisms associated with tolDC functions is ongoing, along with exploring tolDC-based therapies for treating autoimmune diseases. Continued expansion of research in the area of tolDCs will enhance understanding of the role of DCs in the development and treatment of autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiaolan Zhao, Xun Zhang, Zhao Wu, Jie Mei, Lingling Li, Yujue Wang
Summary: This study investigates the role of miR-135 in the inflammatory response of preeclampsia by modulating PCSK6 and NLRP3. Down-regulation of miR-135 and up-regulation of PCSK6 and NLRP3 were observed in preeclampsia patients. Up-regulating miR-135 or silencing PCSK6 can attenuate inflammation in preeclampsia by limiting NLRP3 inflammasome activation, providing a potential therapeutic target for preeclampsia treatment.
MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Nasrin Aktar, Tingting Chen, Ahmed Moudud, Suowen Xu, Xiaohui Zhou
Summary: Autoimmunity arises from reduced tolerance to self-antigens by the immune system, with antigen-specific immunotherapy showing better effects but facing challenges due to inadequate antigen delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Haosheng Zhang, Liang Ding, Xiaoqing Shi, Wei Mei, Zhengquan Huang, Li Zhang, Xiaochen Li, Bo Xu, Peimin Wang
Summary: The study demonstrated that imperatorin can reduce synovial inflammation and fibrosis, inhibit production of inflammatory mediators and cytokines, and decrease expressions of factors promoting synovial fibrosis.
Article
Immunology
Wei Yuan, Teng Liu, Yuan-yi Wang, Shuang He, Feng Zhang, Xiao-bian Wang, Shi-hua Deng, Ting Zhang, Dong-ming Wu, Ying Xu
Summary: Acute gouty arthritis (AGA) is an inflammatory condition caused by the deposition of monosodium urate (MSU) crystals in joints and periarticular tissues of hyperuricemia patients. This study investigates the therapeutic potential of PP121, a pyroptosis-related compound, on AGA. Treatment with PP121 significantly reduces tissue damage, pro-inflammatory cytokine release, and inflammatory cell infiltration caused by MSU crystals. The study suggests that PP121 promotes degradation of the NLRR3 inflammasome through autophagy, indicating its therapeutic benefits for AGA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Benedikt Kaufmann, Aleksandra Leszczynska, Agustina Reca, Laela M. Booshehri, Janset Onyuru, Zhehao Tan, Alexander Wree, Helmut Friess, Daniel Hartmann, Bettina Papouchado, Lori Broderick, Hal M. Hoffman, Ben A. Croker, Yanfang Peipei Zhu, Ariel E. Feldstein
Summary: This study investigates the activation of NLRP3 inflammasome in neutrophils and its role in liver inflammation and fibrosis. The results show that NLRP3 activation leads to increased production of pro-inflammatory cytokines and chemokines, infiltration of neutrophils and macrophages, and cell death in the liver. Additionally, mutant mice also develop liver fibrosis.
Review
Immunology
Nick Giannoukakis
Summary: Tolerogenic dendritic cells (tDC) have the potential to prevent the progression of autoimmune-driven dysglycemia into insulin-requiring type 1 diabetes (T1D) and preserve β cells. tDC act via multiple layers of immune regulation to suppress effector lymphocytes targeting β cells. It is now appropriate to conduct phase II clinical trials for T1D using well-characterized tDC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Dong-ming Wu, Jing Li, Rong Shen, Jin Li, Ye Yu, Li Li, Shi-hua Deng, Teng Liu, Ting Zhang, Ying Xu, De-gui Wang
Summary: Pyroptosis plays a vital role in radiation-induced inflammation, and micheliolide (MCL) has shown anti-radiation effects in vitro. This study found that MCL can ameliorate radiation-induced enteropathy (RIE) by inducing autophagy and degrading the NLR pyrin domain three inflammasome. MCL may be a novel therapeutic target for RIE.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marija Drakul, Sergej Tomic, Marina Bekic, Dusan Mihajlovic, Milos Vasiljevic, Sara Rakocevic, Jelena Dokic, Nikola Popovic, Dejan Bokonjic, Miodrag Colic
Summary: Sitagliptin has an effect on the differentiation and maturation of human dendritic cells, with decreased expression of some immune activity molecules and increased expression of some tolerogenic molecules. Sitagliptin-treated cells have lower ability to stimulate T-cells and suppress certain T-cell responses while enhancing immunoregulatory responses. This effect may be achieved through the inhibition of NF-kB and p38MAPK expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Dan He, Qiangdongzi Mao, Jialin Jia, Zhiyu Wang, Yu Liu, Tingting Liu, Bangwei Luo, Zhiren Zhang
