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Invertebrates facing environmental contamination by endocrine disruptors: Novel evidences and recent insights

Journal

MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 504, Issue -, Pages -

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2020.110712

Keywords

Endocrine disruption; Endocrine disrupting chemicals (EDCs); Nuclear receptors; Oestrogeno-mimetics; Ecdysteroids; Juvenile hormone; Omics; Mollusks; Annelids; Arthropods

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The crisis of biodiversity we currently experience raises the question of the impact of anthropogenic chemicals on wild life health. Endocrine disruptors are notably incriminated because of their possible effects on development and reproduction, including at very low doses. As commonly recorded in the field, the burden they impose on wild species also concerns invertebrates, with possible specificities linked with the specific physiology of these animals. A better understanding of chemically-mediated endocrine disruption in these species has clearly gained from knowledge accumulated on vertebrate models. But the molecular pathways specific to invertebrates also need to be reckoned, which implies dedicated research efforts to decipher their basic functioning in order to be able to assess its possible disruption. The recent rising of omics technologies opens the way to an intensification of these efforts on both aspects, even in species almost uninvestigated so far.

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