Summary: This study reveals that the pentose phosphate pathway (PPP) regulates the clearance of tolerogenic apoptotic cells (ACs) and immune tolerance. ACs decrease the levels of PPP-related genes and metabolites in macrophages. The PPP agonist AG1 increases PPP activity but greatly reduces macrophage phagocytosis of ACs and enhances the inflammatory response during efferocytosis. MiR-323-5p regulates the expression of PPP-related genes and its levels increase during efferocytosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Hongxia Li, Lin Xiao, Hui He, Hongmei Zeng, Jingjing Liu, Chunjie Jiang, Guibin Mei, Jiasheng Yu, Hao Chen, Ping Yao, Yuhan Tang
Summary: This study investigates the anti-atherosclerotic properties of quercetin by modulating the Gal-3-NLRP3 pathway, showing promising effects in reducing atherosclerotic lesions. The findings suggest a potential strategy for the prevention and treatment of atherosclerosis using naturally-occurring quercetin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maria Jose Mansilla, Inigo Gonzalez-Larreategui, Neus Figa-Martin, Jaume Barallat, Federico Fondelli, Ares Selles-Rius, Bibiana Quirant-Sanchez, Aina Teniente-Serra, Eva Martinez-Caceres
Summary: The research indicates that the CSF1R-CSF1 signaling is involved in cell metabolic reprogramming, triggering glycolysis to produce high amounts of lactate, which is a novel suppressive mechanism of T cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Lei Wang, Jiangwei Ding, Changliang Zhu, Baorui Guo, Wu Yang, Wenxin He, Xinxiao Li, Yangyang Wang, Wenchao Li, Feng Wang, Tao Sun
Summary: Semaglutide shows inhibitory effects on NLRP3 inflammasome activation and inflammatory cytokine secretion in both in vitro and in vivo inflammation models. It also reduces seizure severity, improves cognitive function, and decreases neuronal apoptosis, possibly through inhibition of NLRP3 inflammasome activation and inflammatory cytokine secretion. Semaglutide may be a novel and promising adjuvant therapeutic for epilepsy and its associated comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Tianfeng Huang, Yinggang Xiao, Yang Zhang, Cunjin Wang, Xiaoping Chen, Yong Li, Yali Ge, Ju Gao
Summary: Central poststroke pain (CPSP) is a central neuropathic pain syndrome that lacks clinical attention. The study found that miR-223 can improve CPSP by inhibiting NLRP3 inflammasome activity.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jaromir Tomasik, Grzegorz Wladyslaw Basak
Summary: Inflammasomes are intracellular complexes that play an important role in promoting inflammatory responses and have been associated with various diseases. Recent studies have focused on their contribution to hematological diseases, with specific inflammasomes being linked to different types of blood cancers. Gene variants of inflammasomes have also been linked to disease susceptibility. Although the understanding of inflammasomes is still incomplete, the available results provide a valuable basis for clinical applications and potential breakthroughs in innovative treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yi Cheng, Rui Sun, Muye He, Miao Zhang, Xinyu Hou, Yuji Sun, Jie Wang, Jiajun Xu, Hai He, Hongtao Wang, Minbo Lan, Yuzheng Zhao, Yi Yang, Xianjun Chen, Feng Gao
Summary: The study presents a novel treatment strategy for overcoming the therapeutic barrier in breast cancer using a combination of a light-switchable transgene system and losartan. The researchers developed a nanoparticle drug delivery system for targeted and responsive delivery of therapeutic genes to tumor sites. In vivo studies showed improved tumor penetration, inhibited tumor growth, and increased survival rate. This combination strategy provides a promising method for clinical treatment of breast cancer.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Geosciences, Multidisciplinary
Chunhui Zhang, Wanyi Zhang, Yan Liu, Jinjiao Yao, Renchao Wan, Huwei Li, Xinyu Hou, Chengjun Zhang
Summary: The grain size analysis and end-member modeling of clastic fractions in the Selin Co basin sedimentary sequence have revealed the variations of aeolian activity in the central Tibetan Plateau since 3,900 cal yr BP. The results indicate that the aeolian activity occurred under dry and cold conditions, with three strong aeolian activity intervals. Comparison with other records suggests that solar insolation, weakening Indian summer monsoon, and the strengthening westerlies have a direct relationship with the aeolian activity in the central Tibetan Plateau.
FRONTIERS IN EARTH SCIENCE
(2022)
Article
Geosciences, Multidisciplinary
Jun Lin, Xinyu Hou, Guojun Cai, Songyu Liu
Summary: This study presents a framework for uncertainty analysis of the ultimate axial bearing capacity of piles evaluated by the UniCone method in layered soils. The effects of spatial variability of CPTU data and variations of empirical correlation coefficients on the ultimate axial bearing capacity of piles are evaluated. The proper identification of different soil units is crucial for estimating the failure probability of pile capacity.
FRONTIERS IN EARTH SCIENCE
(2022)
Article
Geosciences, Multidisciplinary
Zhang Chengjun, Zhang Wanyi, Cheng Dingshu, Yang Na, Hou Xinyu, Li Huwei, Zhang Xiaojing, Ramamoorthy Ayyamperumal
Summary: This study investigates the sediment record of Sugan Lake in the Qaidam Basin to understand the Holocene climate variations in the region. It reveals that during the Holocene Megathermal Maximum, there was high evaporation and sparse terrestrial vegetation due to high temperatures, resulting in a SO42--type water characteristic. After ca. 5800 cal a BP, there was a shift to Cl-type water and intensified aeolian activities. Between 5800 and 3580 cal a BP, a higher lake level and cool and wet conditions were inferred, with the weakening of the East Asian Summer Monsoon (EASM) and intensification of the westerly jet. After 3580 cal a BP, colder and drier conditions prevailed, possibly due to the strengthening of the mid-latitude westerly circulation. However, the EASM briefly prevailed at around 3580-3000 cal a BP and 1800-810 cal a BP. The Little Ice Age fluctuations between 580 and 280 cal a BP were characterized by cold/dry, cold/wet, and cold/dry conditions, accompanied by increased aeolian activities and risen lake levels.
Article
Engineering, Electrical & Electronic
Xinyu Hou, Zhihui Wang, Yugang Su, Zhe Liu, Zhipeng Deng
Summary: This paper proposes a power supply solution for online monitoring equipment in high-voltage transmission lines, utilizing a dual-frequency dual-load multirelay magnetic coupling wireless power transfer (MC-WPT) system with a shared power channel. The MC-WPT system provides selective power distribution for different loads and maintains a constant current output characteristic. By introducing a dual-frequency inverter and compensation network, cross interference is reduced, and operating frequencies with constant current output characteristics are obtained. Experimental results confirm the effectiveness of constant current output characteristics and selective power distribution for the two power channels.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2022)
Review
Chemistry, Physical
Lang Guo, Pengcheng Zuo, Zequn Zhang, Qianwen Zhang, Mengya Zhao, Xinyu Hou, Junsheng Wu, Bowei Zhang
Summary: This study presents the preparation methods and microstructural characteristics of Cu-Ni-Sn alloys, discusses the influence of alloying elements such as Si, Ti, and Nb on their microstructure and properties, and explores the effects of plastic deformation and heat treatment. The findings of this study can provide valuable insight for the development of high-performance Cu-Ni-Sn alloys.
Article
Engineering, Electrical & Electronic
Xinyu Hou, Hongsheng Hu, Yugang Su, Zhe Liu, Zhipeng Deng, Renwei Deng
Summary: A multirelay wireless power transfer (WPT) system with double-sided LCC compensation network is proposed for online monitoring equipment on high-voltage transmission lines. The system achieves constant-voltage or constant-current output characteristics, and does not use ferrite materials. Three working modes are proposed based on the resonance conditions of the compensation networks and relay coils. The CC and CV output characteristics in each mode are analyzed and compared through simulation.
IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS
(2023)
Article
Economics
Xinyu Hou, Puyang Sun
Summary: State monopoly hinders market integration, and the dismantling of the monopoly can promote market integration. This study empirically analyzes the market reform in China's edible salt market, and finds that the dissolution of state monopoly leads to nationwide market integration.
ECONOMICS OF TRANSITION AND INSTITUTIONAL CHANGE
(2023)
Editorial Material
Clinical Neurology
Quan Li, Xinyu Hou, Jun Li, Jia Bian
ACTA NEUROLOGICA BELGICA
(2023)
Article
Mathematics, Interdisciplinary Applications
Liying Li, Xinyu Hou, Lixia Niu
Summary: Based on uncertain market demand, this paper studies the sharing strategy of each main body of the closed-loop supply chain for demand prediction information and introduces the variable of advertising effect into the model. A manufacturer-led Stackelberg game model based on a two-level closed-loop supply chain is constructed. The manufacturer advertising mode and the retailer advertising mode are set up, and the influence of information sharing is discussed in each advertising mode. The results show that certain conditions should be met to achieve a win-win situation by sharing information, and the advertising effect has positive impacts on various aspects of the supply chain.
DISCRETE DYNAMICS IN NATURE AND SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Muye He, Yuji Sun, Yi Cheng, Jie Wang, Miao Zhang, Rui Sun, Xinyu Hou, Jiajun Xu, Hai He, Hongtao Wang, Zeting Yuan, Minbo Lan, Yuzheng Zhao, Yi Yang, Xianjun Chen, Feng Gao
Summary: Individualized immunotherapy using neoantigen-specific T cells has shown promising results in tumor clearance. However, the immunosuppressive tumor microenvironment poses a challenge to achieve complete tumor eradication. In this study, a spatiotemporally controlled transgene system, combined with tumor neoantigen labeling, was developed to enhance immunological function and recruit T cells to infiltrate tumor tissue. The use of a nanoparticle delivery system improved the efficiency of neoantigen delivery and tumor targeting ability. This approach achieved good tumor inhibition and prolonged survival, highlighting its potential for tumor immunotherapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Neurosciences
Qi-Min Zheng, Zi-Rui Zhou, Xin-Yu Hou, Ning Lv, Yu-Qiu Zhang, Hong Cao
Summary: Using RNA sequencing technology, we investigated the transcriptomic profiles in the medial prefrontal cortex (mPFC) of mice with chronic pain. Our findings revealed differentially expressed genes (DEGs) in the ipsilateral and contralateral mPFC of mice with chronic constriction injury (CCI) model, indicating the involvement of immune- and inflammation-related processes. Further analysis showed the enrichment of genes involved in neuroactive ligand-receptor interaction signaling pathway and Parkinson's disease pathway, which are known to be associated with chronic neuralgia and cognitive dysfunction.
NEUROMOLECULAR MEDICINE
(2023)
Article
Construction & Building Technology
Shuangfeng Guo, Bikai Wang, Peng Zhang, Shengnian Wang, Zihao Guo, Xinyu Hou
Summary: This study investigates the influences of key shield parameters on tunneling-induced ground settlements by considering the dynamic excavation process. Advanced machine learning with principal component analysis is used to evaluate the nonlinear relationships between ground settlements and multiple parameters in soil-rock composite ground. Nonlinear relationships of excavation characteristic parameters are developed through correlation analysis to quantify shield machine performance in mixed ground. The predictive model based on Light-GBM shows good agreement with in-site measurements and can be used to optimize excavation schemes.
TUNNELLING AND UNDERGROUND SPACE TECHNOLOGY
(2023)
Article
Environmental Studies
Xueming Li, Yishan Song, He Liu, Xinyu Hou
Summary: In this study, we integrated the enhanced vegetation index, points of interest, surface temperature, and night light data to extract the built-up area in Dalian. The method using the HSI-POI-LST index achieved the highest accuracy and provided richer spatial details compared to other data types. This method offers more choices for assessing small-scale urban built-up areas in future research.
Article
Oncology
Yuexian Wei, Zubiao Niu, Xinyu Hou, Mengzhe Liu, Yuqi Wang, Yongan Zhou, Chenxi Wang, Qunfeng Ma, Yichao Zhu, Xinyue Gao, Peiyun Li, Shuo Gao, Sibo Zhan, Zi Yang, Yanhong Tai, Qiuju Shao, Jianlin Ge, Jilei Hua, Lihua Gao, Qiang Sun, Hong Jiang, Hongyan Huang
Summary: This study investigated the profiling of cell-in-cell structures (CICs) in non-small cell lung cancer (NSCLC) tissues and found that the presence of CICs is associated with the prognosis of NSCLC patients. CICs were more frequently present in adenocarcinoma and lymphocyte-in-tumor (LiT) was more common in the upper lobe of the lung. Univariate and multivariate analyses revealed that heCICs and lymph node invasion were independent factors associated with the overall survival of NSCLC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
